By Dr Samantha Richelle Oakes

Journal articles

Serrano A; Weber T; Berthelet J; El-Saafin F; Gadipally S; Charafe-Jauffret E; Ginestier C; Mariadason JM; Oakes SR; Britt K; Naik SH; Merino D, 2023, 'Experimental and spontaneous metastasis assays can result in divergence in clonal architecture', Communications Biology, 6, http://dx.doi.org/10.1038/s42003-023-05167-5

Ho WHJ; Law AMK; Masle-Farquhar E; Castillo LE; Mawson A; O’Bryan MK; Goodnow CC; Gallego-Ortega D; Oakes SR; Ormandy CJ, 2022, 'Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases', Breast Cancer Research, 24, http://dx.doi.org/10.1186/s13058-022-01525-z

Zammit NW; McDowell J; Warren J; Muskovic W; Gamble J; Shi YC; Kaczorowski D; Chan CL; Powell J; Ormandy C; Brown D; Oakes SR; Grey ST, 2022, 'TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.811525

Lin FP; Thavaneswaran S; Grady JP; Ballinger M; Kansara M; Oakes SR; Desai J; Lee CK; Simes J; Thomas DM, 2021, 'Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology', npj Precision Oncology, 5, pp. 58, http://dx.doi.org/10.1038/s41698-021-00194-z

Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35, http://dx.doi.org/10.1016/j.celrep.2021.108945

Liang Y; Jeganathan S; Marastoni S; Sharp A; Figueiredo I; Marcellus R; Mawson A; Shalev Z; Pesic A; Sweet J; Guo H; Uehling D; Gurel B; Neeb A; He HH; Montgomery B; Koritzinsky M; Oakes S; De Bono JS; Gleave M; Zoubeidi A; Wouters BG; Joshua AM, 2021, 'Emergence of enzalutamide resistance in prostate cancer is associated with BCL-2 and IKKB dependencies', Clinical Cancer Research, 27, pp. 2340 - 2351, http://dx.doi.org/10.1158/1078-0432.CCR-20-3260

Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829, http://dx.doi.org/10.1038/s41388-019-1091-0

Piggin CL; Roden DL; Law AMK; Molloy MP; Krisp C; Swarbrick A; Naylor MJ; Kalyuga M; Kaplan W; Oakes SR; Gallego-Ortega D; Clark SJ; Carroll JS; Bartonicek N; Ormandy CJ, 2020, 'ELF5 modulates the estrogen receptor cistrome in breast cancer', PLoS Genetics, 16, http://dx.doi.org/10.1371/journal.pgen.1008531

Lin F; Thavaneswaran S; Grady J; Ballinger M; Kansara M; Oakes S; Desai J; Lee CK; Simes J; Thomas D, 2020, 'Criteria-based curation of a therapy-focused compendium to support treatment recommendations in precision oncology', , http://dx.doi.org/10.1101/2020.12.18.20248521

Castillo L; George S; Lin H-M; Yeung N; Mawson A; Young AI; Law AM; Hastings J; Gallego-Ortega D; Deng N; Croucher D; Swarbrick A; Horvath L; Ormandy CJ; Oakes SR, 2019, 'Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p038

Alexandrou S; George SM; Ormandy CJ; Lim E; Oakes SR; Elizabeth Caldon C, 2019, 'The proliferative and apoptotic landscape of basal-like breast cancer', International Journal of Molecular Sciences, 20, http://dx.doi.org/10.3390/ijms20030667

Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, 'Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', , http://dx.doi.org/10.1101/624890

Valdes-Mora F; Handler K; Law AMK; Salomon R; Oakes SR; Ormandy CJ; Gallego-Ortega D, 2018, 'Single-cell transcriptomics in cancer immunobiology: The future of precision oncology', Frontiers in Immunology, 9, http://dx.doi.org/10.3389/fimmu.2018.02582

Young AIJ; Timpson P; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2018, 'Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion', Cell Adhesion and Migration, 12, pp. 513 - 523, http://dx.doi.org/10.1080/19336918.2017.1393591

Marini KD; Croucher DR; McCloy RA; Vaghjiani V; Gonzalez-Rajal A; Hastings JF; Chin V; Szczepny A; Kostyrko K; Marquez C; Samantha W; Jayasekara N; Alamgeer M; Boolell V; Han JZR; Waugh T; Lee HC; Oakes SR; Kumar B; Harrison CA; Hedger MP; Lorensuhewa N; Kita B; Barrow R; Robinson BW; De Kretser DM; Wu J; Ganju V; Alejandro Sweet-Cordero E; Burgess A; Martelotto LG; Rossello FJ; Cain JE; Neil Watkins D, 2018, 'Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy', Science Translational Medicine, 10, http://dx.doi.org/10.1126/scitranslmed.aat3504

