By Dr Krista Siefried

Journal articles

Freestone J; Zhou C; Kypri S; Howes M; Ebdon E; Purcell L; Dessauer P; Beckers C; Chapman B; Weith S; Lamb M; Clifford B; Siefried KJ; Barratt MJ; Peacock A; Sutherland R; Doumany J; Gava P; Standfield M; Kavanagh R; Dicka J; Sidaway P; Farah B; Ezard N, 2026, 'Incorporating experiential reports provided by people who use drugs into drug-related early warning systems: benefits, risks principles and approaches', International Journal of Drug Policy, 147, http://dx.doi.org/10.1016/j.drugpo.2025.105098

Brett J; Lea T; Knock E; Albert S; Acheson L; Siefried KJ; Job S, 2025, 'A qualitative analysis of participant expectations and experiences of psilocybin-assisted psychotherapy for methamphetamine use disorder.', Addiction, http://dx.doi.org/10.1111/add.70284

Freestone J; Kypri S; Schumann JL; Franklin E; Francis C; Barratt MJ; Peacock A; Sutherland R; Clifford B; MacDonald H; Ezard N; Fletcher K; Acheson L; Siefried KJ, 2025, 'The Emergence of Novel Benzodiazepines in Australia, Evidence, Alerts, Clinical Management and Harm Reduction—A Narrative Review', Drug and Alcohol Review, 45, pp. e70086, http://dx.doi.org/10.1111/dar.70086

Sutherland R; Steele M; Rodgers C; Silins E; Gilliver R; Peacock A; Barratt M; Ezard N; Siefried KJ; Page R; Bruno R; Read P, 2025, 'Characteristics of take-home fentanyl test strip use and support for drug checking services among people who use heroin in Australia: learnings for an increasingly complex drug market', Harm Reduction Journal, 22, pp. 75, http://dx.doi.org/10.1186/s12954-025-01205-z

Freestone J; Storer D; Siefried KJ; Bourne A; Prestage G; Ezard N; Maher L; Stirling R; Xiao BJ; Murphy D; Degenhardt L; Hammoud M, 2025, 'Implementation and formative evaluation of a peer-led chemsex intervention targeting sexualised crystal methamphetamine and GHB use: the M3THOD study', Harm Reduction Journal, 22, pp. 181, http://dx.doi.org/10.1186/s12954-025-01329-2

Acheson LS; Siefried KJ; Lintzeris N; Dunlop AJ; Haber PS; Arunogiri S; Christmass M; Doyle M; Donoghoe M; Nagle J; Clifford B; McKetin R; Lubman DI; Brett J; Taylor N; Carr A; Levin FR; Shoptaw S; Ezard N, 2025, 'Study protocol for a randomised controlled trial to determine the efficacy of lisdexamfetamine for the treatment of acute methamphetamine withdrawal in inpatient settings', BMJ Open, 15, pp. e107242 - e107242, http://dx.doi.org/10.1136/bmjopen-2025-107242

Freestone J; Siefried KJ; Peacock A; Fletcher K; Barratt MJ; Sutherland R; Ezard N; Doumany J; MacDonald H; Kypri S; Acheson L; Clifford B, 2025, 'From environmental disasters to emerging drugs; a framework to understand, map and assess drug-related early warning systems', International Journal of Drug Policy, 145, pp. 104946, http://dx.doi.org/10.1016/j.drugpo.2025.104946

Chalabianloo F; Fadnes LT; Mordal J; Spigset O; Løberg EM; Halmøy A; Lid TG; Andersen CD; Daltveit JT; Assmus J; Erga AH; Solli KK; Askjer JF; Hansen MAK; Ohldieck C; Ezard N; Lintzeris N; Johansson KA; Siefried K; Clifford B, 2025, 'Impact of dextroamphetamine substitution on the use of illicit amphetamines in adults with amphetamine dependence: a study protocol for the multicentre double blind randomised controlled trial ATLAS4Dependence', BMJ Open, 15, pp. e095383, http://dx.doi.org/10.1136/bmjopen-2024-095383

