By Professor Jeff Holst

Books

Holst J; Rasko JEJ, 2006, The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells, http://dx.doi.org/10.1016/S0076-6879(06)20006-5

Journal articles

Wahi K; Freidman N; Wang Q; Devadason M; Quek LE; Pang A; Lloyd L; Larance M; Zanini F; Harvey K; O’Toole S; Guan YF; Holst J, 2024, 'Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer', EMBO Journal, 43, pp. 5857 - 5882, http://dx.doi.org/10.1038/s44318-024-00271-6

Filipe EC; Velayuthar S; Philp A; Nobis M; Latham SL; Parker AL; Murphy KJ; Wyllie K; Major GS; Contreras O; Mok ETY; Enriquez RF; McGowan S; Feher K; Quek LE; Hancock SE; Yam M; Tran E; Setargew YFI; Skhinas JN; Chitty JL; Phimmachanh M; Han JZR; Cadell AL; Papanicolaou M; Mahmodi H; Kiedik B; Junankar S; Ross SE; Lam N; Coulson R; Yang J; Zaratzian A; Da Silva AM; Tayao M; Chin IL; Cazet A; Kansara M; Segara D; Parker A; Hoy AJ; Harvey RP; Bogdanovic O; Timpson P; Croucher DR; Lim E; Swarbrick A; Holst J; Turner N; Choi YS; Kabakova IV; Philp A; Cox TR, 2024, 'Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism', Advanced Science, 11, http://dx.doi.org/10.1002/advs.202307963

Johnson KK; Koshy P; Kopecky C; Devadason M; Biazik J; Zheng X; Jiang Y; Wang X; Liu Y; Holst J; Yang JL; Kilian KA; Sorrell CC, 2024, 'ROS-mediated anticancer effects of EGFR-targeted nanoceria', Journal of Biomedical Materials Research - Part A, 112, pp. 754 - 769, http://dx.doi.org/10.1002/jbm.a.37656

Dewdney B; Jenkins MR; Best SA; Freytag S; Prasad K; Holst J; Endersby R; Johns TG, 2023, 'From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress', Signal Transduction and Targeted Therapy, 8, http://dx.doi.org/10.1038/s41392-023-01637-8

K. Johnson K; Kopecky C; Koshy P; Liu Y; Devadason M; Holst J; A. Kilian K; C. Sorrell C, 2023, 'Theranostic Activity of Ceria-Based Nanoparticles toward Parental and Metastatic Melanoma: 2D vs 3D Models', ACS Biomaterials Science and Engineering, 9, pp. 1053 - 1065, http://dx.doi.org/10.1021/acsbiomaterials.2c01258

Wang NF; Jue TR; Holst J; Gunter JH, 2023, 'Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models', BJUI Compass, 4, pp. 44 - 58, http://dx.doi.org/10.1002/bco2.187

Quek LE; van Geldermalsen M; Guan YF; Wahi K; Mayoh C; Balaban S; Pang A; Wang Q; Cowley MJ; Brown KK; Turner N; Hoy AJ; Holst J, 2022, 'Glutamine addiction promotes glucose oxidation in triple-negative breast cancer', Oncogene, 41, pp. 4066 - 4078, http://dx.doi.org/10.1038/s41388-022-02408-5

Leiske MN; Mazrad ZAI; Zelcak A; Wahi K; Davis TP; McCarroll JA; Holst J; Kempe K, 2022, 'Zwitterionic Amino Acid-Derived Polyacrylates as Smart Materials Exhibiting Cellular Specificity and Therapeutic Activity', Biomacromolecules, 23, pp. 2374 - 2387, http://dx.doi.org/10.1021/acs.biomac.2c00143

Dylgjeri E; Kothari V; Shafi AA; Semenova G; Gallagher PT; Guan YF; Pang A; Goodwin JF; Irani S; McCann JJ; Mandigo AC; Chand S; McNair CM; Vasilevskaya I; Schiewer MJ; Lallas CD; McCue PA; Gomella LG; Seifert EL; Carroll JS; Butler LM; Holst J; Kelly WK; Knudsen KE, 2022, 'A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer', Clinical Cancer Research, 28, pp. 1446 - 1459, http://dx.doi.org/10.1158/1078-0432.CCR-21-1846

Noor H; Briggs NE; McDonald KL; Holst J; Vittorio O, 2021, 'Tp53 mutation is a prognostic factor in lower grade glioma and may influence chemotherapy efficacy', Cancers, 13, pp. 5362, http://dx.doi.org/10.3390/cancers13215362

