By Dr Xiaolong Chen

Journal articles

Lu S; Zhu W; Wang Y; Kong C; Wang W; Chen X; Li X, 2024, 'Sagittal imbalance syndrome, a new concept, helps determining a long fusion for patients with degenerative lumbar spinal stenosis and severe global sagittal imbalance', Journal of Orthopaedic Surgery and Research, 19, http://dx.doi.org/10.1186/s13018-024-04613-2

Wang Z; Chen X; Hu X; Kong C; Wang W; Lu S, 2024, 'In Reply: The Role of Pelvic Compensation in Sagittal Balance and Imbalance: The Impact of Pelvic Compensation on Spinal Alignment and Clinical Outcomes After Adult Spinal Deformity Surgery.', Neurosurgery, http://dx.doi.org/10.1227/neu.0000000000003147

Sima S; Chen X; Sheldrick K; Lu A; Diwan AD, 2024, 'Imaging predictors of progression of lumbar spondylolysis to spondylolisthesis: a systematic review', Spine Journal, 24, pp. 1431 - 1442, http://dx.doi.org/10.1016/j.spinee.2024.03.010

Hu X; Wang Z; Wang W; Cui P; Kong C; Chen X; Lu S, 2024, 'Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways', Journal of Advanced Research, 62, pp. 175 - 186, http://dx.doi.org/10.1016/j.jare.2023.09.001

Chen X; Lu S, 2024, 'Reply to a letter to the editor regarding, “Evidence of MRI image features and inflammatory biomarkers association with low back pain in patients with lumbar disc herniation”', Spine Journal, 24, pp. 1539 - 1540, http://dx.doi.org/10.1016/j.spinee.2024.04.014

Sial AW; Sima S; Chen X; Saulys C; Kuan J; Davies M; Diwan AD, 2024, 'Spinal column radiological factors associated with increased spinal cord intramedullary signal intensity − A study evaluating aging spinal cord's relation to spinal disc degeneration', Journal of Clinical Neuroscience, 126, pp. 86 - 94, http://dx.doi.org/10.1016/j.jocn.2024.05.033

Wang SK; Wang QJ; Wang P; Li XY; Cui P; Wang DF; Chen XL; Kong C; Lu SB, 2024, 'The impact of frailty on clinical outcomes of older patients undergoing enhanced recovery after lumbar fusion surgery: a prospective cohort study', International journal of surgery (London, England), 110, pp. 4785 - 4795, http://dx.doi.org/10.1097/JS9.0000000000001594

Chen X; Wang W; Cui P; Li Y; Lu S, 2024, 'Evidence of MRI image features and inflammatory biomarkers association with low back pain in patients with lumbar disc herniation', Spine Journal, 24, pp. 1192 - 1201, http://dx.doi.org/10.1016/j.spinee.2024.02.006

Wang D; Chen X; Han D; Wang W; Kong C; Lu S, 2024, 'Radiographic and surgery-related predictive factors for increased segmental lumbar lordosis following lumbar fusion surgery in patients with degenerative lumbar spondylolisthesis', European Spine Journal, 33, pp. 2813 - 2823, http://dx.doi.org/10.1007/s00586-024-08248-z

Wang Z; Chen X; Hu X; Zhang H; Zhu W; Wang D; Zhang S; Kong C; Wang W; Lu S, 2024, 'The Role of Pelvic Compensation in Sagittal Balance and Imbalance: The Impact of Pelvic Compensation on Spinal Alignment and Clinical Outcomes Following Adult Spinal Deformity Surgery.', Neurosurgery, http://dx.doi.org/10.1227/neu.0000000000003005

Li Y; Wang B; Sun W; Wang W; Wang Y; Kong C; Chen X; Lu S, 2024, 'Single-cell RNA sequencing unveils the activation of EGR1-ATF3 signaling in EGR1 + muscle stem cells during human paravertebral muscle degeneration', Materials and Design, 242, http://dx.doi.org/10.1016/j.matdes.2024.113027

Sun W; Wang S; Wang B; Li Y; Chen X; Kong C; Wang P; Lu S, 2024, 'Surgical treatment of Roussouly type 1 with realigning Roussouly spinal shape and improving SRS-Schwab modifier: effect on minimal clinically important difference', European Spine Journal, 33, pp. 2486 - 2494, http://dx.doi.org/10.1007/s00586-024-08245-2

