By Dr Tom Peat

Journal articles

Dransfield DT; Cohen EH; Chang Q; Sparrow LG; Bentley JD; Dolezal O; Xiao X; Peat TS; Newman J; Pilling PA; Phan T; Priebe I; Brierley GV; Kastrapeli N; Kopacz K; Martik D; Wassaf D; Rank D; Conley G; Huang Y; Adams TE; Cosgrove L, 2010, 'A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo', Molecular Cancer Therapeutics, 9, pp. 1809 - 1819, http://dx.doi.org/10.1158/1535-7163.MCT-09-1134

Chhabra S; Newman J; Peat TS; Fernley RT; Caine J; Simpson JS; Swarbrick JD, 2010, 'Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 575 - 578, http://dx.doi.org/10.1107/S1744309110010857

Newman J; Fazio VJ; Caradoc-Davies TT; Branson K; Peat TS, 2009, 'Practical aspects of the SAMPL challenge: Providing an extensive experimental data set for the modeling community', Journal of Biomolecular Screening, 14, pp. 1245 - 1250, http://dx.doi.org/10.1177/1087057109348220

Newman J; Cohen EH; Cosgrove L; Kopacz K; Dransfield DT; Adams TE; Peat TS, 2009, 'Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 945 - 948, http://dx.doi.org/10.1107/S1744309109024932

Wu N; Zhu Y; Brown S; Oakeshott J; Peat TS; Surjadi R; Easton C; Leech PW; Sexton BA, 2009, 'A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract', Lab on a Chip, 9, pp. 3391 - 3398, http://dx.doi.org/10.1039/b911581a

Newman J; Pham TM; Peat TS, 2008, 'Phoenito experiments: Combining the strengths of commercial crystallization automation', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, pp. 991 - 996, http://dx.doi.org/10.1107/S1744309108029667

Peat TS; Christopher JA; Newman J, 2005, 'Tapping the Protein Data Bank for crystallization information', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 1662 - 1669, http://dx.doi.org/10.1107/S0907444905033202

Badger J; Sauder JM; Adams JM; Antonysamy S; Bain K; Bergseid MG; Buchanan SG; Buchanan MD; Batiyenko Y; Christopher JA; Emtage S; Eroshkina A; Feil I; Furlong EB; Gajiwala KS; Gao X; He D; Hendle J; Huber A; Hoda K; Kearins P; Kissinger C; Laubert B; Lewis HA; Lin J; Loomis K; Lorimer D; Louie G; Maletic M; Marsh CD; Miller I; Molinari J; Muller-Dieckmann HJ; Newman JM; Noland BW; Pagarigan B; Park F; Peat TS; Post KW; Radojicic S; Ramos A; Romero R; Rutter ME; Sanderson WE; Schwinn KD; Tresser J; Winhoven J; Wright TA; Wu L; Xu J; Harris TJR, 2005, 'Structural analysis of a set of proteins resulting from a bacterial genomics project', Proteins: Structure, Function and Genetics, 60, pp. 787 - 796, http://dx.doi.org/10.1002/prot.20541

Park F; Gajiwala K; Eroshkina G; Furlong E; He D; Batiyenko Y; Romero R; Christopher J; Badger J; Hendle J; Lin J; Peat T; Buchanan S, 2004, 'Crystal Structure of YIGZ, a Conserved Hypothetical Protein from Escherichia coli K12 with a Novel Fold', Proteins: Structure, Function and Genetics, 55, pp. 775 - 777, http://dx.doi.org/10.1002/prot.20087

Park F; Gajiwala K; Noland B; Wu L; He D; Molinari J; Loomis K; Pagarigan B; Kearins P; Christopher J; Peat T; Badger J; Hendle J; Lin J; Buchanan S, 2004, 'The 1.59 Å Resolution Crystal Structure of TM0096, a Flavin Mononucleotide Binding Protein from Thermotoga maritima', Proteins: Structure, Function and Genetics, 55, pp. 772 - 774, http://dx.doi.org/10.1002/prot.20086

Peat T; De la Fortelle E; Culpepper J; Newman J, 2002, 'From information management to protein annotation: Preparing protein structures for drug discovery', Acta Crystallographica Section D: Biological Crystallography, 58, pp. 1968 - 1970, http://dx.doi.org/10.1107/S0907444902016852

