By Dr Alexis Estelle Whitton

Journal articles

Han J; Slade A; Fujimoto H; Zheng WY; Shvetcov A; Hoon L; Funke Kupper J; Senadeera M; Gupta S; Venkatesh S; Mouzakis K; Gu Y; Bilgrami A; Saba N; Cutler H; Batterham P; Boydell K; Shand F; Whitton A; Christensen H, 2024, 'A web-based video messaging intervention for suicide prevention in men: study protocol for a five-armed randomised controlled trial', Trials, 25, http://dx.doi.org/10.1186/s13063-024-08308-1

Gunn MP; Rose GM; Whitton AE; Pizzagalli DA; Gilbert DG, 2024, 'Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks', Nicotine and Tobacco Research, 26, pp. 1305 - 1312, http://dx.doi.org/10.1093/ntr/ntae084

Whitton AE; Cooper JA; Merchant JT; Treadway MT; Lewandowski KE, 2024, 'Using Computational Phenotyping to Identify Divergent Strategies for Effort Allocation Across the Psychosis Spectrum', Schizophrenia Bulletin, 50, pp. 1127 - 1136, http://dx.doi.org/10.1093/schbul/sbae024

Beames JR; Han J; Shvetcov A; Zheng WY; Slade A; Dabash O; Rosenberg J; O'Dea B; Kasturi S; Hoon L; Whitton AE; Christensen H; Newby JM, 2024, 'Use of smartphone sensor data in detecting and predicting depression and anxiety in young people (12–25 years): A scoping review', Heliyon, 10, http://dx.doi.org/10.1016/j.heliyon.2024.e35472

Shaw SR; Horne KS; Piguet O; Ahmed RM; Whitton AE; Irish M, 2024, 'Profiles of motivational impairment and their relationship to functional decline in frontotemporal dementia', Journal of Neurology, 271, pp. 4963 - 4971, http://dx.doi.org/10.1007/s00415-024-12430-0

Dan R; Whitton AE; Treadway MT; Rutherford AV; Kumar P; Ironside ML; Kaiser RH; Ren B; Pizzagalli DA, 2024, 'Brain-based graph-theoretical predictive modeling to map the trajectory of anhedonia, impulsivity, and hypomania from the human functional connectome', Neuropsychopharmacology, 49, pp. 1162 - 1170, http://dx.doi.org/10.1038/s41386-024-01842-1

Gollan JK; Liverant G; Jao NC; Lord KA; Whitton AE; Hogarth L; Fox E; Bauer AM; Quinn MH; Pizzagalli DA; Leone FT; Papandonatos GD; Schnoll RA; Hitsman B, 2024, 'Depression Severity Moderates Reward Learning Among Smokers With Current or Past Major Depressive Disorder in a Smoking Cessation Randomized Clinical Trial', Nicotine and Tobacco Research, 26, pp. 639 - 644, http://dx.doi.org/10.1093/ntr/ntad221

Shvetcov A; Funke Kupper J; Zheng WY; Slade A; Han J; Whitton A; Spoelma M; Hoon L; Mouzakis K; Vasa R; Gupta S; Venkatesh S; Newby J; Christensen H, 2024, 'Passive sensing data predicts stress in university students: a supervised machine learning method for digital phenotyping', Frontiers in Psychiatry, 15, http://dx.doi.org/10.3389/fpsyt.2024.1422027

Christensen H; Slade A; Whitton AE, 2024, 'Social media: the root cause of rising youth self-harm or a convenient scapegoat?', Medical Journal of Australia, http://dx.doi.org/10.5694/mja2.52503

Min S; Mazurka R; Pizzagalli DA; Whitton AE; Milev RV; Bagby RM; Kennedy SH; Harkness KL, 2024, 'Stressful Life Events and Reward Processing in Adults: Moderation by Depression and Anhedonia', Depression and Anxiety, 2024, http://dx.doi.org/10.1155/2024/8853631

Whitton AE; Kumar P; Treadway MT; Rutherford AV; Ironside ML; Foti D; Fitzmaurice G; Du F; Pizzagalli DA, 2023, 'Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders', Molecular Psychiatry, 28, pp. 5272 - 5281, http://dx.doi.org/10.1038/s41380-023-02165-1

