By Dr Jason Ciril Kovacic

Journal articles

Kovacic JC; Sharma AB; Roy S; Li JR; Narayan R; Kim DB; Sharma SK; Kini AS, 2013, 'GuideLiner mother-and-child guide catheter extension: A simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions', Journal of Interventional Cardiology, 26, pp. 343 - 350, http://dx.doi.org/10.1111/joic.12040

Pereira CF; Chang B; Qiu J; Niu X; Papatsenko D; Hendry CE; Clark NR; Nomura-Kitabayashi A; Kovacic JC; Ma'Ayan A; Schaniel C; Lemischka IR; Moore K, 2013, 'Induction of a hemogenic program in mouse fibroblasts', Cell Stem Cell, 13, pp. 205 - 218, http://dx.doi.org/10.1016/j.stem.2013.05.024

Kini AS; Baber U; Kovacic JC; Limaye A; Ali ZA; Sweeny J; Maehara A; Mehran R; Dangas G; Mintz GS; Fuster V; Narula J; Sharma SK; Moreno PR, 2013, 'Changes in plaque lipid content after short-term intensive versus standard statin therapy: The YELLOW trial (Reduction in Yellow Plaque by Aggressive Lipid-Lowering Therapy)', Journal of the American College of Cardiology, 62, pp. 21 - 29, http://dx.doi.org/10.1016/j.jacc.2013.03.058

Roleder T; Suh W; Sharma R; Hecht H; Kovacic JC; Narula J; Kini AS, 2013, 'Plaques with high lipid burden: Keeping the fat out of the fire', Heart, 99, pp. 977 - 978, http://dx.doi.org/10.1136/heartjnl-2012-303421

Kovacic JC; Nguyen HT; Karajgikar R; Sharma SK; Kini AS, 2013, 'The impella recover 2.5 and TandemHeart ventricular assist devices are safe and associated with equivalent clinical outcomes in patients undergoing high-risk percutaneous coronary intervention', Catheterization and Cardiovascular Interventions, 82, http://dx.doi.org/10.1002/ccd.22929

Cubeddu RJ; Palacios IF; Blankenship JC; Horvath SA; Xu K; Kovacic JC; Dangas GD; Witzenbichler B; Guagliumi G; Kornowski R; Dudek D; Stone GW; Mehran R, 2013, 'Outcome of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention during on- versus off-hours (A Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction [HORIZONS-AMI] Trial Substudy)', American Journal of Cardiology, 111, pp. 946 - 954, http://dx.doi.org/10.1016/j.amjcard.2012.11.062

Baber U; Bander J; Karajgikar R; Yadav K; Hadi A; Theodoropolous K; Gukathasan N; Roy S; Sayeneni S; Scott SA; Kovacic JC; Yu J; Sartori S; Mehran R; Uribarri J; Badimon JJ; Muntner P; Moreno P; Kini AS; Sharma SK, 2013, 'Combined and independent impact of diabetes mellitus and chronic kidney disease on residual platelet reactivity', Thrombosis and Haemostasis, 110, pp. 118 - 123, http://dx.doi.org/10.1160/TH13-01-0004

Kovacic JC; Fuster V, 2012, 'Smoking gun theory: Angiographically normal or mild coronary plaque as a cause of myocardial infarction', Circulation, 126, pp. 2918 - 2920, http://dx.doi.org/10.1161/CIRCULATIONAHA.112.150425

Kovacic JC; Fuster V, 2012, 'Atherosclerotic risk factors, vascular cognitive impairment, and alzheimer disease', Mount Sinai Journal of Medicine, 79, pp. 664 - 673, http://dx.doi.org/10.1002/msj.21347

Sharma AB; Kovacic JC; Kini AS, 2012, 'Percutaneous Left Ventricular Assist Devices', Interventional Cardiology Clinics, 1, pp. 609 - 622, http://dx.doi.org/10.1016/j.iccl.2012.07.003

Kovacic JC; Lee P; Karajgikar R; Baber U; Narechania B; Suleman J; Moreno PR; Sharma SK; Kini AS, 2012, 'Safety of temporary and permanent suspension of antiplatelet therapy after drug eluting stent implantation in contemporary "real-world" practice', Journal of Interventional Cardiology, 25, pp. 482 - 492, http://dx.doi.org/10.1111/j.1540-8183.2012.00746.x

