By Dr Jason Ciril Kovacic

Journal articles

Schaniel C; Dhanan P; Hu B; Xiong Y; Raghunandan T; Gonzalez DM; Dariolli R; D'Souza SL; Yadaw AS; Hansen J; Jayaraman G; Mathew B; Machado M; Berger SI; Tripodi J; Najfeld V; Garg J; Miller M; Surlyn CS; Michelis KC; Tangirala NC; Weerahandi H; Thomas DC; Beaumont KG; Sebra R; Mahajan M; Schadt E; Vidovic D; Schürer SC; Goldfarb J; Azeloglu EU; Birtwistle MR; Sobie EA; Kovacic JC; Dubois NC; Iyengar R, 2021, 'A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals', Stem Cell Reports, 16, pp. 3036 - 3049, http://dx.doi.org/10.1016/j.stemcr.2021.10.005

Cohain AT; Barrington WT; Jordan DM; Beckmann ND; Argmann CA; Houten SM; Charney AW; Ermel R; Sukhavasi K; Franzen O; Koplev S; Whatling C; Belbin GM; Yang J; Hao K; Kenny EE; Tu Z; Zhu J; Gan LM; Do R; Giannarelli C; Kovacic JC; Ruusalepp A; Lusis AJ; Bjorkegren JLM; Schadt EE, 2021, 'An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-020-20750-8

Georges A; Yang ML; Berrandou TE; Bakker MK; Dikilitas O; Kiando SR; Ma L; Satterfield BA; Sengupta S; Yu M; Deleuze JF; Dupré D; Hunker KL; Kyryachenko S; Liu L; Sayoud-Sadeg I; Amar L; Brummett CM; Coleman DM; d’Escamard V; de Leeuw P; Fendrikova-Mahlay N; Kadian-Dodov D; Li JZ; Lorthioir A; Pappaccogli M; Prejbisz A; Smigielski W; Stanley JC; Zawistowski M; Zhou X; Zöllner S; Amouyel P; De Buyzere ML; Debette S; Dobrowolski P; Drygas W; Gornik HL; Olin JW; Piwonski J; Rietzschel ER; Ruigrok YM; Vikkula M; Warchol Celinska E; Januszewicz A; Kullo IJ; Azizi M; Jeunemaitre X; Persu A; Kovacic JC; Ganesh SK; Bouatia-Naji N, 2021, 'Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases', Nature Communications, 12, http://dx.doi.org/10.1038/s41467-021-26174-2

Kaur K; Hadas Y; Kurian AA; Żak MM; Yoo J; Mahmood A; Girard H; Komargodski R; Io T; Santini MP; Sultana N; Sharkar MTK; Magadum A; Fargnoli A; Yoon S; Chepurko E; Chepurko V; Eliyahu E; Pinto D; Lebeche D; Kovacic JC; Hajjar RJ; Rafii S; Zangi L, 2021, 'Direct reprogramming induces vascular regeneration post muscle ischemic injury', Molecular Therapy, 29, pp. 3042 - 3058, http://dx.doi.org/10.1016/j.ymthe.2021.07.014

Robson PM; Vergani V; Benkert T; Trivieri MG; Karakatsanis NA; Abgral R; Dweck MR; Moreno PR; Kovacic JC; Block KT; Fayad ZA, 2021, 'Assessing the qualitative and quantitative impacts of simple two-class vs multiple tissue-class MR-based attenuation correction for cardiac PET/MR', Journal of Nuclear Cardiology, 28, pp. 2194 - 2204, http://dx.doi.org/10.1007/s12350-019-02002-5

Wolhuter K; Arora M; Kovacic JC, 2021, 'Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID-19 pandemic of 2020 convince us to change our ways?', BioEssays, 43, http://dx.doi.org/10.1002/bies.202100046

