By Dr Tim Murphy

Journal articles

Naser N; Lonj CK; Rikard-Bell M; Sandow SL; Murphy TV, 2024, 'Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries', Microcirculation, 31, http://dx.doi.org/10.1111/micc.12837

Luque NM; Lowe SM; Leader LL; Horrowitz SD; Murphy TV; Sandow SL, 2022, 'Treatment of preeclamptic vessels with pravastatin enhances vessel function and alters caveolae form and distribution through removal of cellular cholesterol', FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36, http://dx.doi.org/10.1096/fasebj.2022.36.S1.R4373

Saunders SL; Hutchinson DS; Britton FC; Liu L; Markus I; Sandow SL; Murphy TV, 2021, 'Effect of β1/β2‐adrenoceptor blockade on β3‐adrenoceptor activity in the rat cremaster muscle artery', British Journal of Pharmacology, 178, pp. 1789 - 1804, http://dx.doi.org/10.1111/bph.15398

Drimousis S; Markus I; Murphy TV; Shevy Perera D; Phan-Thien KC; Zhang L; Liu L, 2020, 'Gender-related differences of tachykinin NK2 receptor expression and activity in human colonic smooth muscle', Journal of Pharmacology and Experimental Therapeutics, 375, pp. 28 - 39, http://dx.doi.org/10.1124/JPET.120.265967

Murphy TV; Sandow SL, 2019, 'Agonist-evoked endothelial Ca ²⁺ signalling microdomains', Current Opinion in Pharmacology, 45, pp. 8 - 15, http://dx.doi.org/10.1016/j.coph.2019.03.005

Grayson TH; Murphy TV; Sandow SL, 2017, 'Transient receptor potential canonical type 3 channels: Interactions, role and relevance - a vascular focus.', Pharmacology and Therapeutics, 174, pp. 79 - 96, http://dx.doi.org/10.1016/j.pharmthera.2017.02.022

Murphy TV; Kanagarajah A; Toemoe S; Bertrand PP; Grayson TH; Britton FC; Leader L; Senadheera S; Sandow SL, 2016, 'TRPV3 expression and vasodilator function in isolated uterine radial arteries from non-pregnant and pregnant rats', Vascular Pharmacology, 83, pp. 66 - 77, http://dx.doi.org/10.1016/j.vph.2016.04.004

Quek KJ; Boyd R; Ameer OZ; Zangerl B; Butlin M; Murphy TV; Avolio AP; Phillips JK, 2016, 'Progressive vascular remodelling, endothelial dysfunction and stiffness in mesenteric resistance arteries in a rodent model of chronic kidney disease', Vascular Pharmacology, 81, pp. 42 - 52, http://dx.doi.org/10.1016/j.vph.2015.12.004

Kerr PM; Wei R; Tam R; Sandow SL; Murphy TV; Ondrusova K; Lunn SE; Tran CHT; Welsh DG; Plane F, 2015, 'Activation of endothelial IKCa channels underlies NO-dependent myoendothelial feedback', Vascular Pharmacology, 74, pp. 130 - 138, http://dx.doi.org/10.1016/j.vph.2015.09.001

Holobotovskyy V; Chong YS; Burchell J; He B; Phillips M; Leader L; Murphy TV; Sandow SL; McKitrick DJ; Charles AK; Tare M; Arnolda LF; Ganss R, 2015, 'Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia', Science Translational Medicine, 7, http://dx.doi.org/10.1126/scitranslmed.aaa5038

Ellinsworth DC; Earley S; Murphy TV; Sandow SL, 2014, 'Endothelial control of vasodilation: Integration of myoendothelial microdomain signalling and modulation by epoxyeicosatrienoic acids', Pflugers Archiv European Journal of Physiology, 466, pp. 389 - 405, http://dx.doi.org/10.1007/s00424-013-1303-3