Li Y; Wang W; Kong C; Chen X; Li C; Lu S, 2024, 'Identifying the miRNA-gene networks contributes to exploring paravertebral muscle degeneration's underlying pathogenesis and therapy strategy', Heliyon, 10, http://dx.doi.org/10.1016/j.heliyon.2024.e30517

Wang D; Wang W; Han D; Muthu S; Cabrera JP; Hamouda W; Ambrosio L; Cheung JPY; Le HV; Vadalà G; Buser Z; Wang JC; Cho S; Yoon ST; Lu S; Chen X; Diwan AD, 2024, 'Clinical effectiveness of reduction and fusion versus in situ fusion in the management of degenerative lumbar spondylolisthesis: a systematic review and meta-analysis', European Spine Journal, 33, pp. 1748 - 1761, http://dx.doi.org/10.1007/s00586-023-08041-4

Wang D; Chen X; Han D; Wang W; Kong C; Lu S, 2024, 'Radiographic predictors of reaching minimal clinically important difference following lumbar fusion surgery in patients with degenerative lumbar spondylolisthesis', European Spine Journal, 33, pp. 1786 - 1795, http://dx.doi.org/10.1007/s00586-023-08051-2

Sima S; Chen X; Sheldrick K; Kuan J; Diwan AD, 2024, 'Reconsidering high intensity zones: its role in intervertebral disk degeneration and low back pain', European Spine Journal, 33, pp. 1474 - 1483, http://dx.doi.org/10.1007/s00586-024-08185-x

Li Y; Wang B; Sun W; Kong C; Ding J; Hu F; Li J; Chen X; Lu S, 2024, 'Construction of circ_0071922-miR-15a-5p-mRNA network in intervertebral disc degeneration by RNA-sequencing', JOR Spine, 7, http://dx.doi.org/10.1002/jsp2.1275

Chen X; Cui P; Li Y; Wang Y; Lu S, 2024, 'Links among MRI features in paraspinal muscles, inflammatory processes, and related back pain in patients with lumbar disc herniation', JOR Spine, 7, http://dx.doi.org/10.1002/jsp2.1310

Wu F; Chen X; Yang S; Lv X; Han F; Xiang H, 2024, 'Editorial: Intervertebral disc degeneration: mechanisms and therapeutics', Frontiers in Cell and Developmental Biology, 12, http://dx.doi.org/10.3389/fcell.2024.1401933

Wang D; Wang W; Wang Y; Kong C; Wang S; Buser Z; Diwan AD; Chen X; Lu S, 2024, 'Identification and impact of failure of pelvic compensation in patients with adult spinal deformity', Spine Journal, http://dx.doi.org/10.1016/j.spinee.2024.06.011

Sima S; Chen X; Diwan AD, 2024, 'The association between inflammatory biomarkers and low back disorder: a systematic review and meta-analysis', Biomarkers, 29, pp. 171 - 184, http://dx.doi.org/10.1080/1354750X.2024.2339285

Narulla RS; Chen X; Diwan AD; Smith GCS, 2024, 'The shoulder microbiome: a systematic review and meta analysis', JSES Reviews, Reports, and Techniques, http://dx.doi.org/10.1016/j.xrrt.2024.06.010

Arora NK; Donath L; Owen PJ; Miller CT; Kaczorowski S; Saueressig T; Pedder H; Mundell NL; Tagliaferri SD; Diwan A; Chen X; Zhao X; Huessler E-M; Ehrenbrusthoff K; Ford JJ; Hahne AJ; Hammel L; Norda H; Belavy DL, 2024, 'DOSage of Exercise for chronic low back pain disorders (DOSE): protocol for a systematic review with dose-response network meta-analysis.', BMJ Open Sport Exerc Med, 10, pp. e002108, http://dx.doi.org/10.1136/bmjsem-2024-002108

Zhao X; Wang Q; Wang W; Chen X; Lu S, 2024, 'Study On Molecular Mechanism of Intervertebral Disc Degeneration by Single Cell hdWGCNA Combined with Transcriptome Sequencing', Non-coding RNA Research, http://dx.doi.org/10.1016/j.ncrna.2024.09.003

