By Associate Professor Orazio Vittorio

Journal articles

Poursani E; Cirillo G; Curcio M; Vittorio O; De Luca M; Leggio A; Nicoletta FP; Iemma F, 2024, 'Dual-responsive chondroitin sulfate self-assembling nanoparticles for combination therapy in metastatic cancer cells', International Journal of Pharmaceutics: X, 7, http://dx.doi.org/10.1016/j.ijpx.2024.100235

Shai-Hee T; Jue TR; Cazzoli R; Rouaen JR; Michniewicz F; Bell J; Gargett T; Brown MP; Vittorio O, 2024, 'Abstract 1418: Priming of the glioblastoma tumour microenvironment via copper chelation to enhance the efficacy of immunotherapies', Cancer Research, 84, pp. 1418 - 1418, http://dx.doi.org/10.1158/1538-7445.am2024-1418

Rouaen JR; Salerno A; Luciani F; Murray J; Shai-Hee T; Tedla N; Haber M; Trahair TN; Vittorio O, 2024, 'Abstract 2673: Copper chelation overcomes the immunosuppressive neuroblastoma microenvironment to potentiate anti-GD2 antibody therapy', Cancer Research, 84, pp. 2673 - 2673, http://dx.doi.org/10.1158/1538-7445.am2024-2673

Bell JL; Abruzzese DK; Kasiou E; Pham VV; Bertoldo JB; Michniewicz F; Vittorio O, 2024, 'Abstract 3056: Copper chelation modulates YTHDF2 RNA-binding protein localization and global translation, in neuronal cancers', Cancer Research, 84, pp. 3056 - 3056, http://dx.doi.org/10.1158/1538-7445.am2024-3056

Brown MP; Gargett T; Truong NT; Vittorio O; Ziegler DS, 2024, 'Abstract 3636: Myeloid cell rebound associated with GD2-CAR-T cell therapy in solid tumor patients', Cancer Research, 84, pp. 3636 - 3636, http://dx.doi.org/10.1158/1538-7445.am2024-3636

Pham VVH; Jue T; Bell J; Luciani F; Michniewicz F; Cirillo G; Vahdat L; Mayoh C; Vittorio O, 2024, 'Abstract 4942: Unraveling a prognostic and predictive 8-gene signature related to cuproplasia in pan-cancer', Cancer Research, 84, pp. 4942 - 4942, http://dx.doi.org/10.1158/1538-7445.am2024-4942

Michniewicz F; Cazzoli R; Bell J; Saletta F; Poursani E; Rouaen JR; Shai-Hee T; Pham V; Jue TR; Biery M; Bramberger L; Lim T; Khan A; Giorgi FM; Mercatelli D; Mayoh C; Cirillo G; Macmillan A; Whan R; Barlow CT; Tsoli M; Vitanza N; Berry S; Faridi P; Ziegler D; Vittorio O, 2024, 'Abstract 525: A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG)', Cancer Research, 84, pp. 525 - 525, http://dx.doi.org/10.1158/1538-7445.am2024-525

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins-Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202300360

Koschmann C; Al-Holou WN; Alonso MM; Anastas J; Bandopadhayay P; Barron T; Becher O; Cartaxo R; Castro MG; Chung C; Clausen M; Dang D; Doherty R; Duchatel R; Dun M; Filbin M; Franson A; Galban S; Garcia Moure M; Garton H; Gowda P; Marques JG; Hawkins C; Heath A; Hulleman E; Ji S; Jones C; Kilburn L; Kline C; Koldobskiy MA; Lim D; Lowenstein PR; Lu QR; Lum J; Mack S; Magge S; Marini B; Martin D; Marupudi N; Messinger D; Mody R; Morgan M; Mota M; Muraszko K; Mueller S; Natarajan SK; Nazarian J; Niculcea M; Nuechterlein N; Okada H; Opipari V; Pai MP; Pal S; Peterson E; Phoenix T; Prensner JR; Pun M; Raju GP; Reitman ZJ; Resnick A; Rogawski D; Saratsis A; Sbergio SG; Souweidane M; Stafford JM; Tzaridis T; Venkataraman S; Vittorio O; Wadden J; Wahl D; Wechsler-Reya RJ; Yadav VN; Zhang X; Zhang Q; Venneti S, 2024, 'A road map for the treatment of pediatric diffuse midline glioma', Cancer Cell, 42, pp. 1 - 5, http://dx.doi.org/10.1016/j.ccell.2023.11.002