Shvetcov A; Whitton A; Kasturi S; Zheng WY; Beames J; Ibrahim O; Han J; Hoon L; Mouzakis K; Gupta S; Venkatesh S; Christensen H; Newby J, 2023, 'Machine learning identifies a COVID-19-specific phenotype in university students using a mental health app', Internet Interventions, 34, http://dx.doi.org/10.1016/j.invent.2023.100666

Darrow SM; Pizzagalli DA; Smoski M; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu D; Murrough JW; Yang H; Weiner RD; Sanacora G; Keefe RSE; Song A; Goodman W; Whitton AE; Potter WZ; Krystal AD, 2023, 'Using latent profile analyses to classify subjects with anhedonia based on reward-related measures obtained in the FAST-MAS study', Journal of Affective Disorders, 339, pp. 584 - 592, http://dx.doi.org/10.1016/j.jad.2023.07.081

Huckvale K; Hoon L; Stech E; Newby JM; Zheng WY; Han J; Vasa R; Gupta S; Barnett S; Senadeera M; Cameron S; Kurniawan S; Agarwal A; Kupper JF; Asbury J; Willie D; Grant A; Cutler H; Parkinson B; Ahumada-Canale A; Beames JR; Logothetis R; Bautista M; Rosenberg J; Shvetcov A; Quinn T; MacKinnon A; Rana S; Tran T; Rosenbaum S; Mouzakis K; Werner-Seidler A; Whitton A; Venkatesh S; Christensen H, 2023, 'Protocol for a bandit-based response adaptive trial to evaluate the effectiveness of brief self-guided digital interventions for reducing psychological distress in university students: the Vibe Up study', BMJ Open, 13, http://dx.doi.org/10.1136/bmjopen-2022-066249

O’Dea B; Parker B; Batterham PJ; Chakouch C; Mackinnon AJ; Whitton AE; Newby JM; Subotic-Kerry M; Gayed A; Harvey SB, 2023, 'A Cluster Randomized Controlled Trial on the Effectiveness of the Building Educators’ Skills in Adolescent Mental Health (BEAM) Program for Improving Secondary School Educators’ Confidence, Behavior, Knowledge, and Attitudes Toward Student Mental Health', Journal of Teacher Education, http://dx.doi.org/10.1177/00224871231208684

Vis C; Schuurmans J; Aouizerate B; Craggs MA; Batterham P; Bührmann L; Calear A; Pashoja AC; Christensen H; Dozeman E; Pedersen CD; Ebert DD; Etzelmueller A; Fanaj N; Finch TL; Hanssen D; Hegerl U; Hoogendoorn A; Mathiasen K; May C; Meksi A; Mustafa S; O'Dea B; Oehler C; Piera-Jiménez J; Potthoff S; Qirjako G; Rapley T; Rosmalen J; Sacco Y; Samalin L; Skjoth MM; Tarp K; Titzler I; Van der Eycken E; van Genugten CR; Whitton A; Zanalda E; Smit JH; Riper H, 2023, 'Effectiveness of Self-guided Tailored Implementation Strategies in Integrating and Embedding Internet-Based Cognitive Behavioral Therapy in Routine Mental Health Care: Results of a Multicenter Stepped-Wedge Cluster Randomized Trial', Journal of Medical Internet Research, 25, http://dx.doi.org/10.2196/41532

Pizzagalli D; Whitton A; Kumar P; Treadway M; Rutherford AV; Ironside ML, 2023, 'Anhedonia and Reward-Related Neural Abnormalities Prospectively Predict Longitudinal Changes in Quality of Life Among Treatment-Seeking Individuals With Mood Disorders', Biological Psychiatry, 93, pp. S2 - S2, http://dx.doi.org/10.1016/j.biopsych.2023.02.026

Pechtel P; Belleau EL; Kaiser RH; Whitton AE; Beltzer M; Clegg R; Goer F; Vitaliano G; Teicher MH; Pizzagalli DA, 2022, 'Stress and reward: A multimodal assessment of childhood sexual abuse', Neurobiology of Stress, 21, http://dx.doi.org/10.1016/j.ynstr.2022.100498