Purushothaman KR; Purushothaman M; Levy AP; Lento PA; Evrard S; Kovacic JC; Briley-Saebo KC; Tsimikas S; Witztum JL; Krishnan P; Kini A; Fayad ZA; Fuster V; Sharma SK; Moreno PR, 2012, 'Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: Possible implications for plaque progression in human atherosclerosis', Journal of the American College of Cardiology, 60, pp. 112 - 119, http://dx.doi.org/10.1016/j.jacc.2012.04.011

Chirumamilla AP; Maehara A; Mintz GS; Mehran R; Kanwal S; Weisz G; Hassanin A; Hakim D; Guo N; Baber U; Pyo R; Moses JW; Fahy M; Kovacic JC; Dangas GD, 2012, 'High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: A volumetric intravascular ultrasound study', JACC: Cardiovascular Imaging, 5, pp. 540 - 549, http://dx.doi.org/10.1016/j.jcmg.2011.12.019

Kovacic JC; Mercader N; Torres M; Boehm M; Fuster V, 2012, 'Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition from cardiovascular development to disease', Circulation, 125, pp. 1795 - 1808, http://dx.doi.org/10.1161/CIRCULATIONAHA.111.040352

Kovacic JC; Sharma SK; Kini AS, 2012, 'Bilateral coronary ostial stenoses post-bentall procedure causing hemodynamic collapse and requiring mechanical assist device placement: Successful intervention using the Szabo technique', Catheterization and Cardiovascular Interventions, 79, pp. 801 - 804, http://dx.doi.org/10.1002/ccd.23132

Evrard SM; Daudigier C; Mauge L; Israël-Biet D; Guerin CL; Bieche I; Kovacic JC; Fischer AM; Gaussem P; Smadja DM, 2012, 'The profibrotic cytokine transforming growth factor-β1 increases endothelial progenitor cell angiogenic properties', Journal of Thrombosis and Haemostasis, 10, pp. 670 - 679, http://dx.doi.org/10.1111/j.1538-7836.2012.04644.x

Kovacic JC; Lee P; Baber U; Karajgikar R; Evrard SM; Moreno P; Mehran R; Fuster V; Dangas G; Sharma SK; Kini AS, 2012, 'Inverse relationship between body mass index and coronary artery calcification in patients with clinically significant coronary lesions', Atherosclerosis, 221, pp. 176 - 182, http://dx.doi.org/10.1016/j.atherosclerosis.2011.11.020

Kovacic JC; Mehran R; Karajgikar R; Baber U; Suleman J; Kim MC; Krishnan P; Dangas G; Sharma SK; Kini A, 2012, 'Female gender and mortality after percutaneous coronary intervention: results from a large registry.', Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 80, pp. 514 - 521, http://dx.doi.org/10.1002/ccd.23338

Kovacic JC; Fuster V, 2012, 'Vascular calcification, diabetes, and cardiovascular disease: Connecting the dots', JACC: Cardiovascular Imaging, 5, pp. 367 - 369, http://dx.doi.org/10.1016/j.jcmg.2012.02.006

Baber U; Zafar MU; uribarri J; Murphy B; Khan A; Akter F; Bander J; Muntner P; Kovacic JC; Yu J; Theodoropoulos K; Mehran R; Dangas G; Kini A; Sharma S; Fuster V; Badimon J, 2012, 'PHYSIOLOGIC IMPACT OF CHRONIC KIDNEY DISEASE ON WHOLE BLOOD CLOT KINETICS AND STRENGTH', Journal of the American College of Cardiology, 59, pp. E2096 - E2096, http://dx.doi.org/10.1016/s0735-1097(12)62097-x

Baber U; Kovacic J; Kini AS; Sharma SK; Dangas G; Mehran R, 2011, 'How serious a problem is bleeding in patients with acute coronary syndromes?', Current Cardiology Reports, 13, pp. 312 - 319, http://dx.doi.org/10.1007/s11886-011-0192-3

Kovacic JC; Randolph GJ, 2011, 'Vascular calcification: Harder than it looks', Arteriosclerosis, Thrombosis, and Vascular Biology, 31, pp. 1249 - 1250, http://dx.doi.org/10.1161/ATVBAHA.111.227868

Kovacic JC; Moreno P; Nabel EG; Hachinski V; Fuster V, 2011, 'Cellular senescence, vascular disease, and aging: Part 2 of a 2-part review: Clinical vascular disease in the elderly', Circulation, 123, pp. 1900 - 1910, http://dx.doi.org/10.1161/CIRCULATIONAHA.110.009118

