Researcher

Dr Angli Xue

Keywords

Fields of Research (FoR)

Bioinformatics and computational biology, Statistical and quantitative genetics, Genomics and transcriptomics, Immunogenetics (incl. genetic immunology)

Biography

Dr. Angli Xue is a Postdoc Scientist and inaugural NHMRC Investigator Fellow (2025-2029) in Powell Lab at the Garvan Institute of Medical Research. His current research is focused on identifying the genetic control of gene expression variability at the single-cell level. To achieve this goal, he is developing novel statistical methods for single-cell eQTL mapping and applying them to the OneK1K cohort which contains gene expression profiles of...view more

Dr. Angli Xue is a Postdoc Scientist and inaugural NHMRC Investigator Fellow (2025-2029) in Powell Lab at the Garvan Institute of Medical Research. His current research is focused on identifying the genetic control of gene expression variability at the single-cell level. To achieve this goal, he is developing novel statistical methods for single-cell eQTL mapping and applying them to the OneK1K cohort which contains gene expression profiles of 1.2 million peripheral blood mononuclear cells (PBMCs) from ~1,000 individuals. This work would help to understand how genetic variants contribute to gene expression regulation at the single-cell level. He is also leading the work on gene regulatory network inference and multi-omics integration for the TenK10K cohort, the extended version of OneK1K.

Angli obtained his PhD in 2021 at The University of Queensland working with Prof. Jian Yang in the field of statistical genetics. During his PhD, he utilised statistical and computational methods to dissect the genetic architecture of human complex diseases, perform meta-analyses and integrate multi-omics data to identify associated gene loci and gene regulatory mechanisms. He conducted the largest genetic study of type 2 diabetes and highlighted three T2D-associated genes with plausible regulatory mechanisms where a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. He also co-developed a software tool (GSMR2) for evaluating the causal relationship between modifiable risk factors and complex diseases. His first-authored papers have been Highly Cited Paper and highlighted by Nature Asia-Pacific. He was awarded the DeLill Nasser Award for Professional Development in Genetics (Genetics Society of America) in recognition of his PhD work. Before moving to Australia, he completed his BSc at Zhejiang University, China in 2015.

Angli is actively participating in scientific community service and serves as an early career reviewer in GENETICS. He was also an ad hoc reviewer for many journals including Nature Medicine, Nature Human Behaviour, Nucleic Acids Research, G3, EBioMedicine, etc.


My Grants

NHMRC Investigator Grant – Emerging Leadership Level 1 (2025-2029)

Identifying and characterising gene regulatory networks of autoimmune diseases at single-cell resolution


My Qualifications

2021 - PhD (Statistical Genetics), The University of Queensland - Australia

2015 - BSc (Agronomy), Zhejiang University - China            

 

My Awards

2021 - CASS (Contributing to Australian Scholarship and Science) Travel Award

2021 - DeLill Nasser Award for Professional Development in Genetics, Genetics Society of America

2020 - Chinese Scholarship Council Award for Outstanding Students Abroad

2020 - UQ IMB Writing-up Award

2019 - UQ IMB Travel Award for International Conference

2018 - UQ IMB Research Higher Degree Top-Up Scholarships

2018 - Outstanding Contribution in Reviewing Award, EBioMedicine Journal

2016 - University of Queensland International (UQI) Scholarship   

2015 - Outstanding Thesis Award for Bachelor Degree, Zhejiang University   

2015 - Summer Program Scholarship of the Council for Higher Education, the Government of Israel

2014 - Scholarship for Outstanding Performance in Research and Innovation, Zhejiang University

2013 - Gold Medal & Best Biobrick Measurement Approach, International Genetically Engineered Machine Competition, Asian region


My Research Activities

Statistical genetics

Computational biology

Statistical modelling

Human complex traits

Single-cell genomics

eQTL mapping


My Research Supervision


Supervision keywords


Areas of supervision

We have several exciting projects including but not limited to:

1. Investigating the genetic control of gene expression (eQTL) at the single-cell resolution;

2. Establishing single-cell multi-omics atlas for human peripheral blood mononuclear cells;

3. Integrating multi-omics data to discover novel genetic regulatory mechanisms;

4. Developing statistical and computational tools to identify the genetic control of chromatin accessibility;

5. Inferring cell-type-specific gene regulatory networks for autoimmune diseases.


Currently supervising

Cell-type-specific genetic regulation in Crohn's disease (2022 - 2026)

Doctor Philosophy — Associated supervisor

Other supervisors: Professor Joseph Powell, Dr Seyhan Yazar


My Engagement

ASI Awards Judging Panel for ASI postgraduate travel award, Australian and New Zealand Society for Immunology (2024 - now)

Team co-lead in THE SYSTEMS IMMUNOLOGY HACKATHON by OzSinglCell and ASI (2022 - now)

Early career reviewer panel in the Statistical Genetics & Genomics section for the journal GENETICS (2019 - now)

Ad hoc reviewer for Nature Medicine, Nature Human Behavior, Nucleic Acids Research, Diabetes, EBioMedicine, Genetics, G3: Genes,Genomes,Genetics, NAR genomics and bioinformatics, Human Genetics, Clinical Obesity, Journal of Human Genetics.

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Location

384 Victoria Street
Darlinghurst
NSW
2010