Mandigo AC; Yuan W; Xu K; Gallagher P; Pang A; Guan YF; Shafi AA; Thangavel C; Sheehan B; Bogdan D; Paschalis A; McCann JJ; Laufer TS; Gordon N; Vasilevskaya IA; Dylgjeri E; Chand SN; Schiewer MJ; Domingo-Domenech J; Den RB; Holst J; McCue PA; de Bono JS; McNair C; Knudsen KE, 2021, 'Rb/e2f1 as a master regulator of cancer cell metabolism in advanced disease', Cancer Discovery, 11, pp. 2334 - 2353, http://dx.doi.org/10.1158/2159-8290.CD-20-1114

Gillis JL; Hinneh JA; Ryan N; Irani S; Moldovan M; Quek LE; Shrestha R; Hanson AR; Xie J; Hoy AJ; Holst J; Centenera MM; Mills IG; Lynn DJ; Selth LA; Butler LM, 2021, 'A feedback loop between the 1 androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth: Cooperativity between 6PGD and AR drives prostate cancer growth', eLife, 10, pp. e62592, http://dx.doi.org/10.7554/eLife.62592

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496

Wang Q; Guan YF; Hancock SE; Wahi K; van Geldermalsen M; Zhang BK; Pang A; Nagarajah R; Mak B; Freidman N; Horvath LG; Turner N; Holst J, 2021, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth', Journal of Pathology, 254, pp. 135 - 146, http://dx.doi.org/10.1002/path.5665

Huxley C; Wibowo M; Lum KY; Gordon S; D'Hyon S; Guan H; Wang X; Chen Y; Si M; Wang M; White JM; Wahi K; Wang Q; Holst J; Davis RA, 2020, 'Synthesis of bilocularin A carbamate derivatives and their evaluation as leucine transport inhibitors in prostate cancer cells', Phytochemistry, 179, pp. 112478, http://dx.doi.org/10.1016/j.phytochem.2020.112478

Nassar ZD; Mah CY; Dehairs J; Burvenich IJG; Irani S; Centenera MM; Helm M; Shrestha RK; Moldovan M; Don AS; Holst J; Scott AM; Horvath LG; Lynn DJ; Selth LA; Hoy AJ; Swinnen JV; Butler LM, 2020, 'Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis', eLife, 9, pp. 1 - 34, http://dx.doi.org/10.7554/eLife.54166

Freidman N; Chen I; Wu Q; Briot C; Holst J; Font J; Vandenberg R; Ryan R, 2020, 'Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer', Neurochemical Research, 45, pp. 1268 - 1286, http://dx.doi.org/10.1007/s11064-019-02934-x

Wang Q; Guan Y; Hancock S; Wahi K; van Geldermalsen M; Zhang B; Pang A; Nagarajah R; Mak B; Horvath L; Turner N; Holst J, 2020, 'Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growthin vitroandin vivo', , http://dx.doi.org/10.1101/2020.09.07.286997

Zhang BK; Moran AM; Bailey CG; Rasko JEJ; Holst J; Wang Q, 2019, 'EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer', Cell Communication and Signaling, 17, pp. 83, http://dx.doi.org/10.1186/s12964-019-0400-0

Wahi K; Holst J, 2019, 'ASCT2: a potential cancer drug target', Expert Opinion on Therapeutic Targets, 23, pp. 555 - 558, http://dx.doi.org/10.1080/14728222.2019.1627328

Guo D; Lui GYL; Lai SL; Wilmott JS; Tikoo S; Jackett LA; Quek C; Brown DL; Sharp DM; Kwan RYQ; Chacon D; Wong JH; Beck D; van Geldermalsen M; Holst J; Thompson JF; Mann GJ; Scolyer RA; Stow JL; Weninger W; Haass NK; Beaumont KA, 2019, 'RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes', International Journal of Cancer, 144, pp. 3070 - 3085, http://dx.doi.org/10.1002/ijc.32064

de Bock CE; Down M; Baidya K; Sweron B; Boyd AW; Fiers M; Burns GF; Molloy TJ; Lock RB; Soulier J; Taghon T; Van Vlierberghe P; Cools J; Holst J; Thorne RF, 2019, 'T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development', Haematologica, 104, pp. e204 - e207, http://dx.doi.org/10.3324/haematol.2018.198424

