By Associate Professor Tao Liu

Journal articles

Liu PY; Atmadibrata B; Mondal S; Tee AE; Liu T, 2016, 'NCYM is upregulated by lncUSMycN and modulates N-Myc expression', International Journal of Oncology, 49, pp. 2464 - 2470, http://dx.doi.org/10.3892/ijo.2016.3730

Lynch JR; Yi H; Casolari DA; Voli F; Gonzales-Aloy E; Fung TK; Liu B; Brown A; Liu T; Haber M; Norris MD; Lewis ID; So CWE; D'Andrea RJ; Wang JY, 2016, 'Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia', Leukemia, 30, pp. 1745 - 1748, http://dx.doi.org/10.1038/leu.2016.24

Guo ST; Chi MN; Yang RH; Guo XY; Zan LK; Wang CY; Xi YF; Jin L; Croft A; Tseng HY; Yan XG; Farrelly M; Wang FH; Lai F; Wang JF; Li YP; Ackland S; Scott R; Agoulnik IU; Hondermarck H; Thorne RF; Liu T; Zhang XD; Jiang CC, 2016, 'INPP4B is an oncogenic regulator in human colon cancer', Oncogene, 35, pp. 3049 - 3061, http://dx.doi.org/10.1038/onc.2015.361

Xi Z; Yao M; Li Y; Xie C; Holst J; Liu T; Cai S; Lao Y; Tan H; Xu HX; Dong Q, 2016, 'Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation', Cell Death and Disease, 7, pp. e2252 - e2252, http://dx.doi.org/10.1038/cddis.2016.123

Shahbazi J; Liu PY; Atmadibrata B; Bradner JE; Marshall GM; Lock RB; Liu T, 2016, 'The bromodomain inhibitor jq1 and the histone deacetylase inhibitor panobinostat synergistically reduce n-myc expression and induce anticancer effects', Clinical Cancer Research, 22, pp. 2534 - 2544, http://dx.doi.org/10.1158/1078-0432.CCR-15-1666

Kim PY; Tan O; Liu B; Trahair T; Liu T; Haber M; Norris MD; Marshall GM; Cheung BB, 2016, 'High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients', Cancer Letters, 374, pp. 315 - 323, http://dx.doi.org/10.1016/j.canlet.2016.02.021

Xue C; Yu DMT; Gherardi S; Koach J; Milazzo G; Gamble L; Liu B; Valli E; Russell AJ; London WB; Liu T; Cheung BB; Marshall GM; Perini G; Haber M; Norris MD, 2016, 'MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4', Oncotarget, 7, pp. 54937 - 54951, http://dx.doi.org/10.18632/oncotarget.10709

Liu PY; Sokolowski N; Guo ST; Siddiqi F; Atmadibrata B; Telfer TJ; Sun Y; Zhang L; Yu D; Mccarroll J; Liu B; Yang RH; Guo XY; Tee AE; Itoh K; Wang J; Kavallaris M; Haber M; Norris MD; Cheung BB; Byrne JA; Ziegler DS; Marshall GM; Dinger ME; Codd R; Zhang XD; Liu T, 2016, 'The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs', Oncotarget, 7, pp. 79217 - 79232, http://dx.doi.org/10.18632/oncotarget.12640

Tee AE; Liu B; Song R; Li J; Pasquier E; Cheung BB; Jiang C; Marshall GM; Haber M; Norris MD; Fletcher JI; Dinger ME; Liu T, 2016, 'The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression', Oncotarget, 7, pp. 8663 - 8675, http://dx.doi.org/10.18632/oncotarget.6675

Sun Y; Bell JL; Carter D; Gherardi S; Poulos RC; Milazzo G; Wong JWH; Al-Awar R; Tee AE; Liu PY; Liu B; Atmadibrata B; Wong M; Trahair T; Zhao Q; Shohet JM; Haupt Y; Schulte JH; Brown PJ; Arrowsmith CH; Vedadi M; MacKenzie KL; Hüttelmaier S; Perini G; Marshall GM; Braithwaite A; Liu T, 2015, 'WDR5 supports an N-myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma', Cancer Research, 75, pp. 5143 - 5154, http://dx.doi.org/10.1158/0008-5472.CAN-15-0423

