Researcher

Dr Dorit Samocha-Bonet

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Biography

Samocha-Bonet is Group leader, Clinical Insulin Resistance at the Healthy Ageing Theme at the Garvan Institute of Medical Research, and a Conjoint Senior Lecturer, School of Medical Sciences UNSW. Samocha-Bonet completed a BSc degree (Cum Laude) in Nutritional Sciences at the Hebrew University, Israel and joined the Nutrition & Dietetics Department at Tel Aviv Medical Centre as a clinical dietician where she worked for a decade (1993-2003)....view more

Samocha-Bonet is Group leader, Clinical Insulin Resistance at the Healthy Ageing Theme at the Garvan Institute of Medical Research, and a Conjoint Senior Lecturer, School of Medical Sciences UNSW. Samocha-Bonet completed a BSc degree (Cum Laude) in Nutritional Sciences at the Hebrew University, Israel and joined the Nutrition & Dietetics Department at Tel Aviv Medical Centre as a clinical dietician where she worked for a decade (1993-2003). She completed MSc degree (with Honours) in Clinical Biochemistry (1996) and PhD in Physiology & Pharmacology (2006) at Tel Aviv University, Israel prior to relocating to Sydney. She joined the Garvan Institute of Medical Research in 2007 as a postdoctoral fellow. In 2013 she established the Clinical Insulin Resistance Group with a focus on exploring the metabolic factors underlying insulin resistance and insulin sensitivity in obesity and on developing approaches to promoting insulin sensitivity in obesity. She has been the Australian Diabetes Society (ADS) Skip Martin Early Career Fellow in 2011, and the recipient of the top ranked project grant from the Diabetes Australia Research Program in 2016.


My Qualifications

Academic Record

2001 - 2006

PhD, Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel.

1993 - 1996

MSc, Clinical Biochemistry, Sackler School of Medicine, Tel-Aviv University, Israel. With Honours.

1989 - 1992

BSc, Nutritional Sciences, Hebrew University, Faculty of Agricultural, Food and Environmental Quality Sciences, Israel. Cum Laude.

 

Other Qualifications

1993                                Dietitian (recognition by the Israeli Ministry of Health, Department of Medical Professions)


My Research Activities

Research at the Clinical Insulin Resistance Group at the Garvan is focused on uncovering the molecular pathways involved in the transition from health to insulin resistance and metabolic disease related to overweight and obesity in humans. In our clinical studies, we use gold-standard protocols to deeply phenotype individuals at risk of type 2 diabetes. Using gold-standard tools to characterise whole-body glucose regulation, abdominal fat distribution and liver fat, we find a wide range of phenotypic variation in obesity and prediabetes.

Current projects:

  1. The effect of weight cycling on insulin resistance and fatty liver in human
  2. Metabolomic and lipidomic screens of liver and muscle insulin resistance in human obesity uncovering bio-markers to predict response to the first-line medication in type 2 diabetes, metformin (in collaboration with Dr O'Sullivan, Dr Koay and Dr Yang, The University of Sydney)
  3. A randomised clinical trial (https://clinicaltrials.gov/NCT03558867) to test the efficacy of an algorithm-based (personalised) diet in combination with metformin on glycaemia in individuals with prediabetes and type 2 diabetes (in collaboration with Prof Elinav and Prof Segal, The Weizmann Institute of Science).
  4. Reverse engineering insulin secretion in health and disease (in collaboration with Dr Danny Ben-Zvi, The Hebrew University of Jerusalem) - Masters project available in clinical study settings

My Research Supervision


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Areas of supervision

Currently seeking a Masters student to undertake a clinical research project at the Clinical Research Facility at the Garvan Institute of Medical Research, Darlinghurst, Sydney.

Project title: ‘Reverse engineering insulin secretion in health and disease’

For further information and expression of interest, please contact Dr Dorit Samocha-Bonet at: d.samochabonet@garvan.org.au or 02-92958309.

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Location

Garvan Institute of Medical Research
384 Victoria Street
Darlinghurst 2010

Contact

+61292958309