Chen X; Xue D; Zhao Y; Cui P; Wang P; Wang Y; Lu SB, 2023, 'Association between periodontitis and disc structural failure in older adults with lumbar degenerative disorders: A prospective cohort study', BMC Surgery, 23, http://dx.doi.org/10.1186/s12893-023-01950-7

Chen X; Xue D; Cui P; Zhao Y; Lu S, 2023, 'Association between periodontitis and disc structural failures in patients with cervical degenerative disorders', Journal of Orthopaedic Surgery and Research, 18, http://dx.doi.org/10.1186/s13018-023-04381-5

Chen X; Li Y; Wang W; Cui P; Wang Y; Lu S, 2023, 'Correlation between inflammatory cytokine expression in paraspinal tissues and severity of disc degeneration in individuals with lumbar disc herniation', BMC Musculoskeletal Disorders, 24, http://dx.doi.org/10.1186/s12891-023-06295-z

Li X; Chen X; Wang Y; Diwan AD; Lu S, 2023, 'Early outcomes of oblique lateral interbody fusion with posterior fixation versus posterior interbody fusion with fixation for treating adult degenerative scoliosis', Journal of Orthopaedic Surgery and Research, 18, http://dx.doi.org/10.1186/s13018-023-04363-7

Wang Z; Hu X; Cui P; Kong C; Chen X; Wang W; Lu S, 2023, 'Progress in understanding the role of cGAS-STING pathway associated with programmed cell death in intervertebral disc degeneration', Cell Death Discovery, 9, http://dx.doi.org/10.1038/s41420-023-01607-7

Wang DF; Chen XL; Han D; Kong C; Lu SB, 2023, 'The effect of sagittal alignment, coronal balance, and segmental stability on preoperative patient-reported outcomes in patients with degenerative lumbar spondylolisthesis', BMC Surgery, 23, http://dx.doi.org/10.1186/s12893-023-01947-2

Chen XL; Li XY; Wang Y; Lu SB, 2023, 'Relation of lumbar intervertebral disc height and severity of disc degeneration based on Pfirrmann scores', Heliyon, 9, http://dx.doi.org/10.1016/j.heliyon.2023.e20764

Li Y; Kong C; Wang W; Hu F; Chen X; Xu B; Lu S, 2023, 'Screening of miR-15a-5p as a potential biomarker for intervertebral disc degeneration through RNA-sequencing', International Immunopharmacology, 123, http://dx.doi.org/10.1016/j.intimp.2023.110717

Hu X; Wang Z; Zhang H; Cui P; Li Y; Chen X; Kong C; Wang W; Lu S, 2023, 'Single-cell sequencing: New insights for intervertebral disc degeneration', Biomedicine and Pharmacotherapy, 165, http://dx.doi.org/10.1016/j.biopha.2023.115224

Wang Z; Hu X; Wang W; Li Y; Cui P; Wang P; Kong C; Chen X; Lu S, 2023, 'Understanding necroptosis and its therapeutic target for intervertebral disc degeneration', International Immunopharmacology, 121, http://dx.doi.org/10.1016/j.intimp.2023.110400

Chen X; Kohan S; Bhargav D; Choi J; Perera S; Dean C; Chopra N; Sial A; Sandhu HS; Apos E; Appleyard R; Diwan AD, 2023, 'Phase 1 evaluation of an elastomeric nucleus pulposus device as an option to augment disc at microdiscectomy: Experimental results from biomechanical and biocompatibility testing and first in human', JOR Spine, 6, http://dx.doi.org/10.1002/jsp2.1250

Chen X; Lu S; Chopra N; Cui P; Zhang S; Narulla R; Diwan AD, 2023, 'The association between low virulence organisms in different locations and intervertebral disc structural failure: A meta-analysis and systematic review', JOR Spine, 6, http://dx.doi.org/10.1002/jsp2.1244

Wang Z; Hu X; Wang W; Cui P; Zhu W; Liu X; Kong C; Chen X; Lu S, 2023, 'Can C7 Slope Accurately Substitute for an Invisible T1 Slope According to Age and Cervical Morphology in Cervical Lateral Radiographs?', Global Spine Journal, http://dx.doi.org/10.1177/21925682231192842

Sun W; Wang B; Hu H; Kong C; Zhu W; Chen X; Pan F; Wang P; Zhang S; Lu S, 2023, 'Clinical application of a classification based on crucial curvature of coronal imbalance in degenerative lumbar scoliosis', National Medical Journal of China, 103, pp. 1119 - 1126, http://dx.doi.org/10.3760/cma.j.cn112137-20220911-01920