Carter DR; Murray J; Cheung BB; Gamble L; Koach J; Tsang J; Sutton S; Kalla H; Syed S; Gifford AJ; Issaeva N; Biktasova A; Atmadibrata B; Sun Y; Sokolowski N; Ling D; Kim PY; Webber H; Clark A; Ruhle M; Liu B; Oberthuer A; Fischer M; Byrne J; Saletta F; Thwe LM; Purmal A; Haderski G; Burkhart C; Speleman F; De Preter K; Beckers A; Ziegler DS; Liu T; Gurova KV; Gudkov AV; Norris MD; Haber M; Marshall GM, 2015, 'Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma', Science Translational Medicine, 7, pp. 312ra176, http://dx.doi.org/10.1126/scitranslmed.aab1803

Cheung BB; Tan O; Koach J; Liu B; Shum MSY; Carter DR; Sutton S; Po'uha ST; Chesler L; Haber M; Norris MD; Kavallaris M; Liu T; O'Neill GM; Marshall GM, 2015, 'Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma', Molecular Oncology, 9, pp. 1484 - 1500, http://dx.doi.org/10.1016/j.molonc.2015.04.005

Bell JL; Turlapati R; Liu T; Schulte JH; Hüttelmaier S, 2015, 'IGF2BP1 harbors prognostic significance by gene gain and diverse expression in neuroblastoma', Journal of Clinical Oncology, 33, pp. 1285 - 1293, http://dx.doi.org/10.1200/JCO.2014.55.9880

Song R; Liu Q; Liu T; Li J, 2015, 'Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships', BMC Genomics, 16, pp. s11, http://dx.doi.org/10.1186/1471-2164-16-S2-S11

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2015, 'Erratum: Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression (Journal of the National Cancer Institute (2014) 106:7 (dju113) DOI: 10.1093/jnci/dju113)', Journal of the National Cancer Institute, 107, http://dx.doi.org/10.1093/jnci/dju359

Chi MN; Guo ST; Wilmott JS; Guo XY; Yan XG; Wang CY; Liu XY; Jin L; Tseng HY; Liu T; Croft A; Hondermarck H; Scolyer RA; Jiang CC; Zhang XD, 2015, 'INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas', Oncotarget, 6, pp. 39891 - 39907, http://dx.doi.org/10.18632/oncotarget.5359

Manchanda R; Loggenberg K; Sanderson S; Burnell M; Wardle J; Gessler S; Side L; Balogun N; Desai R; Kumar A; Dorkins H; Wallis Y; Chapman C; Taylor R; Jacobs C; Tomlinson I; McGuire A; Beller U; Menon U; Jacobs I, 2015, 'Population testing for cancer predisposing BRCA1/BRCA2 mutations in the ashkenazi-jewish community: A randomized controlled trial', Journal of the National Cancer Institute, 107, http://dx.doi.org/10.1093/jnci/dju379

Wong M; Polly P; Liu T, 2015, 'The histone methyltransferase DOT1L: Regulatory functions and a cancer therapy target', American Journal of Cancer Research, 5, pp. 2823 - 2837

Liu PY; Erriquez D; Marshall GM; Tee AE; Polly P; Wong M; Liu B; Bell JL; Zhang XD; Milazzo G; Cheung BB; Fox A; Swarbrick A; Hüttelmaier S; Kavallaris M; Perini G; Mattick JS; Dinger ME; Liu T, 2014, 'Effects of a Novel Long Noncoding RNA, lncUSMycN, on N-Myc Expression and Neuroblastoma Progression', Journal of the National Cancer Institute, 106, http://dx.doi.org/10.1093/jnci/dju113

Atmadibrata B; Liu PY; Sokolowski N; Zhang L; Wong M; Tee AE; Marshall GM; Liu T, 2014, 'The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc', PLoS ONE, 9, pp. e88112, http://dx.doi.org/10.1371/journal.pone.0088112

Tee EL; Ling D; Nelson C; Atmadibrata B; Dinger M; XU N; Mizukami T; Liu PY; Liu B; Cheung B; Pasquier E; Haber M; Norris MD; Suzuki T; Marshall GM; Liu T, 2014, 'The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1', Oncotarget, 5, pp. 1793 - 1804, http://dx.doi.org/10.18632/oncotarget.1785

Kim PY; Tan O; Diakiw SM; Carter D; Sekerye EO; Wasinger VC; Liu T; Kavallaris M; Norris MD; Haber M; Chesler L; Dolnikov A; Trahair TN; Cheung NK; Marshall GM; Cheung BB; Sekyere E, 2014, 'Identification of plasma Complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach', Journal of Proteomics, 96, pp. 1 - 12, http://dx.doi.org/10.1016/j.jprot.2013.10.032