Rubboli A; Kovacic JC; Mehran R; Lip GYH, 2011, 'Coronary stent implantation in patients committed to long-term oral anticoagulation therapy: Successfully navigating the treatment options', Chest, 139, pp. 981 - 987, http://dx.doi.org/10.1378/chest.10-2719

Kovacic JC; Moreno P; Hachinski V; Nabel EG; Fuster V, 2011, 'Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review', Circulation, 123, pp. 1650 - 1660, http://dx.doi.org/10.1161/CIRCULATIONAHA.110.007021

Kovacic JC; Kini A, 2011, 'Inferior outcomes in percutaneous coronary interventions: Narrowing the gap between men and women', Interventional Cardiology, 3, pp. 119 - 121, http://dx.doi.org/10.2217/ica.11.17

Yu J, 2011, 'Impact of the Everolimus-Eluting Stent on Stent Thrombosis : A Meta-Analysis of 13 Randomized Trials', Journal of the American College of Cardiology, 58, pp. 1569 - 1577

Kovacic JC; Khanna D; Kaplish D; Karajgikar R; Sharma SK; Kini A, 2010, 'Safety and efficacy of alcohol septal ablation in patients with symptomatic concentric left ventricular hypertrophy and outflow tract obstruction', Journal of Invasive Cardiology, 22, pp. 586 - 591

Iwasaki H; Kovacic JC; Olive M; Beers JK; Yoshimoto T; Crook MF; Tonelli LH; Nabel EG, 2010, 'Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation', Circulation Research, 107, pp. 992 - 1001, http://dx.doi.org/10.1161/CIRCRESAHA.110.225326

Kovacic JC; Gupta R; Lee AC; Ma M; Fang F; Tolbert CN; Walts AD; Beltran LE; San H; Chen G; St Hilaire C; Boehm M, 2010, 'Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice', Journal of Clinical Investigation, 120, pp. 303 - 314, http://dx.doi.org/10.1172/JCI40364

Ma M; Ding S; Lundqvist A; San H; Fang F; Konoplyannikov M; Berry C; Beltran LE; Chen G; Kovacic JC; Boehm M, 2010, 'Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival', Stem Cells, 28, pp. 1465 - 1475, http://dx.doi.org/10.1002/stem.475

Chih SS; Macdonald P; McCrohon JA; Ma D; John M; Law M; Feneley MP; Herbert A; Kovacic JC; Graham RM; Victor Chang Cardiac Research Institute , 2010, 'GRANULOCYTE-COLONY STIMULATING FACTOR IN ANGINA PATIENTS WITH ISCHAEMIC HEART DIESASE TO STIMULATE NEOVASCULARISATION (GAIN II TRIAL)', Journal of the American College of Cardiology, 55, pp. A126.E1184 - A126.E1184, http://dx.doi.org/10.1016/s0735-1097(10)61185-0

Kovacic JC; Macdonald P; Feneley MP; Graham RM, 2009, 'Granulocyte-colony stimulating factor in refractory ischemic heart disease: Throwing stones from glass houses', American Heart Journal, 157, http://dx.doi.org/10.1016/j.ahj.2009.02.009

Kovacic JC; Boehm M, 2009, 'Resident vascular progenitor cells: An emerging role for non-terminally differentiated vessel-resident cells in vascular biology', Stem Cell Research, 2, pp. 2 - 15, http://dx.doi.org/10.1016/j.scr.2008.05.005

Kovacic J; Macdonald PS; Feneley MP; Graham RM, 2009, 'Granulocyte-colony stimulating factor in refractory ischemic heart disease: Throwing stones from glass houses', American Heart Journal, 157, pp. e39, http://dx.doi.org/10.1016/j.aucc.2009.06.001

Wragg A; Mellad JA; Beltran LE; Konoplyannikov M; San H; Boozer S; Deans RJ; Mathur A; Lederman RJ; Kovacic JC; Boehm M, 2008, 'VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a SDF-1-dependent mechanism', Journal of Molecular Medicine, 86, pp. 1221 - 1232, http://dx.doi.org/10.1007/s00109-008-0390-7

Olive M; Mellad JA; Beltran LE; Ma M; Cimato T; Noguchi AC; San H; Childs R; Kovacic JC; Boehm M, 2008, 'p21^Cip1 modulates arterial wound repair through the stromal cell-derived factor-1/CXCR4 axis in mice', Journal of Clinical Investigation, 118, pp. 2050 - 2061, http://dx.doi.org/10.1172/JCI31244

