Select Publications
Book Chapters
2011, 'Novel Oncology Drug Development Strategies in the Era of Personalised Medicine', in Kapetanovic IM (ed.), Drug Discovery and Development - Present and Future
,Journal articles
2024, 'Approach to the Patient: New Era Emerges for Craniopharyngioma Management', Journal of Clinical Endocrinology and Metabolism, 109, pp. 2986 - 2996, http://dx.doi.org/10.1210/clinem/dgae503
,2024, 'A phase 1a/b, multi-regional, first-in-human study of CS5001, a novel anti-ROR1 ADC, in patients with advanced solid tumors and lymphomas.', Journal of Clinical Oncology, 42, pp. 3023 - 3023, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.3023
,2024, 'Correction to: CXCR2 antagonist navarixin in combination with pembrolizumab in select advanced solid tumors: a phase 2 randomized trial(Investigational New Drugs, (2024), 42, (145-159), 10.1007/s10637-023-01410-2)', Investigational New Drugs, 42, pp. 340 - 341, http://dx.doi.org/10.1007/s10637-024-01444-0
,2024, 'Results of a first-in-human, dose-escalation phase 1 study of the ERK1/2 inhibitor ATG-017 in patients with advanced solid tumors.', Journal of Clinical Oncology, 42, pp. e15114 - e15114, http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15114
,2024, 'Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors', Journal for ImmunoTherapy of Cancer, 12, http://dx.doi.org/10.1136/jitc-2023-008037
,2024, 'A Phase I Study of Acapatamab, a Half-life Extended, PSMA-Targeting Bispecific T-cell Engager for Metastatic Castration-Resistant Prostate Cancer', Clinical Cancer Research, 30, pp. 1488 - 1500, http://dx.doi.org/10.1158/1078-0432.CCR-23-2978
,2024, 'Abstract CT259: Results from monotherapy dose escalation of MDNA11, a long-acting IL-2 superkine, in a phase 1/2 trial show evidence of single-agent activity in advanced solid tumors', Cancer Research, 84, pp. CT259 - CT259, http://dx.doi.org/10.1158/1538-7445.am2024-ct259
,2024, 'CXCR2 antagonist navarixin in combination with pembrolizumab in select advanced solid tumors: a phase 2 randomized trial', Investigational New Drugs, 42, pp. 145 - 159, http://dx.doi.org/10.1007/s10637-023-01410-2
,2024, 'A phase 1 study of the CD40 agonist MEDI5083 in combination with durvalumab in patients with advanced solid tumors', Immunotherapy, 16, pp. 759 - 774, http://dx.doi.org/10.1080/1750743X.2024.2359359
,2024, '3178 – LONGITUDINAL DRUG INCORPORATION, CLONAL COMPOSITION, AND DNA METHYLATION DYNAMICS IN MDS/CMML PATIENTS TREATED WITH AZA', Experimental Hematology, 137, pp. 104498 - 104498, http://dx.doi.org/10.1016/j.exphem.2024.104498
,2024, '345MO IBI354 (anti-HER2 antibody-drug conjugate [ADC]) in patients (pts) with advanced solid tumors and breast cancer (BC): Results from a phase I study', Annals of Oncology, 35, pp. S360 - S360, http://dx.doi.org/10.1016/j.annonc.2024.08.293
,2024, '576P Safety and efficacy of IBI354 (anti-HER2 ADC) in patients (pts) with advanced gastrointestinal (GI) cancers: Results from a phase I study', Annals of Oncology, 35, pp. S467 - S468, http://dx.doi.org/10.1016/j.annonc.2024.08.645
,2024, '676TiP MYE Symphony: A first-in-human study to investigate the safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of the in vivo mRNA CAR therapy, MT-302, targeting TROP2 in adults with advanced epithelial tumors', Annals of Oncology, 35, pp. S528 - S528, http://dx.doi.org/10.1016/j.annonc.2024.08.742
,2024, '678TiP A phase I, first-in-human, dose escalation and expansion study of oral pan-RAF/MEK molecular glue NST-628 in subjects with solid tumors harboring RAS-MAPK pathway alterations', Annals of Oncology, 35, pp. S528 - S529, http://dx.doi.org/10.1016/j.annonc.2024.08.744
,2023, 'Abstract B042: Efficacy and safety outcomes of ABN401 in NSCLC patients with MET Exon 14 Skipping: A clinically relevant subgroup analysis', Molecular Cancer Therapeutics, 22, pp. B042 - B042, http://dx.doi.org/10.1158/1535-7163.targ-23-b042
,2023, 'A first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer', British Journal of Cancer, 129, pp. 1608 - 1618, http://dx.doi.org/10.1038/s41416-023-02431-7