Lecce L; Xu Y; V'Gangula B; Chandel N; Pothula V; Caudrillier A; Santini MP; D'Escamard V; Ceholski DK; Gorski PA; Ma L; Koplev S; Bjørklund MM; Björkegren JLM; Boehm M; Bentzon JF; Fuster V; Kim HW; Weintraub NL; Baker AH; Bernstein E; Kovacic JC, 2021, 'Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype', Journal of Clinical Investigation, 131, http://dx.doi.org/10.1172/JCI131178

Giudicessi JR; Ackerman MJ; Fatkin D; Kovacic JC, 2021, 'Precision Medicine Approaches to Cardiac Arrhythmias: JACC Focus Seminar 4/5 (vol 77, pg 2573, 2021)', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 78, http://dx.doi.org/10.1016/j.jacc.2021.05.032

Blum M; Cao D; Chandiramani R; Goel R; Roumeliotis A; Sartori S; Beyhoff N; Kelle S; Kovacic JC; Krishnan P; Sweeny J; Barman N; Baber U; Dangas GD; Kini A; Sharma SK; Mehran R, 2021, 'Prevalence and prognostic impact of hsCRP elevation are age-dependent in women but not in men undergoing percutaneous coronary intervention', Catheterization and Cardiovascular Interventions, 97, pp. E936 - E944, http://dx.doi.org/10.1002/ccd.29402

Fatkin D; Calkins H; Elliott P; James CA; Peters S; Kovacic JC, 2021, 'Contemporary and Future Approaches to Precision Medicine in Inherited Cardiomyopathies: JACC Focus Seminar 3/5', Journal of the American College of Cardiology, 77, pp. 2551 - 2572, http://dx.doi.org/10.1016/j.jacc.2020.12.072

Barc J; Kovacic JC, 2021, 'From polygenic risk scores to integrative epigenomics: the dawn of a new era for cardiovascular precision medicine', Cardiovascular research, 117, pp. e73 - e75, http://dx.doi.org/10.1093/cvr/cvab146

Giudicessi JR; Ackerman MJ; Fatkin D; Kovacic JC, 2021, 'Precision Medicine Approaches to Cardiac Arrhythmias: JACC Focus Seminar 4/5', Journal of the American College of Cardiology, 77, pp. 2573 - 2591, http://dx.doi.org/10.1016/j.jacc.2021.03.325

Miller CL; Kontorovich AR; Hao K; Ma L; Iyegbe C; Björkegren JLM; Kovacic JC, 2021, 'Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5', Journal of the American College of Cardiology, 77, pp. 2531 - 2550, http://dx.doi.org/10.1016/j.jacc.2021.04.001

Semsarian C; Ingles J; Ross SB; Dunwoodie SL; Bagnall RD; Kovacic JC, 2021, 'Precision Medicine in Cardiovascular Disease: Genetics and Impact on Phenotypes: JACC Focus Seminar 1/5', Journal of the American College of Cardiology, 77, pp. 2517 - 2530, http://dx.doi.org/10.1016/j.jacc.2020.12.071

Priori SG; Mazzanti A; Santiago DJ; Kukavica D; Trancuccio A; Kovacic JC, 2021, 'Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia: JACC Focus Seminar 5/5', Journal of the American College of Cardiology, 77, pp. 2592 - 2612, http://dx.doi.org/10.1016/j.jacc.2020.12.073

Von Scheidt M; Zhao Y; De Aguiar Vallim TQ; Che N; Wierer M; Seldin MM; Franzén O; Kurt Z; Pang S; Bongiovanni D; Yamamoto M; Edwards PA; Ruusalepp A; Kovacic JC; Mann M; Björkegren JLM; Lusis AJ; Yang X; Schunkert H, 2021, 'Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism', Circulation, 143, pp. 1809 - 1823, http://dx.doi.org/10.1161/CIRCULATIONAHA.120.050186