Pham VVH; Jue TR; Bell JL; Luciani F; Michniewicz F; Cirillo G; Vahdat L; Mayoh C; Vittorio O, 2024, 'A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome', Human Genetics, http://dx.doi.org/10.1007/s00439-024-02673-2

Rennie C; Sives C; Boyton I; Diaz D; Gorrie C; Vittorio O; Collins‐Praino L; Care A, 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, 7, http://dx.doi.org/10.1002/adtp.202470003

Mayoh C; Gifford AJ; Terry R; Lau LMS; Wong M; Rao P; Shai-Hee T; Saletta F; Khuong-Quang DA; Qin V; Mateos MK; Meyran D; Miller KE; Yuksel A; Mould EVA; Bowen-James R; Govender D; Senapati A; Zhukova N; Omer N; Dholaria H; Alvaro F; Tapp H; Diamond Y; Pozza LD; Moore AS; Nicholls W; Gottardo NG; McCowage G; Hansford JR; Khaw SL; Wood PJ; Catchpoole D; Cottrell CE; Mardis ER; Marshall GM; Tyrrell V; Haber M; Ziegler DS; Vittorio O; Trapani JA; Cowley MJ; Neeson PJ; Ekert PG, 2023, 'A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer', Genome Medicine, 15, http://dx.doi.org/10.1186/s13073-023-01170-x

Poursani EM; Mercatelli D; Raninga P; Bell JL; Saletta F; Kohane FV; Neumann DP; Zheng Y; Rouaen JRC; Jue TR; Michniewicz FT; Schadel P; Kasiou E; Tsoli M; Cirillo G; Waters S; Shai-Hee T; Cazzoli R; Brettle M; Slapetova I; Kasherman M; Whan R; Souza-Fonseca-Guimaraes F; Vahdat L; Ziegler D; Lock JG; Giorgi FM; Khanna KK; Vittorio O, 2023, 'Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer', Cell and Bioscience, 13, http://dx.doi.org/10.1186/s13578-023-01083-7

Cazzoli R; Zamborlin A; Ermini ML; Salerno A; Curcio M; Nicoletta FP; Iemma F; Vittorio O; Voliani V; Cirillo G, 2023, 'Evolving approaches in glioma treatment: harnessing the potential of copper metabolism modulation', RSC Advances, 13, pp. 34045 - 34056, http://dx.doi.org/10.1039/d3ra06434d

Di Luca M; Poursani E; Curcio M; Cirillo G; Salerno A; Bolognini S; De Filpo G; Filippi S; Vittorio O; Iemma F; Nicoletta FP, 2023, 'Evaluating the Efficiency of Chitosan-Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems', Macromolecular Materials and Engineering, 308, http://dx.doi.org/10.1002/mame.202300166

Cazzoli R; Romeo F; Pallavicini I; Peri S; Romanenghi M; Pérez-Valencia JA; Hagag E; Ferrucci F; Elgendy M; Vittorio O; Pece S; Foiani M; Westermarck J; Minucci S, 2023, 'Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition', Cell Reports, 42, http://dx.doi.org/10.1016/j.celrep.2023.112616

Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585

Allan KM; Astore MA; Kardia E; Wong SL; Fawcett LK; Bell JL; Visser S; Chen PC; Griffith R; Jaffe A; Sivam S; Vittorio O; Kuyucak S; Waters SA, 2023, 'Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient', Frontiers in Molecular Biosciences, 10, http://dx.doi.org/10.3389/fmolb.2023.1148501

