By Dr Chansavath Phetsouphanh

Journal articles

Phetsouphanh C; Jacka B; Ballouz S; Jackson KJL; Wilson DB; Manandhar B; Klemm V; Tan HX; Wheatley A; Aggarwal A; Akerman A; Milogiannakis V; Starr M; Cunningham P; Turville SG; Kent SJ; Byrne A; Brew BJ; Darley DR; Dore GJ; Kelleher AD; Matthews GV, 2024, 'Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection', Nature Communications, 15, http://dx.doi.org/10.1038/s41467-024-47720-8

Ma J; Moussawi KA; Lou H; Chan HF; Wang Y; Chadwick J; Phetsouphanh C; Slee EA; Zhong S; Leissing TM; Roth A; Qin X; Chen S; Yin J; Ratnayaka I; Hu Y; Louphrasitthiphol P; Taylor L; Bettencourt PJG; Muers M; Greaves DR; McShane H; Goldin R; Soilleux EJ; Coleman ML; Ratcliffe PJ; Lua X, 2024, 'Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment', Proceedings of the National Academy of Sciences of the United States of America, 121, http://dx.doi.org/10.1073/pnas.2309957121

Cysique LA; Jakabek D; Bracken SG; Allen-Davidian Y; Heng B; Chow S; Dehhaghi M; Staats Pires A; Darley DR; Byrne A; Phetsouphanh C; Kelleher A; Dore GJ; Matthews GV; Guillemin GJ; Brew BJ, 2023, 'The kynurenine pathway relates to post-acute COVID-19 objective cognitive impairment and PASC', Annals of Clinical and Translational Neurology, 10, pp. 1338 - 1352, http://dx.doi.org/10.1002/acn3.51825

Carroll TM; Chadwick JA; Owen RP; White MJ; Kaplinsky J; Peneva I; Frangou A; Xie PF; Chang J; Roth A; Amess B; James SA; Rei M; Fuchs HS; McCann KJ; Omiyale AO; Jacobs BA; Lord SR; Norris-Bulpitt S; Dobbie ST; Griffiths L; Ramirez KA; Ricciardi T; Macri MJ; Ryan A; Venhaus RR; Van den Eynde BJ; Karydis I; Schuster-Böckler B; Middleton MR; Lu X; Ahern D; Berridge G; Cheng J; Drozdz M; Fischer R; Inoue M; Kessler BM; Lou H; McGregor N; Phetsouphanh C; Puig CR; Siejka-Zielińska P; Song C; Tomkova M; Velikova G, 2023, 'Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma', Cancer Cell, 41, pp. 1222 - 1241.e7, http://dx.doi.org/10.1016/j.ccell.2023.06.006

Beaton B; Sasson SC; Rankin K; Raedemaeker J; Wong A; Hastak P; Phetsouphanh C; Warden A; Klemm V; Munier CML; Hoppe AC; Tea F; Pillay A; Stella AO; Aggarwal A; Lavee O; Caterson ID; Turville S; Kelleher AD; Brilot F; Trotman J; Carey Hoppe A, 2023, 'Patients with treated indolent lymphomas immunized with BNT162b2 have reduced anti-spike neutralizing IgG to SARS-CoV-2 variants, but preserved antigen-specific T cell responses', American Journal of Hematology, 98, pp. 131 - 139, http://dx.doi.org/10.1002/ajh.26619

Khoo WH; Jackson K; Phetsouphanh C; Zaunders JJ; Alquicira-Hernandez J; Yazar S; Ruiz-Diaz S; Singh M; Dhenni R; Kyaw W; Tea F; Merheb V; Lee FXZ; Burrell R; Howard-Jones A; Koirala A; Zhou L; Yuksel A; Catchpoole DR; Lai CL; Vitagliano TL; Rouet R; Christ D; Tang B; West NP; George S; Gerrard J; Croucher PI; Kelleher AD; Goodnow CG; Sprent JD; Powell JE; Brilot F; Nanan R; Hsu PS; Deenick EK; Britton PN; Phan TG, 2023, 'Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19', Clinical Immunology, 246, http://dx.doi.org/10.1016/j.clim.2022.109209