Cort JR; Santhana Mariappan SV; Kim CY; Park MS; Peat TS; Waldo GS; Terwilliger TC; Kennedy MA, 2001, 'Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase', European Journal of Biochemistry, 268, pp. 5842 - 5850, http://dx.doi.org/10.1046/j.0014-2956.2001.02529.x

Lewis HA; Furlong EB; Laubert B; Eroshkina GA; Batiyenko Y; Adams JM; Bergseid MG; Marsh CD; Peat TS; Sanderson WE; Sauder JM; Buchanan SG, 2001, 'A structural genomics approach to the study of quorum sensing: Crystal structures of three LuxS orthologs', Structure, 9, pp. 527 - 537, http://dx.doi.org/10.1016/S0969-2126(01)00613-X

Peat TS; Newman JM, 2000, 'Structural genomics in the post-genomics era: The shapes of things to come', Current Opinion in Drug Discovery and Development, 3, pp. 399 - 407

Newman J; Peat TS; Richard R; Kan L; Swanson PE; Affholter JA; Holmes IH; Schindler JF; Unkefer CJ; Terwilliger TC, 1999, 'Haloalkane dehalogenases: Structure of a Rhodococcus enzyme', Biochemistry, 38, pp. 16105 - 16114, http://dx.doi.org/10.1021/bi9913855

McDonald JP; Peat TS; Levine AS; Woodgate R, 1999, 'Intermolecular cleavage by UmuD-like enzymes: Identification of residues required for cleavage and substrate specificity', Journal of Molecular Biology, 285, pp. 2199 - 2209, http://dx.doi.org/10.1006/jmbi.1998.2433

Peat TS; Newman J; Waldo GS; Berendzen J; Terwilliger TC, 1998, 'Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution', Structure, 6, pp. 1207 - 1214, http://dx.doi.org/10.1016/S0969-2126(98)00120-8

Ruscetti T; Newman J; Peat TS; Francis J; Nolan R; Terwilliger TC; Peterson SR; Lehnert BE, 1998, 'A nondenaturing purification scheme for the DNA-binding domain of poly(ADP-ribose) polymerase, a structure-specific DNA-binding protein', Protein Expression and Purification, 14, pp. 79 - 86, http://dx.doi.org/10.1006/prep.1998.0919

Terwilliger TC; Waldo G; Peat TS; Newman JM; Chu K; Berendzen J, 1998, 'Class-directed structure determination: Foundation for a protein structure initiative', Protein Science, 7, pp. 1851 - 1856, http://dx.doi.org/10.1002/pro.5560070901

McLenigan M; Peat TS; Frank EG; McDonald JP; Gonzalez M; Levine AS; Hendrickson WA; Woodgate R, 1998, 'Novel Escherichia coli umuD' mutants: Structure-function insights into SOS mutagenesis', Journal of Bacteriology, 180, pp. 4658 - 4666, http://dx.doi.org/10.1128/jb.180.17.4658-4666.1998

Peat TS; Frank EG; McDonald JP; Levine AS; Woodgate R; Hendrickson WA, 1996, 'Structure of the UmuD′ protein and its regulation in response to DNA damage', Nature, 380, pp. 727 - 730, http://dx.doi.org/10.1038/380727a0

Peat TS; Frank EG; Woodgate R; Hendrickson WA, 1996, 'Production and crystallization of a selenomethionyl variant of UmuD', an Escherichia coli SOS response protein', Proteins: Structure, Function and Genetics, 25, pp. 506 - 509, http://dx.doi.org/10.1002/(SICI)1097-0134(199608)25:4<506::AID-PROT10>3.3.CO;2-Z

Peat TS; Frank EG; McDonald JP; Levine AS; Woodgate R; Hendrickson WA, 1996, 'The UmuD' protein filament and its potential role in damage induced mutagenesis', Structure, 4, pp. 1401 - 1412, http://dx.doi.org/10.1016/S0969-2126(96)00148-7

Urs UK; Sharkey DJ; Peat TS; Hendrickson WA; Krishna Murthy HM, 1995, 'Characterization of crystals of the thermostable DNA polymerase I from thermus aquaticus', Proteins: Structure, Function, and Bioinformatics, 23, pp. 111 - 114, http://dx.doi.org/10.1002/prot.340230112

