Select Publications
Journal articles
2024, 'Generating mutants of monotone affinity towards stronger protein complexes through adversarial learning', Nature Machine Intelligence, http://dx.doi.org/10.1038/s42256-024-00803-z
,2023, 'Exploring neurotransmitters and their receptors for breast cancer prevention and treatment', Theranostics, 13, pp. 1109 - 1129, http://dx.doi.org/10.7150/thno.81403
,2023, 'LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53‐Defective Cancer Cells', Advanced Science, http://dx.doi.org/10.1002/advs.202204599
,2022, 'Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis (vol 104, pg 18682, 2007)', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120, http://dx.doi.org/10.1073/pnas.2220015120
,2022, 'The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining', Proceedings of the National Academy of Sciences of the United States of America, 119, http://dx.doi.org/10.1073/pnas.2208904119
,2022, 'Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells', Discover Oncology, 13, http://dx.doi.org/10.1007/s12672-022-00505-1
,2022, 'Density-based detection of cell transition states to construct disparate and bifurcating trajectories', Nucleic acids research, 50, pp. e122 - e122, http://dx.doi.org/10.1093/nar/gkac785
,2022, 'Editorial: Neuroblastoma: Signal Crosstalk and Future Insight Into Clinical Trials', Frontiers in Oncology, 12, http://dx.doi.org/10.3389/fonc.2022.861963
,2022, 'Histone acetyltransferases CBP/p300 in tumorigenesis and CBP/p300 inhibitors as promising novel anticancer agents', Theranostics, 12, pp. 4935 - 4948, http://dx.doi.org/10.7150/thno.73223
,2022, 'Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma', International Journal of Cancer, http://dx.doi.org/10.1002/ijc.34349
,2022, 'NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma', EMBO Reports, pp. 1 - 19, http://dx.doi.org/10.15252/embr.202254977
,2021, 'An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-22143-x
,2021, 'The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-24099-4
,2021, 'Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design.', Brief Funct Genomics, 20, pp. 289 - 303, http://dx.doi.org/10.1093/bfgp/elab027
,2021, 'A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma', Oncogene, 40, pp. 2367 - 2381, http://dx.doi.org/10.1038/s41388-021-01712-w
,2021, 'The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma', Molecular Oncology, 15, pp. 1162 - 1179, http://dx.doi.org/10.1002/1878-0261.12906
,2021, 'The emerging roles of RNA m6A methylation and demethylation as critical regulators of tumorigenesis, drug sensitivity, and resistance', Cancer Research, pp. canres.4107.2020 - canres.4107.2020, http://dx.doi.org/10.1158/0008-5472.can-20-4107
,2021, 'NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma', Cellular and Molecular Life Sciences, 78, pp. 2213 - 2230, http://dx.doi.org/10.1007/s00018-020-03632-6
,2021, 'Targeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy', Clinical Cancer Research, 27, pp. 1438 - 1451, http://dx.doi.org/10.1158/1078-0432.CCR-20-3044
,2021, 'Visualization of endogenous p27 and Ki67 reveals the importance of a c-Myc-driven metabolic switch in promoting survival of quiescent cancer cells', Theranostics, 11, pp. 9605 - 9622, http://dx.doi.org/10.7150/THNO.63763
,2020, 'Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN-amplified neuroblastoma', International Journal of Cancer, 147, pp. 1928 - 1938, http://dx.doi.org/10.1002/ijc.32936
,2020, 'Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia', Cancer Cell, 38, pp. 263 - 278.e6, http://dx.doi.org/10.1016/j.ccell.2020.05.014
,2020, 'Identification of rna-binding proteins as targetable putative oncogenes in neuroblastoma', International Journal of Molecular Sciences, 21, pp. 1 - 27, http://dx.doi.org/10.3390/ijms21145098
,2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, 24, pp. 2229 - 2239, http://dx.doi.org/10.1111/jcmm.14897
,2020, 'c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-18735-8