Phetsouphanh C; Khoo WH; Jackson K; Klemm V; Howe A; Aggarwal A; Akerman A; Milogiannakis V; Stella AO; Rouet R; Schofield P; Faulks ML; Law H; Danwilai T; Starr M; Munier CML; Christ D; Singh M; Croucher PI; Brilot-Turville F; Turville S; Phan TG; Dore GJ; Darley D; Cunningham P; Matthews GV; Kelleher AD; Zaunders JJ, 2022, 'High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1032911

Rankin K; Beaton B; Sasson S; Raedemaecker J; Wong A; Hastak P; Phetsouphanh C; Warden A; Patel M; Klemm V; Munier CML; Carey Hoppe A; Tea F; Pillay A; Ospina A; Aggarwal A; Lavee O; Caterson ID; Turville S; Kelleher AD; Brilot F; Trotman J, 2022, 'PB2087: EFFICACY OF A 3RD COVID VACCINE, INCLUDING DURING A BTKI PAUSE, IN INDIVIDUALS WITH WALDENSTRÖM MACROGLOBULINEMIA AND FOLLICULAR LYMPHOMA', HemaSphere, 6, pp. 1958 - 1959, http://dx.doi.org/10.1097/01.hs9.0000851180.32970.18

Krishnan A; Ellenberger KA; Phetsouphanh C; Kelleher AP; Matthews GV; Darley DR; Holloway CJ, 2022, 'Myocardial fibrosis occurs in non-hospitalised patients with chronic symptoms after COVID-19', IJC Heart and Vasculature, 39, http://dx.doi.org/10.1016/j.ijcha.2022.100964

Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson SC; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer DE; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2022, 'Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses', Cell Reports, 38, pp. 110345, http://dx.doi.org/10.1016/j.celrep.2022.110345

Phetsouphanh C; Darley DR; Wilson DB; Howe A; Munier CML; Patel SK; Juno JA; Burrell LM; Kent SJ; Dore GJ; Kelleher AD; Matthews GV, 2022, 'Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection', Nature Immunology, 23, pp. 210 - 216, http://dx.doi.org/10.1038/s41590-021-01113-x

Phetsouphanh C; Phalora P; Hackstein CP; Thornhill J; Munier ML; Meyerowitz J; Murray L; Vuuren CV; Goedhals D; Drexhage L; Moore R; Sattentau Q; Mak JYW; Fairlie DP; Fidler S; Kelleher A; Frater J; Klenerman P, 2021, 'Human MAIT cells respond to and suppress HIV-1', eLife, 10, http://dx.doi.org/10.7554/eLife.50324

Beaton B; Sasson SC; Rankin K; Raedemaeker J; Wong A; Hastak P; Warden A; Stella AO; Aggarwal A; Caterson ID; Phetsouphanh C; Turville S; Kelleher AD; Brilot F; Trotman J, 2021, 'Efficacy of Vaccine BNT162b2 (Pfizer-BioNTech) in Individuals with Waldenstrom's Macroglobulinemia and Follicular Lymphoma in Australia', BLOOD, 138, http://dx.doi.org/10.1182/blood-2021-149348

Zaunders J; Phetsouphanh C, 2021, 'Long-term and short-term immunity to SARS-CoV-2: Why it matters', Microbiology Australia, 42, pp. 34 - 38, http://dx.doi.org/10.1071/MA21010

Seddiki N; Zaunders J; Phetsouphanh C; Brezar V; Xu Y; McGuire HM; Bailey M; McBride K; Hey-Cunningham W; Munier CML; Cook L; Kent S; Lloyd A; Cameron B; De St Groth BF; Koelsch K; Danta M; Hocini H; Levy Y; Kelleher AD, 2021, 'CD73⁺ CD127^high long-term memory CD4 T cells are highly proliferative in response to recall antigens and are early targets in hiv-1 infection', International Journal of Molecular Sciences, 22, pp. 1 - 28, http://dx.doi.org/10.3390/ijms22020912

