By Associate Professor Vladimir Sytnyk

Book Chapters

Schachner M; Leshchyns’ka I; Sytnyk V, 2016, 'Functions of the neural cell adhesion molecule (NCAM) at the synapse', in The Curated Reference Collection in Neuroscience and Biobehavioral Psychology, pp. 91 - 96, http://dx.doi.org/10.1016/B978-0-12-809324-5.02402-0

Journal articles

Su F; Pfundstein G; Sah S; Zhang S; Keable R; Hagan DW; Sharpe LJ; Clemens KJ; Begg D; Phelps EA; Brown AJ; Leshchyns'ka I; Sytnyk V, 2025, 'Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65).', J Neurochem, 169, pp. e16279, http://dx.doi.org/10.1111/jnc.16279

Kozlova I; Sytnyk V, 2024, 'Cell Adhesion Molecules as Modulators of the Epidermal Growth Factor Receptor', Cells, 13, http://dx.doi.org/10.3390/cells13221919

Fath T; Sytnyk V; Martínez-Mármol R, 2024, '‘10th cell architecture in development and disease (CADD)’: Meeting report', Cytoskeleton, 81, pp. 264 - 265, http://dx.doi.org/10.1002/cm.21815

Horowitz A; Mammoto A; Sytnyk V; Jakovcevski I, 2024, 'Editorial: Editors’ showcase 2023: insights in cell adhesion and migration', Frontiers in Cell and Developmental Biology, 12, http://dx.doi.org/10.3389/fcell.2024.1497689

Sah S; Keable R; Pfundstein G; Clemens KJ; Begg D; Schachner M; Leshchyns’ka I; Sytnyk V, 2023, 'Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits', Cerebral Cortex, 33, pp. 10047 - 10065, http://dx.doi.org/10.1093/cercor/bhad264

Keable R; Hu S; Pfundstein G; Kozlova I; Su F; Du X; Yang H; Gunnersen J; Schachner M; Leshchyns’ka I; Sytnyk V, 2022, 'The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-022-04575-w

Pfundstein G; Nikonenko AG; Sytnyk V, 2022, 'Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology', Frontiers in Cell and Developmental Biology, 10, http://dx.doi.org/10.3389/fcell.2022.969547

Xu SM; Curry-Hyde A; Sytnyk V; Janitz M, 2022, 'RNA polyadenylation patterns in the human transcriptome', Gene, 816, http://dx.doi.org/10.1016/j.gene.2021.146133

Sytnyk V; Leshchyns’ka I; Schachner M, 2021, 'Neural glycomics: the sweet side of nervous system functions', Cellular and Molecular Life Sciences, 78, pp. 93 - 116, http://dx.doi.org/10.1007/s00018-020-03578-9

Kozlova I; Sah S; Keable R; Leshchyns’ka I; Janitz M; Sytnyk V, 2020, 'Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons', Frontiers in Molecular Neuroscience, 13, http://dx.doi.org/10.3389/fnmol.2020.592126

Keable R; Leshchyns’ka I; Sytnyk V, 2020, 'Trafficking and Activity of Glutamate and GABA Receptors: Regulation by Cell Adhesion Molecules', Neuroscientist, 26, pp. 415 - 437, http://dx.doi.org/10.1177/1073858420921117

Sytnyk V; Fath T, 2020, 'Editorial: From Structure to Function - The Interplay Between Cell Adhesion Molecules and the Cytoskeleton', Frontiers in Cell and Developmental Biology, 8, pp. 104, http://dx.doi.org/10.3389/fcell.2020.00104

Huang R; Yuan DJ; Li S; Liang XS; Gao Y; Lan XY; Qin HM; Ma YF; Xu GY; Schachner M; Sytnyk V; Boltze J; Ma QH; Li S, 2020, 'NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis', Journal of Cell Biology, 219, http://dx.doi.org/10.1083/jcb.201902164

Bliim N; Leshchyns'ka I; Keable R; Chen BJ; Curry-Hyde A; Gray L; Sytnyk V; Janitz M, 2019, 'Early transcriptome changes in response to chemical long-term potentiation induced via activation of synaptic NMDA receptors in mouse hippocampal neurons', Genomics, 111, pp. 1676 - 1686, http://dx.doi.org/10.1016/j.ygeno.2018.11.019

