By Professor Jeff Holst

Journal articles

Hnit SST; Xie C; Yao M; Holst J; Bensoussan A; De Souza P; Li Z; Dong Q, 2015, 'P27^Kip1 signaling: Transcriptional and post-translational regulation', International Journal of Biochemistry and Cell Biology, 68, pp. 9 - 14, http://dx.doi.org/10.1016/j.biocel.2015.08.005

Wang Q; Hardie RA; Hoy AJ; Van Geldermalsen M; Gao D; Fazli L; Sadowski MC; Balaban S; Schreuder M; Nagarajah R; Wong JJL; Metierre C; Pinello N; Otte NJ; Lehman ML; Gleave M; Nelson CC; Bailey CG; Ritchie W; Rasko JE; Holst J, 2015, 'Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development', Journal of Pathology, 236, pp. 278 - 289, http://dx.doi.org/10.1002/path.4518

Grkovic T; Pouwer RH; Wang Q; Guymer GP; Holst J; Quinn RJ, 2015, 'LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis', Journal of Natural Products, 78, pp. 1215 - 1220, http://dx.doi.org/10.1021/np500968t

Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Erratum: Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome [Oncotarget. 2015; 6:16135-16150]', Oncotarget, 6, pp. 36923, http://dx.doi.org/10.18632/oncotarget.6263

Wang Q; Holst J, 2015, 'L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia', American Journal of Cancer Research, 5, pp. 1281 - 1294

Colas C; Grewer C; Otte NJ; Gameiro A; Albers T; Singh K; Shere H; Bonomi M; Holst J; Schlessinger A, 2015, 'Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening', PLoS Computational Biology, 11, http://dx.doi.org/10.1371/journal.pcbi.1004477

Leach DA; Need EF; Toivanen R; Trotta AP; Palenthorpe HM; Tamblyn DJ; Kopsaftis T; England GM; Smith E; Drew PA; Pinnock CB; Lee P; Holst J; Risbridger GP; Chopra S; DeFranco DB; Taylor RA; Buchanan G, 2015, 'Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome', Oncotarget, 6, pp. 16135 - 16150, http://dx.doi.org/10.18632/oncotarget.3873

Yao M; Xie C; Kiang MY; Teng Y; Harman D; Tiffen J; Wang Q; Sved P; Bao S; Witting P; Holst J; Dong Q, 2015, 'Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells', Oncotarget, 6, pp. 34458 - 34474, http://dx.doi.org/10.18632/oncotarget.5277

Wang Q; Beaumont KA; Otte NJ; Font J; Bailey CG; Van Geldermalsen M; Sharp DM; Tiffen JC; Ryan RM; Jormakka M; Haass NK; Rasko JEJ; Holst J, 2014, 'Targeting glutamine transport to suppress melanoma cell growth', International Journal of Cancer, 135, pp. 1060 - 1071, http://dx.doi.org/10.1002/ijc.28749

Wang Q; Grkovic T; Font J; Bonham S; Pouwer RH; Bailey CG; Moran AM; Ryan RM; Rasko JEJ; Jormakka M; Quinn RJ; Holst J, 2014, 'Monoterpene glycoside ESK246 from pittosporum targets LAT3 amino acid transport and prostate cancer cell growth', ACS Chemical Biology, 9, pp. 1369 - 1376, http://dx.doi.org/10.1021/cb500120x

Wong JJL; Ritchie W; Gao D; Lau KA; Gonzalez M; Choudhary A; Taft RJ; Rasko JEJ; Holst J, 2014, 'Identification of nuclear-enriched miRNAs during mouse granulopoiesis', Journal of Hematology and Oncology, 7, http://dx.doi.org/10.1186/1756-8722-7-42

Wang Q; Hardie R-A; Balaban S; Schreuder M; Hoy A; van Geldermalsen M; Fazli L; Nagarajah R; Bailey C; Rasko J; Holst J, 2014, 'Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer', CANCER & METABOLISM, 2, http://dx.doi.org/10.1186/2049-3002-2-S1-P27

Wong JJL; Holst J, 2014, 'Changes in CpG methylation marks differentiation of human myeloid progenitors to neutrophils.', Stem Cell Investig, 1, pp. 10, http://dx.doi.org/10.3978/j.issn.2306-9759.2014.05.01