Phetsouphanh C; Darley D; Wilson D; Howe A; Ling Munier M; Patel S; Juno J; Burrell L; Kent S; Dore G; Kelleher A; Matthews G, 2021, 'Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection', , http://dx.doi.org/10.1101/2021.06.01.21257759

Hartnell F; Esposito I; Swadling L; Brown A; Phetsouphanh C; de Lara C; Gentile C; Turner B; Dorrell L; Capone S; Folgori A; Barnes E; Klenerman P, 2020, 'Characterizing Hepatitis C Virus–Specific CD4⁺ T Cells Following Viral-Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure', Hepatology, 72, pp. 1541 - 1555, http://dx.doi.org/10.1002/hep.31160

Thornhill JP; Pace M; Martin GE; Hoare J; Peake S; Herrera C; Phetsouphanh C; Meyerowitz J; Hopkins E; Brown H; Dunn P; Olejniczak N; Willberg C; Klenerman P; Goldin R; Fox J; Fidler S; Frater J, 2019, 'CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype', Mucosal Immunology, 12, pp. 1212 - 1219, http://dx.doi.org/10.1038/s41385-019-0180-2

Juno JA; Phetsouphanh C; Klenerman P; Kent SJ, 2019, 'Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection', Current Opinion in HIV and AIDS, 14, pp. 77 - 84, http://dx.doi.org/10.1097/COH.0000000000000526

D'Souza RR; Gopalan BP; Rajnala N; Phetsouphanh C; Shet A, 2019, 'Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation', HIV Medicine, 20, pp. 513 - 522, http://dx.doi.org/10.1111/hiv.12751

Phetsouphanh C; Aldridge D; Marchi E; Munier CML; Meyerowitz J; Murray L; Van Vuuren C; Goedhals D; Fidler S; Kelleher A; Klenerman P; Frater J, 2019, 'Maintenance of functional CD57+ cytolytic CD4+ T cells in HIV+ elite controllers', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.01844

Highton AJ; Zinser ME; Lee LN; Hutchings CL; De Lara C; Phetsouphanh C; Willberg CB; Gordon CL; Klenerman P; Marchi E, 2019, 'Single-cell transcriptome analysis of CD8⁺ T-cell memory inflation.', Wellcome Open Research, 4, http://dx.doi.org/10.12688/wellcomeopenres.15115.1

Zinser ME; Highton AJ; Kurioka A; Kronsteiner B; Hagel J; Leng T; Marchi E; Phetsouphanh C; Willberg CB; Dunachie SJ; Klenerman P, 2018, 'Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation', Immunology and Cell Biology, 96, pp. 666 - 674, http://dx.doi.org/10.1111/imcb.12020

Martin GE; Pace M; Thornhill JP; Phetsouphanh C; Meyerowitz J; Gossez M; Brown H; Olejniczak N; Lwanga J; Ramjee G; Kaleebu P; Porter K; Willberg CB; Klenerman P; Nwokolo N; Fox J; Fidler S; Frater J; Lever A; Wills M; Weber J; Dorrell L; Malim M; Gupta R; Jolly C, 2018, 'CD32-expressing CD4 T cells are phenotypically diverse and can contain proviral HIV DNA', Frontiers in Immunology, 9, http://dx.doi.org/10.3389/fimmu.2018.00928

Phetsouphanh C; Xu Y; Munier ML; Zaunders JJ; Kelleher AD, 2017, 'Single-cell profiling of lineage determining transcription factors in antigen-specific CD4⁺ T cells reveals unexpected complexity in recall responses during immune reconstitution', Immunology and Cell Biology, 95, pp. 640 - 646, http://dx.doi.org/10.1038/icb.2017.28

Xu Y; Phetsouphanh C; Suzuki K; Aggrawal A; Graff-Dubois S; Roche M; Bailey M; Alcantara S; Cashin K; Sivasubramaniam R; Koelsch KK; Autran B; Harvey R; Gorry PR; Moris A; Cooper DA; Turville S; Kent SJ; Kelleher AD; Zaunders J; Aggarwal A, 2017, 'HIV-1 and SIV predominantly use CCR5 expressed on a precursor population to establish infection in T follicular helper cells', Frontiers in Immunology, 8, pp. 376, http://dx.doi.org/10.3389/fimmu.2017.00376

