By Associate Professor John Walter Frew

Journal articles

Pham JP; Staeger R; Frew JW, 2024, 'More data are needed to confirm the utility of screening for atypical fibroxanthoma and pleomorphic dermal sarcoma recurrence', Journal of the American Academy of Dermatology, 90, pp. e171 - e173, http://dx.doi.org/10.1016/j.jaad.2023.11.064

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Alterations to the Hidradenitis Suppurativa Serum Proteome with Spleen Tyrosine Kinase Antagonism: Proteomic Results from a Phase 2 Clinical Trial', Journal of Investigative Dermatology, 144, pp. 786 - 793.e1, http://dx.doi.org/10.1016/j.jid.2023.10.005

Pham JP; Jepsen R; Frew JW, 2024, 'Comment on Kridin et al.—Considering both relative and absolute risk differences in infection risk between biologics classes in patients with psoriasis', Journal of the European Academy of Dermatology and Venereology, 38, pp. e351 - e353, http://dx.doi.org/10.1111/jdv.19615

Wainman HE; Chandran NS; Frew JW; Garg A; Gibbons A; Gierbolini A; Horvath B; Jemec GB; Kirby B; Kirby J; Lowes MA; Martorell A; McGrath BM; Naik HB; Oon HH; Prens E; Sayed CJ; Thorlacius L; Van Der Zee HH; Villumsen B; Ingram JR, 2024, 'Global consensus process to establish a core dataset for hidradenitis suppurativa registries', British Journal of Dermatology, 190, pp. 510 - 518, http://dx.doi.org/10.1093/bjd/ljad454

Flora A; Pham J; Jepsen R; Frew JW, 2024, 'The serum proteome of pyoderma gangrenosum is more expansive than that of hidradenitis suppurativa', Journal of the European Academy of Dermatology and Venereology, 38, pp. e348 - e350, http://dx.doi.org/10.1111/jdv.19611

Pham JP; Rosenø NAL; Roccuzzo G; Saal RC; Egeberg A; Ring HC; Frew JW, 2024, 'Drug Survival of Biologics in Hidradenitis Suppurativa: A Systematic Review and Meta-Analysis.', J Am Acad Dermatol, http://dx.doi.org/10.1016/j.jaad.2024.03.028

Krueger JG; Frew J; Jemec GBE; Kimball AB; Kirby B; Bechara FG; Navrazhina K; Prens E; Reich K; Cullen E; Wolk K, 2024, 'Hidradenitis suppurativa: New insights into disease mechanisms and an evolving treatment landscape', British Journal of Dermatology, 190, pp. 149 - 162, http://dx.doi.org/10.1093/bjd/ljad345

Flora A; Jepsen R; Pham J; Frew JW, 2024, 'Rapid Attenuation of B-Cell and IFN-γ–Associated Chemokines in Clinical Responders to Jak Inhibition with Upadacitinib in Hidradenitis Suppurativa', Journal of Investigative Dermatology, 144, pp. 416 - 419.e5, http://dx.doi.org/10.1016/j.jid.2023.07.023

Garcia-Doval I; Rajan N; Hunter H; Frew J; Naldi L; Mellerio JE; Hay R, 2024, 'Clinical reports: the overarching home for case series and case reports in the BJD', British Journal of Dermatology, 190, pp. 1 - 2, http://dx.doi.org/10.1093/bjd/ljad301

Greenlund L; Herzog C; Wendland Z; Rypka K; Frew JW; Kirby JS; Alavi A; Khalid B; Lowes MA; Garg A; Marzano AV; Zouboulis CC; Tzellos T; Jaleel T; Goldfarb N, 2024, 'Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients', Journal of the European Academy of Dermatology and Venereology, http://dx.doi.org/10.1111/jdv.19999

Navrazhina K; Garcet S; Williams SC; Gulati N; Kiecker F; Frew JW; Mitsui H; Krueger JG, 2024, 'Laser capture microdissection provides a novel molecular profile of human primary cutaneous melanoma', Pigment Cell and Melanoma Research, 37, pp. 81 - 89, http://dx.doi.org/10.1111/pcmr.13121

Flora A; Jepsen R; Kozera EK; Woods JA; Cains GD; Radzieta M; Jensen SO; Malone M; Frew JW, 2024, 'Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism', Experimental Dermatology, 33, http://dx.doi.org/10.1111/exd.14894

