By Dr Tom Peat

Journal articles

Warden AC; Williams M; Peat TS; Seabrook SA; Newman J; Dojchinov G; Haritos VS, 2015, 'Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms10278

Basnet SKC; Diab S; Schmid R; Yu M; Yang Y; Gillam TA; Teo T; Li P; Peat T; Albrecht H; Wang S, 2015, 'Identification of a highly conserved allosteric binding site on Mnk1 and Mnk2 s', Molecular Pharmacology, 88, pp. 935 - 948, http://dx.doi.org/10.1124/mol.115.100131

Balotra S; Warden AC; Newman J; Briggs LJ; Scott C; Peat TS, 2015, 'X-Ray structure and mutagenesis studies of the n-isopropylammelide isopropylaminohydrolase, AtzC', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0137700

Suryadinata R; Seabrook SA; Adams TE; Nuttall SD; Peat TS, 2015, 'Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 1505 - 1513, http://dx.doi.org/10.1107/S1399004715009219

Peat TS; Newman J; Balotra S; Lucent D; Warden AC; Scott C, 2015, 'The structure of the hexameric atrazine chlorohydrolase AtzA', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 710 - 720, http://dx.doi.org/10.1107/S1399004715000619

Tanpure RP; Ren B; Peat TS; Bornaghi LF; Vullo D; Supuran CT; Poulsen SA, 2015, 'Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site', Journal of Medicinal Chemistry, 58, pp. 1494 - 1501, http://dx.doi.org/10.1021/jm501798g

Ryan JH; Jarvis KE; Mulder RJ; Francis CL; Savage GP; Dolezal O; Peat TS; Deadman JJ, 2015, 'Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain', Australian Journal of Chemistry, 68, pp. 1871 - 1879, http://dx.doi.org/10.1071/CH15587

Balotra S; Newman J; Cowieson NP; French NG; Campbell PM; Briggs LJ; Warden AC; Easton CJ; Peat TS; Scott C, 2015, 'X-Ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex', Applied and Environmental Microbiology, 81, pp. 470 - 480, http://dx.doi.org/10.1128/AEM.02783-14

Boersma YL; Newman J; Adams TE; Cowieson N; Krippner G; Bozaoglu K; Peat TS, 2014, 'The structure of vanin 1: A key enzyme linking metabolic disease and inflammation', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 3320 - 3329, http://dx.doi.org/10.1107/S1399004714022767

Dennis ML; Chhabra S; Wang ZC; Debono A; Dolezal O; Newman J; Pitcher NP; Rahmani R; Cleary B; Barlow N; Hattarki M; Graham B; Peat TS; Baell JB; Swarbrick JD, 2014, 'Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from staphylococcus aureus', Journal of Medicinal Chemistry, 57, pp. 9612 - 9626, http://dx.doi.org/10.1021/jm501417f

Fazio VJ; Peat TS; Newman J, 2014, 'A drunken search in crystallization space', Acta Crystallographica Section F: Structural Biology Communications, 70, pp. 1303 - 1311, http://dx.doi.org/10.1107/S2053230X1401841X

Moeker J; Peat TS; Bornaghi LF; Vullo D; Supuran CT; Poulsen SA, 2014, 'Cyclic secondary sulfonamides: Unusually good inhibitors of cancer-related carbonic anhydrase enzymes', Journal of Medicinal Chemistry, 57, pp. 3522 - 3531, http://dx.doi.org/10.1021/jm500255y

Kenny PW; Newman J; Peat TS, 2014, 'Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 565 - 571, http://dx.doi.org/10.1107/S1399004713031052

Jackson CJ; Coppin CW; Carr PD; Aleksandrov A; Wilding M; Sugrue E; Ubels J; Paks M; Newman J; Peat TS; Russell RJ; Field M; Weik M; Oakeshott JG; Scott C, 2014, '300-fold increase in production of the Zn²⁺-dependent dechlorinase trzN in soluble form via apoenzyme stabilization', Applied and Environmental Microbiology, 80, pp. 4003 - 4011, http://dx.doi.org/10.1128/AEM.00916-14

Balotra S; Newman J; French NG; Briggs LJ; Peat TS; Scott C, 2014, 'Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 310 - 315, http://dx.doi.org/10.1107/S2053230X13034705

Peat TS; Dolezal O; Newman J; Mobley D; Deadman JJ, 2014, 'Interrogating HIV integrase for compounds that bind - A SAMPL challenge', Journal of Computer-Aided Molecular Design, 28, pp. 347 - 362, http://dx.doi.org/10.1007/s10822-014-9721-7

Ren B; Peat TS; Streltsov VA; Pollard M; Fernley R; Grusovin J; Seabrook S; Pilling P; Phan T; Lu L; Lovrecz GO; Graham LD; Hill RJ, 2014, 'Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 1954 - 1964, http://dx.doi.org/10.1107/S1399004714009626

