By Professor Adam Jaffe

Preprints

Sabino LR; Kaiko GE; Dorahy D; Goodsall TT; Jaffe A; Schultz A; Waters S; Cook D; Kok H; Tong K; Totterdell J; McGree J; Snelling T; Wark PAB, 2026, Organoid Guided N-of-1 (ORIGIN-1) Clinical Trial: A phase 4 study to investigate if people with cystic fibrosis with rare non-F508del CFTR mutations with an in-vitro response to Elexacaftor/ Tezacaftor/ Ivacaftor have a clinically meaningful response to Elexacaftor/ Tezacaftor/ Ivacaftor versus placebo., http://dx.doi.org/10.21203/rs.3.rs-7787221/v1

Coffey MJ; van Dorst J; Pushpakumara BLDU; Halim J; Hudson J; Plush L; Christi K; Foster C; Carzino R; Zajakovski N; Appleton L; Cheney J; Wood J; Monaghan SJ; Rawlinson W; Day AS; Oliver M; Ranganathan S; Selvadurai H; Wainwright C; Thomas T; Jaffe A; Ooi CY, 2025, Probiotics and the EARly Life effects on intestinal bacteria and inflammation in children with Cystic Fibrosis (The “PEARL-CF” Study), http://dx.doi.org/10.64898/2025.12.04.25341620

Fawcett L; Chew Z; Schneider-Futschik E; Allan K; Patel H; Jaffe A; Waters S, 2025, INTEGRATING GENOMIC AND FUNCTIONAL TESTING TO IMPROVE CFTR MODULATOR RESPONSE PREDICTION IN CHILDREN WITH CYSTIC FIBROSIS, http://dx.doi.org/10.1101/2025.07.09.25331152

Umashankar B; Capraro A; Vijayan A; Wong S; Nielsen B; Zhong L; Raftery M; Allan K; Ooi C; Sivam S; Visser S; Prentice B; Fawcett L; Kovacevic Z; Eliasson L; Faurholt-Jepsen D; Jaffe A; Shaw JAM; Vafaee F; Waters S, 2025, Serum Exosomal Multi-Omic Signatures Stratify Glucose Tolerance in Cystic Fibrosis and Reveal Partial Therapeutic Reprogramming by CFTR Modulators, http://dx.doi.org/10.1101/2025.07.07.25331056

Chan C; Coffey M; Murphy C; McKay I; Abdu J; Paida K; Tam R; Wrigley-Carr H; Prentice B; Owens L; Belessis Y; Chuang S; Jaffe A; van Dorst J; Ooi C, 2025, The Prevalence of pks⁺ E. coli in Cystic Fibrosis, http://dx.doi.org/10.20944/preprints202502.0874.v1

Homaira N; Chan M; Owens L; Thomsen A; Gray M; Chuang S; Prentice B; Belessis Y; Islam S; Foster J; Jaffe A, 2024, Parent/carers opinions about COVID-19 vaccination for children with chronic lung diseases, http://dx.doi.org/10.22541/au.170666146.66053164/v1

Dayaratne WL; Torres-Cadena R; Schmitt BP; Westrick EM; Jaffe A, 2023, Hybrid bronzes: mixed-valence organic-inorganic metal oxides as a tunable material platform, http://dx.doi.org/10.26434/chemrxiv-2023-v6h2h

Hartley NA; Pugh SM; Xu Z; Leong DCY; Jaffe A; Forse AC, 2023, Quinone-functionalised carbons as new materials for electrochemical carbon dioxide capture, http://dx.doi.org/10.26434/chemrxiv-2023-ls7mc-v2

Stiboy E; Chan M; Islam MS; L GS; Lui K; Jaffe A; Homaira N, 2022, Variation in clinical practice guidelines for use of palivizumab in preventing severe respiratory syncytial viral (RSV) disease in high-risk infants, http://dx.doi.org/10.22541/au.166419726.62754781/v1

McKnight L; Schultz A; Vidic N; Palmer E; Jaffe A, 2022, Learning to make a difference for chILD: Value creation through network collaboration and team science, http://dx.doi.org/10.22541/au.166740302.29601419/v1

Stiboy E; Chan M; Islam MS; L GS; Lui K; Jaffe A; Homaira N, 2022, Variation in clinical practice guidelines for use of palivizumab in preventing severe respiratory syncytial viral (RSV) disease in high-risk infants, http://dx.doi.org/10.22541/au.166419726.62754781/v2

