By Associate Professor Tao Liu

Journal articles

Cheung BB; Mittra R; Murray J; Wang Q; Seneviratne JA; Raipuria M; Wong IPL; Restuccia D; Gifford A; Salib A; Sutton S; Huang L; Ferdowsi PV; Tsang J; Sekyere E; Mayoh C; Luo L; Brown DL; Stow JL; Zhu S; Young RJ; Solomon BJ; Chappaz S; Kile B; Kueh A; Herold MJ; Hilton DJ; Liu T; Norris MD; Haber M; Carter DR; Parker MW; Marshall GM, 2024, 'Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis', Communications Biology, 7, pp. 1322, http://dx.doi.org/10.1038/s42003-024-06899-8

Seneviratne JA; Ravindrarajah D; Carter DR; Zhai V; Lalwani A; Krishan S; Balachandran A; Ng E; Pandher R; Wong M; Nero TL; Wang S; Norris MD; Haber M; Liu T; Parker MW; Cheung BB; Marshall GM, 2024, 'Combined inhibition of histone methyltransferases EZH2 and DOT1L is an effective therapy for neuroblastoma', Cancer Medicine, 13, pp. e70082, http://dx.doi.org/10.1002/cam4.70082

Hassan N; Yi H; Malik B; Gaspard-Boulinc L; Samaraweera SE; Casolari DA; Seneviratne J; Balachandran A; Chew T; Duly A; Carter DR; Cheung BB; Norris M; Haber M; Kavallaris M; Marshall GM; Zhang XD; Liu T; Wang J; Liebermann DA; D'Andrea RJ; Wang JY, 2024, 'Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML', Blood, 144, pp. 84 - 98, http://dx.doi.org/10.1182/blood.2024024072

Zheng SM; Feng YC; Zhu Q; Li RQ; Yan QQ; Teng L; Yue YM; Han MM; Ye K; Zhang SN; Qi TF; Tang CX; Zhao XH; Zhang YY; Xu L; Xu R; Xing J; Baker M; Liu T; Thorne RF; Jin L; Preiss T; Zhang XD; Cang S; Gao JN, 2024, 'MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer', Cancer Research, 84, pp. 1460 - 1474, http://dx.doi.org/10.1158/0008-5472.CAN-23-3046

Lan T; Su S; Ping P; Hutvagner G; Liu T; Pan Y; Li J, 2024, 'Generating mutants of monotone affinity towards stronger protein complexes through adversarial learning', Nature Machine Intelligence, 6, pp. 315 - 325, http://dx.doi.org/10.1038/s42256-024-00803-z

Li RQ; Zhao XH; Zhu Q; Liu T; Hondermarck H; Thorne RF; Zhang XD; Gao JN, 2023, 'Exploring neurotransmitters and their receptors for breast cancer prevention and treatment', Theranostics, 13, pp. 1109 - 1129, http://dx.doi.org/10.7150/thno.81403

La T; Chen S; Zhao XH; Zhou S; Xu R; Teng L; Zhang YY; Ye K; Xu L; Guo T; Jamaluddin MF; Feng YC; Tang HJ; Wang Y; Xu Q; Gu Y; Cao H; Liu T; Thorne RF; Shao F; Zhang XD; Jin L, 2023, 'LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53‐Defective Cancer Cells', Advanced Science, 10, http://dx.doi.org/10.1002/advs.202204599

Wang PL; Teng L; Feng YC; Yue YM; Han MM; Yan Q; Ye K; Tang CX; Zhang SN; Qi TF; Zhao XH; La T; Zhang YY; Li JM; Hu B; Xu D; Cang S; Wang L; Jin L; Thorne RF; Zhang Y; Liu T; Zhang XD, 2022, 'The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining', Proceedings of the National Academy of Sciences of the United States of America, 119, pp. e2208904119, http://dx.doi.org/10.1073/pnas.2208904119

Hnit SST; Yao M; Xie C; Bi L; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2022, 'Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells', Discover Oncology, 13, pp. 44, http://dx.doi.org/10.1007/s12672-022-00505-1