Law AMK; Yin JXM; Castillo L; Young AIJ; Piggin C; Rogers S; Caldon CE; Burgess A; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2017, 'Andy's Algorithms: New automated digital image analysis pipelines for FIJI', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-15885-6

Oakes SR; Gallego-Ortega D; Stanford PM; Junankar S; Au WWY; Kikhtyak Z; von Korff A; Sergio CM; Law AMK; Castillo LE; Allerdice SL; Young AIJ; Piggin C; Whittle B; Bertram E; Naylor MJ; Roden DL; Donovan J; Korennykh A; Goodnow CC; O’Bryan MK; Ormandy CJ, 2017, 'A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation', PLoS Genetics, 13, pp. e1007072, http://dx.doi.org/10.1371/journal.pgen.1007072

Peng V; Suchowerska N; Rogers L; Claridge Mackonis E; Oakes S; McKenzie DR, 2017, 'Grid therapy using high definition multileaf collimators: realizing benefits of the bystander effect', Acta Oncologica, 56, pp. 1048 - 1059, http://dx.doi.org/10.1080/0284186X.2017.1299939

Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-016-0781-6

Piggin CL; Roden DL; Gallego-Ortega D; Lee HJ; Oakes SR; Ormandy CJ, 2016, 'ELF5 isoform expression is tissue-specific and significantly altered in cancer', Breast Cancer Research, 18, http://dx.doi.org/10.1186/s13058-015-0666-0

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Oakes SR; Gallego-Ortega D; Ormandy CJ, 2014, 'The mammary cellular hierarchy and breast cancer', Cellular and Molecular Life Sciences, 71, pp. 4301 - 4324, http://dx.doi.org/10.1007/s00018-014-1674-4

Hilton HN; Doan TB; Dinny Graham J; Oakes SR; Silvestri A; Santucci N; Kantimm S; Huschtscha LI; Ormandy CJ; Funder JW; Simpson ER; Kuczek ES; Leedman PJ; Tilley WD; Fuller PJ; Muscat GEO; Clarke CL, 2014, 'Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease', Oncotarget, 5, pp. 8651 - 8664, http://dx.doi.org/10.18632/oncotarget.2354

Gallego-Ortega D; Oakes SR; Lee HJ; Piggin CL; Ormandy CJ, 2013, 'ELF5, normal mammary development and the heterogeneous phenotypes of breast cancer', BREAST CANCER MANAGEMENT, 2, pp. 489 - 498, http://dx.doi.org/10.2217/BMT.13.50

O'Toole S; Beith JM; Millar EKA; West R; McLean A; Cazet A; Swarbrick A; Oakes , 2013, 'Therapeutic targets in triple negative breast cancer', Journal of Clinical Pathology, 66, pp. 530 - 542, http://dx.doi.org/10.1136/jclinpath-2012-201361

Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE; Lindeman GJ, 2012, 'Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737', Proceedings of the National Academy of Sciences of the United States of America, 109, pp. 2766 - 2771, http://dx.doi.org/10.1073/pnas.1104778108

Kalyuga M; Gallego-Ortega D; Lee H; Roden DL; Cowley MJ; Caldon CE; Stone A; Allerdice SL; Valdes-Mora F; Rosalind launchbury R; Statham A; Armstrong NJ; Alles MC; Adelaide young A; Egger A; Au W; Piggin CL; Evans C; Ledger A; Brummer T; Oakes SR; Kaplan W; Gee JMW; Robert i nicholson RI; Sutherland RL; Swarbrick A; Naylor MJ; Clark SJ; Carroll JS; Ormandy CJ, 2012, 'ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer', PLoS Biology, 10, pp. e1001461, http://dx.doi.org/10.1371/journal.pbio.1001461

Oakes SR; Vaillant F; Lim E; Lee L; Breslin K; Feleppa F; Deb S; Ritchie ME; Takano E; Ward T; Fox SB; Generali D; Smyth GK; Strasser A; Huang DCS; Visvader JE; Lindeman GJ, 2012, 'Targeting BCL-2–expressing basal-like breast cancer with BH3-mimetics', Hereditary cancer in clinical practice, 10, pp. A25 - A25, http://dx.doi.org/10.1186/1897-4287-10-s2-a25