,2023, 'Safety, Pharmacokinetics and Preliminary Efficacy of IL4-Rα Monoclonal Antibody AK120 in Both Healthy and Atopic Dermatitis Subjects: A Phase I, Randomized, Two-Part, Double-Blind, Placebo-Controlled, Dose-Escalation, First-In-Human Clinical Study', Dermatology and Therapy, 13, pp. 2357 - 2373, http://dx.doi.org/10.1007/s13555-023-01010-1
,2023, 'Strong CD4+T-Cell Responses to Ancestral and Variant Spike Proteins Are Established by NVX-CoV2373 Severe Acute Respiratory Syndrome Coronavirus 2 Primary Vaccination', Journal of Infectious Diseases, 228, pp. 734 - 741, http://dx.doi.org/10.1093/infdis/jiad163
,2023, 'P624: PHASE 1 STUDY OF JNJ-67856633, A FIRST-IN-HUMAN HIGHLY SELECTIVE MALT1 INHIBITOR, IN RELAPSED/REFRACTORY (R/R) B-CELL NON-HODGKIN LYMPHOMA (B-NHL) AND CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)', HemaSphere, 7, pp. e60782b9 - e60782b9, http://dx.doi.org/10.1097/01.hs9.0000969400.60782.b9
,2023, 'ABN401 in patients with NSCLC with MET exon 14 (METex14) skipping: Result from the pilot expansion study.', Journal of Clinical Oncology, 41, pp. e21148 - e21148, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e21148
,2023, 'Abstract CT180: Activation of innate and adaptive immune response with a clinical stage TLR7 agonist prodrug PRTX007', Cancer Research, 83, pp. CT180 - CT180, http://dx.doi.org/10.1158/1538-7445.am2023-ct180
,2023, 'Abstract 2155: Joint modeling of safety and peripheral mode-of-action (MoA) biomarkers to support RP2D identification in Phase 1 study of SAR444245 (SAR’245) as monotherapy (mono) or combined with pembrolizumab (pembro) in patients with advanced solid tumors', Cancer Research, 83, pp. 2155 - 2155, http://dx.doi.org/10.1158/1538-7445.am2023-2155
,2023, 'ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study', Oncogene, 42, pp. 541 - 544, http://dx.doi.org/10.1038/s41388-022-02582-6
,2023, 'Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors', Journal for ImmunoTherapy of Cancer, 11, http://dx.doi.org/10.1136/jitc-2022-006136
,2023, 'Sotorasib in KRAS p.G12C-Mutated Advanced Pancreatic Cancer', New England Journal of Medicine, 388, pp. 33 - 43, http://dx.doi.org/10.1056/NEJMoa2208470
,2023, '1047P AXA-042, a systemically administered TLR2/6 agonist, demonstrates target engagement and TLR pathway activation in patients with advanced solid tumors', Annals of Oncology, 34, pp. S635 - S635, http://dx.doi.org/10.1016/j.annonc.2023.09.2186
,2023, '711TiP A phase I/II, first-in-human, open-label, dose-escalation study of TAK-186, an EGFR × CD3ε COBRA T cell engager, in adult patients with unresectable, locally advanced, or metastatic solid tumors', Annals of Oncology, 34, pp. S492 - S492, http://dx.doi.org/10.1016/j.annonc.2023.09.1897
,2023, 'Novel Use of Micra AV Pacemaker for Immune Checkpoint Inhibitor-associated Myocarditis, Life-sustaining Ventricular Tachycardia and Atrioventricular Dissociation', Heart, Lung and Circulation, 32, pp. S343 - S343, http://dx.doi.org/10.1016/j.hlc.2023.06.782
,2023, 'PHASE 1 STUDY OF JNJ‐67856633, A FIRST‐IN‐HUMAN MALT1 INHIBITOR, IN RELAPSED/REFRACTORY (R/R) B‐CELL NON‐HODGKIN LYMPHOMA (B‐NHL) AND CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)', Hematological Oncology, 41, pp. 131 - 132, http://dx.doi.org/10.1002/hon.3163_88
,2022, 'In Vivo Drug Incorporation and Intracellular Dynamics of Injectable Versus Oral Azacytidine: A Phase II Open Label Multicentre Trial', Blood, 140, pp. 6927 - 6929, http://dx.doi.org/10.1182/blood-2022-157634
,2022, 'Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial', The Lancet Infectious Diseases, 22, pp. 1565 - 1576, http://dx.doi.org/10.1016/S1473-3099(22)00420-0
,2022, 'Abstract CT189: PRTX007, an optimized TLR7 agonist for systemic immunotherapy of cancers: Interim analysis of phase I study in healthy volunteers', Cancer Research, 82, pp. CT189 - CT189, http://dx.doi.org/10.1158/1538-7445.am2022-ct189
,2022, 'A randomized, adaptive design, double-blind, 3-arm, parallel study assessing the pharmacokinetics and safety of AVT02, a high-concentration (100 mg/mL) Adalimumab biosimilar, in healthy adult subjects (ALVOPAD FIRST)', Expert Opinion on Investigational Drugs, 31, pp. 965 - 976, http://dx.doi.org/10.1080/13543784.2022.2035359
