Select Publications
Book Chapters
2009, 'Protocol III: Detection of Alternative Lengthening of Telomeres', in Telomeres and Telomerase in Cancer, Humana Press, pp. 351 - 364, http://dx.doi.org/10.1007/978-1-60327-879-9_16
,Journal articles
2024, 'Comment on “Hall et al., Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain”', Journal of Cannabis Research, 6, http://dx.doi.org/10.1186/s42238-023-00206-8
,2024, 'Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression', Cellular Oncology, http://dx.doi.org/10.1007/s13402-024-00986-y
,2023, 'Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus', Biomolecules, 13, http://dx.doi.org/10.3390/biom13091307
,2022, 'Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain', PLoS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0270543
,2022, 'Tetrahydrocannabinol and cannabidiol medicines for chronic pain and mental health conditions', Inflammopharmacology, 30, pp. 1167 - 1178, http://dx.doi.org/10.1007/s10787-022-01020-z
,2022, 'Re: "Cannabidiol for COVID-19 Patients with Mild to Moderate Symptoms (CANDIDATE Study): A Randomized, Double-Blind, Placebo-Controlled Clinical Trial" by Crippa et al.', Cannabis and Cannabinoid Research, 7, pp. 231 - 233, http://dx.doi.org/10.1089/can.2022.0034
,2022, 'Intestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis', International Journal of Tryptophan Research, 15, http://dx.doi.org/10.1177/11786469211070533
,2022, 'Comment on: Cannabis use among Danish patients with cancer: a cross‑sectional survey of sociodemographic traits, quality of life, and patient experiences', Supportive Care in Cancer, http://dx.doi.org/10.1007/s00520-022-06995-7
,2021, 'Enhancing endocannabinoid control of stress with cannabidiol', Journal of Clinical Medicine, 10, http://dx.doi.org/10.3390/jcm10245852
,2021, 'Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-96096-y
,2021, 'The intestinal microbiota and improving the efficacy of COVID-19 vaccinations', Journal of Functional Foods, 87, http://dx.doi.org/10.1016/j.jff.2021.104850
,2021, 'The c-circle biomarker is secreted by alternative-lengthening-of-telomeres positive cancer cells inside exosomes and provides a blood-based diagnostic for alt activity', Cancers, 13, http://dx.doi.org/10.3390/cancers13215369
,2021, 'A pilot safety, tolerability and pharmacokinetic study of an oro-buccal administered cannabidiol-dominant anti-inflammatory formulation in healthy individuals: a randomized placebo-controlled single-blinded study', Inflammopharmacology, 29, pp. 1361 - 1370, http://dx.doi.org/10.1007/s10787-021-00859-y
,2020, 'An oro-buccal nanoparticle delivered cannabis medicine for pain management in cancer: A clinical trial in progress.', Journal of Clinical Oncology, 38, pp. TPS12127 - TPS12127, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps12127
,2020, 'Probiotics and synbiotics targeting the intestinal microbiome attenuate non-alcoholic fatty liver disease.', Hepatobiliary Surg Nutr, 9, pp. 526 - 529, http://dx.doi.org/10.21037/hbsn.2019.11.24
,2018, 'CBMT-45. A NOVEL C-CIRCLE ASSAY FOR DETECTING ALTERNATIVE LENGTHENING OF TELOMERES (ALT) MECHANISMS', Neuro-Oncology, 20, pp. vi42 - vi42, http://dx.doi.org/10.1093/neuonc/noy148.164
,2018, 'Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4737 - 4742, http://dx.doi.org/10.1073/pnas.1720391115
,2017, 'BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres', EMBO Journal, 36, pp. 2907 - 2919, http://dx.doi.org/10.15252/embj.201796889
,2017, 'Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres', Cell Reports, 19, pp. 2544 - 2556, http://dx.doi.org/10.1016/j.celrep.2017.05.087
,2017, 'The C-Circle Assay for alternative-lengthening-of-telomeres activity', Methods, 114, pp. 74 - 84, http://dx.doi.org/10.1016/j.ymeth.2016.08.016
,2015, 'Control ALT, delete cancer', Scientist, 29
,2014, 'Non‐telomerase telomere maintenance in human cells (97.2)', The FASEB Journal, 28, http://dx.doi.org/10.1096/fasebj.28.1_supplement.97.2
,2013, 'Detection of alternative lengthening of telomeres by telomere quantitative PCR', Nucleic Acids Research, 41, pp. e34 - e34, http://dx.doi.org/10.1093/nar/gks781
,2011, 'Normal mammalian cells negatively regulate telomere length by telomere trimming', Human Molecular Genetics, 20, pp. 4684 - 4692, http://dx.doi.org/10.1093/hmg/ddr402
,2010, 'For cancers there is more to life than a longer G-strand', Asian Journal of Andrology, 12, pp. 779 - 782, http://dx.doi.org/10.1038/aja.2010.103
,2010, 'Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers', FEBS Letters, 584, pp. 3800 - 3811, http://dx.doi.org/10.1016/j.febslet.2010.06.009