Wang Q; Tiffen J; Bailey CG; Lehman ML; Ritchie W; Fazli L; Metierre C; Feng YJ; Li E; Gleave M; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2013, 'Targeting amino acid transport in metastatic castration-resistant prostate cancer: Effects on cell cycle, cell growth, and tumor development', Journal of the National Cancer Institute, 105, pp. 1463 - 1473, http://dx.doi.org/10.1093/jnci/djt241

Tiffen JC; Bailey CG; Marshall AD; Metierre C; Feng Y; Wang Q; Watson SL; Holst J; Rasko JEJ, 2013, 'The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells', International Journal of Cancer, 133, pp. 1603 - 1613, http://dx.doi.org/10.1002/ijc.28184

Khoo TL; Xiros N; Guan F; Orellana D; Holst J; Joshua DE; Rasko JEJ, 2013, 'Performance evaluation of the abbott CELL-DYN emerald for use as a bench-top analyzer in a research setting', International Journal of Laboratory Hematology, 35, pp. 447 - 456, http://dx.doi.org/10.1111/ijlh.12040

Wong JJL; Ritchie W; Ebner OA; Selbach M; Wong JWH; Huang Y; Gao D; Pinello N; Gonzalez M; Baidya K; Thoeng A; Khoo TL; Bailey CG; Holst J; Rasko JEJ, 2013, 'XOrchestrated intron retention regulates normal granulocyte differentiation', Cell, 154, http://dx.doi.org/10.1016/j.cell.2013.06.052

Holst J, 2013, 'Letter to the Editor', International Journal of Pharmaceutics, 455, pp. 393, http://dx.doi.org/10.1016/j.ijpharm.2013.07.008

De Bock CE; Ardjmand A; Molloy TJ; Bone SM; Johnstone D; Campbell DM; Shipman KL; Yeadon TM; Holst J; Spanevello MD; Nelmes G; Stewart D; Lincz LF; Boyd AW; Burns GF; Thorne RF, 2012, 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26, pp. 918 - 926, http://dx.doi.org/10.1038/leu.2011.319

Wang Q; Bailey CG; Ng C; Tiffen J; Thoeng A; Minhas V; Lehman ML; Hendy SC; Buchanan G; Nelson CC; Rasko JEJ; Holst J, 2011, 'Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression', Cancer Research, 71, pp. 7525 - 7536, http://dx.doi.org/10.1158/0008-5472.CAN-11-1821

Bröer A; Juelich T; Vanslambrouck JM; Tietze N; Solomon PS; Holst J; Bailey CG; Rasko JEJ; Bröer S, 2011, 'Impaired nutrient signaling and body weight control in a Na ⁺ neutral amino acid cotransporter (Slc6a19)-deficient mouse', Journal of Biological Chemistry, 286, pp. 26638 - 26651, http://dx.doi.org/10.1074/jbc.M111.241323

Kranias G; Watt LF; Carpenter H; Holst J; Ludowyke R; Strack S; Sim ATR; Verrills NM, 2010, 'Protein phosphatase 2A carboxymethylation and regulatory B subunits differentially regulate mast cell degranulation', Cellular Signalling, 22, pp. 1882 - 1890, http://dx.doi.org/10.1016/j.cellsig.2010.07.017

Tiffen JC; Bailey CG; Ng C; Rasko JEJ; Holst J, 2010, 'Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo', Molecular Cancer, 9, http://dx.doi.org/10.1186/1476-4598-9-299

Flamant S; Ritchie W; Guilhot J; Holst J; Bonnet ML; Chomel JC; Guilhot F; Turhan AG; Rasko JEJ, 2010, 'Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia', Haematologica, 95, pp. 1325 - 1333, http://dx.doi.org/10.3324/haematol.2009.020636

Taft RJ; Simons C; Nahkuri S; Oey H; Korbie DJ; Mercer TR; Holst J; Ritchie W; Wong JJL; Rasko JEJ; Rokhsar DS; Degnan BM; Mattick JS, 2010, 'Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans', Nature Structural and Molecular Biology, 17, pp. 1030 - 1034, http://dx.doi.org/10.1038/nsmb.1841