Bröer A; Gauthier-Coles G; Rahimi F; van Geldermalsen M; Dorsch D; Wegener A; Holst J; Bröer S, 2019, 'Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells', Journal of Biological Chemistry, 294, pp. 4012 - 4026, http://dx.doi.org/10.1074/jbc.RA118.006378

da Silva IP; Wang KYX; Wilmott JS; Holst J; Carlino MS; Park JJ; Quek C; Wongchenko M; Yan Y; Mann G; Johnson DB; McQuade JL; Rai R; Kefford RF; Rizos H; Scolyer RA; Yang JYH; Long GV; Menzies AM, 2019, 'Distinct molecular profiles and immunotherapy treatment outcomes of V600E and V600K BRAF-mutant melanoma', Clinical Cancer Research, 25, pp. 1272 - 1279, http://dx.doi.org/10.1158/1078-0432.CCR-18-1680

Gide TN; Quek C; Menzies AM; Tasker AT; Shang P; Holst J; Madore J; Lim SY; Velickovic R; Wongchenko M; Yan Y; Lo S; Carlino MS; Guminski A; Saw RPM; Pang A; McGuire HM; Palendira U; Thompson JF; Rizos H; Silva IPD; Batten M; Scolyer RA; Long GV; Wilmott JS, 2019, 'Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy', Cancer Cell, 35, pp. 238 - 255.e6, http://dx.doi.org/10.1016/j.ccell.2019.01.003

Gordon S; Wibowo M; Wang Q; Holst J; Davis RA, 2019, 'Dihydro-β-agarofurans from the Australian rainforest plant Denhamia celastroides that inhibit leucine transport in prostate cancer cells', Magnetic Resonance in Chemistry, 57, pp. 101 - 109, http://dx.doi.org/10.1002/mrc.4801

Gao D; Pinello N; Nguyen TV; Thoeng A; Nagarajah R; Holst J; Rasko JEJ; Wong JJL, 2019, 'DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis', Epigenomics, 11, pp. 95 - 109, http://dx.doi.org/10.2217/epi-2018-0050

Balaban S; Nassar ZD; Zhang AY; Hosseini-Beheshti E; Centenera MM; Schreuder M; Lin HM; Aishah A; Varney B; Liu-Fu F; Lee LS; Nagarajan SR; Shearer RF; Hardie RA; Raftopulos NL; Kakani MS; Saunders DN; Holst J; Horvath LG; Butler LM; Hoy AJ, 2019, 'Extracellular fatty acids are the major contributor to lipid synthesis in prostate cancer', Molecular Cancer Research, 17, pp. 949 - 962, http://dx.doi.org/10.1158/1541-7786.MCR-18-0347

Rajasekhar M; Schmitz U; Flamant S; Wong JJL; Bailey CG; Ritchie W; Holst J; Rasko JEJ, 2018, 'Identifying microRNA determinants of human myelopoiesis', Scientific Reports, 8, pp. 7264, http://dx.doi.org/10.1038/s41598-018-24203-7

Ryan RM; Holst J, 2018, 'Regulation of SLC1A4 and SLC1A5 in prostate cancer-letter', Molecular Cancer Research, 16, pp. 1809 - 1810, http://dx.doi.org/10.1158/1541-7786.MCR-18-0239

van Geldermalsen M; Quek LE; Turner N; Freidman N; Pang A; Guan YF; Krycer JR; Ryan R; Wang Q; Holst J, 2018, 'Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways', BMC Cancer, 18, pp. 689, http://dx.doi.org/10.1186/s12885-018-4599-8

Thientosapol ES; Bosnjak D; Durack T; Stevanovski I; Van Geldermalsen M; Holst J; Jahan Z; Shepard C; Weninger W; Kim B; Brink R; Jolly CJ, 2018, 'SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. 4921 - 4926, http://dx.doi.org/10.1073/pnas.1719771115

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2018, 'Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors', Phytochemistry, 148, pp. 71 - 77, http://dx.doi.org/10.1016/j.phytochem.2018.01.009

Garibsingh RAA; Otte NJ; Ndaru E; Colas C; Grewer C; Holst J; Schlessinger A, 2018, 'Homology modeling informs ligand discovery for the glutamine transporter ASCT2', Frontiers in Chemistry, 6, pp. 279, http://dx.doi.org/10.3389/fchem.2018.00279

Zhao Y; Ting KK; Li J; Cogger VC; Chen J; Johansson-Percival A; Ngiow SF; Holst J; Grau G; Goel S; Muller T; Dejana E; McCaughan G; Smyth MJ; Ganss R; Vadas MA; Gamble JR, 2017, 'Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell–mediated immunotherapy', Cancer Research, 77, pp. 4434 - 4447, http://dx.doi.org/10.1158/0008-5472.CAN-16-3129