Monteiro JP; Rodor J; Caudrillier A; Scanlon JP; Spiroski AM; Dudnakova T; Pflüger-Müller B; Shmakova A; Von Kriegsheim A; Deng L; Taylor RS; Wilson-Kanamori JR; Chen SH; Stewart K; Thomson A; Mitić T; McClure JD; Iynikkel J; Hadoke PWF; Denby L; Bradshaw AC; Caruso P; Morrell NW; Kovacic JC; Ulitsky I; Henderson NC; Caporali A; Leisegang MS; Brandes RP; Baker AH, 2021, 'MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease', Circulation Research, 128, pp. 1173 - 1190, http://dx.doi.org/10.1161/CIRCRESAHA.120.318124

Georges A; Albuisson J; Berrandou T; Dupré D; Lorthioir A; D'Escamard V; Di Narzo AF; Kadian-Dodov D; Olin JW; Warchol-Celinska E; Prejbisz A; Januszewicz A; Bruneval P; Baranowska AA; Webb TR; Hamby SE; Samani NJ; Adlam D; Fendrikova-Mahlay N; Hazen S; Wang Y; Yang ML; Hunker K; Combaret N; Motreff P; Chédid A; Fiquet B; Plouin PF; Mousseaux E; Azarine A; Amar L; Azizi M; Gornik HL; Ganesh SK; Kovacic JC; Jeunemaitre X; Bouatia-Naji N, 2021, 'Rare loss-of-function mutations of PTGIR are enriched in fibromuscular dysplasia', Cardiovascular Research, 117, pp. 1154 - 1165, http://dx.doi.org/10.1093/cvr/cvaa161

Hartman RJG; Owsiany K; Ma L; Koplev S; Hao K; Slenders L; Civelek M; Mokry M; Kovacic JC; Pasterkamp G; Owens G; Björkegren JLM; Den Ruijter HM, 2021, 'Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching', Circulation, 143, pp. 713 - 726, http://dx.doi.org/10.1161/CIRCULATIONAHA.120.051231

Iismaa SE; Hesselson S; McGrath-Cadell L; Muller DW; Fatkin D; Giannoulatou E; Kovacic J; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women', Heart Lung and Circulation, 30, pp. 27 - 35, http://dx.doi.org/10.1016/j.hlc.2020.05.110

Bax M; Junday K; Hesselson S; Iismaa S; Tarr I; McGrath-Cadell L; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham R, 2021, 'Modelling Spontaneous Coronary Artery Dissection With iPSC-Derived Vascular Cells', Heart, Lung and Circulation, 30, pp. S131 - S131, http://dx.doi.org/10.1016/j.hlc.2021.06.089

McGrath-Cadell L; Iismaa SE; Hesselson S; Muller DW; Fatkin D; Giannoulatou E; Kovacic JC; Graham RM, 2021, 'Recent Updates on Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia', International Journal of Integrative Cardiology, 3, http://dx.doi.org/10.47275/2690-862x-121

McGrath-Cadell L; Hesselson S; Tarr I; Iismaa S; Bax M; Junday K; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham B, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a Family History of Aortic Artery Dissection—A Case Series', Heart, Lung and Circulation, 30, pp. S252 - S252, http://dx.doi.org/10.1016/j.hlc.2021.06.350

Beyhoff N; Cao D; Mehran R; Dangas G; Baber U; Sartori S; Blum M; Roumeliotis A; Chandiramani R; Goel R; Zhang Z; Kovacic J; Krishnan P; Barman N; Kapur V; Sweeny J; Sharma SK; Kini A, 2020, 'Prognostic Impact of High-Sensitivity C-Reactive Protein in Patients Undergoing Percutaneous Coronary Intervention According to BMI', JACC: Cardiovascular Interventions, 13, pp. 2882 - 2892, http://dx.doi.org/10.1016/j.jcin.2020.09.024