Vanslambrouck JM; Bröer A; Thavyogarajah T; Holst J; Bailey CG; Bröer S; Rasko JEJ, 2010, 'Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria', Biochemical Journal, 428, pp. 397 - 407, http://dx.doi.org/10.1042/BJ20091667

Wang H; Holst J; Woo SR; Guy C; Bettini M; Wang Y; Shafer A; Naramura M; Mingueneau M; Dragone LL; Hayes SM; Malissen B; Band H; Vignali DAA, 2010, 'Tonic ubiquitylation controls T-cell receptor: CD3 complex expression during T-cell development', EMBO Journal, 29, pp. 1285 - 1298, http://dx.doi.org/10.1038/emboj.2010.10

Holst J; Watson S; Lord MS; Eamegdool SS; Bax DV; Nivison-Smith LB; Kondyurin A; Ma L; Overhauser AF; Weiss AS; Rasko JEJ, 2010, 'Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells', Nature Biotechnology, 28, pp. 1123 - 1130, http://dx.doi.org/10.1038/nbt.1687

Rajasekhar M; Holst J; Rasko JEJ, 2009, 'MicroRNA expression in myeloid differentiation', CYTOKINE, 48, pp. 78 - 78, http://dx.doi.org/10.1016/j.cyto.2009.07.269

Holst J; Wang H; Eder KD; Workman CJ; Boyd KL; Baquet Z; Singh H; Forbes K; Chruscinski A; Smeyne R; van Oers NSC; Utz PJ; Vignali DAA, 2008, 'Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity', Nature Immunology, 9, pp. 658 - 666, http://dx.doi.org/10.1038/ni.1611

El Kasmi KC; Holst J; Coffre M; Mielke L; De Pauw A; Lhocine N; Smith AM; Rutschman R; Kaushal D; Shen Y; Suda T; Donnelly RP; Myers MG; Alexander W; Vignali DAA; Watowich SS; Ernst M; Hilton DJ; Murray PJ, 2006, 'General nature of the STAT3-activated anti-inflammatory response', Journal of Immunology, 177, pp. 7880 - 7888, http://dx.doi.org/10.4049/jimmunol.177.11.7880

Holst J; Szymczak-Workman AL; Vignali KM; Burton AR; Workman CJ; Vignali DAA, 2006, 'Generation of T-cell receptor retrogenic mice', Nature Protocols, 1, pp. 406 - 417, http://dx.doi.org/10.1038/nprot.2006.61

Holst J; Vignali KM; Burton AR; Vignali DAA, 2006, 'Erratum: Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice (Nature Methods) (2006) vol. 3 (191-197))', Nature Methods, 3, pp. 327, http://dx.doi.org/10.1038/nmeth0406-327

Holst J; Vignali KM; Burton AR; Vignali DAA, 2006, 'Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.', Nature methods, 3, pp. 191 - 197, http://dx.doi.org/10.1038/nmeth858

Sim ATR; Baldwin ML; Rostas JAP; Holst J; Ludowyke RI, 2003, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373, pp. 641 - 659, http://dx.doi.org/10.1042/BJ20030484

Sim ATR; Holst J; Ludowyke RI, 2003, '[10] Protein Phosphatase Translocation in RBL-2H3 Cells', Methods in Enzymology, 366, pp. 113 - 124, http://dx.doi.org/10.1016/S0076-6879(03)66010-6

Sim A; Holst JA; Ludowyke RI, 2003, 'Protein phosphatase translocation in RBL-2H3 cells', Methods in Enzymology, 366, pp. 113 - 124

Holst J; Sim ATR; Ludowyke RI, 2002, 'Protein phosphatases 1 and 2A transiently associate with myosin during the peak rate of secretion from mast cells', Molecular Biology of the Cell, 13, pp. 1083 - 1098, http://dx.doi.org/10.1091/mbc.01-12-0587

Ludowyke RI; Holst J; Mudge LM; Sim ATR, 2000, 'Transient translocation and activation of protein phosphatase 2A during mast cell secretion', Journal of Biological Chemistry, 275, pp. 6144 - 6152, http://dx.doi.org/10.1074/jbc.275.9.6144