Wang K; Bertrand RL; Senadheera S; Polglaze KE; Murphy TV; Sandow SL; Liu L; Bornstein JC; Bertrand PP, 2014, 'Motility changes induced by intraluminal FeSO4 in guinea pig jejunum', Neurogastroenterology and Motility, 26, pp. 385 - 396, http://dx.doi.org/10.1111/nmo.12276

Howitt L; Morris MJ; Sandow SL; Murphy TV, 2014, 'Effect of diet-induced obesity on BKCa function in contraction and dilation of rat isolated middle cerebral artery', Vascular Pharmacology, 61, pp. 10 - 15, http://dx.doi.org/10.1016/j.vph.2014.02.002

Senadheera S; Bertrand PP; Grayson TH; Leader L; Tare M; Murphy TV; Sandow SL, 2013, 'Enhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 305, pp. R917 - R926, http://dx.doi.org/10.1152/ajpregu.00225.2013

Naser M; Januszeski AS; Brown BE; Jenkins AJ; Hill MA; Murphy TV, 2013, 'Advanced glycation end products acutely impair Ca2+ signaling in bovine aortic endothelial cells', Frontiers in Physiology, 4, pp. Article No. 38, http://dx.doi.org/10.3389/fphys.2013.00038

Grayson TH; Chadha P; Bertrand PP; Chen H; Morris MJ; Senadheera S; Murphy TV; Sandow SL, 2013, 'Increased caveolae density and caveolin-1 expression accompany impaired NO-mediated vasorelaxation in diet-induced obesity', Histochemistry and Cell Biology, 139, pp. 309 - 321, http://dx.doi.org/10.1007/s00418-012-1032-2

Senadheera S; Bertrand PP; Grayson TH; Leader L; Murphy TV; Sandow SL, 2013, 'Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions', Journal of Anatomy, 223, pp. 677 - 686, http://dx.doi.org/10.1111/joa.12127

Sandow SL; Senadheera S; Grayson TH; Welsh DG; Murphy TV, 2012, 'Calcium and endothelium-mediated vasodilator signaling', Advances in Experimental Medicine and Biology, 740, pp. 811 - 831, http://dx.doi.org/10.1007/978-94-007-2888-2_36

Howitt L; Grayson TH; Morris MJ; Sandow SL; Murphy TV, 2012, 'Dietary obesity increases NO and inhibits BKCa-mediated, endothelium-dependent dilation in rat cremaster muscle artery: association with caveolins and caveolae', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H2464 - H2476, http://dx.doi.org/10.1152/ajpheart.00965.2011

Sandow S; Senadheera S; Bertrand PP; Murphy TV; Tare M, 2012, 'Myoendothelial contacts, gap junctions and microdomains: anatomical links to function?', Microcirculation, 19, pp. 403 - 415, http://dx.doi.org/10.1111/j.1549-8719.2011.00146.x

Bertrand R; Senadheera SN; Tanoto A; Tan K; Howitt L; Chen H; Murphy TV; Sandow S; Liu L; Bertrand PP, 2012, 'Serotonin availability in rat colon is reduced during a Western diet model of obesity', American Journal of Physiology - Gastrointestinal and Liver Physiology, 303, pp. G424 - G434, http://dx.doi.org/10.1152/ajpgi.00048.2012

Senadheera S; Kim YS; Grayson TH; Toemoe S; Kochukov MY; Abramowitz J; Housley GD; Bertrand RL; Chadha PS; Bertrand PP; Murphy TV; Tare M; Birnbaumer L; Marrelli SP; Sandow SL, 2012, 'Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity', Cardiovascular Research, 95, pp. 439 - 447, http://dx.doi.org/10.1093/cvr/cvs208

Bertrand R; Senadheera SN; Markus I; Liu L; Howitt L; Chen H; Murphy TV; Sandow S; Bertrand PP, 2011, 'A western diet increases serotonin availability in rat small intestine', Endocrinology, 152, pp. 36 - 47, http://dx.doi.org/10.1210/en.2010-0377

