By Dr Lindsay Edward Wu

Journal articles

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009

Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism

Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, 25, pp. 12 - 19, http://dx.doi.org/10.1016/j.ccr.2013.12.005

Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, 34, pp. 3607 - 3617, http://dx.doi.org/10.1128/MCB.00583-14

North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, 33, pp. 1438 - 1453, http://dx.doi.org/10.15252/embj.201386907

Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, 63, pp. 2656 - 2667, http://dx.doi.org/10.2337/db13-1665

Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology, http://dx.doi.org/10.1002/hep.26072

Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, 59, pp. 3008 - 3016, http://dx.doi.org/10.2337/db10-0483

Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, 1, pp. 26 - 34, http://dx.doi.org/10.1007/s13340-010-0003-x

Wu LE; Carter EA; Rayner BS; McLeod AI; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon Nitride as a Versatile Growth Substrate for Microspectroscopic Imaging and Mapping of Individual Cells.', Molecular Biosystems, 6, pp. 1316 - 1322

Zhang SH; Chen XY; Wong KS; Leung T; Wu LE; Fan XJ, 2009, 'FP08-MO-02 Compliance of patients with guideline in secondary prevention of stroke: a multicentre study in China', Journal of the Neurological Sciences, 285, pp. S69 - S69, http://dx.doi.org/10.1016/s0022-510x(09)70303-x

Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, 10, pp. 40 - 47

Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, 7, pp. 421 - 433, http://dx.doi.org/10.1016/j.cmet.2008.04.005

Vogt S; Lai B; Finney L; Palmer B; Wu LE; Harris H; Paunesku T; de Jonge M; Legnini D; Maser J; Glesne D; Lay P; Woloschak G, 2007, 'Imaging trace elements in cells with x-ray fluorescence microscopy', MICROSCOPY AND MICROANALYSIS, 13, pp. 40 - 41, http://dx.doi.org/10.1017/S1431927607076283

Conference Papers

Mahbub SB; Campbell J; Tan TCY; Habibalahi A; Bertoldo MJ; Goss DM; Walter K; Wu LE; Dunning KR; Goldys E, 2021, 'Label-free multispectral identification of native fluorophores to assess embryo and oocyte quality', in Leary JF; Tarnok A; Georgakoudi I (eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, SPIE, pp. 7 - 7, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 06 March 2021 - 12 March 2021, http://dx.doi.org/10.1117/12.2579141

Riepsamen A; Listijono D; Kalani S; Cooke S; Ledger W; Wu L; Sinclair D, 2019, 'Sirtuins are required for forming fertilization-ready eggs', BJOG: An International Journal of Obstetrics & Gynaecology, Brisbane, Australia, presented at Royal College of Obstetricians and Gynaecologists World Congress, Brisbane, Australia, 10 April 2019, http://dx.doi.org/10.1111/1471-0528.13368

Riepsamen A; Listijono D; Ledger W; Wu L; Sinclair D; Homer H, 2015, 'Inhibition of sirtuin activity and impaired synthesis of the sirtuin NAD plus co-factor disrupts oocyte meiotic maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 309 - 309, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740302106&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Homer H; Riepsamen A; Wu LE; Sinclair D, 2015, 'Sirt2-mediated BubR1 regulation promotes oocyte maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 11 - 11, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359740300024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Cogger V; Mohamad M; Wu L; De Cabo R; Le Couteur DG, 2014, 'DEFENESTRATION OF THE LIVER SINUSOIDAL ENDOTHELIAL CELL IMPAIRS INSULIN AND GLUCOSE UPTAKE', in GERONTOLOGIST, OXFORD UNIV PRESS INC, pp. 164 - 164, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346337501490&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wu LE; James DE; Cantley J, 2010, 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, pp. S58 - S58, presented at 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), SWEDEN, Stockholm, 20 September 2010 - 24 September 2010, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000280689700124&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wu LE; Larance M; Ramm G; Raftery M; Guilhaus M; James DE, 2009, 'Proteomic Analysis of Adipokine Secretion in Insulin Resistance', in DIABETES, AMER DIABETES ASSOC, LA, New Orleans, pp. A333 - A334, presented at 69th Annual Meeting of the American-Diabetes-Association, LA, New Orleans, 05 June 2009 - 09 June 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000266352602014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020, http://dx.doi.org/10.1096/fasebj.2020.34.s1.04752

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', in ESMO Open, Elsevier BV, Vol. 3, pp. A25 - A25, http://dx.doi.org/10.1136/esmoopen-2018-eacr25.56

Chowdhury MKH; Morris M; Turner N; Wu L; Shepherd P; Smith G, 2017, 'Niclosamide blocks glucagon phosphorylation of serine 552 on beta-catenin leading to decrease target genes expression and improve glucose metabolism via PKA signalling pathway', in FASEB JOURNAL, WILEY, IL, Chicago, Vol. 31, presented at Experimental Biology (EB) Annual Meeting, IL, Chicago, 22 April 2017 - 26 April 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405461402087&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Patents

Wu L; Sinclair D; Das A, 2023, Methods for enhancing vascular density, Australia, Patent No. 2017383100

Wu L; Sinclair D, 2022, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. Belgium, Denmark, Europe, France, Germany, Ireland, Italy, Netherlands, Poland, Portugal, Spain, Sweden, Switzerland, United Kingdom - 3288637; Japan - 7193232; United States - 11389469

Wu L; Sinclair D, 2020, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. United Stated Patent no. 10603334

Sinclair D; Gomes A; Wu L, 2018, NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation, Patent No. 9877981, https://pdfpiw.uspto.gov/.piw?Docid=09877981&homeurl=http:%2F%2Fpatft.uspto.gov%2Fnetacgi%2Fnph-Parser%3FSect1%3DPTO1%2526Sect2%3DHITOFF%2526d%3DPALL%2526p%3D1%2526u%3D%25252Fnetahtml%25252FPTO%25252Fsrchnum.htm%2526r%3D1%2526f%3DG%2526l%3D50%2526s1%3D9877981.PN.%2526OS%3DPN%2F9877981%2526RS%3DPN%2F9877981&PageNum=&Rtype=&SectionNum=&idkey=NONE&Input=View+first+page

Working Papers

Bertoldo MJ; Listijono DR; Ho W-HJ; Riepsamen AH; Jin XL; Selesniemi K; Goss DM; Mahbub S; Campbell JM; Habibalahi A; Loh W-GN; Youngson NA; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O’Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2019, NAD+ repletion rescues female fertility during reproductive ageing, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/721985

Preprints

Madawala R; Banks JL; Hancock SE; Quek L-E; Turner N; Wu LE, 2024, CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN), http://dx.doi.org/10.1101/2024.08.08.607247

Habibalahi A; Bertoldo M; Mahbub S; Campbell J; Goss D; Ledger W; Gilchrist R; Wu L; Goldys E, 2021, NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice, http://dx.doi.org/10.21203/rs.3.rs-951364/v1

Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, 2020, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, http://dx.doi.org/10.21203/rs.3.rs-87047/v1

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