Guseva D; Jakovcevski I; Irintchev A; Leshchyns’Ka I; Sytnyk V; Ponimaskin E; Schachner M, 2018, 'Cell adhesion molecule close homolog of L1 (CHL1) guides the regrowth of regenerating motor axons and regulates synaptic coverage of motor neurons', Frontiers in Molecular Neuroscience, 11, http://dx.doi.org/10.3389/fnmol.2018.00174

Sheng L; Leshchyns'ka I; Sytnyk V, 2018, 'Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.', Cereb Cortex, 29, http://dx.doi.org/10.1093/cercor/bhy041

Tan RPA; Leshchyns’Ka I; Sytnyk V; Leshchynska I, 2017, 'Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation', Frontiers in Molecular Neuroscience, 10, pp. 378, http://dx.doi.org/10.3389/fnmol.2017.00378

Duncan T; Lowe A; Sidhu K; Sachdev P; Lewis T; Lin RCY; Sytnyk V; Valenzuela M, 2017, 'Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin.', Stem Cell Reports, 9, pp. 557 - 570, http://dx.doi.org/10.1016/j.stemcr.2017.07.008

Sytnyk V; Leshchyns'ka I; Schachner M, 2017, 'Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function', Trends in Neurosciences, 40, pp. 295 - 308, http://dx.doi.org/10.1016/j.tins.2017.03.003

Bliim N; Leshchyns’ka I; Sytnyk V; Janitz M, 2016, 'Transcriptional regulation of long-term potentiation', Neurogenetics, 17, pp. 201 - 210, http://dx.doi.org/10.1007/s10048-016-0489-x

Cheng YY; Wright CM; Kirschner MB; Williams M; Sarun KH; Sytnyk V; Leshchynska I; Edelman JJ; Vallely MP; McCaughan BC; Klebe S; van Zandwijk N; Lin RCY; Reid G, 2016, 'KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma', Molecular Cancer, 15, pp. 44, http://dx.doi.org/10.1186/s12943-016-0529-z

Leshchyns'ka I; Sytnyk V, 2016, 'Reciprocal interactions between cell adhesion molecules of the immunoglobulin superfamily and the cytoskeleton in neurons', Frontiers in Cell and Developmental Biology, 4, http://dx.doi.org/10.3389/fcell.2016.00009

Leshchyns'Ka I; Sytnyk V, 2016, 'Synaptic Cell Adhesion Molecules in Alzheimer's Disease', Neural Plasticity, 2016, pp. 6427537, http://dx.doi.org/10.1155/2016/6427537

Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms9836

Schmalbach B; Lepsveridze E; Djogo N; Papashvili G; Kuang F; Leshchyns'Ka I; Sytnyk V; Nikonenko AG; Dityatev A; Jakovcevski I; Schachner M, 2015, 'Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene', Journal of Neurochemistry, 135, pp. 830 - 844, http://dx.doi.org/10.1111/jnc.13284

Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of cell science, 128, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.169391

Sytnyk V; Fath T, 2015, 'Synapse Function in Dementia and Neurodegenerative Disorders', Australian Biochemist, 46, https://www.asbmb.org.au/magazine/2015_April_Issue46-1/Showcase%204%20-%20Fath.pdf

Leshchyns'ka I; Sytnyk V, 2015, 'Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM)', Bioarchitecture, 5, pp. 54 - 60, http://dx.doi.org/10.1080/19490992.2015.1118194

Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of Cell Science, 128, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.169391

Sheng L; Leshchyns’Ka I; Sytnyk V, 2015, 'Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca²⁺ levels', Journal of Neuroscience, 35, pp. 1739 - 1752, http://dx.doi.org/10.1523/JNEUROSCI.1714-14.2015

Robinson JW; Leshchyns'ka I; Farghaian H; Hughes WE; Sytnyk V; Neely GG; Cole AR, 2014, 'PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes', Biochemical Journal, 464, pp. 145 - 156, http://dx.doi.org/10.1042/BJ20140497

Sheng L; Leshchyns'Ka I; Sytnyk V, 2013, 'Cell adhesion and intracellular calcium signaling in neurons', Cell Communication and Signaling, 11, http://dx.doi.org/10.1186/1478-811X-11-94