Thornhill JP; Fidler S; Klenerman P; Frater J; Phetsouphanh C, 2017, 'The role of CD4+ T follicular helper cells in HIV infection: From the germinal center to the periphery', Frontiers in Immunology, 8, http://dx.doi.org/10.3389/fimmu.2017.00046

Martin GE; Pace M; Thornhill JP; Phetsouphanh C; Hopkins E; Meyerowitz J; Nwokolo N; Fox J; Willberg C; Klenerman P; Fidler S; Frater J, 2017, 'OA1-2 Enrichment of the HIV reservoir in CD32 + CD4 T cells occurs early and is closely associated with immune checkpoint receptor expression', Journal of Virus Eradication, 3, pp. 1 - 2, http://dx.doi.org/10.1016/s2055-6640(20)30834-7

Li J; Hardy K; Phetsouphanh C; Tu WJ; Sutcliffe EL; McCuaig R; Sutton CR; Zafar A; Mee Ling Munier C; Zaunders JJ; Xu Y; Theodoratos A; Tan A; SiewLim P; Knaute T; Masch A; Zerweck J; Brezar V; Milburn PJ; Dunn J; Casarotto MG; Turner SJ; Seddiki N; Kelleher AD; Rao S; Munier ML, 2016, 'Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4⁺T cells through p65 and H2B phosphorylation', Journal of Cell Science, 129, pp. 2448 - 2461, http://dx.doi.org/10.1242/jcs.181248

Phetsouphanh C; Zaunders JJ; Kelleher AD, 2015, 'Detecting antigen-specific T cell responses: From bulk populations to single cells', International Journal of Molecular Sciences, 16, pp. 18878 - 18893, http://dx.doi.org/10.3390/ijms160818878

Phetsouphanh C; Xu Y; Zaunders J, 2015, 'CD4 T cells mediate both positive and negative regulation of the immune response to HIV infection: Complex role of T follicular helper cells and regulatory T cells in pathogenesis', Frontiers in Immunology, 6, http://dx.doi.org/10.3389/fimmu.2014.00681

Phetsouphanh C; Kelleher AD, 2015, 'The role of PKC-θ in CD4+ T cells and HIV infection: To the nucleus and back again', Frontiers in Immunology, 6, pp. 391, http://dx.doi.org/10.3389/fimmu.2015.00391

Seddiki N; Cook L; Hsu DC; Phetsouphanh C; Brown K; Xu Y; Kerr SJ; Cooper DA; Munier CML; Pett S; Ananworanich J; Zaunders J; Kelleher AD, 2014, 'Human antigen-specific CD4⁺CD25⁺CD134⁺CD39⁺ T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses', European Journal of Immunology, 44, pp. 1644 - 1661, http://dx.doi.org/10.1002/eji.201344102

Phetsouphanh C; Xu Y; Bailey M; Pett S; Zaunders J; Seddiki N; Kelleher AD, 2014, 'Ratios of effector to central memory antigen-specific CD4 + T cells vary with antigen exposure in HIV+ patients', Immunology and Cell Biology, 92, pp. 384 - 388, http://dx.doi.org/10.1038/icb.2013.101

Phetsouphanh C; Xu Y; Amin J; Seddiki N; Procopio F; Sekaly RP; Zaunders JJ; Kelleher AD, 2013, 'Characterization of Transcription Factor Phenotypes within Antigen-Specific CD4+ T Cells Using Qualitative Multiplex Single-Cell RT-PCR', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0074946

Seddiki N; Phetsouphanh C; Swaminathan S; Xu Y; Rao S; Li J; Sutcliffe E; Denyer G; Finlayson R; Gelgor L; Cooper DA; Zaunders J; Kelleher AD, 2013, 'The microRNA-9/B-lymphocyte-induced maturation protein-1/IL-2 axis is differentially regulated in progressive HIV infection', European Journal of Immunology, 43, pp. 510 - 520, http://dx.doi.org/10.1002/eji.201242695

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