Pham JP; Flora A; Frew JW, 2024, 'Understanding multi-kinase inhibitor-associated cutaneous ulcers may provide molecular insights into the aetiology of pyoderma gangrenosum: A comment on Jeon et al.', Australasian Journal of Dermatology, http://dx.doi.org/10.1111/ajd.14221

Frew JW; Piguet V, 2023, 'Attenuated PBMC Cytokine Production in Hidradenitis Suppurativa May Be Indicative of Cellular Exhaustion, Providing Novel Biomarkers, and Future Therapeutic Potential', Journal of Investigative Dermatology, 143, pp. 2334 - 2337, http://dx.doi.org/10.1016/j.jid.2023.05.020

Pham JP; Wark KJL; Woods J; Frew JW, 2023, 'Resident cutaneous memory T cells: a clinical review of their role in chronic inflammatory dermatoses and potential as therapeutic targets', British Journal of Dermatology, 189, pp. 656 - 663, http://dx.doi.org/10.1093/bjd/ljad303

Kozera EK; Porter M; Paek SY; Mintoff D; McMeniman E; Oon HH; Chandran NS; Glasenhardt K; Ring HC; Frew JW, 2023, 'Infectious Disease Screening Prior to Systemic Immunomodulatory Therapy in Hidradenitis Suppurativa: Consensus Guidelines from the Asia-Pacific Hidradenitis Suppurativa Foundation.', Dermatology, http://dx.doi.org/10.1159/000534575

Flora A; Jepsen R; Kozera EK; Woods JA; Cains GD; Radzieta M; Jensen SO; Malone M; Frew JW, 2023, 'Human dermal fibroblast subpopulations and epithelial mesenchymal transition signals in hidradenitis suppurativa tunnels are normalized by spleen tyrosine kinase antagonism in vivo', PLoS ONE, 18, pp. e0282763, http://dx.doi.org/10.1371/journal.pone.0282763

Jepsen R; Edwards C; Flora A; Kozera E; Frew JW, 2023, 'A proof-of-concept open-label clinical trial of spleen tyrosine kinase antagonism using fostamatinib in moderate-to-severe hidradenitis suppurativa', Journal of the American Academy of Dermatology, 89, pp. 694 - 702, http://dx.doi.org/10.1016/j.jaad.2023.05.076

Pham JP; Dwyer L; Phan K; Menzies AM; Frew JW, 2023, 'Efficacy of topical diphencyprone for melanoma in-transit metastases: a systematic review and meta-analysis', Melanoma Research, 33, pp. 434 - 436, http://dx.doi.org/10.1097/CMR.0000000000000914

Ng MSP; Lim JG; Koh JMY; Lee SY; Seah CHX; Chang SJY; Tan JTA; Tan VWS; Kumar DS; Choi ECE; Jemec G; Frew J; Seow WJ; Chandran NS, 2023, 'Knowledge, attitudes, and perceptions of hidradenitis suppurativa among young adults in Singapore', JAAD International, 12, pp. 72 - 80, http://dx.doi.org/10.1016/j.jdin.2023.03.010

Mintoff D; Agius R; Benhadou F; Das A; Frew JW; Pace NP, 2023, 'Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain', Clinical and Experimental Dermatology, 48, pp. 984 - 990, http://dx.doi.org/10.1093/ced/llad182

Pham JP; Frew JW, 2023, 'Reply to Tilotta and Bongiorno: Considering the role of resident cutaneous memory T-cell suppression in providing durable atopic dermatitis remission', Journal of the European Academy of Dermatology and Venereology, 37, pp. e1173 - e1174, http://dx.doi.org/10.1111/jdv.19179

Xu J; Gill K; Flora A; Kozera E; Frew JW, 2023, 'The impact of psoriasis biologic therapy on HIV viral load and CD4⁺ cell counts in HIV-positive individuals: A real-world cohort study', Journal of the European Academy of Dermatology and Venereology, 37, pp. 1659 - 1663, http://dx.doi.org/10.1111/jdv.19020

Flora A; Kozera E; Frew JW, 2023, 'Treatment of alopecia areata with the janus kinase inhibitor upadacitinib: A retrospective cohort study', Journal of the American Academy of Dermatology, 89, pp. 137 - 138, http://dx.doi.org/10.1016/j.jaad.2022.12.056