Newman J; Peat TS; Paul Savage G, 2014, 'What's in a name? Moving towards a limited vocabulary for macromolecular crystallisation', Australian Journal of Chemistry, 67, pp. 1813 - 1817, http://dx.doi.org/10.1071/CH14199

Francis CL; Kenny PW; Dolezal O; Saubern S; Kruger M; Savage GP; Peat TS; Ryan JH, 2013, 'Construction of the CSIRO fragment library', Australian Journal of Chemistry, 66, pp. 1473 - 1482, http://dx.doi.org/10.1071/CH13325

Dolezal O; Doughty L; Hattarki MK; Fazio VJ; Caradoc-Davies TT; Newman J; Peat TS, 2013, 'Fragment screening for the modelling community: SPR, ITC, and crystallography', Australian Journal of Chemistry, 66, pp. 1507 - 1517, http://dx.doi.org/10.1071/CH13302

Chhabra S; Dolezal O; Hattarki M; Peat TS; Simpson JS; Swarbrick JD, 2013, 'Fragment screening on Staphylococcus aureus HPPK - A folate pathway target', Australian Journal of Chemistry, 66, pp. 1537 - 1543, http://dx.doi.org/10.1071/CH13298

Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Paul Savage G; Francis CL; Deadman JJ, 2013, 'Correction: Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design (PLoS ONE)', PLoS ONE, 8, http://dx.doi.org/10.1371/annotation/eb238f0f-7582-4318-af95-64ac98d3b0be

Zhang L; Holmes IP; Hochgräfe F; Walker SR; Ali NA; Humphrey ES; Wu J; De Silva M; Kersten WJA; Connor T; Falk H; Allan L; Street IP; Bentley JD; Pilling PA; Monahan BJ; Peat TS; Daly RJ, 2013, 'Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling', Journal of Proteome Research, 12, pp. 3104 - 3116, http://dx.doi.org/10.1021/pr3008495

Newman J; Burton DR; Caria S; Desbois S; Gee CL; Fazio VJ; Kvansakul M; Marshall B; Mills G; Richter V; Seabrook SA; Wu M; Peat TS, 2013, 'Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 712 - 718, http://dx.doi.org/10.1107/S1744309113014152

Peat TS; Balotra S; Wilding M; French NG; Briggs LJ; Panjikar S; Cowieson N; Newman J; Scott C, 2013, 'Cyanuric acid hydrolase: Evolutionary innovation by structural concatenation', Molecular Microbiology, 88, pp. 1149 - 1163, http://dx.doi.org/10.1111/mmi.12249

Chhabra S; Barlow N; Dolezal O; Hattarki MK; Newman J; Peat TS; Graham B; Swarbrick JD, 2013, 'Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0059535

Newman J; Seabrook S; Surjadi R; Williams CC; Lucent D; Wilding M; Scott C; Peat TS, 2013, 'Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0058298

Ren B; Pham TM; Surjadi R; Robinson CP; Le TK; Scott Chandry P; Peat TS; McKinstry WJ, 2013, 'Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 275 - 279, http://dx.doi.org/10.1107/S174430911300184X

Wielens J; Headey SJ; Rhodes DI; Mulder RJ; Dolezal O; Deadman JJ; Newman J; Chalmers DK; Parker MW; Peat TS; Scanlon MJ, 2013, 'Parallel screening of low molecular weight fragment libraries: Do differences in methodology affect hit identification?', Journal of Biomolecular Screening, 18, pp. 147 - 159, http://dx.doi.org/10.1177/1087057112465979

Peat TS; Rhodes DI; Vandegraaff N; Le G; Smith JA; Clark LJ; Jones ED; Coates JAV; Thienthong N; Newman J; Dolezal O; Mulder R; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2012, 'Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0040147

Newman J; Bolton EE; Müller-Dieckmann J; Fazio VJ; Gallagher DT; Lovell D; Luft JR; Peat TS; Ratcliffe D; Sayle RA; Snell EH; Taylor K; Vallotton P; Velanker S; Von Delft F, 2012, 'On the need for an international effort to capture, share and use crystallization screening data', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 253 - 258, http://dx.doi.org/10.1107/S1744309112002618

Chhabra S; Dolezal O; Collins BM; Newman J; Simpson JS; Macreadie IG; Fernley R; Peat TS; Swarbrick JD, 2012, 'Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0029444

Peat TS; Böttcher C; Newman J; Lucent D; Cowieson N; Davies C, 2012, 'Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis', Plant Cell, 24, pp. 4525 - 4538, http://dx.doi.org/10.1105/tpc.112.102921

Newman J; Dolezal O; Fazio V; Caradoc-Davies T; Peat TS, 2012, 'The DINGO dataset: A comprehensive set of data for the SAMPL challenge', Journal of Computer-Aided Molecular Design, 26, pp. 497 - 503, http://dx.doi.org/10.1007/s10822-011-9521-2