Bahceci D; Siefried K; Steele M; Harrod M; Bell G; Barratt MJ; Nicholas CR; Rodgers A; Hendricks PS; Stauffer CS; Liknaitzky P; Brett J, 2025, 'Exploring psychedelic experiences among people who regularly use methamphetamine: Findings from an international survey', Drug and Alcohol Dependence, 272, pp. 112699, http://dx.doi.org/10.1016/j.drugalcdep.2025.112699

Rance J; Belackova V; Bell J; Dunlop AJ; Ezard N; Jauncey M; Lintzeris N; Oviedo-Joekes E; Ritter A; Roberts DM; Rodgers C; Siefried KJ; Strang J; van den Brink W; Treloar C, 2025, 'Hydromorphone Hopes: A Qualitative Study of People Initiating Supervised Short-Acting Injectable Opioid Treatment in Australia', Drug and Alcohol Review, 44, pp. 1533 - 1542, http://dx.doi.org/10.1111/dar.14092

Ezard N; Siefried KJ; Clifford B, 2025, 'Commentary on Young et al.: Clinical guidance is required for stimulant co-prescription with opioid agonist therapy', Addiction, 120, pp. 1195 - 1197, http://dx.doi.org/10.1111/add.70061

van der Helder S; Siefried K; Acheson L; Steele M; Harrod ME; Brett J, 2025, 'Exploring the perceived usefulness of integration support after naturalistic psychedelic experiences in people concerned about their substance use: A survey', Journal of Psychedelic Studies, http://dx.doi.org/10.1556/2054.2025.00422

Ritter A; Bell J; Strang J; Ezard N; Rodgers C; Belackova V; Jauncey M; Siefried KJ; Roberts DM; van den Brink W; Lintzeris N; Dunlop A; Oviedo-Joekes E; Treloar C, 2025, 'Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia', International Journal of Drug Policy, 138, pp. 104749, http://dx.doi.org/10.1016/j.drugpo.2025.104749

Clifford B; Peacock A; Siefried KJ; Gobeil J; Smith JL; Ezard N, 2025, 'Responding to reports of nitazene toxicity in Australia', Medical Journal of Australia, 222, pp. 216 - 219, http://dx.doi.org/10.5694/mja2.52605

Freestone J; Xiao BJ; Siefried KJ; Bourne A; Ezard N; Maher L; Stirling R; Degenhardt L; Varma R; Prestage G; Hammoud M; Varma R, 2025, 'Exploring experiences of talk therapies among gay and bisexual men seeking to reduce or abstain from using crystal methamphetamine in the context of chemsex', Drug and Alcohol Review, 44, pp. 711 - 722, http://dx.doi.org/10.1111/dar.13999

Fletcher K; Ezard N; Siefried KJ; MacDonald H; Acheson L; Bedi G; Guerin A; Knock E; Millard M; May R; Brett J; Doumany J; Morgan C; Clifford B, 2025, 'Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial)', BMJ Open, 15, pp. e092504, http://dx.doi.org/10.1136/BMJOPEN-2024-092504

Siefried KJ; Acheson L; Clifford B; Moller C; Brett J; Christmass M; Dunlop AJ; Haber PS; Jutras-Aswad D; Lintzeris N; Morley K; Shoptaw S; Trivedi MH; Ezard N, 2025, 'Trial protocol of an open-label pilot study of oral naltrexone–bupropion combination pharmacotherapy for the treatment of methamphetamine use disorder (the NABU trial)', BMJ Open, 15, pp. e092032, http://dx.doi.org/10.1136/BMJOPEN-2024-092032

Siefried KJ; Hill P; Clifford B; Brown J; Camilleri A; Crawford S; Dessauer P; Dilkes-Frayne E; Freestone J; Gobeil J; Harrod ME; Hudson S; Hull P; Lenton S; Lyons T; Oh G; Peacock A; Pierce A; Sidaway P; Soderstrom J; Tzanetis S; Ezard N, 2025, 'Co-design of the Australian Prompt Response Network for a public-health focused intersectoral approach to information sharing on emerging drugs of concern', Frontiers in Public Health, 13, pp. 1521911, http://dx.doi.org/10.3389/fpubh.2025.1521911