Whitton A; Lewandowski K; Hall M-H, 2022, 'P532. Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders', Biological Psychiatry, 91, pp. S304 - S304, http://dx.doi.org/10.1016/j.biopsych.2022.02.769

Reinen JM; Whitton AE; Pizzagalli DA; Slifstein M; Abi-Dargham A; McGrath PJ; Iosifescu DV; Schneier FR, 2021, 'Differential reinforcement learning responses to positive and negative information in unmedicated individuals with depression', European Neuropsychopharmacology, 53, pp. 89 - 100, http://dx.doi.org/10.1016/j.euroneuro.2021.08.002

Costi S; Morris LS; Collins A; Fernandez NF; Patel M; Xie H; Kim-Schulze S; Stern ER; Collins KA; Cathomas F; Parides MK; Whitton AE; Pizzagalli DA; Russo SJ; Murrough JW, 2021, 'Peripheral immune cell reactivity and neural response to reward in patients with depression and anhedonia', Translational Psychiatry, 11, http://dx.doi.org/10.1038/s41398-021-01668-1

Whitton AE; Lewandowski KE; Hall MH, 2021, 'Smoking as a Common Modulator of Sensory Gating and Reward Learning in Individuals with Psychotic Disorders', Brain Sciences, 11, http://dx.doi.org/10.3390/brainsci11121581

Parker BL; Anderson M; Batterham PJ; Gayed A; Subotic-Kerry M; Achilles MR; Chakouch C; Werner-Seidler A; Whitton AE; O Dea B, 2021, 'Examining the Preliminary Effectiveness and Acceptability of a Web-Based Training Program for Australian Secondary School Teachers: Pilot Study of the BEAM (Building Educators Skills in Adolescent Mental Health) Program', JMIR Mental Health, 8, http://dx.doi.org/10.2196/29989

Whitton AE; Rabinovich NE; Lindt JD; Pergadia ML; Pizzagalli DA; Gilbert DG, 2021, 'Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers', Nicotine and Tobacco Research, 23, pp. 1779 - 1786, http://dx.doi.org/10.1093/ntr/ntab072

Whitton AE; Hardy R; Cope K; Gieng C; Gow L; MacKinnon A; Gale N; O'Moore K; Anderson J; Proudfoot J; Cockayne N; O'Dea B; Christensen H; Newby JM, 2021, 'Mental health screening in general practices as a means for enhancing uptake of digital mental health interventions: Observational cohort study', Journal of Medical Internet Research, 23, http://dx.doi.org/10.2196/28369

Shaw SR; El-Omar H; Ramanan S; Piguet O; Ahmed RM; Whitton AE; Irish M, 2021, 'Anhedonia in semantic dementia—exploring right hemispheric contributions to the loss of pleasure', Brain Sciences, 11, http://dx.doi.org/10.3390/brainsci11080998

Eren-Yazicioglu CY; Kara B; Sancak S; Uysal SP; Yazici D; Okuroglu N; Whitton AE; Rutherford AV; Yapici-Eser H, 2021, 'Effect of Exenatide Use on Cognitive and Affective Functioning in Obese Patients with Type 2 Diabetes Mellitus: Exenatide Use Mediates Depressive Scores through Increased Perceived Stress Levels', Journal of Clinical Psychopharmacology, 41, pp. 428 - 435, http://dx.doi.org/10.1097/JCP.0000000000001409

Whitton AE; Kumar P; Treadway MT; Rutherford AV; Ironside ML; Foti D; Fitzmaurice G; Du F; Pizzagalli DA, 2021, 'Mapping Disease Course Across the Mood Disorder Spectrum Through a Research Domain Criteria Framework', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6, pp. 706 - 715, http://dx.doi.org/10.1016/j.bpsc.2021.01.004

Costi S; Morris LS; Kirkwood KA; Hoch M; Corniquel M; Vo-Le B; Iqbal T; Chadha N; Pizzagalli DA; Whitton A; Bevilacqua L; Jha MK; Ursu S; Swann AC; Collins KA; Salas R; Bagiella E; Parides MK; Stern ER; Iosifescu DV; Han MH; Mathew SJ; Murrough JW, 2021, 'Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: Results from a randomized controlled trial', American Journal of Psychiatry, 178, pp. 437 - 446, http://dx.doi.org/10.1176/appi.ajp.2020.20050653