Flora A; Kozera EK; Jepsen R; Gill K; Xu J; Frew JW, 2023, 'Baseline clinical, hormonal and molecular markers associated with clinical response to IL-23 antagonism in hidradenitis suppurativa: A prospective cohort study', Experimental Dermatology, 32, pp. 869 - 877, http://dx.doi.org/10.1111/exd.14789

Selvaraj KJ; Stewart T; Frew JW, 2023, 'Maintenance of response to dupilumab in prurigo nodularis: A retrospective cohort study', JAAD International, 11, pp. 143 - 144, http://dx.doi.org/10.1016/j.jdin.2023.02.006

Pham JP; Yang A; Frew JW, 2023, 'Academic dermatology in Australia and New Zealand between 2017 and 2022: A cross-sectional bibliometric analysis', Australasian Journal of Dermatology, 64, pp. 213 - 220, http://dx.doi.org/10.1111/ajd.14025

Frew JW, 2023, 'In search of therapeutic biomarkers to interleukin-23 antagonism in hidradenitis suppurativa', British Journal of Dermatology, 188, pp. 588 - 589, http://dx.doi.org/10.1093/bjd/ljad027

Flora A; Frew JW, 2023, 'Angiotensin-converting enzyme 2 expression is elevated in tissue of hidradenitis suppurativa and pyoderma gangrenousm and demonstrates a different pattern of expression to psoriasis vulgaris', Journal of the European Academy of Dermatology and Venereology, 37, pp. e372 - e374, http://dx.doi.org/10.1111/jdv.18543

Frew JW, 2023, 'Monkeypox: Cutaneous clues to clinical diagnosis', Journal of the American Academy of Dermatology, 88, pp. 698 - 700, http://dx.doi.org/10.1016/j.jaad.2022.08.048

Gill K; Xu J; Kozera E; Stewart T; Flora A; Frew JW, 2023, 'Strongyloides screening prior to dupilumab therapy in atopic dermatitis: a retrospective cohort study evaluating screening utility', British Journal of Dermatology, 188, pp. 294 - 295, http://dx.doi.org/10.1093/bjd/ljac060

Kozera E; Flora A; Stewart T; Gill K; Xu J; De La Vega MA; Frew JW, 2023, 'Dupilumab-associated head and neck dermatitis resolves temporarily with itraconazole therapy and rapidly with transition to upadacitinib, with Malassezia-specific immunoglobulin E levels mirroring clinical response', Journal of the American Academy of Dermatology, 88, pp. 255 - 257, http://dx.doi.org/10.1016/j.jaad.2022.05.021

Flora A; Jepsen R; Kozera E; Woods J; Cains G; Radzieta M; Malone M; Frew JW, 2023, '1323 Human dermal fibroblasts and mast cell populations are altered in hidradenitis suppurativa, with epithelial-mesenchymal-transition signals ameliorated by spleen tyrosine kinase antagonism.', Journal of Investigative Dermatology, 143, pp. S227 - S227, http://dx.doi.org/10.1016/j.jid.2023.03.1339

Jepsen R; Flora A; Kozera E; Frew JW, 2023, 'LB1700 SYK antagonism in hidradenitis suppurativa demonstrates clinical efficacy with grearter response in B-cell predominant disease: Results of a open-label, proof-of-concept phase 2 clinical trial', Journal of Investigative Dermatology, 143, pp. B15 - B15, http://dx.doi.org/10.1016/j.jid.2023.06.074

Tatian A; Bordbar S; Sarkissian SD; Woods JA; Cains GD; Chong CW; Mariño E; Frew JW, 2022, 'Adalimumab therapy is associated with increased faecal short chain fatty acids in hidradenitis suppurativa', Experimental Dermatology, 31, pp. 1872 - 1880, http://dx.doi.org/10.1111/exd.14665

Kozera E; Flora A; Frew JW, 2022, 'Real-world safety and clinical response of Janus kinase inhibitor upadacitinib in the treatment of hidradenitis suppurativa: A retrospective cohort study', Journal of the American Academy of Dermatology, 87, pp. 1440 - 1442, http://dx.doi.org/10.1016/j.jaad.2022.07.047

Mintoff D; Benhadou F; Pace NP; Frew JW, 2022, 'Metabolic syndrome and hidradenitis suppurativa: epidemiological, molecular, and therapeutic aspects', International Journal of Dermatology, 61, pp. 1175 - 1186, http://dx.doi.org/10.1111/ijd.15910