,2010, 'Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival', Journal of Neuropathology and Experimental Neurology, 69, pp. 729 - 736, http://dx.doi.org/10.1097/NEN.0b013e3181e576cf
,2009, 'DNA C-circles are specific and quantifiable markers of alternative- lengthening-of-telomeres activity', Nature Biotechnology, 27, pp. 1181 - 1185, http://dx.doi.org/10.1038/nbt.1587
,2009, 'Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins', Journal of Cell Biology, 185, pp. 797 - 810, http://dx.doi.org/10.1083/jcb.200810084
,2006, 'Telomere maintenance mechanisms in liposarcomas: Association with histologic subtypes and disease progression', Cancer Research, 66, pp. 8918 - 8924, http://dx.doi.org/10.1158/0008-5472.CAN-06-0273
,2005, 'Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome', Human Molecular Genetics, 14, pp. 1785 - 1794, http://dx.doi.org/10.1093/hmg/ddi185
,2005, 'Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex', Molecular and Cellular Biology, 25, pp. 2708 - 2721, http://dx.doi.org/10.1128/MCB.25.7.2708-2721.2005
,2005, 'A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas', Clinical Cancer Research, 11, pp. 217 - 225, http://dx.doi.org/10.1158/1078-0432.217.11.1
,2002, 'Alternative lengthening of telomeres in mammalian cells', Oncogene, 21, pp. 598 - 610, http://dx.doi.org/10.1038/sj/onc/1205058
,Conference Papers
2020, 'Pilot clinical and pharmacokinetic study of a water soluble nanoparticle cannabis-based medicine in advanced cancer with intractable pain', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, pp. 117 - 118, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000790145400136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2014, 'Non-telomerase telomere maintenance in human cells', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 26 April 2014 - 30 April 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346646705193&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2012, 'Abstract 4597: Telomere maintenance mechanism and expression in colorectal cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 4597 - 4597, http://dx.doi.org/10.1158/1538-7445.am2012-4597
,Conference Abstracts
2015, 'Identification of new alternative lengthening of telomeres (ALT)-positive cancer cell lines using the C-circle assay', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, Vol. 75, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-3768
,2014, 'THE C-CIRCLE ASSAY AS A BLOOD TEST FOR ALT CANCER ACTIVITY', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 10, pp. 12 - 12, http://dx.doi.org/10.1111/ajco.12284
,2014, 'Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A', in Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, http://dx.doi.org/10.1073/pnas.1411370111
,2010, 'LONGER SURVIVAL FOR PATIENTS WITH ALTERNATIVE LENGTHENING OF TELOMERES (ALT) GLIOBLASTOMA MULTIFORME IS DUE TO A LESS AGGRESSIVE PHENOTYPE AND NOT TO IMPROVED RESPONSE TO ADJUVANT THERAPY', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, SCOTLAND, Glasgow, Vol. 12, pp. 3 - 3, presented at Meeting of the British-Neuro-Oncology-Society, SCOTLAND, Glasgow, 23 June 2010 - 25 June 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279583000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, JAPAN, Yokohama, Vol. 11, pp. 897 - 897, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, JAPAN, Yokohama, 11 May 2009 - 14 May 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100111&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2009, 'PRESENCE OF AN ALTERNATIVE LENGTHENING OF TELOMERE (ALT) MECHANISM AS A FAVORABLE PROGNOSTIC MARKER IN PATIENTS WITH GLIOBLASTOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, JAPAN, Yokohama, Vol. 11, pp. 928 - 928, presented at 3rd Quadrennial Meeting of the World-Federation-of-Neuro-Oncoloyg/6th Meeting of the Asian-Society-for-Neuro-Oncology, JAPAN, Yokohama, 11 May 2009 - 14 May 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000272974100244&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
,2007, 'Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference', in Oncogene, Vol. 26, pp. 4635 - 4647, http://dx.doi.org/10.1038/sj.onc.1210260
,Preprints
2020, Pilot Clinical and Pharmacokinetic Study of Δ9-Tetrahydrocannabinol and Cannabidiol Oro-Buccal Spray in Advanced Cancer with Uncontrolled Pain., http://dx.doi.org/10.22541/au.159969847.76735495
,Other
2005, Erratum: Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex (Molecular and Cellular Biology (2005) 25:7 (2708-2721)), http://dx.doi.org/10.1128/MCB.25.10.4334.2005
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