By Associate Professor Laurence P. G. Wakelin

Journal articles

Searcy M; McClean S; Madden B; Wakelin L, 1997, 'Bleomycin mimics. Design and synthesis of an acridine derivative which cleaves DNA in a sequence-neutral manner.', Journal of the Chemical Society, Perkin Transactions 2, pp. 523 - 532

Wilcock DJ; Adams A; Cardin CJ; Wakelin L, 1996, 'Crystal and molecular structure of the DNA octanucleotide d(ACGTACGT)2.', Acta Crystallographica D, 52, pp. 481 - 485

Searcy M; Martin PN; Howarth N; Madden B; Wakelin L, 1996, 'DNA threading agents: Effect of sidechain bulk on DNA binding and cytotoxicity of 9-anilinoacridine-4-carboxamides.', Bioorganic and Medicinal Chemistry Letters, 6, pp. 1831 - 1836

Webster LK; Hillcoat BL; Roos IAG; Wakelin LPG; Deacon GB; Buxton DP; James AM; Thomson RJ; Williams TL, 1992, 'Cis-Bis(pyridine)platinum(II) Organoamides with Unexpected Growth Inhibition Properties and Antitumor Activity', Journal of Medicinal Chemistry, 35, pp. 3349 - 3353, http://dx.doi.org/10.1021/jm00096a007

Deacon G; Webster L; Buxton D; Hillcoat B; James A; Roos I; Thomson R; Wakelin L; Williams T, 1992, 'Cis-Dipyridineplatinum(II) organoamides with unexpected growth inhibition properties and antitumour activity.', Journal Medicinal Chemistry, 35, pp. 3349 - 3353

Lee H; Palmer B; Baguley BC; Mcfadyen DW; Wickham G; Thorsborn-Palmer D; Wakelin L; Denny WA, 1992, 'DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of cis-ethane-1,2-diamminodichloro-platinum (II).', Journal Medicinal Chemistry, 35, pp. 2983 - 2987

Bailly C; Denny WA; Mellor E; Wakelin L; Waring M, 1992, 'Sequence specificity of the binding of antitumour amsacrine-4-carboxamides to DNA studied by DNase I footprinting.', Biochemistry, 31, pp. 3514 - 3524

Palmer B; Wickham G; McFadyen DW; Craik D; Wakelin L; Baguley BC; Denny WA, 1992, 'Synthesis, DNA binding interactions and biological activity of bis platinum (II) complexes of N,N,N',N'-tetrakis(2-aminoethyl)-diamines.', Anti-Cancer Drug Design, 7, pp. 385 - 401

Searle M; Bicknell W; Wakelin L; Denny WA, 1991, 'Anthracycline antibiotic arugomycin binds in both grooves of the DNA helix simultaneously: an NMR and molecular modelling study.', Nucleic Acids Research, 19, pp. 2897 - 2906

Wickham G; Prakash AS; Wakelin L; McFadyen DW, 1991, 'DNA-binding properties and antitumour activity of monofunctional alkylating groups attached to the DNA-intercalating chromophore phenanthridine: n-bromo-alkylphenanthridinium bromides.', Biochimica Biophysica Acta, 1073, pp. 528 - 537

Plummer S; Parker N; De Kretser T; Wakelin L, 1991, 'Selective inhibition of c-myc and c-myb transcription by antitumour anthracyclines in human tumour cells.', Journal of Cellular Pharmacology, 2, pp. 248 - 256

Prakash AS; Valu K; Wakelin L; Woodgate P; Denny WA, 1991, 'Synthesis and antitumour activity of the spatially-separated mustard bis-N,N'-[3-(N-(2-chloroethyl)-N-ethyl)amino-5-((N,N-dimethylamino)-methyl)aminophenyl]-1,4-benzenedicarboxamide, which alkylates DNA exclusively at adenines in the minor groove.', Anti-Cancer Drug Design, 6, pp. 195 - 206

Gourdie T; Prakash AS; Wakelin L; Woodgate P; Denny WA, 1991, 'Synthesis and evaluation of DNA-targeted spatially-separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability', Journal Medicinal Chemistry, 34, pp. 240 - 248

Bray AM; Kelly DP; Mack OLP; Martin RF; Wakelin LPG, 1990, 'DNA-Binding Compounds. III. Synthesis of a Peptide-Linked Binuclear Platinum(II)-Terpyridine Complex', Australian Journal of Chemistry, 43, pp. 629 - 634, http://dx.doi.org/10.1071/CH9900629