Lan T; Hutvagner G; Zhang X; Liu T; Wong L; Li J, 2022, 'Density-based detection of cell transition states to construct disparate and bifurcating trajectories', Nucleic acids research, 50, pp. e122 - e122, http://dx.doi.org/10.1093/nar/gkac785

Ando K; Sanda T; Suenaga Y; Liu T, 2022, 'Editorial: Neuroblastoma: Signal Crosstalk and Future Insight Into Clinical Trials', Frontiers in Oncology, 12, pp. 861963, http://dx.doi.org/10.3389/fonc.2022.861963

Nik Nabil WN; Xi Z; Liu M; Li Y; Yao M; Liu T; Dong Q; Xu H, 2022, 'Advances in therapeutic agents targeting quiescent cancer cells', Acta Materia Medica, 1, pp. 56 - 71, http://dx.doi.org/10.15212/AMM-2021-0005

Chen Q; Yang B; Liu X; Zhang XD; Zhang L; Liu T, 2022, 'Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents', Theranostics, 12, pp. 4935 - 4948, http://dx.doi.org/10.7150/thno.73223

Seneviratne JA; Carter DR; Mittra R; Gifford A; Kim PY; Luo JS; Mayoh C; Salib A; Rahmanto AS; Murray J; Cheng NC; Nagy Z; Wang Q; Kleynhans A; Tan O; Sutton SK; Xue C; Chung SA; Zhang Y; Sun C; Zhang L; Haber M; Norris MD; Fletcher JI; Liu T; Dilda PJ; Hogg PJ; Cheung BB; Marshall GM, 2022, 'Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma', International Journal of Cancer, 152, pp. 1399 - 1413, http://dx.doi.org/10.1002/ijc.34349

Zhang S; Cooper JAL; Chong YS; Naveed A; Mayoh C; Jayatilleke N; Liu T; Amos S; Kobelke S; Marshall AC; Meers O; Choi YS; Bond CS; Fox AH, 2022, 'NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma', EMBO Reports, 24, pp. 1 - 19, http://dx.doi.org/10.15252/embr.202254977

Nagy Z; Seneviratne JA; Kanikevich M; Chang W; Mayoh C; Venkat P; Du Y; Jiang C; Salib A; Koach J; Carter DR; Mittra R; Liu T; Parker MW; Cheung BB; Marshall GM, 2021, 'An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability', Nature Communications, 12, pp. 1881, http://dx.doi.org/10.1038/s41467-021-22143-x

Teng L; Feng YC; Guo ST; Wang PL; Qi TF; Yue YM; Wang SX; Zhang SN; Tang CX; La T; Zhang YY; Zhao XH; Gao JN; Wei LY; Zhang D; Wang JY; Shi Y; Liu XY; Li JM; Cao H; Liu T; Thorne RF; Jin L; Shao FM; Zhang XD, 2021, 'The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis', Nature Communications, 12, pp. 3734, http://dx.doi.org/10.1038/s41467-021-24099-4

Cai X; Li JJ; Liu T; Brian O; Li J, 2021, 'Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design.', Brief Funct Genomics, 20, pp. 289 - 303, http://dx.doi.org/10.1093/bfgp/elab027

Cheung BB; Kleynhans A; Mittra R; Kim PY; Holien JK; Nagy Z; Ciampa OC; Seneviratne JA; Mayoh C; Raipuria M; Gadde S; Massudi H; Wong IPL; Tan O; Gong A; Suryano A; Diakiw SM; Liu B; Arndt GM; Liu T; Kumar N; Sangfelt O; Zhu S; Norris MD; Haber M; Carter DR; Parker MW; Marshall GM, 2021, 'A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma', Oncogene, 40, pp. 2367 - 2381, http://dx.doi.org/10.1038/s41388-021-01712-w

Putra V; Hulme AJ; Tee AE; Sun JQJ; Atmadibrata B; Ho N; Chen J; Gao J; Norris MD; Haber M; Kavallaris M; Henderson MJ; McCarroll J; Trahair T; Liu T; Liu PY, 2021, 'The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma', Molecular Oncology, 15, pp. 1162 - 1179, http://dx.doi.org/10.1002/1878-0261.12906