Shaw SR; El-Omar H; Roquet D; Hodges JR; Piguet O; Ahmed RM; Whitton AE; Irish M, 2021, 'Uncovering the prevalence and neural substrates of anhedonia in frontotemporal dementia', Brain, 144, pp. 1551 - 1564, http://dx.doi.org/10.1093/brain/awab032

Parker BL; Chakouch C; Subotic-Kerry M; Batterham PJ; Mackinnon A; Newby JM; Whitton AE; McGoldrick J; Cockayne N; O'Dea B, 2021, 'The building educators’ skills in adolescent mental health training program for secondary school educators: Protocol for a cluster randomized controlled trial', JMIR Research Protocols, 10, http://dx.doi.org/10.2196/25870

Reilly EE; Whitton AE; Pizzagalli DA; Rutherford AV; Stein MB; Paulus MP; Taylor CT, 2020, 'Diagnostic and dimensional evaluation of implicit reward learning in social anxiety disorder and major depression', Depression and Anxiety, 37, pp. 1221 - 1230, http://dx.doi.org/10.1002/da.23081

Murphy M; Whitton AE; Deccy S; Ironside ML; Rutherford A; Beltzer M; Sacchet M; Pizzagalli DA, 2020, 'Abnormalities in electroencephalographic microstates are state and trait markers of major depressive disorder', Neuropsychopharmacology, 45, pp. 2030 - 2037, http://dx.doi.org/10.1038/s41386-020-0749-1

Whitton AE; Merchant JT; Lewandowski KE, 2020, 'Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum', Schizophrenia Research, 224, pp. 133 - 140, http://dx.doi.org/10.1016/j.schres.2020.09.014

Pizzagalli DA; Smoski M; Ang YS; Whitton AE; Sanacora G; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu DV; Murrough JW; Yang H; Weiner RD; Calabrese JR; Goodman W; Potter WZ; Krystal AD, 2020, 'Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)', Neuropsychopharmacology, 45, pp. 1656 - 1663, http://dx.doi.org/10.1038/s41386-020-0738-4

Tan A; Costi S; Morris LS; Van Dam NT; Kautz M; Whitton AE; Friedman AK; Collins KA; Ahle G; Chadha N; Do B; Pizzagalli DA; Iosifescu DV; Nestler EJ; Han MH; Murrough JW, 2020, 'Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder', Molecular Psychiatry, 25, pp. 1323 - 1333, http://dx.doi.org/10.1038/s41380-018-0283-2

Krystal AD; Pizzagalli DA; Smoski M; Mathew SJ; Nurnberger J; Lisanby SH; Iosifescu D; Murrough JW; Yang H; Weiner RD; Calabrese JR; Sanacora G; Hermes G; Keefe RSE; Song A; Goodman W; Szabo ST; Whitton AE; Gao K; Potter WZ, 2020, 'A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia', Nature Medicine, 26, pp. 760 - 768, http://dx.doi.org/10.1038/s41591-020-0806-7

Murphy M; Whitton A; Deccy S; Ironside M; Beltzer M; Sacchet M; Pizzagalli D, 2020, 'Abnormal Electroencephalographic Microstate Dynamics Are Associated With Active but Not Remitted Major Depressive Disorder', BIOLOGICAL PSYCHIATRY, 87, pp. S137 - S138, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000535308200327&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Carpenter JS; Iorfino F; Cross S; Nichles A; Zmicerevska N; Crouse JJ; Palmer JR; Whitton AE; White D; Naismith SL; Guastella AJ; Hermens DF; Scott J; Scott EM; Hickie IB, 2020, 'Cohort profile: The Brain and Mind Centre Optymise cohort: Tracking multidimensional outcomes in young people presenting for mental healthcare', BMJ Open, 10, http://dx.doi.org/10.1136/bmjopen-2019-030985

Whitton AE; Reinen JM; Slifstein M; Ang YS; McGrath PJ; Iosifescu DV; Abi-Dargham A; Pizzagalli DA; Schneier FR, 2020, 'Baseline reward processing and ventrostriatal dopamine function are associated with pramipexole response in depression', Brain, 143, pp. 701 - 710, http://dx.doi.org/10.1093/brain/awaa002