Searle M; Wakelin L, 1990, 'Conformation and dynamics of the deoxyribose rings in the (nogalamycin)2/d(GCATGC)2 complex studied in solution by 1H NMR spectroscopy.', Biochemical Journal, 269, pp. 341 - 346

Prakash AS; Denny WA; Wakelin L, 1990, 'Differences in sequence selectivity of DNA alkylation by isomeric intercalating aniline mustards.', Chemistry-Biology Interactions, 76, pp. 241 - 248

Gourdie T; Valu K; Gravatt G; Boritzki T; Baguley BC; Wakelin L; Wilson W; Woodgate P; Denny WA, 1990, 'DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard', Journal Medicinal Chemistry, 33, pp. 1177 - 1186

Palmer B; Lee H; Johnson P; Baguley BC; Wickham G; Wakelin L; McFadyen DW; Denny WA, 1990, 'DNA-directed alkylating agents. 2. Synthesis and biological activity of platinum complexes linked to 9-anilinoacridine.', Journal Medicinal Chemistry, 33, pp. 3008 - 3014

Valu K; Gourdie T; Boritzki T; Gravatt G; Baguley BC; Wilson W; Wakelin L; Woodgate P; Denny WA, 1990, 'DNA-directed alkylating agents. 3. Structure activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain.', Journal Medicinal Chemistry, 33, pp. 3014 - 3019

Prakash AS; Denny WA; Gourdie T; Valu K; Woodgate P; Wakelin L, 1990, 'DNA-directed alkylating ligands as potential antitumour agents: sequence specificity of alkylation by intercalating aniline mustards', Biochemistry, 29, pp. 9799 - 9807

McFadyen DW; Sotirellis N; Denny WA; Wakelin L, 1990, 'Interaction of substituted and rigidly-linked diquinolines with DNA.', Biochimica Biophysica Acta, 1048, pp. 50 - 58

Wakelin L; Chetcuti P; Denny WA, 1990, 'Kinetic and equilibrium studies of amsacrine-4-carboxamides: a class of asymmetrical DNA intercalating agent which must bind by threading through the DNA helix.', Journal Medicinal Chemistry, 33, pp. 2039 - 2044

Denny WA; Wakelin L, 1990, 'Kinetics of the binding of mitoxantrone, ametantrone and analogues to DNA: relationship to binding mode and antitumour activity.', Anti-Cancer Drug Design, 5, pp. 189 - 200

Roberts A; Denny WA; Wakelin L; Anderson B; Wilson W, 1990, 'Radio-sensitisation of mammalian cells in vitro by nitroacridines', Radiation Research, 123, pp. 153 - 164

Searle M; Wakelin L, 1990, 'Sequence-specific conformation of a DNA decamer containing an adenine tract studied in solution by 1H NMR spectroscopy.', Biochimica Biophysica Acta, 1049, pp. 69 - 77

Bray A; Kelly D; Mack P; Martin R; Wakelin L, 1990, 'Synthesis of a peptide-linked binuclear platinum (II) terpyridine complex', Australian Journal Chemistry, 43, pp. 629 - 634

Searle M; Hall J; Kyratsis L; Wakelin L, 1989, 'Didemnin B: conformation and dynamics of an antitumour and antiviral depsipeptide studied in solution by 1H and 13C NMR.', International Journal of Peptide and Protein Research, 34, pp. 445 - 454

Searle M; Hall J; Denny WA; Wakelin L, 1989, 'Interaction of the antitumour antibiotic luzopeptin with the hexanucleotide d(5'-GCATGC)2: one and two-dimensional NMR studies.', Biochemical Journal, 259, pp. 433 - 441

Searle M; Hall J; Wakelin L, 1988, '1H and 13C NMR studies of the antitumour antibiotic luzopeptin: resonance assignments, conformation and flexibility in solution.', Biochemical Journal, 256, pp. 271 - 278

Mcfadyen DW; Denny WA; Wakelin L, 1988, 'Alkyl-linked diquinolines are monofunctional AT-selective DNA intercalating agents.', FEBS Letters, 228, pp. 235 - 240

Searle M; Hall J; Denny WA; Wakelin L, 1988, 'NMR studies of the interaction of the antibiotic nogalamycin with the hexadeoxyribonucleotide duplex d(5'-GCATGC)2.', Biochemistry, 27, pp. 4340 - 4349