Gargett T; Ebert LM; Truong NTH; Kollis PM; Sedivakova K; Yu W; Yeo ECF; Wittwer NL; Gliddon BL; Tea MN; Ormsby R; Poonnoose S; Nowicki J; Vittorio O; Ziegler DS; Pitson SM; Brown MP, 2022, 'GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma', Journal for ImmunoTherapy of Cancer, 10, http://dx.doi.org/10.1136/jitc-2022-005187

Curcio M; Vittorio O; Bell JL; Iemma F; Nicoletta FP; Cirillo G, 2022, 'Hyaluronic Acid within Self-Assembling Nanoparticles: Endless Possibilities for Targeted Cancer Therapy', Nanomaterials, 12, http://dx.doi.org/10.3390/nano12162851

Madeo LF; Sarogni P; Cirillo G; Vittorio O; Voliani V; Curcio M; Shai-Hee T; Büchner B; Mertig M; Hampel S, 2022, 'Curcumin and Graphene Oxide Incorporated into Alginate Hydrogels as Versatile Devices for the Local Treatment of Squamous Cell Carcinoma', Materials, 15, pp. 1648, http://dx.doi.org/10.3390/ma15051648

Noor H; Briggs NE; McDonald KL; Holst J; Vittorio O, 2021, 'Tp53 mutation is a prognostic factor in lower grade glioma and may influence chemotherapy efficacy', Cancers, 13, pp. 5362, http://dx.doi.org/10.3390/cancers13215362

Michniewicz F; Saletta F; Rouaen JRC; Hewavisenti RV; Mercatelli D; Cirillo G; Giorgi FM; Trahair T; Ziegler D; Vittorio O, 2021, 'Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics', ChemMedChem, 16, pp. 2315 - 2329, http://dx.doi.org/10.1002/cmdc.202100172

Bevacqua E; Curcio M; Saletta F; Vittorio O; Cirillo G; Tucci P, 2021, 'Dextran‐curcumin nanosystems inhibit cell growth and migration regulating the epithelial to mesenchymal transition in prostate cancer cells', International Journal of Molecular Sciences, 22, http://dx.doi.org/10.3390/ijms22137013

Ehteda A; Simon S; Franshaw L; Giorgi FM; Liu J; Joshi S; Rouaen JRC; Pang CNI; Pandher R; Mayoh C; Tang Y; Khan A; Ung C; Tolhurst O; Kankean A; Hayden E; Lehmann R; Shen S; Gopalakrishnan A; Trebilcock P; Gurova K; Gudkov AV; Norris MD; Haber M; Vittorio O; Tsoli M; Ziegler DS, 2021, 'Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG', Cell Reports, 35, pp. 108994, http://dx.doi.org/10.1016/j.celrep.2021.108994

Cirillo G; Pantuso E; Curcio M; Vittorio O; Leggio A; Iemma F; De Filpo G; Nicoletta FP, 2021, 'Alginate bioconjugate and graphene oxide in multifunctional hydrogels for versatile biomedical applications', Molecules, 26, pp. 1355, http://dx.doi.org/10.3390/molecules26051355

Ung C; Tsoli M; Liu J; Cassano D; Pocoví-Martínez S; Upton DH; Ehteda A; Mansfeld FM; Failes TW; Farfalla A; Katsinas C; Kavallaris M; Arndt GM; Vittorio O; Cirillo G; Voliani V; Ziegler DS, 2021, 'Doxorubicin-loaded gold nanoarchitectures as a therapeutic strategy against diffuse intrinsic pontine glioma', Cancers, 13, pp. 1 - 20, http://dx.doi.org/10.3390/cancers13061278

Curcio M; Cirillo G; Saletta F; Michniewicz F; Nicoletta FP; Vittorio O; Hampel S; Iemma F, 2021, 'Carbon Nanohorns as Effective Nanotherapeutics in Cancer Therapy', C-JOURNAL OF CARBON RESEARCH, 7, http://dx.doi.org/10.3390/c7010003