,2022, '747P Phase I study of SAR444245 (SAR’245) as monotherapy (mono) and combined with pembrolizumab (pembro) or cetuximab (cetux) in patients (pts) with advanced solid tumors', Annals of Oncology, 33, pp. S885 - S886, http://dx.doi.org/10.1016/j.annonc.2022.07.873
,2021, 'Phase I dose-escalation study to evaluate safety and clinical activity of c-MET inhibitor ABN401 in patients with advanced solid tumor', ANNALS OF ONCOLOGY, 32, pp. S1029 - S1030, http://dx.doi.org/10.1016/j.annonc.2021.08.1958
,2021, 'Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors.', Journal of Clinical Oncology, 39, pp. 2037 - 2037, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.2037
,2021, 'Safety and efficacy of AK112, an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors in a phase I dose escalation study.', Journal of Clinical Oncology, 39, pp. 2515 - 2515, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.2515
,2021, 'Safety profile and disease stabilization in late stage, heavily pretreated, solid tumor patients in a first-in-human (FIH) study of ATX-101, a drug targeting proliferating cell nuclear antigen (PCNA).', Journal of Clinical Oncology, 39, pp. 3067 - 3067, http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3067
,2021, 'Trial in progress: A phase 1-2 multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of ABN401 in patients with advanced solid tumors.', JOURNAL OF CLINICAL ONCOLOGY, 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.TPS3157
,2021, '427 Efficacy and safety of AK112, an anti-PD-1/VEGF-A bispecific antibody, in patients with platinum-resistant/refractory epithelial ovarian cancer in a Phase 1 study', Regular and Young Investigator Award Abstracts, pp. A457 - A457, http://dx.doi.org/10.1136/jitc-2021-sitc2021.427
,2020, 'A first-in-human, phase 1, dose-escalation study of ABBV-176, an antibody-drug conjugate targeting the prolactin receptor, in patients with advanced solid tumors', Investigational New Drugs, 38, pp. 1815 - 1825, http://dx.doi.org/10.1007/s10637-020-00960-z
,2020, 'Mammographic breast density and urbanization: Interactions with BMI, environmental, lifestyle, and other patient factors', Diagnostics, 10, http://dx.doi.org/10.3390/diagnostics10060418
,2020, 'A phase I study of AK112, a bispecific antibody that targets PD-1 and VEGF co-expressing T cells, in patients with advanced solid tumors.', Journal of Clinical Oncology, 38, pp. TPS3155 - TPS3155, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps3155
,2019, 'Correction: 33rd Annual meeting & pre-conference programs of the Society for Immunotherapy of Cancer (SITC 2018) (Journal for ImmunoTherapy of Cancer (2018) 6:Suppl 1 DOI: 10.1186/s40425-018-0422-y)', Journal for ImmunoTherapy of Cancer, 7, http://dx.doi.org/10.1186/s40425-019-0519-y
,2018, 'Phase I/II study of CTLA-4 inhibitor AGEN1884 + PD-1 Inhibitor AGEN2034 in patients with advanced/refractory solid tumors, with expansion into 2L cervical cancer and solid tumors', Annals of oncology : official journal of the European Society for Medical Oncology, 29, pp. viii417, http://dx.doi.org/10.1093/annonc/mdy288.041
,2018, 'Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors', JOURNAL OF CLINICAL ONCOLOGY, 36, http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e14048
,2017, 'A first-time-in-human study of GSK2636771, a phosphoinositide 3 kinase beta-selective inhibitor, in patients with advanced solid tumors', Clinical Cancer Research, 23, pp. 5981 - 5992, http://dx.doi.org/10.1158/1078-0432.CCR-17-0725
,2017, 'New molecular and immunotherapeutic approaches in biliary cancer', ESMO Open, 2, pp. e000152, http://dx.doi.org/10.1136/esmoopen-2016-000152
,2017, 'BRAF +/- MEK inhibition in patients (pts) with BRAF-mutant (mut) metastatic colorectal cancer (mCRC): The Sarah Cannon Research Institute UK’s experience.', Journal of Clinical Oncology, 35, pp. 645 - 645, http://dx.doi.org/10.1200/jco.2017.35.4_suppl.645
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