Lu S; Zhu W; Diwan AD; Wang JC; Zhao G; Buser Z; Wang D; Cui P; Wang Y; Kong C; Wang W; Chen X, 2023, 'Global Coronal Malalignment in Degenerative Lumbar Scoliosis and Priority-Matching Correction Technique to Prevent Postoperative Coronal Decompensation', Global Spine Journal, http://dx.doi.org/10.1177/21925682231178202

Li Y; Wang B; Sun W; Kong C; Li G; Chen X; Lu S, 2022, 'Screening the immune-related circRNAs and genes in mice of spinal cord injury by RNA sequencing', Frontiers in Immunology, 13, http://dx.doi.org/10.3389/fimmu.2022.1060290

Sun W; Li Y; Chen X; Wang B; Kong C; Wang P; Lu S, 2022, 'Roussouly type 2 could evolve into type 1 shape as sagittal spinal alignment deterioration progresses with age', Frontiers in Surgery, 9, http://dx.doi.org/10.3389/fsurg.2022.1049020

Belavy DL; Tagliaferri SD; Buntine P; Saueressig T; Ehrenbrusthoff K; Chen X; Diwan A; Miller CT; Owen PJ, 2022, 'Interventions for promoting evidence-based guideline-consistent surgery in low back pain: a systematic review and meta-analysis of randomised controlled trials', European Spine Journal, 31, pp. 2851 - 2865, http://dx.doi.org/10.1007/s00586-022-07378-6

Li Y; Kong C; Wang B; Sun W; Chen X; Zhu W; Ding J; Lu S, 2022, 'Identification of differentially expressed genes in mouse paraspinal muscle in response to microgravity', Frontiers in Endocrinology, 13, http://dx.doi.org/10.3389/fendo.2022.1020743

Chen X; Sial A; Stewart C; Vargas Castillo J; Diwan AD, 2022, 'Stand-alone anterior cervical decompression and fusion surgery: A cohort study evaluating a shaped cage without plates or screws', Frontiers in Surgery, 9, http://dx.doi.org/10.3389/fsurg.2022.934018

Chen X; Sima S; Sandhu HS; Kuan J; Diwan AD, 2022, 'Radiographic evaluation of lumbar intervertebral disc height index: An intra and inter-rater agreement and reliability study', Journal of Clinical Neuroscience, 103, pp. 153 - 162, http://dx.doi.org/10.1016/j.jocn.2022.07.018

Lu HB; Wang LS; Li MQ; Chen X, 2022, 'The association between changes in multifidus muscle morphology and back pain scores following discectomy surgery for lumbar disc herniation: a systematic review and meta-analysis', European Spine Journal, 31, pp. 1784 - 1794, http://dx.doi.org/10.1007/s00586-022-07181-3

Belavy DL; Diwan AD; Ford J; Miller CT; Hahne AJ; Mundell N; Tagliaferri S; Bowe S; Pedder H; Saueressig T; Zhao X; Chen X; Balasundaram AP; Arora NK; Owen PJ, 2021, 'Network meta-analysis for comparative effectiveness of treatments for chronic low back pain disorders: Systematic review protocol', BMJ Open, 11, http://dx.doi.org/10.1136/bmjopen-2021-057112

Chen X; Sandhu HS; Vargas Castillo J; Diwan AD, 2021, 'The association between pain scores and disc height change following discectomy surgery in lumbar disc herniation patients: a systematic review and meta-analysis', European Spine Journal, 30, pp. 3265 - 3277, http://dx.doi.org/10.1007/s00586-021-06891-4

Chen X; Hodges PW; James G; Diwan AD, 2021, 'Do markers of inflammation and/or muscle regeneration in lumbar multifidus muscle and fat differ between individuals with good or poor outcome following microdiscectomy for lumbar disc herniation?', Spine, 46, pp. 678 - 686, http://dx.doi.org/10.1097/BRS.0000000000003863

Koremans FW; Chen X; Das A; Diwan AD, 2021, 'Changes in back pain scores after bariatric surgery in obese patients: A systematic review and meta-analysis', Journal of Clinical Medicine, 10, pp. 1443, http://dx.doi.org/10.3390/jcm10071443

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