Shetty A; Sytnyk V; Leshchyns'ka I; Puchkov D; Haucke V; Schachner M, 2013, 'The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms', Journal of Neuroscience, 33, pp. 16828 - 16845, http://dx.doi.org/10.1523/JNEUROSCI.2192-13.2013

Leshchyns’ka I; Sytnyk V, 2013, 'Isolation of Growth Cones from Mouse Brain', BIO-PROTOCOL, 3, http://dx.doi.org/10.21769/bioprotoc.853

Li S; Leshchyns'ka I; Chernyshova Y; Schachner M; Sytnyk V, 2013, 'The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated Kinase 1 (Pak1)', Journal of Neuroscience, 33, pp. 790 - 803, http://dx.doi.org/10.1523/JNEUROSCI.1238-12.2013

Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012

Poplawski GHD; Transziska AK; Leshchyns'ka I; Meier ID; Streichert T; Sytnyk V; Schachner M, 2012, 'L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth', Molecular and Cellular Neuroscience, 50, pp. 169 - 178, http://dx.doi.org/10.1016/j.mcn.2012.03.010

Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, 287, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973

Chernyshova Y; Leshchyns'ka I; Hsu SC; Schachner M; Sytnyk V, 2011, 'The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones', Journal of Neuroscience, 31, pp. 3522 - 3535, http://dx.doi.org/10.1523/JNEUROSCI.3109-10.2011

Leshchyns'ka I; Tanaka M; Schachner M; Sytnyk V, 2011, 'Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions', The Journal of Biological Chemistry, 286, pp. 23397 - 23406, http://dx.doi.org/10.1074/jbc.M111.252098

Puchkov D; Leshchyns ka I; Nikonenko A; Schachner M; Sytnyk V, 2011, 'NCAM/Spectrin Complex Disassembly Results in PSD Perforation and Postsynaptic Endocytic Zone Formation.', Cerebral cortex, 21, pp. 2217 - 2232, http://dx.doi.org/10.1093/cercor/bhq283

Chernyshova Y; Leshchyns'ka I; Hsu SC; Schachner M; Sytnyk V, 2011, 'The Neural Cell Adhesion Molecule Promotes FGFR-Dependent Phosphorylation and Membrane Targeting of the Exocyst Complex to Induce Exocytosis in Growth Cones', Journal of Neuroscience, 31, pp. 3522 - 3535, http://dx.doi.org/10.1523/?JNEUROSCI.3109-10.2011

Devanathan V; Jakovcevski I; Santuccione A; Li S; Lee HJ; Peles E; Leshchyns ka I; Sytnyk V; Schachner M, 2010, 'Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.', Journal of Neuroscience, 30, pp. 9292 - 9305, http://www.jneurosci.org/cgi/content/full/30/27/9292

Andreyeva A; Leshchyns ka I; Knepper M; Betzel C; Redecke L; Sytnyk V; Schachner M, 2010, 'CHL1 Is a Selective Organizer of the Presynaptic Machinery Chaperoning the SNARE Complex', PLoS One, 5, pp. e12018, http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0012018

Westphal D; Sytnyk V; Schachner M; Leshchyns ka I, 2010, 'Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8 and -3 dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth.', The Journal of Biological Chemistry, 285, pp. 42046 - 42057, http://dx.doi.org/10.1074/jbc.M110.177147

Bodrikov V; Sytnyk V; Leshchyns ka I; den Hertog J; Schachner M, 2008, 'NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.', Journal of Cell Biology, 182, pp. 1185 - 1200

Jakovcevski I; Wu J; Karl N; Leshchyns ka I; Sytnyk V; Chen J; Irintchev A; Schachner M, 2007, 'Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury.', Journal of Neuroscience, 27, pp. 7222 - 7233

Sytnyk V; Leshchyns ka I; Nikonenko I; Schachner M, 2006, 'NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.', Journal of Cell Biology, 174, pp. 1071 - 1085

Leshchyns ka I; Sytnyk V; Richter M; Andreyeva A; Puchkov D; Schachner M, 2006, 'The adhesion molecule close homologue of L1 (CHL1) regulates uncoating of clathrin-coated synaptic vesicles.', Neuron, 52, pp. 1011 - 1025

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