Brownlee R; McFadyen DW; O'Connor M; Rook T; Roos I; Wakelin L, 1987, 'An NMR study of substituent effects in platinum (II) intercalating agents.', Magnetic Resonance in Chemistry, 25, pp. 492 - 496

Mcfadyen DW; Wakelin L; Roos I; Hillcoat B, 1987, 'Binding of dimeric platinum (II) terpyridine complexes to DNA.', Biochemical Journal, 242, pp. 177 - 183

Mack P; Kelly D; Martin R; Wakelin L, 1987, 'DNA-binding compounds. II. Synthesis of a peptide-linked triacridine.', Australian Journal of Chemistry, 40, pp. 97 - 105

Denny WA; Wakelin L, 1987, 'Mode and kinetics of DNA binding of the antitumour agent bisantrene.', Anti-Cancer Drug Design, 2, pp. 71 - 77

Wakelin L; Atwel G; Rewcastle ; Denny WA, 1987, 'Relationships between DNA binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumour agent.', Journal Medicinal Chemistry, 30, pp. 855 - 861

Mcfadyen DW; Wakelin L; Roos I; Hillcoat B, 1986, 'Binuclear platinum (II) terpyridine complexes: a new class of bifunctional DNA intercalating agent.', Biochemical Journal, 238, pp. 757 - 763

Adams A; Jarrott B; Denny WA; Wakelin L, 1986, 'Differences between central and peripheral alpha-adrenoceptors revealed using binuclear ligands.', European Journal of Pharmacology, 127, pp. 27 - 35

Denny WA; Roos I; Wakelin L, 1986, 'Inter-relationships between antitumour activity, DNA breakage and DNA binding kinetics for 9-aminoacridinecarboxamide antitumour agents.', Anti-Cancer Drug Design, 1, pp. 141 - 146

Denny WA; Wakelin L, 1986, 'Kinetic and equilibrium studies of the interaction of amsacrine and anilino-ring substituted analogues with DNA.', Cancer Research, 46, pp. 1717 - 1721

Wakelin L, 1986, 'Polyfunctional DNA intercalating agents.', Medicinal Research Reviews, 6, pp. 275 - 340

KELLY DP; MACK PO; MARTIN RF; WAKELIN LPG, 1985, 'DNA‐binding compounds – synthesis and intercalating properties of a peptide‐diamino diacridine', International Journal of Peptide and Protein Research, 26, pp. 400 - 406, http://dx.doi.org/10.1111/j.1399-3011.1985.tb01006.x

Kelly D; Mack P; Martin R; Wakelin L, 1985, 'A linear peptide as linker chain in polyfunctional DNA-binding agents. Synthesis of a peptide diamino bisacridine.', International Journal of Peptide and Protein Research, 26, pp. 400 - 406

Mcfadyen DW; Wakelin L; Roos I; Leopold V, 1985, 'Activity of platinum (II) intercalating agents against murine leukaemia L1210.', Journal Medicinal Chemistry, 28, pp. 1113 - 1116

Roos I; Wakelin L; Hakkennes J; Coles J, 1985, 'Collection and analysis of kinetic data from a stopped-flow spectrophotometer using a microcomputer.', Analytical Biochemistry, 146, pp. 287 - 298

Adams A; Jarrott B; Elmes B; Denny WA; Wakelin L, 1985, 'Interaction of DNA-intercalating antitumour agents with adrenoceptors.', Molecular Pharmacology, 27, pp. 480 - 492

Denny WA; Atwel G; Willmott ; Wakelin L, 1985, 'Interaction of paired homologous series of diacridines and triacridines with deoxyribonucleic acid.', Journal of Biophysical Chemistry, 22, pp. 17 - 26

Roos I; Wakelin L; Henry S, 1985, 'Intracellular DNA damage produced by a series of diacridines.', Biochemical Journal, 226, pp. 175 - 182

Denny WA; Atwel G; Baguley BC; Wakelin L, 1985, 'Potential antitumour agents. Part 44. Synthesis and antitumour activity of new classes of diacridines: the importance of linker chain rigidity for DNA-binding kinetics and antitumour activity.', Journal Medicinal Chemistry, 28, pp. 1568 - 1574

Wakelin L; McFadyen DW; Walpole A; Roos I, 1984, 'Interaction of phenylthiolato (2,2',2''-terpyridine) platinum (II) cation with DNA.', Biochemical Journal, 222, pp. 203 - 215

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