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453

Michniewicz F; Saletta F; Rouen J; Ziegler D; Vittorio O, 2020, 'DIPG-83. USING COPPER CHELATING AGENTS TO TARGET RECEPTOR TYROSINE KINASE SIGNALLING IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', Neuro-Oncology, 22, pp. iii303 - iii303, http://dx.doi.org/10.1093/neuonc/noaa222.124

Curcio M; Cirillo G; Rouaen JRC; Saletta F; Nicoletta FP; Vittorio O; Iemma F, 2020, 'Natural polysaccharide carriers in brain delivery: Challenge and perspective', Pharmaceutics, 12, http://dx.doi.org/10.3390/pharmaceutics12121183

Voli F; Valli E; Lerra L; Kimpton K; Saletta F; Giorgi FM; Mercatelli D; Rouaen JRC; Shen S; Murray JE; Ahmed-Cox A; Cirillo G; Mayoh C; Beavis PA; Haber M; Trapani JA; Kavallaris M; Vittorio O, 2020, 'Intratumoral copper modulates PD-L1 expression and influences tumor immune evasion', Cancer Research, 80, pp. 4129 - 4144, http://dx.doi.org/10.1158/0008-5472.CAN-20-0471

Curcio M; Farfalla A; Saletta F; Valli E; Pantuso E; Nicoletta FP; Iemma F; Vittorio O; Cirillo G, 2020, 'Functionalized carbon nanostructures versus drug resistance: Promising scenarios in cancer treatment', Molecules, 25, http://dx.doi.org/10.3390/molecules25092102

Vittorio O; Kamili A; Valli E; Kavallaris M; LE GRAND M, 2020, 'Interplay between MycN and c-Myc regulates radioresistance and cancer stem cell phenotype in neuroblastoma upon glutamine deprivation', Theranostics, 10, pp. 6411 - 6429, http://dx.doi.org/10.7150/thno.42602

Curcio M; Cirillo G; Tucci P; Farfalla A; Bevacqua E; Vittorio O; Iemma F; Nicoletta FP, 2020, 'Dextran-curcumin nanoparticles as a methotrexate delivery vehicle: A step forward in breast cancer combination therapy', Pharmaceuticals, 13, pp. 2, http://dx.doi.org/10.3390/ph13010002

Liu A; Cohen J; Vittorio O, 2019, 'Poor dietary polyphenol intake in childhood cancer patients', Nutrients, 11, http://dx.doi.org/10.3390/nu11112835

Cirillo G; Vittorio O; Kunhardt D; Valli E; Voli F; Farfalla A; Curcio M; Spizzirri UG; Hampel S, 2019, 'Combining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cells', Materials, 12, http://dx.doi.org/10.3390/ma12182889

Makharza SA; Cirillo G; Vittorio O; Valli E; Voli F; Farfalla A; Curcio M; Iemma F; Nicoletta FP; El-Gendy AA; Goya GF; Hampel S, 2019, 'Magnetic graphene oxide nanocarrier for targeted delivery of cisplatin: A perspective for glioblastoma treatment', Pharmaceuticals, 12, http://dx.doi.org/10.3390/ph12020076

Cirillo G; Curcio M; Spizzirri UG; Vittorio O; Valli E; Farfalla A; Leggio A; Nicoletta FP; Iemma F, 2019, 'Chitosan–Quercetin Bioconjugate as Multi-Functional Component of Antioxidants and Dual-Responsive Hydrogel Networks', Macromolecular Materials and Engineering, 304, http://dx.doi.org/10.1002/mame.201800728

Di Luca M; Curcio M; Valli E; Cirillo G; Voli F; Butini ME; Farfalla A; Pantuso E; Leggio A; Nicoletta FP; Tavanti A; Iemma F; Vittorio O, 2019, 'Combining antioxidant hydrogels with self-assembled microparticles for multifunctional wound dressings', Journal of Materials Chemistry B, 7, pp. 4361 - 4370, http://dx.doi.org/10.1039/c9tb00871c

