By Dr Lauren Brown

Journal articles

Gu A; Schmidt B; Lonsdale A; Jalaldeen R; Kosasih HJ; Brown LM; Sadras T; Ekert PG; Oshlack A, 2023, 'TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data', Blood Advances, 7, pp. 7402 - 7406, http://dx.doi.org/10.1182/bloodadvances.2023010385

De Coninck S; De Smedt R; Lintermans B; Reunes L; Kosasih HJ; Reekmans A; Brown LM; Van Roy N; Palhais B; Roels J; Van der Linden M; Van Dorpe J; Ntziachristos P; Van Delft FW; Mansour MR; Pieters T; Lammens T; De Moerloose B; De Bock CE; Goossens S; Van Vlierberghe P, 2023, 'Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma.', Haematologica, 109, http://dx.doi.org/10.3324/haematol.2023.283981

Brown LM; Ekert PG; Fleuren EDG, 2023, 'Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers', Oncogene, 42, pp. 1875 - 1888, http://dx.doi.org/10.1038/s41388-023-02705-7

Sadras T; Jalud FB; Kosasih HJ; Horne CR; Brown LM; El-Kamand S; de Bock CE; McAloney L; Ng AP; Davidson NM; Ludlow LEA; Oshlack A; Cowley MJ; Khaw SL; Murphy JM; Ekert PG, 2023, 'Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL', Leukemia, 37, pp. 1 - 5, http://dx.doi.org/10.1038/s41375-023-01843-x

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2023, 'Toblerone: detecting exon deletion events in cancer using RNA-seq', F1000Research, 12, http://dx.doi.org/10.12688/f1000research.129490.1

Brown LM, 2023, 'BASEMENTS, BARS, AND BURIALS: EXPLORING EXCEPTIONALIST FANTASY AND VIOLENCE IN TONI MORRISON?S HOME', STUDIES IN THE NOVEL, 55, pp. 37 - 57, http://dx.doi.org/10.1353/sdn.2023.0002

Schmidt B; Brown LM; Ryland GL; Lonsdale A; Kosasih HJ; Ludlow LE; Majewski IJ; Blombery P; Ekert PG; Davidson NM; Oshlack A, 2022, 'ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 4093 - 4097, http://dx.doi.org/10.1182/bloodadvances.2021005894

Brown LM; Hediyeh-Zadeh S; Sadras T; Huckstep H; Sandow JJ; Bartolo RC; Kosasih HJ; Davidson NM; Schmidt B; Bjelosevic S; Johnstone R; Webb AI; Khaw SL; Oshlack A; Davis MJ; Ekert PG, 2022, 'SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia', Blood Advances, 6, pp. 2373 - 2387, http://dx.doi.org/10.1182/bloodadvances.2021006076

Brown LM, 2022, '"It's Not My Freedom or Free": The Big Box and Toni Morrison's Meditations on Violence, Justice, and Power', MELUS, 46, pp. 14 - 36, http://dx.doi.org/10.1093/melus/mlab043

Schmidt B; Brown L; Ryland G; Lonsdale A; Kosasih H; Ludlow L; Majewski I; Blombery P; Ekert P; Davidson N; Oshlack A, 2021, 'ALLSorts: a RNA-Seq classifier for B-Cell Acute Lymphoblastic Leukemia', , http://dx.doi.org/10.1101/2021.08.01.454393

Khuong-Quang DA; Brown LM; Wong M; Mayoh C; Sexton-Oates A; Kumar A; Pinese M; Nagabushan S; Lau L; Ludlow LE; Gifford AJ; Rodriguez M; Desai J; Fox SB; Haber M; Ziegler DS; Hansford JR; Marshall GM; Cowley MJ; Ekert PG; Wong-Erasmus M, 2020, 'Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors', Cold Spring Harbor Molecular Case Studies, 6, pp. mcs.a005710, http://dx.doi.org/10.1101/MCS.A005710

Moujalled DM; Hanna DT; Hediyeh-Zadeh S; Pomilio G; Brown L; Litalien V; Bartolo R; Fleming S; Chanrion M; Banquet S; Maragno AL; Kraus-Berthier L; Schoumacher M; Mullighan CG; Georgiou A; White CA; Lessene G; Huang DCS; Roberts AW; Geneste O; Rasmussen L; Davis MJ; Ekert PG; Wei A; Ng AP; Khaw SL, 2020, 'Cotargeting BCL-2 and MCL-1 in high-risk B-ALL', Blood Advances, 4, pp. 2762 - 2767, http://dx.doi.org/10.1182/bloodadvances.2019001416

Brown LM; Lonsdale A; Zhu A, 2020, 'Erratum: The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia (Blood Advances (2020) 4:5 (930-942)DOI: 10.1182/bloodadvances.2019001008)', Blood Advances, 4, pp. 1217, http://dx.doi.org/10.1182/bloodadvances.2020001859

Brown LM; Lonsdale A; Zhu A; Davidson NM; Schmidt B; Hawkins A; Wallach E; Martin M; Mechinaud FM; Khaw SL; Bartolo RC; Ludlow LEA; Challis J; Brooks I; Petrovic V; Venn NC; Sutton R; Majewski IJ; Oshlack A; Ekert PG, 2020, 'The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia', Blood Advances, 4, pp. 930 - 942, http://dx.doi.org/10.1182/bloodadvances.2019001008

Brown LM; Bartolo RC; Davidson NM; Schmidt B; Brooks I; Challis J; Petrovic V; Khuong-Quang DA; Mechinaud F; Khaw SL; Majewski IJ; Oshlack A; Ekert PG, 2019, 'Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia', Pediatric Blood and Cancer, 66, http://dx.doi.org/10.1002/pbc.27897