Whitton A; Reinen J; Slifstein M; Ang Y-S; McGrath P; Iosifescu D; Abi-Dargham A; Pizzagalli D; Schneier F, 2020, 'Computational Approaches to Improving Treatment Precision for Anhedonia', Biological Psychiatry, 87, pp. S50 - S51, http://dx.doi.org/10.1016/j.biopsych.2020.02.153

Murrough J; Costi S; Morris L; Collins A; Collins K; Whitton A; Pizzagalli D; Russo S, 2020, 'Dynamic Peripheral Immune Profiles and Neurocircuit Responses to Reward in Depression', Biological Psychiatry, 87, pp. S15 - S16, http://dx.doi.org/10.1016/j.biopsych.2020.02.066

Whitton AE; Green AI; Pizzagalli DA; Roth RM; Williams JM; Brunette MF, 2019, 'Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers with Schizophrenia', Schizophrenia Bulletin, 45, pp. 1300 - 1308, http://dx.doi.org/10.1093/schbul/sby185

Whitton A; Kumar P; Treadway M; Foti D; Rutherford A; Ironside ML; Du F; Pizzagalli D, 2019, 'Multimodal Assessment of Frontostriatal Circuitry as a Tool for Parsing Motivational Impairments', BIOLOGICAL PSYCHIATRY, 85, pp. S26 - S26, http://dx.doi.org/10.1016/j.biopsych.2019.03.076

Whitton AE; Webb CA; Dillon DG; Kayser J; Rutherford A; Goer F; Fava M; McGrath P; Weissman M; Parsey R; Adams P; Trombello JM; Cooper C; Deldin P; Oquendo MA; McInnis MG; Carmody T; Bruder G; Trivedi MH; Pizzagalli DA, 2019, 'Pretreatment Rostral Anterior Cingulate Cortex Connectivity With Salience Network Predicts Depression Recovery: Findings From the EMBARC Randomized Clinical Trial', Biological Psychiatry, 85, pp. 872 - 880, http://dx.doi.org/10.1016/j.biopsych.2018.12.007

Finan PH; Whitton AE; Letzen JE; Remeniuk B; Robinson ML; Irwin MR; Pizzagalli DA; Smith MT, 2019, 'Experimental sleep disruption and reward learning: Moderating role of positive affect responses', Sleep, 42, http://dx.doi.org/10.1093/sleep/zsz026

Sperl MFJ; Panitz C; Rosso IM; Dillon DG; Kumar P; Hermann A; Whitton AE; Hermann C; Pizzagalli DA; Mueller EM, 2019, 'Fear Extinction Recall Modulates Human Frontomedial Theta and Amygdala Activity', Cerebral Cortex, 29, pp. 701 - 715, http://dx.doi.org/10.1093/cercor/bhx353

Kaiser RH; Treadway MT; Wooten DW; Kumar P; Goer F; Murray L; Beltzer M; Pechtel P; Whitton A; Cohen AL; Alpert NM; El Fakhri G; Normandin MD; Pizzagalli DA, 2018, 'Frontostriatal and dopamine markers of individual differences in reinforcement learning: A multi-modal investigation', Cerebral Cortex, 28, pp. 4281 - 4290, http://dx.doi.org/10.1093/cercor/bhx281

Schneier FR; Slifstein M; Whitton AE; Pizzagalli DA; Reinen J; McGrath PJ; Iosifescu DV; Abi-Dargham A, 2018, 'Dopamine Release in Antidepressant-Naive Major Depressive Disorder: A Multimodal [¹¹C]-(+)-PHNO Positron Emission Tomography and Functional Magnetic Resonance Imaging Study', Biological Psychiatry, 84, pp. 563 - 573, http://dx.doi.org/10.1016/j.biopsych.2018.05.014

Whitton AE; Mehta M; Ironside ML; Murray G; Pizzagalli DA, 2018, 'Evidence of a diurnal rhythm in implicit reward learning', Chronobiology International, 35, pp. 1104 - 1114, http://dx.doi.org/10.1080/07420528.2018.1459662

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