Trivieri MG; Spagnolo P; Birnie D; Liu P; Drake W; Kovacic JC; Baughman R; Fayad ZA; Judson MA, 2020, 'Challenges in Cardiac and Pulmonary Sarcoidosis: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 76, pp. 1878 - 1901, http://dx.doi.org/10.1016/j.jacc.2020.08.042

Ma L; Chandel N; Ermel R; Sukhavasi K; Hao K; Ruusalepp A; Björkegren JLM; Kovacic JC, 2020, 'Multiple independent mechanisms link gene polymorphisms in the region of ZEB2 with risk of coronary artery disease', Atherosclerosis, 311, pp. 20 - 29, http://dx.doi.org/10.1016/j.atherosclerosis.2020.08.013

Aoi S; Baber U; Kovacic JC; Mehran R; Aquino M; Dangas G; Sweeny J; Vijay P; Shah S; Barman N; Moreno P; Kini AS; Sharma SK, 2020, 'Combined and independent impact of coronary artery calcification and inflammation on risk for adverse cardiovascular events after percutaneous coronary intervention: Results from a large single-center registry', Catheterization and Cardiovascular Interventions, 96, pp. E278 - E286, http://dx.doi.org/10.1002/ccd.28784

Plitt A; Claessen BE; Sartori S; Baber U; Chandrasekhar J; Aquino M; Vijay P; Elsayed S; Kovacic JC; Sweeny J; Barman N; Moreno P; Krishnan P; Demopoulos A; Dangas G; Kini AS; Mehran R; Sharma SK, 2020, 'Impact of stent diameter on outcomes following percutaneous coronary intervention with second-generation drug-eluting stents: Results from a large single-center registry', Catheterization and Cardiovascular Interventions, 96, pp. 558 - 564, http://dx.doi.org/10.1002/ccd.28488

Chandrasekhar J; Dangas G; Baber U; Sartori S; Qadeer A; Aquino M; Vogel B; Faggioni M; Vijay P; Claessen BE; Goel R; Moreno P; Krishnan P; Kovacic JC; Kini A; Mehran R; Sharma S, 2020, 'Impact of insulin treated and non-insulin-treated diabetes compared to patients without diabetes on 1-year outcomes following contemporary PCI', Catheterization and Cardiovascular Interventions, 96, pp. 298 - 308, http://dx.doi.org/10.1002/ccd.28841

Tang GHL; Lerakis S; Kini A; Khan JM; Kovacic JC, 2020, '4-Dimensional Transesophageal Echocardiographic Guidance During TAVR With BASILICA', JACC: Cardiovascular Imaging, 13, pp. 1601 - 1614, http://dx.doi.org/10.1016/j.jcmg.2019.11.022

Tang GHL; Zaid S; Fuchs A; Yamabe T; Yazdchi F; Gupta E; Ahmad H; Kofoed KF; Goldberg JB; Undemir C; Kaple RK; Shah PB; Kaneko T; Lansman SL; Khera S; Kovacic JC; Dangas GD; Lerakis S; Sharma SK; Kini A; Adams DH; Khalique OK; Hahn RT; Søndergaard L; George I; Kodali SK; De Backer O; Leon MB; Bapat VN, 2020, 'Alignment of Transcatheter Aortic-Valve Neo-Commissures (ALIGN TAVR): Impact on Final Valve Orientation and Coronary Artery Overlap', JACC: Cardiovascular Interventions, 13, pp. 1030 - 1042, http://dx.doi.org/10.1016/j.jcin.2020.02.005

del Monte-Nieto G; Fischer JW; Gorski DJ; Harvey RP; Kovacic JC, 2020, 'Basic Biology of Extracellular Matrix in the Cardiovascular System, Part 1/4: JACC Focus Seminar', Journal of the American College of Cardiology, 75, pp. 2169 - 2188, http://dx.doi.org/10.1016/j.jacc.2020.03.024

Frangogiannis NG; Kovacic JC, 2020, 'Extracellular Matrix in Ischemic Heart Disease, Part 4/4: JACC Focus Seminar', Journal of the American College of Cardiology, 75, pp. 2219 - 2235, http://dx.doi.org/10.1016/j.jacc.2020.03.020