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2017, 'Celastrofurans A-G: Dihydro-β-Agarofurans from the Australian Rainforest Vine Celastrus subspicata and Their Inhibitory Effect on Leucine Transport in Prostate Cancer Cells', Journal of Natural Products, 80, pp. 1918 - 1925, http://dx.doi.org/10.1021/acs.jnatprod.7b00220

Wong JJL; Gao D; Nguyen TV; Kwok CT; Van Geldermalsen M; Middleton R; Pinello N; Thoeng A; Nagarajah R; Holst J; Ritchie W; Rasko JEJ, 2017, 'Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment', Nature Communications, 8, http://dx.doi.org/10.1038/ncomms15134

Guan FHX; Bailey CG; Metierre C; O’Young P; Gao D; Khoo TL; Holst J; Rasko JEJ, 2017, 'The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo', Journal of Hematology and Oncology, 10, http://dx.doi.org/10.1186/s13045-017-0446-7

Chen Y; Ma J; Lu W; Tian M; Thauvin M; Yuan C; Volovitch M; Wang Q; Holst J; Liu M; Vriz S; Ye S; Wang L; Li D, 2017, 'Heritable expansion of the genetic code in mouse and zebrafish', Cell Research, 27, pp. 294 - 297, http://dx.doi.org/10.1038/cr.2016.145

Marshall AD; van Geldermalsen M; Otte NJ; Lum T; Vellozzi M; Thoeng A; Pang A; Nagarajah R; Zhang B; Wang Q; Anderson L; Rasko JEJ; Holst J, 2017, 'ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma', Oncogenesis, 6, http://dx.doi.org/10.1038/oncsis.2017.70

Balaban S; Shearer RF; Lee LS; van Geldermalsen M; Schreuder M; Shtein HC; Cairns R; Thomas KC; Fazakerley DJ; Grewal T; Holst J; Saunders DN; Hoy AJ, 2017, 'Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration', Cancer & Metabolism, 5, pp. 1, http://dx.doi.org/10.1186/s40170-016-0163-7

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Dihydro-β-agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells', Asian Journal of Organic Chemistry, 5, pp. 1461 - 1466, http://dx.doi.org/10.1002/ajoc.201600462

Marshall AD; van Geldermalsen M; Otte NJ; Anderson LA; Lum T; Vellozzi MA; Zhang BK; Thoeng A; Wang Q; Rasko JEJ; Holst J, 2016, 'LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma', International Journal of Cancer, 139, pp. 2529 - 2539, http://dx.doi.org/10.1002/ijc.30371

Shklovskaya E; Terry AM; Guy TV; Buckley A; Bolton HA; Zhu E; Holst J; De St Groth BF, 2016, 'Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen', Immunology and Cell Biology, 94, pp. 593 - 603, http://dx.doi.org/10.1038/icb.2016.14

Van Geldermalsen M; Wang Q; Nagarajah R; Marshall AD; Thoeng A; Gao D; Ritchie W; Feng Y; Bailey CG; Deng N; Harvey K; Beith JM; Selinger CI; O'Toole SA; Rasko JEJ; Holst J, 2016, 'ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer', Oncogene, 35, pp. 3201 - 3208, http://dx.doi.org/10.1038/onc.2015.381

Xi Z; Yao M; Li Y; Xie C; Holst J; Liu T; Cai S; Lao Y; Tan H; Xu HX; Dong Q, 2016, 'Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation', Cell Death and Disease, 7, pp. e2252 - e2252, http://dx.doi.org/10.1038/cddis.2016.123

Wibowo M; Levrier C; Sadowski MC; Nelson CC; Wang Q; Holst J; Healy PC; Hofmann A; Davis RA, 2016, 'Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis', Journal of Natural Products, 79, pp. 1445 - 1453, http://dx.doi.org/10.1021/acs.jnatprod.6b00190

Wong JJL; Au AYM; Gao D; Pinello N; Kwok CT; Thoeng A; Lau KA; Gordon JEA; Schmitz U; Feng Y; Nguyen TV; Middleton R; Bailey CG; Holst J; Rasko JEJ; Ritchie W, 2016, 'RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever', Nucleic Acids Research, 44, pp. 2888 - 2897, http://dx.doi.org/10.1093/nar/gkw041

Wibowo M; Wang Q; Holst J; White JM; Hofmann A; Davis RA, 2016, 'Inside Cover: Dihydro‐β‐agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016)', Asian Journal of Organic Chemistry, 5, pp. 1412 - 1412, http://dx.doi.org/10.1002/ajoc.201600548

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