Researcher

Dr Robert Ernest Nordon

My Expertise

Cell separation; bioreactor systems for cell therapies

Field of Research (FoR)

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Biography

I was trained as a medical doctor and practised medicine for 3 years before commencing my biomedical engineering research career in 1994. My research in interdisciplinary spanning the gaps between basic, applied and commercialisation of medical devices.

I am currently a Senior Lecturer with the Graduate School of Biomedical Engineering. I have published 40 journal articles and 5 patents, My publications are in the fields of stem cell science,...view more

I was trained as a medical doctor and practised medicine for 3 years before commencing my biomedical engineering research career in 1994. My research in interdisciplinary spanning the gaps between basic, applied and commercialisation of medical devices.

I am currently a Senior Lecturer with the Graduate School of Biomedical Engineering. I have published 40 journal articles and 5 patents, My publications are in the fields of stem cell science, biomicrofluidics, and development of medical devices for cell separation and expansion. I was the inventor of the Quantum Cell Expansion System, marketed by TerumoBCT. This is a closed-automated systems form large scale expansion of cells for clinical therapies. 

I have great interest in helping the medical device industry access expertise and infrastructure at the University of New South Wales.

 

 


My Grants

Scaling microfluidics for cell manufacture. Australian Research Council Linkage Grant LP160100570 (2016-2019)

Manufacturing 3D microstructures for the medical device industry. Australian Research Council Linkage Grant LP160100573 (2016-2019)


My Qualifications

MB BS BMedSci PhD


My Research Activities

1. Developing single use-disposables for plant scale production of cells for clinical therapies

The biopharmaceutical sector has relied  on large-volume, batch-fed, stainless-steel fermentation reactors to manufacture biologics at great scale where one batch run equals thousands of products. However, a rapidly evolving biopharmaceutical industry now requires cost-effective technologies to manufacture multiple diverse biologics. This problem is particularly acute for manufacture of personalised cell and gene therapy products where one batch run equals one product. Our research focuses on developing microfluidic devices for cell manufacture, and fabricating these devices as single-use disposables for plant scale production.

2. Modelling human heart and blood development from pluripotent stem cells on a microfluidic chip

We have used lab-on-chip to mimic foetal circulation and to model human blood formation from cells that line blood vessels. We are currently studying the influence of pulsatile fluid shears stress on generation of blood stem cells. We are also investigating the use of hydrogels to pattern embyonic development of the cardiovascular system.

3. Single cell analysis by live cell imaging and RNA seq
We develop software and microfluidic tools for single cell analysis including software to automate cell tracking and to analysis cell fate using single cell RNA seq.


My Research Supervision


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Areas of supervision

I am currently recruiting PhD students with Engineering and Physical Science background, majoring in Biomedical Engineering.'

PhD Topics include:

1. Application of lab-on-a chip to study stem cell biology

2. Manufacturing 3D microdevices for the medical device industry

3. Developing microfluidic devices for the biopharmaceutical industry

4. Applying machine learning to automate cell recognition and tracking.

5. Developing a point-of-care blood diagnostic

I also run 2 courses in the Graduate School of Biomedical Engineering that run in the 3rd Trimester:

1. Biological Signal Analysis BIOM9621

2. Medical Imaging BIOM9027


Currently supervising

Farzaneh Ziaee

Eric Du

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Location

Samuels Building
UNSW Sydney NSW 2052
Australia

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Contact

+61 2 9385 0559
+61 2 9663 2108