Howitt L; Sandow SL; Grayson TH; Ellis ZE; Morris MJ; Murphy TV, 2011, 'Differential effects of diet-induced obesity on BKCa β1-subunit expression and function in rat skeletal muscle arterioles and small cerebral arteries', American Journal of Physiology - Heart and Circulatory Physiology, 301, pp. H29 - H40, http://dx.doi.org/10.1152/ajpheart.00134.2011

Chadha PS; Liu L; Rikard-Bell MJ; Senadheera S; Howitt L; Bertrand RL; Grayson TH; Murphy TV; Sandow SL, 2011, 'Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide', Journal of Pharmacology and Experimental Therapeutics, 336, pp. 701 - 708, http://dx.doi.org/10.1124/jpet.110.165795

Murphy TV; Jenkins AJ; Hill MA; Naser N, 2010, 'Effect of advanced glycation end products on dilation of rat skeletal muscle arterioles', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675507367&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Chadha PS; Haddock RE; Howitt L; Morris MJ; Murphy TV; Grayson TH; Sandow SL, 2010, 'Obesity up-regulates intermediate conductance calcium-activated potassium channels and myoendothelial gap junctions to maintain endothelial vasodilator function', Journal of Pharmacology and Experimental Therapeutics, 335, pp. 284 - 293, http://dx.doi.org/10.1124/jpet.110.167593

Sandow S; Murphy TV, 2010, 'Under Pressure - Kv channels and myogenic control of cerebral blood flow', The Journal of Physiology, 588, pp. 3635 - 3636

Potocnik S; McSherry I; Ding H; Murphy TV; Kotecha N; Dora K; Yuill KH; Triggle C; Hill M, 2009, 'Endothelium-dependent Vasodilation in Myogenically Active Mouse Skeletal Muscle Arterioles: Role of EDH and K+ Channels', Microcirculation, 16, pp. 377 - 390

Yang Y; Murphy TV; Ella SR; Grayson TH; Haddock R; Hwang YT; Braun AP; Peichun G; Korthuis RJ; Davis MJ; Hill MA, 2009, 'Heterogeneity in function of small artery smooth muscle BKCa: involvement of the β1-subunit', The Journal of Physiology, 587, pp. 3025 - 3044, http://dx.doi.org/10.1113/jphysiol.2009.169920

Murphy TV; Kotecha N, 2007, 'Endothelium-independent constriction of isolated, pressurized arterioles by N-omega nitro-L-arginine methyl ester (L- NAME)', British Journal of Pharmacology, 151, pp. 602 - 609

Murphy TV, 2007, 'I don`t need this pressure on; src-farnily kinases, ERK 1/2 kinase and mechanotransduction in arteries', Journal of Hypertension, 25, pp. 1791 - 1793

Potocnik S; Jenkins NA; Murphy TV; Hill MA, 2007, 'Membrane cholesterol depletion with beta-cyclodextrin impairs pressure-induced contraction and calcium signalling in isolated skeletal muscle arterioles', Journal of Vascular Research, 44, pp. 292 - 302

Hill MA; Murphy TV; Gui P; Hwang Y; Howitt L; Davis M; Sun ZQ; Howitt L, 2007, 'Properties of the large conductance K+ channel (BKCa) in skeletal muscle arterioles', Federation of American Societies for Experimantal Biology Journal, 21, pp. A846 - A846

Hill MA; Davis M; Meininger G; Potocnik S; Murphy TV, 2006, 'Arteriolar myogenic signalling mechanisms: Implications for local vascular function', Clinical Hemorheology and Microcirculation, 34, pp. 67 - 79

de Dios ST; Murphy TV; Sandow SL; Meininger GA; Hill MA, 2006, 'Atomic force microscopy in the study of the endothelial cell cytoskeleton', Vascular Pharmacology, 45, pp. e25 - e25, http://dx.doi.org/10.1016/j.vph.2006.08.111

Murphy TV; Howitt L; Hill MA; Howitt L, 2006, 'Pharmacological characterization of potassium channels regulating arteriolar myogenic tone in vitro and in vivo', ACTA Pharmacologica Sinica, 27, pp. 183 - 183