BLITZ J; PEAT TS, 1981, 'THE APPLICATION OF MULTIFREQUENCY EDDY CURRENTS TO TESTING FERROMAGNETIC METALS', NDT INTERNATIONAL, 14, pp. 15 - 17, http://dx.doi.org/10.1016/0308-9126(81)90058-4

Conference Papers

Sharma S; Chung J; Uryu S; Rickard A; Nady N; Khan S; Wang Z; Zhang Y; Zhang H; Kung P-P; Greenwald E; Maegley K; Bingham P; Lam H; Bozikis YE; Falk H; Allan E; Avery VM; Butler MS; Camerino MA; Carrasco-Pozo C; Charman SA; Davis MJ; Dawson MA; Sarah-Jane D; de Silva M; Dennis ML; Dolezal O; Lagiakos R; Lindeman GJ; MacPherson L; Nuttall S; Peat TS; Ren B; Stupple AE; Surgenor E; Tan CW; Thomas T; Visvader JE; Voss AK; Vaillant F; White KL; Whittle J; Yang Y; Hediyeh-Zadeh S; Stupple PA; Street IP; Monahan BJ; Paul T, 2021, 'First-in-class KAT6A/KAT6B inhibitor CTx-648 (PF-9363) demonstrates potent anti-tumor activity in ER plus breast cancer with KAT6A dysregulation.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263503465&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Peat TS; Dennis M; Dolezal O; Newman J; Morrow B; Monahan B; Foitzik R; Khoo PS; Stupple P; Street I, 2018, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. A139 - A139, http://dx.doi.org/10.1107/S0108767318098604

Falk H; Foitzik RC; Allan E; deSilva M; Yang H; Bozikis YE; Nikac M; Walker SR; Camerino MA; Morrow BJ; Stupple AE; Lagiakos R; Pinson J-A; Lessene R; Kersten WJA; Ganame DG; Holmes IP; Lunniss GE; Chung M; Hermans SJ; Parker MW; Thistlethwaite A; White K; Charman SA; Monahan BJ; Pilling P; Grusovin J; Peat TS; Sonderegger S; Toulmin E; Jane SM; Curtis DJ; Stupple PA; Street IP, 2015, 'PRMT5 inhibitors as novel treatment for cancers', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, PA, Philadelphia, presented at 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), PA, Philadelphia, 18 April 2015 - 22 April 2015, http://dx.doi.org/10.1158/1538-7445.AM2015-5371

Lapierre F; Cameron NR; Oakeshott J; Peat T; Zhu Y, 2013, 'How to fabricate robust microfluidic systems for a dollar', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033508

Lapierre F; Best M; Stewart R; Oakeshott J; Peat T; Zhu Y, 2013, 'Integrated microdroplet-based system for enzyme synthesis and sampling', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033569

Peat TS; Deadman JJ; Rhodes DI; Newman J; Dolezal O; Vandegraaff N; Smith JA; Le G; Ryan JH; Francis CL; Savage GP, 2011, 'New HIV Integrase inhibitors discovered through fragment screening', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C291 - C291, http://dx.doi.org/10.1107/S0108767311092737

Peat TS; Christopher J; Schmidt K, 2005, 'AFITT-Working with Good Chemistry', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C165 - C165, http://dx.doi.org/10.1107/S0108767305092974

Lewis HA; Furlong EB; Laubert B; Eroshkina GA; Batiyenko Y; Adams JM; Bergseid MG; Winhoven J; Marsh CD; Peat TS; Sanderson WE; Sauder JM; Buchanan SG, 2002, 'THE QUORUM SENSING PROTEIN LuxS: FUNCTIONAL INSIGHTS FROM STRUCTURE', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. C194 - C194, http://dx.doi.org/10.1107/S0108767302092784

Peat TS; Newman J; Waldo G; Terwilliger TC, 1999, 'PROTEOMICS AND THE SHOTGUN APPROACH TO STRUCTURE.', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. 317 - 317, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000475706303043&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Kaczmarski JA; Hong N-S; Mukherjee B; Wey LT; Rourke L; Förster B; Peat TS; Price GD; Jackson CJ, 2019, Structural basis for the allosteric regulation of the SbtA bicarbonate transporter by the P_II-like protein, SbtB, fromCyanobiumsp. PCC7001, http://dx.doi.org/10.1101/762807

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