Ring HC; Yao Y; Maul JT; Ingram JR; Frew JW; Thorsen J; Nielsen ML; Wu JJ; Thyssen JP; Thomsen SF; Egeberg A, 2022, 'The road to biologics in patients with hidradenitis suppurativa: a nationwide drug utilization study*', British Journal of Dermatology, 187, pp. 523 - 530, http://dx.doi.org/10.1111/bjd.21673

Ring HC; Frew JW; Thyssen JP; Egeberg A; Thomsen SF, 2022, 'Can we increase the drug survival time of biologic therapies in hidradenitis suppurativa?', Clinical and Experimental Dermatology, 47, pp. 1585 - 1586, http://dx.doi.org/10.1111/ced.15232

Navrazhina K; Frew JW; Grand D; Williams SC; Hur H; Gonzalez J; Garcet S; Krueger JG, 2022, 'Interleukin-17RA blockade by brodalumab decreases inflammatory pathways in hidradenitis suppurativa skin and serum', British Journal of Dermatology, 187, pp. 223 - 233, http://dx.doi.org/10.1111/bjd.21060

Ring HC; Thorsen J; Fuursted K; Bjarnsholt T; Bay L; Egeberg A; Ingham AC; Vedel Nielsen H; Frew JW; Saunte DML; Thomsen SF; Jemec GB, 2022, 'Amplicon sequencing demonstrates comparable follicular mycobiomes in patients with hidradenitis suppurativa compared with healthy controls', Journal of the European Academy of Dermatology and Venereology, 36, pp. e580 - e583, http://dx.doi.org/10.1111/jdv.18075

Rick JW; De DR; Shih T; Alavi A; Kirby JS; Naik HB; Frew JW; Sayed CJ; Hsiao JL; Shi VY, 2022, 'Guidance on COVID-19 Vaccination in Hidradenitis Suppurativa Patients: A Modified Delphi Consensus of Experts', Skin Appendage Disorders, 8, pp. 287 - 290, http://dx.doi.org/10.1159/000521268

Flora A; Frew JW, 2022, 'A case series of early biologic therapy in guttate psoriasis: Targeting resident memory T cell activity as a potential novel therapeutic modality', JAAD Case Reports, 24, pp. 82 - 87, http://dx.doi.org/10.1016/j.jdcr.2022.04.019

Kozera E; Stewart T; Gill K; De La Vega MA; Frew JW, 2022, 'Dupilumab-associated head and neck dermatitis is associated with elevated pretreatment serum Malassezia-specific IgE: a multicentre, prospective cohort study', British Journal of Dermatology, 186, pp. 1050 - 1052, http://dx.doi.org/10.1111/bjd.21019

Kozera EK; Kossard S; Frew JW, 2022, 'Extramammary Paget's disease Harbinger of internal malignancy', Australian Journal of General Practice, 51, pp. 351 - 352, http://dx.doi.org/10.31128/AJGP-05-21-5981

Navrazhina K; Renert-Yuval Y; Frew JW; Grand D; Gonzalez J; Williams SC; Garcet S; Krueger JG, 2022, 'Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa*', British Journal of Dermatology, 186, pp. 684 - 693, http://dx.doi.org/10.1111/bjd.20642

Flora A; Kozera E; Frew JW, 2022, 'Pyoderma gangrenosum: A systematic review of the molecular characteristics of disease', Experimental Dermatology, 31, pp. 498 - 515, http://dx.doi.org/10.1111/exd.14534

Frew JW, 2022, 'Autoantibody-Mediated Macrophage Responses Provide the Missing Link between Innate and Adaptive Immune Dysfunction in Hidradenitis Suppurativa', Journal of Investigative Dermatology, 142, pp. 747 - 749, http://dx.doi.org/10.1016/j.jid.2021.08.400

Frew JW, 2022, 'Dermatology and wound research: Targeting inflammation through cooperation and collaboration', Wound Practice and Research, 30, pp. 5, http://dx.doi.org/10.33235/wpr.30.1.5

Der Sarkissian S; Hessam S; Kirby JS; Lowes MA; Mintoff D; Naik HB; Ring HC; Suyien NC; Frew JW, 2022, 'Identification of Biomarkers and Critical Evaluation of Biomarker Validation in Hidradenitis Suppurativa: A Systematic Review', JAMA Dermatology, 158, pp. 300 - 313, http://dx.doi.org/10.1001/jamadermatol.2021.4926

Back to profile page