Lan Q; Liu PY; Bell JL; Wang JY; Hüttelmaier S; Zhang XD; Zhang L; Liu T, 2021, 'The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance', Cancer Research, 81, pp. canres.4107.2020 - canres.4107.2020, http://dx.doi.org/10.1158/0008-5472.can-20-4107

Naveed A; Cooper JA; Li R; Hubbard A; Chen J; Liu T; Wilton SD; Fletcher S; Fox AH, 2021, 'NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma', Cellular and Molecular Life Sciences, 78, pp. 2213 - 2230, http://dx.doi.org/10.1007/s00018-020-03632-6

Chen J; Nelson C; Wong M; Tee AE; Liu PY; La T; Fletcher JI; Kamili A; Mayoh C; Bartenhagen C; Trahair TN; Xu N; Jayatilleke N; Wong M; Peng H; Atmadibrata B; Cheung BB; Lan Q; Bryan TM; Mestdagh P; Vandesompele J; Combaret V; Boeva V; Wang JY; Janoueix-Lerosey I; Cowley MJ; MacKenzie KL; Dolnikov A; Li J; Polly P; Marshall GM; Reddel RR; Norris MD; Haber M; Fischer M; Zhang XD; Pickett HA; Liu T, 2021, 'Targeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy', Clinical Cancer Research, 27, pp. 1438 - 1451, http://dx.doi.org/10.1158/1078-0432.CCR-20-3044

La T; Chen S; Guo T; Zhao XH; Teng L; Li D; Carnell M; Zhang YY; Feng YC; Cole N; Brown AC; Zhang D; Dong Q; Wang JY; Cao H; Liu T; Thorne RF; Shao FM; Zhang XD; Jin L, 2021, 'Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells', Theranostics, 11, pp. 9605 - 9622, http://dx.doi.org/10.7150/THNO.63763

Tee AE; Ciampa OC; Wong M; Fletcher JI; Kamili A; Chen J; Ho N; Sun Y; Carter DR; Cheung BB; Marshall GM; Liu PY; Liu T, 2020, 'Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma', International Journal of Cancer, 147, pp. 1928 - 1938, http://dx.doi.org/10.1002/ijc.32936

Salik B; Yi H; Hassan N; Santiappillai N; Vick B; Connerty P; Duly A; Trahair T; Woo AJ; Beck D; Liu T; Spiekermann K; Jeremias I; Wang J; Kavallaris M; Haber M; Norris MD; Liebermann DA; D'Andrea RJ; Murriel C; Wang JY, 2020, 'Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia', Cancer Cell, 38, pp. 263 - 278.e6, http://dx.doi.org/10.1016/j.ccell.2020.05.014

Bell JL; Hagemann S; Holien JK; Liu T; Nagy Z; Chulte JH; Misiak D; Hüttelmaier S, 2020, 'Identification of rna-binding proteins as targetable putative oncogenes in neuroblastoma', International Journal of Molecular Sciences, 21, pp. 1 - 27, http://dx.doi.org/10.3390/ijms21145098

Hnit SST; Yao M; Xie C; Ge G; Bi L; Jin S; Jiao L; Xu L; Long L; Nie H; Jin Y; Rogers L; Suchowerska N; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2020, 'Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe', Journal of Ethnopharmacology, 251, pp. 112526, http://dx.doi.org/10.1016/j.jep.2019.112526

Bi L; Xie C; Jiao L; Jin S; Hnit SST; Mu Y; Wang Y; Wang Q; Ge G; Wang Y; Zhao X; Shi X; Kang Y; De Souza P; Liu T; Zhou J; Xu L; Dong Q, 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, 24, pp. 2229 - 2239, http://dx.doi.org/10.1111/jcmm.14897

Feng YC; Liu XY; Teng L; Ji Q; Wu Y; Li JM; Gao W; Zhang YY; La T; Tabatabaee H; Yan XG; Jamaluddin MFB; Zhang D; Guo ST; Scott RJ; Liu T; Thorne RF; Zhang XD; Jin L, 2020, 'c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis', Nature Communications, 11, pp. 4980, http://dx.doi.org/10.1038/s41467-020-18735-8