Barallobre-Barreiro J; Loeys B; Mayr M; Rienks M; Verstraeten A; Kovacic JC, 2020, 'Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar', Journal of the American College of Cardiology, 75, pp. 2189 - 2203, http://dx.doi.org/10.1016/j.jacc.2020.03.018

Díez J; González A; Kovacic JC, 2020, 'Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4: JACC Focus Seminar', Journal of the American College of Cardiology, 75, pp. 2204 - 2218, http://dx.doi.org/10.1016/j.jacc.2020.03.019

Zaid S; Sengupta A; Okoli K; Tsoi M; Khan A; Ahmad H; Goldberg JB; Undemir C; Rozenshtein A; Patel N; Khan M; Gupta E; Kovacic J; Lansman SL; Dangas GD; Sharma SK; Kini A; Tang GHL, 2020, 'Novel Anatomic Predictors of New Persistent Left Bundle Branch Block After Evolut Transcatheter Aortic Valve Implantation', American Journal of Cardiology, 125, pp. 1222 - 1229, http://dx.doi.org/10.1016/j.amjcard.2020.01.008

Santini MP; Malide D; Hoffman G; Pandey G; D'Escamard V; Nomura-Kitabayashi A; Rovira I; Kataoka H; Ochando J; Harvey RP; Finkel T; Kovacic JC, 2020, 'Tissue-Resident PDGFRα⁺ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner', Cell Reports, 30, pp. 555 - 570.e7, http://dx.doi.org/10.1016/j.celrep.2019.12.045

Fernandez-Jimenez R; Jaslow R; Bansilal S; Diaz-Munoz R; Fatterpekar M; Santana M; Clarke-Littman A; Latina J; Soto AV; Hill CA; Al-Kazaz M; Samtani R; Vedanthan R; Giannarelli C; Kovacic JC; Bagiella E; Kasarskis A; Fayad ZA; Fuster V, 2020, 'Different Lifestyle Interventions in Adults From Underserved Communities: The FAMILIA Trial', Journal of the American College of Cardiology, 75, pp. 42 - 56, http://dx.doi.org/10.1016/j.jacc.2019.10.021

Olin JW; Di Narzo AF; D'Escamard V; Kadian-Dodov D; Cheng H; Georges A; King A; Thomas A; Barwari T; Michelis KC; Bouchareb R; Bander E; Anyanwu A; Stelzer P; Filsoufi F; Florman S; Civelek M; Debette S; Jeunemaitre X; Björkegren JLM; Mayr M; Bouatia-Naji N; Hao K; Kovacic JC, 2020, 'A plasma proteogenomic signature for fibromuscular dysplasia', Cardiovascular Research, 116, pp. 63 - 77, http://dx.doi.org/10.1093/cvr/cvz219

Sengupta A; Alexis SL; Kovacic JC; Tang GHL, 2020, 'Current challenges in TAVI: Neo-commissural alignment to mimic more physiologic valve implantation', Vessel Plus, 4, http://dx.doi.org/10.20517/2574-1209.2020.55

Haider N; Boscá L; Zandbergen HR; Kovacic JC; Narula N; González-Ramos S; Fernandez-Velasco M; Agrawal S; Paz-García M; Gupta S; DeLeon-Pennell K; Fuster V; Ibañez B; Narula J, 2019, 'Transition of Macrophages to Fibroblast-Like Cells in Healing Myocardial Infarction', Journal of the American College of Cardiology, 74, pp. 3124 - 3135, http://dx.doi.org/10.1016/j.jacc.2019.10.036

Fatkin D; Huttner IG; Kovacic JC; Seidman JG; Seidman CE, 2019, 'Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review', Journal of the American College of Cardiology, 74, pp. 2921 - 2938, http://dx.doi.org/10.1016/j.jacc.2019.10.011