Kovacic JC; Moore JJ; Herbert AD; Ma DD; Boehm M; Graham RM, 2008, 'Endothelial progenitor cells, angioblasts, and angiogenesis - Old terms reconsidered from a current perspective', Trends in Cardiovascular Medicine, 18, pp. 45 - 51

Matthews J; Pitney M; Kovacic J; Lindeman R; Loh E; Jepson N; Cranney G; Ooi S-Y, 2008, 'Feasibility and Safety of Erythropoietin (EPO) Administration in Patients with Acute Myocardial Infarction to Improve Cardiac Function and Remodelling: Pilot Study', Heart, Lung and Circulation, 17, pp. S173 - S173, http://dx.doi.org/10.1016/j.hlc.2008.05.412

Kovacic JC; Macdonald PS; Feneley MP; Muller DW; Freund J; Dodds AJ; Milliken ST; Tao H; Itescu S; Moore JJ; Ma DD; Graham RM, 2008, 'Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor, and an intracoronary CD 133(+) cell infusion in patients with chronic refractory ischemic heart disease: The G-CSF in Angina patients with IHD to stimulate Neovascul', American Heart Journal, 156, pp. 954 - 963

Kovacic JC; Harvey RP; Dimmeler S, 2007, 'Cardiovascular Regenerative Medicine: Digging In for the Long Haul', Cell Stem Cell, 1, pp. 628 - 633, http://dx.doi.org/10.1016/j.stem.2007.11.011

Kovacic JC; Macdonald P; Feneley MP; Muller DW; Ma D; Tao H; Freund J; Milliken S; Dodds A; Moore J; Itescu S; Graham RM, 2007, 'Abstract 2669: The Use of Granulocyte-Colony Stimulating Factor in Angina Patients to Stimulate Neovascularization: the GAIN I study', Circulation, 116, http://dx.doi.org/10.1161/circ.116.suppl_16.ii_591-d

Kovacic JC; Muller DW; Graham RM, 2007, 'Actions and therapeutic potential of G-CSF and GM-CSF in cardiovascular disease', Journal of Molecular and Cellular Cardiology, 42, pp. 19 - 33

Kovacic JC; Ma DD; Tao H; Herbert AD; Moore JJ; Graham RM, 2007, 'Phenotypic characterization of CD133+cells suggests a potent hemangioblast population', Circulation Research, 101, pp. E55 - E56

Kovacic JC; Macdonald PS; Freund J; Rasko J; Allan RM; Fernandes VB; Ma DD; Moore JJ; Graham RM, 2007, 'Profound thrombocytopenia related to G-CSF', American Journal of Hematology, 82, pp. 229 - 230

Mallon PW; Miller JE; Kovacic JC; Kent-Hughes J; Norris RP; Samaras K; Feneley MP; Cooper DA; Carr AD, 2006, 'Effect of pravastatin on body composition and markers of cardiovascular disease in HIV-infected men - a randomized, placebo-controlled study', AIDS, 20, pp. 1003 - 1010

Kovacic JC; Roy PR; Baron D; Muller DW, 2006, 'Staged carotid artery stenting and coronary artery bypass graft surgery: Initial results from a single center', Catheterization and Cardiovascular Interventions, 67, pp. 142 - 148

Ma DDF; Kovacic JC; Dodds A; Tao H; McDonald P; Feneley MP; Muller DW; Fruend J; Milliken S; Moore J; Itescu S; Graham RM, 2005, 'Granulocyte-Colony Stimulating Factor Decreases Angina and Improves Exercise Capacity in Patients with Chronic Refractory ‘No Option’ Ischemic Heart Disease.', Blood, 106, pp. 4215 - 4215, http://dx.doi.org/10.1182/blood.v106.11.4215.4215

Kovacic JC; Graham RM, 2005, 'Are improvements in cardiac function due to stem cell uptake and engraftment?', American Journal of Cardiology, 95, pp. 159, http://dx.doi.org/10.1016/j.amjcard.2004.07.138

Mallon PW; Miller JM; Kovacic JC; Kent-Hughes J; Norris RP; Samaras K; Feneley MP; Cooper DA; Carr AD, 2005, 'Changes in body composition and cardiovascular measures in hypercholesterolaemic HIV-infected men treated with pravastatin: a randomized, placebo-controlled study', Antiviral Therapy, 10, pp. L15 - L16

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