Spurrell BE; Murphy TV; Hill MA, 2003, 'Intraluminal pressure stimulates MAPK phosphorylation in arterioles: Temporal dissociation from myogenic contractile response', American Journal of Physiology - Heart and Circulatory Physiology, 285, http://dx.doi.org/10.1152/ajpheart.00468.2003

Richards K; Davis MJ; Potocnik SJ; Murphy TV; Bishara NB; Rajanayagam MAS; Darby IA; Hill MA, 2003, 'Approaches for introducing peptides into intact and functional arteriolar smooth muscle: Manipulation of protein kinase-based signalling', Clinical and Experimental Pharmacology and Physiology, 30, pp. 653 - 658, http://dx.doi.org/10.1046/j.1440-1681.2003.03892.x

Bishara NB; Dunlop ME; Murphy TV; Darby IA; Sharmini Rajanayagam MA; Hill MA, 2002, 'Matrix protein glycation impairs agonist-induced intracellular Ca²⁺ signaling in endothelial cells', Journal of Cellular Physiology, 193, pp. 80 - 92, http://dx.doi.org/10.1002/jcp.10153

Murphy TV; Spurrell BE; Hill MA, 2002, 'Cellular signalling in arteriolar myogenic constriction: Involvement of tyrosine phosphorylation pathways', Clinical and Experimental Pharmacology and Physiology, 29, pp. 612 - 619, http://dx.doi.org/10.1046/j.1440-1681.2002.03698.x

Murphy TV; Spurrell BE; Hill MA, 2002, 'Mechanisms underlying pervanadate-induced contraction of rat cremaster muscle arterioles', European Journal of Pharmacology, 442, pp. 107 - 114, http://dx.doi.org/10.1016/S0014-2999(02)01498-X

Bishara NB; Murphy TV; Hill MA, 2002, 'Capacitative Ca²⁺ entry in vascular endothelial cells is mediated via pathways sensitive to 2 aminoethoxydiphenyl borate and xestospongin C', British Journal of Pharmacology, 135, pp. 119 - 128, http://dx.doi.org/10.1038/sj.bjp.0704465

Murphy TV; Spurrell BE; Hill MA, 2001, 'Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension.', American Journal of Physiology - Heart and Circulatory Physiology, 281, pp. H1047 - H1056, http://ajpheart.physiology.org/content/281/3/H1047.long

Murphy TV; Spurrell BE; Hill MA, 2001, 'Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension', American Journal of Physiology - Heart and Circulatory Physiology, 281, http://dx.doi.org/10.1152/ajpheart.2001.281.3.h1047

Spurrell BE; Murphy TV; Hill MA, 2000, 'Tyrosine phosphorylation modulates arteriolar tone but is not fundamental to myogenic response.', American Journal of Physiology - Heart and Circulatory Physiology, 278, pp. H373 - H382, http://ajpheart.physiology.org/content/278/2/H373.long

Potocnik SJ; Murphy TV; Kotecha N; Hill MA, 2000, 'Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca²⁺', British Journal of Pharmacology, 131, pp. 1065 - 1072, http://dx.doi.org/10.1038/sj.bjp.0703650

Spurrell BE; Murphy TV; Hill MA, 2000, 'Tyrosine phosphorylation modulates arteriolar tone but is not fundamental to myogenic response', American Journal of Physiology - Heart and Circulatory Physiology, 278, http://dx.doi.org/10.1152/ajpheart.2000.278.2.h373

Murphy TV; Prountzos C; Kotsonis P; Iannazzo L; Majewski H, 1999, 'Structural determinants of phorbol ester binding in synaptosomes: Pharmacokinetics and pharmacodynamics', European Journal of Pharmacology, 381, pp. 77 - 84, http://dx.doi.org/10.1016/S0014-2999(99)00540-3

Binko J; Murphy TV; Majewski H, 1998, '17β-Oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta', Clinical and Experimental Pharmacology and Physiology, 25, pp. 120 - 127, http://dx.doi.org/10.1111/j.1440-1681.1998.tb02188.x

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