Siefried KJ; Smith JL; Harvey CA; Nedanoski A; Brown JA; Cullinan U; Ezard N; Jiranantakan T; Roberts DM; Brett J, 2025, 'Emergency department presentations, hospitalisations and police seizure data related to gamma-hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024', Addiction, http://dx.doi.org/10.1111/add.70202

Matepi QGJ; Clifford B; Acheson LS; McKetin R; Montebello M; Siefried KJ; Chan DKE; Olsen N; May R; Ezard N, 2025, 'Insomnia is associated with psychological distress in individuals with methamphetamine dependence', Australasian Psychiatry, http://dx.doi.org/10.1177/10398562251406035

Knock E; Siefried KJ; Bedi G; Albert S; Day RO; Ezard N; Ross M; Liknaitzky P; Brett J, 2025, 'Psilocybin-assisted psychotherapy for methamphetamine use disorder: A pilot open-label safety and feasibility study', Addiction, http://dx.doi.org/10.1111/add.70187

Clifford B; Bruno R; Acheson L; Cecilio ME; Siefried KJ; Freestone J; Cornelisse VJ; Crozier B; Bath N; Ezard N, 2025, 'Substance Use and Sex Index version 2 (SUSI-2): Validation of a brief questionnaire for the measurement of behaviours associated with transmission of blood borne viruses and sexually transmitted infections', Addiction, http://dx.doi.org/10.1111/add.70253

Ezard N; Clifford B; Siefried KJ; Ali R; Dunlop A; McKetin R; Bruno R; Carr A; Ward J; Farrell M; Graham R; Haber P; Lubman D; Donoghoe MW; Olsen N; Baker A; Hall M; Arunogiri S; Lintzeris N; Gill A; Rodgers C; Montebello M; Liaw W; Liu Z, 2025, 'Lisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo-controlled trial', Addiction, 120, pp. 1345 - 1359, http://dx.doi.org/10.1111/add.16730

Heijstee N; Black E; Black E; Demirkol A; Mammen K; Mills L; Deacon R; Ezard N; Montebello M; Reid D; Bruno R; Shakeshaft A; Siefried KJ; Farrell M; Lintzeris N, 2024, 'Sociodemographic and Health Factors of the Alcohol Treatment-seeking Population in New South Wales, Australia', Journal of Addiction Medicine, 18, pp. 619 - 627, http://dx.doi.org/10.1097/ADM.0000000000001311

Rodgers C; Siefried KJ; Ritter A; Belackova V; Treloar C; Jauncey M; Ezard N; Roberts D; Steele M; van den Brink W; Strang J; Oviedo-Joekes E; Lintzeris N; Dunlop AJ; Bell J, 2024, 'Implementation of time-limited parenteral hydromorphone in people with treatment-resistant injecting opioid use disorder: a protocol for a single-site, uncontrolled, open-label study to assess feasibility, safety and cost', BMJ Open, 14, pp. e082553, http://dx.doi.org/10.1136/bmjopen-2023-082553

Harris O; Siefried KJ; Chiew A; Jamshidi N; Chung DT; Moore N; Nic Ionmhain U; Roberts DM; Ezard N; Brett J, 2024, 'Trends in reported GHB-related presentations to Sydney emergency departments between 2012 and 2021', EMA Emergency Medicine Australasia, 36, pp. 604 - 608, http://dx.doi.org/10.1111/1742-6723.14402

Acheson LS; Clay S; McKetin R; Lintzeris N; Dunlop A; Brett J; Christmass M; Rodgers C; Shoptaw S; Farrell M; Ezard N; Siefried KJ, 2024, 'Participant experiences in a pilot study for methamphetamine withdrawal treatment: Implications for retention', International Journal of Drug Policy, 126, pp. 104383, http://dx.doi.org/10.1016/j.drugpo.2024.104383

Acheson LS; Gordon C; Mcketin R; Brett J; Christmass M; Rodgers C; Lintzeris N; Dunlop A; Farrell M; Shoptaw S; Ezard N; Siefried KJ, 2024, 'Measuring Objective and Subjective Sleep during Lisdexamfetamine Treatment of Acute Methamphetamine Withdrawal: A Feasibility Study', European Addiction Research, 30, pp. 121 - 125, http://dx.doi.org/10.1159/000536328