Lerra L; Farfalla A; Sanz B; Cirillo G; Vittorio O; Voli F; Grand ML; Curcio M; Nicoletta FP; Dubrovska A; Hampel S; Iemma F; Goya GF; LE GRAND M, 2019, 'Graphene oxide functional nanohybrids with magnetic nanoparticles for improved vectorization of doxorubicin to neuroblastoma cells', Pharmaceutics, 11, http://dx.doi.org/10.3390/pharmaceutics11010003

Yee EMH; Cirillo G; Brandl MB; Black DSC; Vittorio O; Kumar N, 2019, 'Synthesis of dextran–phenoxodiol and evaluation of its physical stability and biological activity', Frontiers in Bioengineering and Biotechnology, 7, http://dx.doi.org/10.3389/fbioe.2019.00183

Cirillo G; Peitzsch C; Vittorio O; Curcio M; Farfalla A; Voli F; Dubrovska A; Iemma F; Kavallaris M; Hampel S, 2019, 'When polymers meet carbon nanostructures: Expanding horizons in cancer therapy', Future Medicinal Chemistry, 11, pp. 2205 - 2231, http://dx.doi.org/10.4155/fmc-2018-0540

di Luca M; Vittorio O; Cirillo G; Curcio M; Czuban M; Voli F; Farfalla A; Hampel S; Nicoletta FP; Iemma F, 2018, 'Electro-responsive graphene oxide hydrogels for skin bandages: The outcome of gelatin and trypsin immobilization', International Journal of Pharmaceutics, 546, pp. 50 - 60, http://dx.doi.org/10.1016/j.ijpharm.2018.05.027

Oliver S; Yee E; Kavallaris M; Vittorio O; Boyer C, 2018, 'Water Soluble Antioxidant Dextran–Quercetin Conjugate with Potential Anticancer Properties', Macromolecular Bioscience, 18, http://dx.doi.org/10.1002/mabi.201700239

Vittorio O; Le Grand M; Makharza SA; Curcio M; Tucci P; Iemma F; Nicoletta FP; Hampel S; Cirillo G, 2018, 'Doxorubicin synergism and resistance reversal in human neuroblastoma BE(2)C cell lines: An in vitro study with dextran-catechin nanohybrids', European Journal of Pharmaceutics and Biopharmaceutics, 122, pp. 176 - 185, http://dx.doi.org/10.1016/j.ejpb.2017.11.005

Parmar A; Pascali G; Voli F; Lerra L; Yee E; Ahmed-Cox A; Kimpton K; Cirillo G; Arthur A; Zahra D; Rahardjo G; Liu GJ; Lengkeek N; Saletta F; Charil A; Kavallaris M; Vittorio O, 2018, 'In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis', Theranostics, 8, pp. 5645 - 5659, http://dx.doi.org/10.7150/thno.29840

Voli F; Lerra L; Kimpton K; Saletta F; Cirillo G; Kavallaris M; Vittorio O, 2018, 'Harnessing copper in cancer to enhance anti-tumor immune response', Annals of Oncology, 29, pp. x35 - x35, http://dx.doi.org/10.1093/annonc/mdy487.030

Oliver S; Jofri A; Thomas DS; Vittorio O; Kavallaris M; Boyer C, 2017, 'Tuneable catechin functionalisation of carbohydrate polymers', Carbohydrate Polymers, 169, pp. 480 - 494, http://dx.doi.org/10.1016/j.carbpol.2017.04.032

Yee EMH; Hook JM; Bhadbhade MM; Vittorio O; Kuchel RP; Brandl MB; Tilley RD; Black DSC; Kumar N, 2017, 'Preparation, characterization and in vitro biological evaluation of (1:2) phenoxodiol-β-cyclodextrin complex', Carbohydrate Polymers, 165, pp. 444 - 454, http://dx.doi.org/10.1016/j.carbpol.2017.02.081

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