Zardawi SJ; Zardawi I; Mcneil CM; Millar E; Mcleod D; Morey AL; Crea P; Murphy NC; Pinese M; Lopez-Knowles E; Oakes SR; Ormandy CJ; Qiu MR; Hamilton A; Spillane AJ; Lee CS; Sutherland RL; Musgrove EA; O'Toole S, 2010, 'High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype', Histopathology, 56, pp. 286 - 296, http://dx.doi.org/10.1111/j.1365-2559.2009.03475.x

Bouras T; Pal B; Vaillant F; Harburg G; Asselin-Labat ML; Oakes SR; Lindeman GJ; Visvader JE, 2008, 'Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment', Cell Stem Cell, 3, pp. 429 - 441, http://dx.doi.org/10.1016/j.stem.2008.08.001

Hilton HN; Stanford PM; Harris J; Oakes SR; Kaplan W; Daly RJ; Ormandy CJ, 2008, 'KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling', Biochimica et Biophysica ACTA - Molecular Cell Research, 1783, pp. 383 - 393, http://dx.doi.org/10.1016/j.bbamcr.2007.12.007

Oakes SR; Rogers R; Naylor MJ; Ormandy CJ, 2008, 'Prolactin regulation of mammary gland development', Journal of Mammary Gland Biology and Neoplasia, 13, pp. 13 - 28, http://dx.doi.org/10.1007/s10911-008-9069-5

Oakes SR; Naylor MJ; Asselin-Labat M; Blazek K; Gardiner-Garden M; Hilton HN; Kazlauskas M; Pritchard M; Chodosh L; Pfeffer P; Lindeman GJ; Visvader J; Ormandy CJ, 2008, 'The Ets transcription factor Elf5 specifies mammary alveolar cell fate', Genes and Development, 22, pp. 581 - 586, http://dx.doi.org/10.1101/gad.1614608

Oakes SR; Robertson FG; Kench JG; Gardiner-Garden M; Wand MP; Green JE; Ormandy CJ, 2007, 'Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions', Oncogene, 26, pp. 543 - 553

Oakes SR; Hilton HN; Ormandy CJ, 2006, 'Key stages in mammary gland development - The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium', Breast Cancer Research, 8

Harris J; Stanford PM; Sutherland K; Oakes SR; Naylor MJ; Robertson F; Blazek K; Kazlauskas M; Hilton HN; Wittlin S; Alexander WS; Lindeman GJ; Visvader J; Ormandy CJ, 2006, 'Socs2 and Elf5 mediate prolactin-induced mammary gland development', Molecular Endocrinology, 20, pp. 1177 - 1187

Naylor MJ; Oakes SR; Gardiner-Garden M; Harris J; Blazek K; Ho TW; Li F; Wynick D; Walker AM; Ormandy CJ, 2005, 'Transcriptional changes underlying the secretory activation phase of mammary gland development', Molecular Endocrinology, 19, pp. 1868 - 1883

Harris J; Stanford PM; Oakes SR; Ormandy CJ, 2004, 'Prolactin and the prolactin receptor: new targets of an old hormone', Annals of Medicine, 36, pp. 414 - 425, http://www.sciencedirect.com/science/article/B6WVB-4DPTTDJ-115/2/64c9f2829ad0aa962efbb9ba7f7f6f0c

Robertson F; Harris J; Naylor MJ; Oakes S; Kindblom J; Dillner K; Wennbo H; Tornell J; Kelly PA; Green J; Ormandy CJ, 2003, 'Prostate development and carcinogenesis in prolactin receptor knockout mice', Endocrinology, 144, pp. 3196 - 3205

Davison EA; Lee CM; Naylor MJ; Oakes SR; Sutherland RL; Henninghausen L; Ormandy CJ; Musgrove EA, 2003, 'The Cyclin-Dependent Kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy.', Molecular Endocrinology, 17, pp. 2436 - 2447

Sainsbury A; Schwarzer C; Couzens M; Jenkins A; Oakes SR; Ormandy CJ; Herzog H, 2002, 'Y4 receptor knockout rescues fertility in ob/ob mice', Genes and Development, 16, pp. 1077 - 1088, http://dx.doi.org/10.1101/gad.979102

Gorrie CA; Oakes SR; Duflou J; Blumbergs P; Waite PM, 2002, 'Axonal Injury in Children after Motor Vehicle Crashes: Extent, Distribution and Size of Axonal Swellings Using B-App Immunohistochemistry', Neurorehabilitation and Neural Repair, 19, pp. 1171 - 1182

Back to profile page