Paul MJ; Probst CK; Brown LM; de Vries GJ, 2018, 'Dissociation of Puberty and Adolescent Social Development in a Seasonally Breeding Species', CURRENT BIOLOGY, 28, pp. 1116 - +, http://dx.doi.org/10.1016/j.cub.2018.02.030

Brown LM; Hanna DT; Khaw SL; Ekert PG, 2017, 'Dysregulation of BCL-2 family proteins by leukemia fusion genes', Journal of Biological Chemistry, 292, pp. 14325 - 14333, http://dx.doi.org/10.1074/jbc.R117.799056

Narayan N; Morenos L; Phipson B; Willis SN; Brumatti G; Eggers S; Lalaoui N; Brown LM; Kosasih HJ; Bartolo RC; Zhou L; Catchpoole D; Saffery R; Oshlack A; Goodall GJ; Ekert PG, 2017, 'Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia', Leukemia, 31, pp. 808 - 820, http://dx.doi.org/10.1038/leu.2016.279

Nashold FE; Nelson CD; Brown LM; Hayes CE, 2013, 'One calcitriol dose transiently increases Helios⁺FoxP3⁺ T cells and ameliorates autoimmune demyelinating disease', JOURNAL OF NEUROIMMUNOLOGY, 263, pp. 64 - 74, http://dx.doi.org/10.1016/j.jneuroim.2013.07.016

Bursac P; York A; Kuznia P; Brown LM; Arnoczky SP, 2009, 'Influence of Donor Age on the Biomechanical and Biochemical Properties of Human Meniscal Allografts', AMERICAN JOURNAL OF SPORTS MEDICINE, 37, pp. 884 - 889, http://dx.doi.org/10.1177/0363546508330140

Skaggs BJ; Gorre ME; Ryvkin A; Burgess MR; Xie Y; Han Y; Komisopoulou E; Brown LM; Loo JA; Landaw EM; Sawyers CL; Graeber TG, 2006, 'Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103, pp. 19466 - 19471, http://dx.doi.org/10.1073/pnas.0609239103

Fontana J; Atanasiu D; Saw WT; Gallagher JR; Cox RG; Whitbeck JC; Brown LM; Eisenberg RJ; Cohen GH, 'The Fusion Loops of the Initial Prefusion Conformation of Herpes Simplex Virus 1 Fusion Protein Point Toward the Membrane', MBIO, 8, http://dx.doi.org/10.1128/mBio.01268-17

Conference Papers

Fordham A; Brown L; Mayoh C; Wong M; Barger Z; O'Regan L; Lim Kan Siam T; Xie J; Gunther K; Barahona P; Ajuyah P; Lau L; Ziegler D; Haber M; Tyrrell V; Lock R; Cowley M; Nicholls W; Daly R; Ekert P; Fleuren E, 2022, 'MULTI-PLATFORM TYROSINE KINASE PROFILING REVEALS NOVEL ACTIONABLE FGFR ABERRATIONS ACROSS PEDIATRIC AND ADOLESCENT AND YOUNG ADULT SARCOMAS', Vancouver, Canada, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting 2022, Vancouver, Canada, 17 November 2022

Brown LM; Huckstep H; Sandow J; Bartolo RC; Davidson N; Schmidt B; Bjelosevic S; Johnstone RW; Oshlack A; Davis M; Ekert PG, 2018, 'Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117844

Conference Abstracts

Brown LM; Mayoh C; Mateos PA; De Weck A; Salomon R; Sadras T; Manoharan N; Wong M; Cowley MJ; Ekert PG, 2024, 'Right oncogene, wrong tumor - CBL mutations in pediatric CNS and solid tumors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, San Diego, Vol. 84, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), CA, San Diego, 05 April 2024 - 10 April 2024, http://dx.doi.org/10.1158/1538-7445.AM2024-1770

Preprints

Fordham A; Brown L; Mayoh C; Salib A; Barger Z; Wong M; Sian TCCLK; Xie J; Gunther K; Trebilcock P; Terry R; Barahona P; Ajuyah P; Sherstyuk A; Avila A; Cadiz R; Perkins C; Gifford A; Mao J; Zhao A; O’Regan L; Gorgels D; Lau LMS; Ziegler D; Haber M; Tyrrell V; Lock R; Cowley M; Nicholls W; Daly R; Ekert P; Fleuren EDG, 2023, Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas, http://dx.doi.org/10.1101/2023.07.19.548825

Gu A; Schmidt B; Lonsdale A; Brown L; Sadras T; Ekert P; Oshlack A, 2023, TALLSorts: a T-cell acute lymphoblastic leukaemia subtype classifier using RNA-seq expression data, http://dx.doi.org/10.1101/2023.04.05.535648

Hu W; Hu W; Kumar A; Qi S; Sadras T; Casan J; Ma D; Brown L; Haber M; Voskoboinik I; Trapani J; Ekert P; Fareh M, 2022, Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions, http://dx.doi.org/10.21203/rs.3.rs-1714034/v1

Hu W; Kumar A; Qi S; Sadras T; Casan JML; Ma D; Brown L; Haber M; Voskoboinik I; Trapani J; Ekert P; Fareh M, 2022, Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusions, http://dx.doi.org/10.1101/2022.06.22.497105

Lonsdale A; Halman A; Brown L; Kosasih H; Ekert P; Oshlack A, 2022, Toblerone: detecting exon deletion events in cancer using RNA-seq, http://dx.doi.org/10.1101/2022.10.27.514132

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