Wong S; Awatade N; Astore M; Allan K; Carnell M; Slapetova I; Chen P-C; Capraro A; Fawcett L; Whan R; Griffith R; Ooi C; Kuyucak S; Jaffe A; Waters S, 2021, In silicoand functional characterisation of an ultra-rareCFTRmutation identifies novel lasso motif interactions regulating channel gating, http://dx.doi.org/10.1101/2021.12.12.472297

Wong S; Awatade N; Astore M; Allan K; Carnell M; Slapetova I; Chen P-C; Setiadi J; Pandzic E; Fawcett L; Widger J; Whan R; Griffith R; Ooi C; Kuyucak S; Jaffe A; Waters S, 2021, Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect, http://dx.doi.org/10.1101/2021.08.11.456003

Singh J; Jaffe A; Schultz A; Selvadurai H, 2020, Surfactant Protein Deficiency Syndrome in Childhood Interstitial Lung Disease, http://dx.doi.org/10.22541/au.160037735.51250770

Jaffe A; Ziebel M; Halat DM; Biggins N; Murphy R; Chakarawet K; Reimer JA; Long JR, 2020, Selective, High-Temperature O2 Adsorption in Chemically Reduced, Redox-Active Iron-Pyrazolate Metal–Organic Frameworks, http://dx.doi.org/10.26434/chemrxiv.9922541

Jaffe A; Ziebel M; Halat DM; Biggins N; Murphy R; Chakarawet K; Reimer JA; Long JR, 2020, Selective, High-Temperature O2 Adsorption in Chemically Reduced, Redox-Active Iron-Pyrazolate Metal–Organic Frameworks, http://dx.doi.org/10.26434/chemrxiv.9922541.v3

Hewson C; Capraro A; Wong S; Pandzic E; Fernando BSM; Awatade N; Zhong L; Hart-Smith G; Whan R; Thomas S; Jaffe A; Bridge W; Waters S, 2020, Novel antioxidant therapy with the immediate precursor to glutathione, γ-glutamylcysteine (GGC), ameliorates LPS-induced cellular stress in an in vitro cystic fibrosis model, http://dx.doi.org/10.1101/2020.05.27.119990

Jaffe A; Ziebel M; Halat D; Biggins N; Murphy R; Chakarawet K; Reimer J; Long J, 2020, Selective, High-Temperature O2 Adsorption in Chemically Reduced, Redox-Active Iron-Pyrazolate Metal–Organic Frameworks, http://dx.doi.org/10.26434/chemrxiv.9922541.v4

Awatade N; Wong S; Pandzic E; Slapetova I; Capraro A; Zhong L; Turgutoglu N; Fawcett L; Whan R; Jaffe A; Waters S, 2020, Significant functional differences despite morphological and molecular similarity in fully differentiated matched Conditionally Reprogrammed (CRC) and Feeder free dual SMAD inhibited expanded human nasal epithelial cells, http://dx.doi.org/10.1101/2020.05.29.120006

Jaffe A; Ziebel M; Halat DM; Biggins N; Murphy R; Chakarawet K; Reimer JA; Long JR, 2019, Selective, High-Temperature O2 Adsorption in Chemically Reduced, Redox-Active Iron-Pyrazolate Metal–Organic Frameworks, http://dx.doi.org/10.26434/chemrxiv.9922541.v2

Jaffe A; Ziebel M; Halat DM; Biggins N; Murphy R; Chakarawet K; Reimer JA; Long JR, 2019, Selective, High-Temperature O2 Adsorption in Chemically Reduced, Redox-Active Iron-Pyrazolate Metal–Organic Frameworks, http://dx.doi.org/10.26434/chemrxiv.9922541.v1

Allan KM; Zhang S; Wong SL; Capraro A; McCarron A; Skinner D; Kardia E; Zheng Y; Zhong L; Ng C-A; Bell JL; Farrow N; Umashankar B; Banks C; Herbert C; Kilian KA; Pandzic E; Vittorio O; Vandenberg JI; Lock JG; Jaffe A; Donnelley M; Parsons D; Woodworth BA; Cho D-Y; Waters SA, Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model, http://dx.doi.org/10.1101/2025.07.21.666023

Stick SM; Foti A; Ware RS; Tiddens HAWM; Clements BS; Armstrong DS; Selvadurai H; Tai A; Cooper PJ; Byrnes CA; Belessis Y; Wainwright C; Jaffe A; Robinson P; Saiman L; Sly PD, The Effect of Azithromycin on Structural Lung Disease in Infants with Cystic Fibrosis (COMBAT CF): A Phase 3, Randomised, Double-Blind, Placebo-Controlled Clinical Trial, http://dx.doi.org/10.2139/ssrn.3990938

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