Conference Papers

Persson M; Jackson E; Duchatel R; Bramberger L; McEwen H; Kearney P; Findlay I; Douglas A; Kobbe B; Wagener R; Larsen M; Faridi P; Holst J; Mayall J; Gedye C; Hondermarck H; Horvat J; Nixon B; Cartaxo R; Koschmann C; Valdes-Mora F; Ortega DG; Nazarian J; Alonso MM; Hulleman E; Van der Lugt J; Vitanza N; Mueller S; Dun M, 2022, 'ANTAGONISM OF DRD2 USING ONC201 INCREASED EXPRESSION OF ANTIGEN PRESENTATION PATHWAY PROTEINS IN DIFFUSE MIDLINE GLIOMA, RECRUITING TUMOR INFILTRATING LYMPHOCYTES IN VIVO', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, FL, Tampa, pp. 272 - 272, presented at 27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), FL, Tampa, 16 November 2022 - 20 November 2022, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000888571001365&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Wang QK; Geldermalsen MV; Pang A; Zhang B; Holst J, 2018, 'Abstract A036: Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. A036 - A036, http://dx.doi.org/10.1158/1538-7445.prca2017-a036

Geldermalsen MV; Quek L-E; Turner N; Balaban S; Hoy A; Wang Q; Holst J, 2018, 'Abstract B20: Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets', in Molecular Cancer Research, American Association for Cancer Research (AACR), pp. B20 - B20, http://dx.doi.org/10.1158/1557-3125.advbc17-b20

Guo D; Lui GY; Sharp DM; Lai SL; Tikoo S; Kwan R; van Geldermalsen M; Holst J; Haass NK; Weninger W; Beaumont KA, 2018, 'Rab27a promotes melanoma cell invasion and metastasis via the regulation of exosome secretion', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, IL, Chicago, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), IL, Chicago, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-5167

Wang QK; van Geldermalsen M; Pang A; Zhang B; Holst J, 2017, 'Blocking DNA and RNA synthesis by targeting glutamine metabolism in prostate cancer.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, FL, Orlando, pp. 43 - 43, presented at AACR Special Conference on Prostate Cancer - Advances in Basic, Translational, and Clinical Research, FL, Orlando, 02 December 2017 - 05 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000441803800054&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

van Geldermalsen M; Quek L-E; Turner N; Balaban S; Hoy A; Wang Q; Holst J, 2017, 'Glutamine metabolic vulnerabilities define triple-negative from luminal A breast cancer subsets.', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, Hollywood, pp. 72 - 72, presented at AACR Special Conference on Advances in Breast Cancer Research, CA, Hollywood, 07 October 2017 - 10 October 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440602000103&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

van Geldermalsen M; Wang Q; Holst J, 2016, 'Targeting ASCT2-mediated glutamine uptake and metabolism in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, LA, New Orleans, presented at AACR 107th Annual Meeting on Bioinformatics and Systems Biology, LA, New Orleans, 16 April 2016 - 20 April 2016, http://dx.doi.org/10.1158/1538-7445.AM2016-1043

Otte NJ; Broer A; O'Young P; van Geldermalsen M; Wang Q; Bailey CG; Broer S; Holst J, 2016, 'The amino acid transporter SNAT4: Potential role as a tumor suppressor in melanoma', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, LA, New Orleans, presented at AACR 107th Annual Meeting on Bioinformatics and Systems Biology, LA, New Orleans, 16 April 2016 - 20 April 2016, http://dx.doi.org/10.1158/1538-7445.AM2016-1007

Wang QK; Hardie R-A; Hoy AJ; van Geldermalsen M; Gao D; Fazli L; Sadowski MC; Balaban S; Schreuder M; van Geldermalsen M; Otte NJ; Lehman ML; Gleave M; Nelson CC; Bailey CG; Ritchie W; Rasko JEJ; Holst J, 2015, 'Inhibition of ASCT2-mediated glutamine uptake blocks prostate cancer growth', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 32 - 32, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Zhang K; Moran A; Holst J; Wang Q, 2015, 'PI3K/Akt signalling regulates leucine transport in prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 34 - 35, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hardie R-A; Wang Q; Otte N; Simmons M; Holst J, 2015, 'Targeting adaptive nutrient metabolism pathways as a therapy for prostate cancer', in BJU INTERNATIONAL, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 47 - 47, presented at 2nd Prostate Cancer World Congress (PCWC), AUSTRALIA, Cairns, 17 August 2015 - 21 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000359254200134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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