Sharafi H; Bakouni H; McAnulty C; Drouin S; Coronado-Montoya S; Bahremand A; Bach P; Ezard N; Le Foll B; Schütz CG; Siefried KJ; Tardelli VS; Ziegler D; Jutras-Aswad D, 2024, 'Prescription psychostimulants for the treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of randomized placebo-controlled trials', Addiction, 119, pp. 211 - 224, http://dx.doi.org/10.1111/add.16347

Siefried KJ; Bascombe F; Clifford B; Liu Z; Middleton P; Kay-Lambkin F; Freestone J; Herman D; Millard M; Steele M; Acheson L; Moller C; Bath N; Ezard N, 2024, 'Effect of a Smartphone App (S-Check) on Actual and Intended Help-Seeking and Motivation to Change Methamphetamine Use Among Adult Consumers of Methamphetamine in Australia: Randomized Waitlist-Controlled Trial', Jmir Mhealth and Uhealth, 12, pp. e55663 - e55663, http://dx.doi.org/10.2196/55663

Brett J; Knock E; Watson K; Albert S; Siefried KJ; Guss J, 2024, 'Psilocybin-assisted psychotherapy for methamphetamine dependence: a case report involving daily methamphetamine use', Frontiers in Psychiatry, 15, pp. 1490907, http://dx.doi.org/10.3389/fpsyt.2024.1490907

Clifford B; Van Gordon K; Magee F; Malone V; Siefried KJ; Graham D; Ezard N, 2023, '“There’s a big tag on my head”: exploring barriers to treatment seeking with women who use methamphetamine in Sydney, Australia', BMC Health Services Research, 23, pp. 162, http://dx.doi.org/10.1186/s12913-023-09125-z

Bakouni H; Sharafi H; Bahremand A; Drouin S; Ziegler D; Bach P; Le Foll B; Schütz CG; Tardelli V; Ezard N; Siefried K; Jutras-Aswad D, 2023, 'Bupropion for treatment of amphetamine-type stimulant use disorder: A systematic review and meta-analysis of placebo-controlled randomized clinical trials', Drug and Alcohol Dependence, 253, pp. 111018, http://dx.doi.org/10.1016/j.drugalcdep.2023.111018

Freestone J; Ezard N; Bourne A; Brett J; Roberts DM; Hammoud M; Nedanoski A; Prestage G; Siefried KJ, 2023, 'Understandings, attitudes, practices and responses to GHB overdose among GHB consumers', Harm Reduction Journal, 20, pp. 121, http://dx.doi.org/10.1186/s12954-023-00857-z

Bascombe F; Siefried KJ; Clifford B; Child S; Loos R; Sgouras H; Stevens L; Wilson H; Ezard N, 2023, 'Methamphetamine and emerging drugs of concern: A training needs analysis of Australian alcohol and other drug helplines', Drug and Alcohol Review, 42, pp. 1744 - 1753, http://dx.doi.org/10.1111/dar.13719

Black E; Bruno R; Mammen K; Mills L; Siefried KJ; Deacon RM; Shakeshaft A; Dunlop AJ; Ezard N; Montebello M; Childs S; Reid D; Holmes J; Lintzeris N, 2023, 'Substance use, socio-demographic characteristics, and self-rated health of people seeking alcohol and other drug treatment in New South Wales: baseline findings from a cohort study', Medical Journal of Australia, 219, pp. 218 - 226, http://dx.doi.org/10.5694/mja2.52039

Black E; Mammen K; Deacon RM; Ezard N; Mills L; Dunlop AJ; Montebello M; Reid D; Childs S; Bruno R; Shakeshaft A; Siefried KJ; Farrell M; Holmes J; Lintzeris N, 2023, 'Health and social characteristics of clients reporting amphetamine type substance use at entry to public alcohol and other drug services in New South Wales, Australia, 2016–2019', Drug and Alcohol Review, 42, pp. 389 - 400, http://dx.doi.org/10.1111/dar.13588

Aung HL; Siefried KJ; Gates TM; Brew BJ; Mao L; Carr A; Cysique LA, 2023, 'Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not', Eclinicalmedicine, 56, pp. 101792, http://dx.doi.org/10.1016/j.eclinm.2022.101792