Lan T; Hutvagner G; Lan Q; Liu T; Li J, 2020, 'Sequencing dropout-and-batch effect normalization for single-cell mRNA profiles: a survey and comparative analysis', Briefings in Bioinformatics, 22, pp. bbaa248, http://dx.doi.org/10.1093/bib/bbaa248

Wong M; Sun Y; Xi Z; Milazzo G; Poulos RC; Bartenhagen C; Bell JL; Mayoh C; Ho N; Tee AE; Chen X; Li Y; Ciaccio R; Liu PY; Jiang CC; Lan Q; Jayatilleke N; Cheung BB; Haber M; Norris MD; Zhang XD; Marshall GM; Wang JY; Hüttelmaier S; Fischer M; Wong JWH; Xu H; Perini G; Dong Q; George RE; Liu T, 2019, 'JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma', Nature Communications, 10, pp. 3319, http://dx.doi.org/10.1038/s41467-019-11132-w

Yari H; Jin L; Teng L; Wang Y; Wu Y; Liu GZ; Gao W; Liang J; Xi Y; Feng YC; Zhang C; Zhang YY; Tabatabaee H; La T; Yang RH; Wang FH; Yan XG; Farrelly M; Scott R; Liu T; Thorne RF; Guo ST; Zhang XD, 2019, 'LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription', Nature Communications, 10, pp. 5334, http://dx.doi.org/10.1038/s41467-019-13313-z

Liu PY; Tee AE; Milazzo G; Hannan KM; Maag J; Mondal S; Atmadibrata B; Bartonicek N; Peng H; Ho N; Mayoh C; Ciaccio R; Sun Y; Henderson MJ; Gao J; Everaert C; Hulme AJ; Wong M; Lan Q; Cheung BB; Shi L; Wang JY; Simon T; Fischer M; Zhang XD; Marshall GM; Norris MD; Haber M; Vandesompele J; Li J; Mestdagh P; Hannan RD; Dinger ME; Perini G; Liu T, 2019, 'The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35', Nature Communications, 10, pp. 5026, http://dx.doi.org/10.1038/s41467-019-12971-3

Koach J; Holien JK; Massudi H; Carter DR; Ciampa OC; Herath M; Lim T; Seneviratne JA; Milazzo G; Murray JE; McCarroll JA; Liu B; Mayoh C; Keenan B; Stevenson BW; Gorman MA; Bell JL; Doughty L; Hüttelmaier S; Oberthuer A; Fischer M; Gifford AJ; Liu T; Zhang X; Zhu S; Gustafson WC; Haber M; Norris MD; Fletcher JI; Perini G; Parker MW; Cheung BB; Marshall GM, 2019, 'Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface', Cancer Research, 79, pp. 5652 - 5667, http://dx.doi.org/10.1158/0008-5472.CAN-19-1112

Lynch JR; Salik B; Connerty P; Vick B; Leung H; Pijning A; Jeremias I; Spiekermann K; Trahair T; Liu T; Haber M; Norris MD; Woo AJ; Hogg P; Wang J; Wang JY, 2019, 'JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis', Leukemia, 33, pp. 1400 - 1410, http://dx.doi.org/10.1038/s41375-018-0354-z

Lan Q; Liu PY; Haase J; Bell JL; Huttelmaier S; Liu T, 2019, 'The critical role of RNA M⁶A methylation in cancer', Cancer Research, 79, pp. 1285 - 1292, http://dx.doi.org/10.1158/0008-5472.CAN-18-2965

Wang Q; Liu PY; Liu T; Lan Q, 2019, 'The histone demethylase NO66 induces glioma cell proliferation', Anticancer Research, 39, pp. 6007 - 6014, http://dx.doi.org/10.21873/anticanres.13806

La T; Liu GZ; Farrelly M; Cole N; Feng YC; Zhang YY; Sherwin SK; Yari H; Tabatabaee H; Yan XG; Guo ST; Liu T; Thorne RF; Jin L; Zhang XD, 2018, 'A p53-responsive miRNA network promotes cancer cell quiescence', Cancer Research, 78, pp. 6666 - 6679, http://dx.doi.org/10.1158/0008-5472.CAN-18-1886