Falk H; Connor T; Yang H; Loft KJ; Alcindor JL; Nikolakopoulos G; Surjadi RN; Bentley JD; Hattarki MK; Dolezal O; Murphy JM; Monahan BJ; Peat TS; Thomas T; Baell JB; Parisot JP; Street IP, 2011, 'An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets', Journal of Biomolecular Screening, 16, pp. 1196 - 1205, http://dx.doi.org/10.1177/1087057111421631

Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Newman J; Martyn J; Coates JAV; Ede NJ; Rea P; Deadman JJ, 2011, 'Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site', ChemBioChem, 12, pp. 2311 - 2315, http://dx.doi.org/10.1002/cbic.201100350

Kennedy DF; Drummond CJ; Peat TS; Newman J, 2011, 'Evaluating protic ionic liquids as protein crystallization additives', Crystal Growth and Design, 11, pp. 1777 - 1785, http://dx.doi.org/10.1021/cg1017104

Wu N; Oakeshott JG; Easton CJ; Peat TS; Surjadi R; Zhu Y, 2011, 'A double-emulsion microfluidic platform for in vitro green fluorescent protein expression', Journal of Micromechanics and Microengineering, 21, http://dx.doi.org/10.1088/0960-1317/21/5/054032

Wu N; Courtois F; Surjadi R; Oakeshott J; Peat TS; Easton CJ; Abell C; Zhu Y, 2011, 'Enzyme synthesis and activity assay in microfluidic droplets on a chip', Engineering in Life Sciences, 11, pp. 157 - 164, http://dx.doi.org/10.1002/elsc.201000043

Rhodes DI; Peat TS; Vandegraaff N; Jeevarajah D; Le G; Jones ED; Smith JA; Coates JAV; Winfield LJ; Thienthong N; Newman J; Lucent D; Ryan JH; Savage GP; Francis CL; Deadman JJ, 2011, 'Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design', Antiviral Chemistry and Chemotherapy, 21, pp. 155 - 168, http://dx.doi.org/10.3851/IMP1716

Newman J; Pearce L; Lesburg CA; Strickland C; Peat TS, 2011, 'Crystallization of an apo form of human arginase: Using all the tools in the toolbox simultaneously', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67, pp. 90 - 93, http://dx.doi.org/10.1107/S1744309110046208

Ernberg K; McGrath AP; Peat TS; Adams TE; Xiao X; Pham T; Newman J; McDonald IA; Collyer CA; Guss JM, 2010, 'A new crystal form of human vascular adhesion protein 1', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 1572 - 1578, http://dx.doi.org/10.1107/S1744309110041515

Taylor MC; Jackson CJ; Tattersall DB; French N; Peat TS; Newman J; Briggs LJ; Lapalikar GV; Campbell PM; Scott C; Russell RJ; Oakeshott JG, 2010, 'Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation', Molecular Microbiology, 78, pp. 561 - 575, http://dx.doi.org/10.1111/j.1365-2958.2010.07356.x

Oakley AJ; Barrett S; Peat TS; Newman J; Streltsov VA; Waddington L; Saito T; Tashiro M; McKimm-Breschkin JL, 2010, 'Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses', Journal of Medicinal Chemistry, 53, pp. 6421 - 6431, http://dx.doi.org/10.1021/jm100621s

Newman J; Fazio VJ; Lawson B; Peat TS, 2010, 'The C6 Web Tool: A resource for the rational selection of crystallization conditions', Crystal Growth and Design, 10, pp. 2785 - 2792, http://dx.doi.org/10.1021/cg1004209

Dransfield DT; Cohen EH; Chang Q; Sparrow LG; Bentley JD; Dolezal O; Xiao X; Peat TS; Newman J; Pilling PA; Phan T; Priebe I; Brierley GV; Kastrapeli N; Kopacz K; Martik D; Wassaf D; Rank D; Conley G; Huang Y; Adams TE; Cosgrove L, 2010, 'A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo', Molecular Cancer Therapeutics, 9, pp. 1809 - 1819, http://dx.doi.org/10.1158/1535-7163.MCT-09-1134

Chhabra S; Newman J; Peat TS; Fernley RT; Caine J; Simpson JS; Swarbrick JD, 2010, 'Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 575 - 578, http://dx.doi.org/10.1107/S1744309110010857

Newman J; Fazio VJ; Caradoc-Davies TT; Branson K; Peat TS, 2009, 'Practical aspects of the SAMPL challenge: Providing an extensive experimental data set for the modeling community', Journal of Biomolecular Screening, 14, pp. 1245 - 1250, http://dx.doi.org/10.1177/1087057109348220

Newman J; Cohen EH; Cosgrove L; Kopacz K; Dransfield DT; Adams TE; Peat TS, 2009, 'Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 945 - 948, http://dx.doi.org/10.1107/S1744309109024932

Wu N; Zhu Y; Brown S; Oakeshott J; Peat TS; Surjadi R; Easton C; Leech PW; Sexton BA, 2009, 'A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract', Lab on a Chip, 9, pp. 3391 - 3398, http://dx.doi.org/10.1039/b911581a

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