Siefried KJ; Freeman G; Roberts DM; Lindsey R; Rodgers C; Ezard N; Brett J, 2023, 'Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review', Psychopharmacology, 240, pp. 127 - 135, http://dx.doi.org/10.1007/s00213-022-06283-6

Freeman G; Siefried KJ; Roberts DM; Rodgers C; Nic Ionmhain U; Ramanathan J; Ezard N; Brett J, 2023, 'Phenobarbital to manage severe gamma-hydroxybutyrate withdrawal: A case series', Drug and Alcohol Review, 42, pp. 27 - 32, http://dx.doi.org/10.1111/dar.13556

Acheson LS; Ezard N; Lintzeris N; Dunlop A; Brett J; Rodgers C; Gill A; Christmass M; McKetin R; Farrell M; Shoptaw S; Siefried KJ, 2022, 'Lisdexamfetamine for the treatment of acute methamphetamine withdrawal: A pilot feasibility and safety trial', Drug and Alcohol Dependence, 241, pp. 109692, http://dx.doi.org/10.1016/j.drugalcdep.2022.109692

Freestone J; Bourne A; Layard E; Prestage G; Murray J; Siefried KJ, 2022, 'Playing at the edges, navigating sexual boundaries, and narrating sexual distress; Practices and perspectives of sexuality and gender diverse people who use GHB', International Journal of Drug Policy, 108, pp. 103811, http://dx.doi.org/10.1016/j.drugpo.2022.103811

Acheson LS; Ezard N; Lintzeris N; Dunlop A; Brett J; Rodgers C; Gill A; Christmass M; McKetin R; Farrell M; Shoptaw S; Siefried KJ, 2022, 'Trial protocol of an open label pilot study of lisdexamfetamine for the treatment of acute methamphetamine withdrawal', Plos One, 17, pp. e0275371, http://dx.doi.org/10.1371/journal.pone.0275371

Page R; Healey A; Siefried KJ; Harrod ME; Franklin E; Peacock A; Barratt MJ; Brett J; Peacock A, 2022, 'Barriers to help-seeking among music festival attendees in New South Wales, Australia', Drug and Alcohol Review, 41, pp. 1322 - 1330, http://dx.doi.org/10.1111/dar.13479

Freestone J; Prestage G; Bourne A; Ezard N; Race K; Nedanoski A; Murray J; Siefried KJ, 2022, 'Controlling for pleasure and risk: The experiences of sexuality and gender diverse people who use GHB', International Journal of Drug Policy, 105, pp. 103747, http://dx.doi.org/10.1016/j.drugpo.2022.103747

Freestone J; Siefried KJ; Prestage G; Hammoud M; Molyneux A; Bourne A, 2022, 'Individual level peer interventions for gay and bisexual men who have sex with men between 2000 and 2020: A scoping review', PLoS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0270649

Siefried KJ; Ezard N; Christmass M; Haber P; Ali R, 2022, 'A clinical research priority setting study for issues related to the use of methamphetamine and emerging drugs of concern in Australia', Drug and Alcohol Review, 41, pp. 309 - 319, http://dx.doi.org/10.1111/dar.13350

Healey A; Siefried KJ; Harrod ME; Franklin E; Peacock A; Barratt MJ; Brett J; Peacock A, 2022, 'Correlates of higher-risk drug-related behaviours at music festivals in New South Wales, Australia', Drug and Alcohol Review, 41, pp. 320 - 329, http://dx.doi.org/10.1111/dar.13404

Acheson LS; Williams BH; Farrell M; McKetin R; Ezard N; Siefried KJ, 2022, 'Pharmacological treatment for methamphetamine withdrawal: A systematic review and meta-analysis of randomised controlled trials', Drug and Alcohol Review, 42, http://dx.doi.org/10.1111/dar.13511

Brett J; Siefried KJ; Healey A; Harrod ME; Franklin E; Barratt MJ; Masters J; Nguyen L; Adiraju S; Gerber C, 2022, 'Wastewater analysis for psychoactive substances at music festivals across New South Wales, Australia in 2019–2020', Clinical Toxicology, 60, pp. 440 - 445, http://dx.doi.org/10.1080/15563650.2021.1979233

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