Shahbazi J; Scarlett CJ; Norris MD; Liu B; Haber M; Tee AE; Carrier A; Biankin AV; London WB; Marshall GM; Lock RB; Liu T, 2014, 'Histone Deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', Oncotarget, 5, pp. 4257 - 4268, http://dx.doi.org/10.18632/oncotarget.1991

Zhang L; Sokolowski N; Atmadibrata B; Liu T, 2014, 'Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein', Oncology Reports, 31, pp. 1935 - 1939, http://dx.doi.org/10.3892/or.2014.3006

Vignarajan S; Xie C; Yao M; Sun Y; Simanainen U; Sved P; Liu T; Dong Q, 2014, 'Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A2a via AKT in prostate cancer cells', Oncotarget, 5, pp. 6289 - 6299, http://dx.doi.org/10.18632/oncotarget.2198

Marshall GM; Carter DR; Cheung BB; Liu T; Mateos MK; Meyerowitz JG; Weiss WA, 2014, 'The prenatal origins of cancer', Nature Reviews Cancer, 14, pp. 277 - 289, http://dx.doi.org/10.1038/nrc3679

Sutton SK; Koach J; Tan O; Liu B; Carter DR; Wilmott JS; Yosufi B; Haydu LE; Mann GJ; Thompson JF; Long GV; Liu T; McArthur G; Zhang XD; Scolyer RA; Cheung BB; Marshall GM, 2014, 'TRIM16 inhibits proliferation and migration through regulation of interferon beta 1 in melanoma cells', Oncotarget, 5, pp. 10127 - 10139, http://dx.doi.org/10.18632/oncotarget.2466

Lai F; Guo ST; Jin L; Jiang CC; Wang CY; Croft A; Chi MN; Tseng HY; Farrelly M; Atmadibrata B; Norman J; Liu T; Hersey P; Zhang XD, 2013, 'Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3', Cell Death and Disease, 4, pp. e655 - e655, http://dx.doi.org/10.1038/cddis.2013.192

Sekyere E; Thomas WD; Keating J; Calao M; Cui HJ; Chen JB; Raif A; Jankowski K; Cheung B; Davies NP NP; Trahair TN; Liu T; Wainwright BJ; Ding HF; Marshall GM; Haber M; Norris M; Tan O; Chen B; van Bekkum M, 2013, 'Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation', Oncogene, 32, pp. 3616 - 3626, http://dx.doi.org/10.1038/onc.2012.368

Malyukova A; Papa R; O'Brien R; Giles JE; Trahair TN; Pozza LD; Sutton R; Liu T; Haber M; Norris MD; Lock RB; Marshall GM; Giles J, 2013, 'FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation', Leukemia, 27, pp. 1053 - 1062, http://dx.doi.org/10.1038/leu.2012.361

Sun YT; Liu PY; Scarlett CJ; Malyukova A; Liu B; Mackenzie KL; Biankin AV; Liu T; Marshall G, 2013, 'Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc', Oncogene, 33, pp. 2987 - 2994, http://dx.doi.org/10.1038/onc.2013.253

Ye Y; Jin L; Wilmott J; Hu WL; Yosufi B; Thorne RF; Liu T; Rizos H; Yan XG; Dong L; Tay KH; Tseng HT; Guo ST; De Bock CE; Jiang CC; Wang CY; Wu M; Zhang LJ; Hersey P; Scolyer RA; Zhang XD, 2013, 'PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma', Nature communications, 4, pp. Article number 1508, http://dx.doi.org/10.1038/ncomms2489

Wauters E; Sanchez-Arevalo Lobo VJ; Pinho AV; Mawson A; Herranz D; Wu J; Cowley MJ; Colvin EK; Njicop EN; Sutherland RL; Liu T; Serrano M; Bouwens L; Real FX; Biankin AV; Rooman I; Mawson A, 2013, 'Sirtuin-1 regulates acinar to ductal metaplasia and supports cancer cell viability in pancreatic cancer', Cancer research, 73, pp. 2357 - 2367, http://dx.doi.org/10.1158/0008-5472.CAN-12-3359

Liu PY; Xu N; Malyukova A; Scarlett CJ; Sun YT; Zhang XD; Ling D; Su SP; Nelson CA; Chang DK; Koach J; Tee AE; Haber M; Norris MD; Rooman I; Toon C; Xue C; Cheung B; Kumar S; Marshall GM; Biankin AV; Liu T; Shih-Ping Su J; Toon CCW, 2013, 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', Cell Death and Differentiation, 20, pp. 503 - 514, http://dx.doi.org/10.1038/cdd.2012.147