Glicksberg BS; Amadori L; Akers NK; Sukhavasi K; Franzén O; Li L; Belbin GM; Ayers KL; Shameer K; Badgeley MA; Johnson KW; Readhead B; Darrow BJ; Kenny EE; Betsholtz C; Ermel R; Skogsberg J; Ruusalepp A; Schadt EE; Dudley JT; Ren H; Kovacic JC; Giannarelli C; Li SD; Björkegren JLM; Chen R, 2019, 'Correction to: Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits (BMC Medical Genomics DOI: 10.1186/s12920-019-0542-3)', BMC Medical Genomics, 12, http://dx.doi.org/10.1186/s12920-019-0573-9

Hulshoff MS; Del Monte-Nieto G; Kovacic J; Krenning G, 2019, 'Non-coding RNA in endothelial-to-mesenchymal transition', Cardiovascular Research, 115, pp. 1716 - 1731, http://dx.doi.org/10.1093/cvr/cvz211

Tadros RO; Tang GHL; Barnes HJ; Mousavi I; Kovacic JC; Faries P; Olin JW; Marin ML; Adams DH, 2019, 'Optimal Treatment of Uncomplicated Type B Aortic Dissection: JACC Review Topic of the Week', Journal of the American College of Cardiology, 74, pp. 1494 - 1504, http://dx.doi.org/10.1016/j.jacc.2019.07.063

Glicksberg BS; Amadori L; Akers NK; Sukhavasi K; Franzén O; Li L; Belbin GM; Akers KL; Shameer K; Badgeley MA; Johnson KW; Readhead B; Darrow BJ; Kenny EE; Betsholtz C; Ermel R; Skogsberg J; Ruusalepp A; Schadt EE; Dudley JT; Ren H; Kovacic JC; Giannarelli C; Li SD; Björkegren JLM; Chen R, 2019, 'Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits', BMC Medical Genomics, 12, http://dx.doi.org/10.1186/s12920-019-0542-3

Guedeney P; Claessen BE; Kalkman DN; Aquino M; Sorrentino S; Giustino G; Farhan S; Vogel B; Sartori S; Montalescot G; Sweeny J; Kovacic JC; Krishnan P; Barman N; Dangas G; Kini A; Baber U; Sharma S; Mehran R, 2019, 'Residual Inflammatory Risk in Patients With Low LDL Cholesterol Levels Undergoing Percutaneous Coronary Intervention (vol 73, pg 2401, 2019)', JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 74, pp. 481 - 482, http://dx.doi.org/10.1016/j.jacc.2019.06.009

Tang GHL; Zaid S; Gupta E; Ahmad H; Khan A; Kovacic JC; Lansman SL; Dangas GD; Sharma SK; Kini A, 2019, 'Feasibility of Repeat TAVR After SAPIEN 3 TAVR: A Novel Classification Scheme and Pilot Angiographic Study', JACC: Cardiovascular Interventions, 12, pp. 1290 - 1292, http://dx.doi.org/10.1016/j.jcin.2019.02.020

Tang GHL; Zaid S; Gupta E; Ahmad H; Patel N; Khan M; Khan A; Kovacic JC; Lansman SL; Dangas GD; Sharma SK; Kini A, 2019, 'Impact of Initial Evolut Transcatheter Aortic Valve Replacement Deployment Orientation on Final Valve Orientation and Coronary Reaccess: A Pilot Study', Circulation: Cardiovascular Interventions, 12, http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008044

Zeng L; Talukdar HA; Koplev S; Giannarelli C; Ivert T; Gan LM; Ruusalepp A; Schadt EE; Kovacic JC; Lusis AJ; Michoel T; Schunkert H; Björkegren JLM, 2019, 'Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease', Journal of the American College of Cardiology, 73, pp. 2946 - 2957, http://dx.doi.org/10.1016/j.jacc.2019.03.520

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