Peng H; Zheng Y; Zhao Z; Liu T; Li J, 2018, 'Recognition of CRISPR/Cas9 off-target sites through ensemble learning of uneven mismatch distributions', Bioinformatics, 34, pp. i757 - i765, http://dx.doi.org/10.1093/bioinformatics/bty558

Zhang YY; Tabataba H; Liu XY; Wang JY; Yan XG; Farrelly M; Jiang CC; Guo ST; Liu T; Kao HY; Thorne RF; Zhang XD; Jin L, 2018, 'ACTN4 regulates the stability of RIPK1 in melanoma', Oncogene, 37, pp. 4033 - 4045, http://dx.doi.org/10.1038/s41388-018-0260-x

Ooi CY; Carter DR; Liu B; Mayoh C; Beckers A; Lalwani A; Nagy Z; De Brouwer S; Decaesteker B; Hung TT; Norris MD; Haber M; Liu T; De Preter K; Speleman F; Cheung BB; Marshall GM, 2018, 'Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN', Cancer Research, 78, pp. 3122 - 3134, http://dx.doi.org/10.1158/0008-5472.CAN-17-3034

Wang YF; Liu F; Sherwin S; Farrelly M; Yan XG; Croft A; Liu T; Jin L; Zhang XD; Jiang CC, 2018, 'Cooperativity of HOXA5 and STAT3 Is Critical for HDAC8 Inhibition-Mediated Transcriptional Activation of PD-L1 in Human Melanoma Cells', Journal of Investigative Dermatology, 138, pp. 922 - 932, http://dx.doi.org/10.1016/j.jid.2017.11.009

Ho N; Peng H; Mayoh C; Liu PY; Atmadibrata B; Marshall GM; Li J; Liu T, 2018, 'Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma', Cell Cycle, 17, pp. 749 - 758, http://dx.doi.org/10.1080/15384101.2017.1421875

Bi L; Xie C; Yao M; Thae Hnit SS; Vignarajan S; Wang Y; Wang Q; Xi Z; Xu H; Li Z; de Souza P; Tee A; Wong M; Liu T; Zhao X; Zhou J; Xu L; Dong Q, 2018, 'The histone chaperone complex FACT promotes proliferative switch of G0 cancer cells', International Journal of Cancer, 145, pp. 164 - 178, http://dx.doi.org/10.1002/ijc.32065

Qiu S; Liu PY; Liu T, 2017, 'Up-regulation of LYAR blocks Myc-induced cell death', Cell Cycle, 16, pp. 1857 - 1858, http://dx.doi.org/10.1080/15384101.2017.1374682

Melaiu O; Mina M; Chierici M; Boldrini R; Jurman G; Romania P; D'Alicandro V; Benedetti MC; Castellano A; Liu T; Furlanello C; Locatelli F; Fruci D, 2017, 'PD-L1 is a therapeutic target of the bromodomain inhibitor JQ1 and, combined with HLA class I, a promising prognostic biomarker in neuroblastoma', Clinical Cancer Research, 23, pp. 4462 - 4472, http://dx.doi.org/10.1158/1078-0432.CCR-16-2601

Wong M; Tee AEL; Milazzo G; Bell JL; Poulos RC; Atmadibrata B; Sun Y; Jing D; Ho N; Ling D; Liu PY; Zhang XD; Hüttelmaier S; Wong JWH; Wang J; Polly P; Perini G; Scarlett CJ; Liu T, 2017, 'The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription', Cancer Research, 77, pp. 2522 - 2533, http://dx.doi.org/10.1158/0008-5472.CAN-16-1663

Tang Y; Cheung BB; Atmadibrata B; Marshall GM; Dinger ME; Liu PY; Liu T, 2017, 'The regulatory role of long noncoding RNAs in cancer', Cancer Letters, 391, pp. 12 - 19, http://dx.doi.org/10.1016/j.canlet.2017.01.010

Jung MS; Russell AJ; Liu B; George J; Liu PY; Liu T; DeFazio A; Bowtell DDL; Oberthuer A; London WB; Fletcher JI; Haber M; Norris MD; Henderson MJ, 2017, 'A Myc activity signature predicts poor clinical outcomes in Myc-associated cancers', Cancer Research, 77, pp. 971 - 981, http://dx.doi.org/10.1158/0008-5472.CAN-15-2906

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