,2020, 'Sequencing dropout-and-batch effect normalization for single-cell mRNA profiles: a survey and comparative analysis', Briefings in Bioinformatics, http://dx.doi.org/10.1093/bib/bbaa248
,2019, 'JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-11132-w
,2019, 'LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-13313-z
,2019, 'The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35', Nature Communications, 10, http://dx.doi.org/10.1038/s41467-019-12971-3
,2019, 'Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface', Cancer Research, 79, pp. 5652 - 5667, http://dx.doi.org/10.1158/0008-5472.CAN-19-1112
,2019, 'JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis', Leukemia, 33, pp. 1400 - 1410, http://dx.doi.org/10.1038/s41375-018-0354-z
,2019, 'The critical role of RNA M6A methylation in cancer', Cancer Research, 79, pp. 1285 - 1292, http://dx.doi.org/10.1158/0008-5472.CAN-18-2965
,2019, 'The histone demethylase NO66 induces glioma cell proliferation', Anticancer Research, 39, pp. 6007 - 6014, http://dx.doi.org/10.21873/anticanres.13806
,2018, 'A p53-responsive miRNA network promotes cancer cell quiescence', Cancer Research, 78, pp. 6666 - 6679, http://dx.doi.org/10.1158/0008-5472.CAN-18-1886
,2018, 'Recognition of CRISPR/Cas9 off-target sites through ensemble learning of uneven mismatch distributions', Bioinformatics, 34, pp. i757 - i765, http://dx.doi.org/10.1093/bioinformatics/bty558
,2018, 'ACTN4 regulates the stability of RIPK1 in melanoma', Oncogene, 37, pp. 4033 - 4045, http://dx.doi.org/10.1038/s41388-018-0260-x
,2018, 'Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN', Cancer Research, 78, pp. 3122 - 3134, http://dx.doi.org/10.1158/0008-5472.CAN-17-3034
,2018, 'Cooperativity of HOXA5 and STAT3 Is Critical for HDAC8 Inhibition-Mediated Transcriptional Activation of PD-L1 in Human Melanoma Cells', Journal of Investigative Dermatology, 138, pp. 922 - 932, http://dx.doi.org/10.1016/j.jid.2017.11.009
,2018, 'Delineation of the frequency and boundary of chromosomal copy number variations in paediatric neuroblastoma', Cell Cycle, 17, pp. 749 - 758, http://dx.doi.org/10.1080/15384101.2017.1421875
,2018, 'The histone chaperone complex FACT promotes proliferative switch of G
2017, 'Up-regulation of LYAR blocks Myc-induced cell death', Cell Cycle, 16, pp. 1857 - 1858, http://dx.doi.org/10.1080/15384101.2017.1374682
,2017, 'PD-L1 is a therapeutic target of the bromodomain inhibitor JQ1 and, combined with HLA class I, a promising prognostic biomarker in neuroblastoma', Clinical Cancer Research, 23, pp. 4462 - 4472, http://dx.doi.org/10.1158/1078-0432.CCR-16-2601
,2017, 'The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription', Cancer Research, 77, pp. 2522 - 2533, http://dx.doi.org/10.1158/0008-5472.CAN-16-1663
,2017, 'The regulatory role of long noncoding RNAs in cancer', Cancer Letters, 391, pp. 12 - 19, http://dx.doi.org/10.1016/j.canlet.2017.01.010
,2017, 'A Myc activity signature predicts poor clinical outcomes in Myc-associated cancers', Cancer Research, 77, pp. 971 - 981, http://dx.doi.org/10.1158/0008-5472.CAN-15-2906
,2017, 'Chromosome preference of disease genes and vectorization for the prediction of non-coding disease genes', Oncotarget, 8, pp. 78901 - 78916, http://dx.doi.org/10.18632/oncotarget.20481
,2017, 'Upregulation of LYAR induces neuroblastoma cell proliferation and survival', Cell Death and Differentiation, 24, pp. 1645 - 1654, http://dx.doi.org/10.1038/cdd.2017.98
,2016, 'NCYM is upregulated by lncUSMycN and modulates N-Myc expression', International Journal of Oncology, 49, pp. 2464 - 2470, http://dx.doi.org/10.3892/ijo.2016.3730
,2016, 'Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia', Leukemia, 30, pp. 1745 - 1748, http://dx.doi.org/10.1038/leu.2016.24
,2016, 'INPP4B is an oncogenic regulator in human colon cancer', Oncogene, 35, pp. 3049 - 3061, http://dx.doi.org/10.1038/onc.2015.361
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