Shahbazi J; Lock RB; Liu T, 2013, 'Tumor protein 53-induced nuclear protein 1 enhances p53 function and represses tumorigenesis', Frontiers in Genetics, 13, pp. Art. No. 80, http://dx.doi.org/10.3389/fgene.2013.00080

Kan C; Petti C; Bracken L; Maritz M; Xu N; O'Brien R; Yang C; Liu T; Yuan J; Lock RB; Mackenzie KL, 2013, 'Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress', The Journal of Biological Chemistry, 288, pp. 12032 - 12041, http://dx.doi.org/10.1074/jbc.M112.447821

Petti C; Kan C-Y; Dietrich PA; Lauryn B; Xu N; Yuan J; Liu T; MacKenzie KL, 2012, 'Upregulation of survivin during immortalization is linked to repression of p16INK4a and confers resistance to oxidative stress', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-2196

Liu T, 2012, 'Amide-based derivatives of â-alanine hydroxamic acid as histone deacetylase inhibitors: Attenuation of potency through resonance effects', Bioorganic and Medicinal Chemistry Letters, 22, pp. 6200 - 6204, http://dx.doi.org/10.1016/j.bmcl.2012.08.006

Liu T; Marshall G; Iismaa S; Liu P; Xu N, 2012, 'Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase', European Journal of Cancer, 48, pp. 3278 - 3287, http://dx.doi.org/10.1016/j.ejca.2012.02.067

Tay KH; Jin L; Tseng H; Jiang CC; Ye Y; Thorne RF; Liu T; Guo ST; Verrills NM; Hersey P; Zhang XD, 2012, 'Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress', Cell Death & Disease, 3, pp. e337, http://dx.doi.org/10.1038/cddis.2012.79

Marshall GM; Liu PY; Gherardi S; Scarlett CJ; Bedalov A; Xu N; Iraci N; Valli E; Ling D; Thomas W; Van bekkum M; Sekyere E; Jankowski K; Trahair T; Mackenzie K; Haber M; Norris MD; Biankin AV; Perini G; Liu T, 2011, 'SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability', PLOS Genetics, 7, pp. e1 - e14, http://dx.doi.org/10.1371/journal.pgen.1002135

Liu T, 2011, 'The histone deacetylase SIRT1 promotes N-Myc-induced neuroblastoma by stabilizing N-Myc protein', PLoS Genetics, 7, pp. e1002135

Bell E; Chen L; Liu T; Marshall GM; Lunec J; Tweddle DA, 2010, 'MYCN oncoprotein targets and their therapeutic potential', Cancer Letters, 293, pp. 144 - 157, http://dx.doi.org/10.1016/j.canlet.2010.01.015

Liu T, 2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041

Marshall GM; Gherardi S; Xu N; Neiron Z; Trahair TN; Scarlett CJ; Chang DK; Liu PY; Jankowski K; Iraci N; Haber M; Norris MD; Keating J; Sekyere E; Jonquieres G; Biankin AV; Stossi F; Katzenellenbogen BS; Perini G; Liu T, 2010, 'Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', Oncogene, 29, pp. 5957 - 5968, http://dx.doi.org/10.1038/onc.2010.332

Liu T; Bell J; Koach J; Malyukova A; Thomas W; Sekyere E; Cunningham A; Norris M; Haber M; Kavallaris M; Cheung B-B; Kim P; Tan O; Marshall G, 2010, 'TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells', Oncogene, 29, pp. 6172 - 6183, http://dx.doi.org/10.1038/onc.2010.340

Liu T, 2009, 'Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors', European Journal of Cancer, 45, pp. 1846 - 1854, http://dx.doi.org/10.1016/j.ejca.2009.03.002

Liu T, 2009, 'The critical role of the class III histone deacetylase SIRT1 in cancer', Cancer Research, 69, pp. 1702 - 1705, http://dx.doi.org/10.1158/0008-5472.CAN-08-3365

Liu T, 2009, 'The cyclin-dependent kinase inhibitor, p21WAF1, promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein 2 in cancer cells', Carcinogenesis, 30, pp. 1865 - 1871, http://dx.doi.org/10.1093/carcin/bgp225

Liu T; Tee AEL; Porro A; Smith SA; Dwarte T; Pei YL; Iraci N; Sekyere E; Haber M; Norris MD; Diolaiti D; Della Valle G; Perini G; Marshall GM, 2007, 'Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis (Proceedings of the National Academy of Science of the United States of America (November 20, 2007) 104; 47, (18682-18687) DOI: 10.1073/pnas.0705524104)', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 21021, http://dx.doi.org/10.1073/pnas.0711060105

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