Select Publications

Journal articles

Malhi NK; Allen CL; Stewart E; Horton KL; Riu F; Batson J; Amoaku W; Morris JC; Arkill KP; Bates DO, 2022, 'Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy.', Am J Physiol Heart Circ Physiol, vol. 322, pp. H1014 - H1027,

Maiocchi S; Ku J; Hawtrey T; De Silvestro I; Malle E; Rees M; Thomas SR; Morris JC, 2021, 'Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase', Chemical Research in Toxicology, vol. 34, pp. 1681 - 1692,

Duchatel RJ; Mannan A; Woldu AS; Hawtrey T; Hindley PA; Douglas AM; Jackson ER; Findlay IJ; Germon ZP; Staudt D; Kearney PS; Smith ND; Hindley KE; Cain JE; André N; La Madrid AM; Nixon B; De Iuliis GN; Nazarian J; Irish K; Alvaro F; Eisenstat DD; Beck A; Vitanza NA; Mueller S; Morris JC; Dun MD, 2021, 'Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.', Neurooncol Adv, vol. 3, pp. vdab169,

Dun MD; Mannan A; Rigby CJ; Butler S; Toop HD; Beck D; Connerty P; Sillar J; Kahl RGS; Duchatel RJ; Germon Z; Faulkner S; Chi M; Skerrett-Byrne D; Murray HC; Flanagan H; Almazi JG; Hondermarck H; Nixon B; De Iuliis G; Chamberlain J; Alvaro F; de Bock CE; Morris JC; Enjeti AK; Verrills NM, 2020, 'Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia', Leukemia,

Collison AM; Li J; De Siqueira AP; Lv X; Toop HD; Morris JC; Starkey MR; Hansbro PM; Zhang J; Mattes J, 2019, 'TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis', BMC Pulmonary Medicine, vol. 19,

Nair PM; Starkey MR; Haw TJ; Liu G; Collison AM; Mattes J; Wark PA; Morris JC; Verrills NM; Clark AR; Ammit AJ; Hansbro PM, 2019, 'Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease', Clinical and Translational Immunology, vol. 8,

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, vol. 9,

Tzelepis K; De Braekeleer E; Aspris D; Barbieri I; Vijayabaskar MS; Liu WH; Gozdecka M; Metzakopian E; Toop HD; Dudek M; Robson SC; Hermida-Prado F; Yang YH; Babaei-Jadidi R; Garyfallos DA; Ponstingl H; Dias JML; Gallipoli P; Seiler M; Buonamici S; Vick B; Bannister AJ; Rad R; Prinjha RK; Marioni JC; Huntly B; Batson J; Morris JC; Pina C; Bradley A; Jeremias I; Bates DO; Yusa K; Kouzarides T; Vassiliou GS, 2018, 'SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4', Nature Communications, vol. 9, pp. 5378,

Nair PM; Starkey MR; Haw TJ; Liu G; Horvat JC; Morris JC; Verrills NM; Clark AR; Ammit AJ; Hansbro PM, 2017, 'Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice', Allergy: European Journal of Allergy and Clinical Immunology, vol. 72, pp. 1891 - 1903,

Toop HD; Brusnahan JS; Morris JC, 2017, 'Concise Total Synthesis of Dioncophylline E through an ortho-Arylation Strategy', Angewandte Chemie - International Edition, vol. 56, pp. 8536 - 8538,

Maiocchi SL; Morris JC; Rees MD; Thomas SR, 2017, 'Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents', Biochemical Pharmacology, vol. 135, pp. 90 - 115,

Li Y; Zhou T; Wang Y; Ning C; Lv Z; Han G; Morris JC; Taylor EN; Wang R; Xiao H; Hou C; Ma Y; Shen B; Feng J; Guo R; Li Y; Chen G, 2017, 'The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation', Oncogene, vol. 36, pp. 3760 - 3771,

Batson J; Toop HD; Redondo C; Babaei-Jadidi R; Chaikuad A; Wearmouth SF; Gibbons B; Allen C; Tallant C; Zhang J; Du C; Hancox JC; Hawtrey T; Da Rocha J; Griffith R; Knapp S; Bates DO; Morris JC, 2017, 'Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease', ACS Chemical Biology, vol. 12, pp. 825 - 832,

Bates DO; Morris JC; Oltean S; Donaldson LF, 2017, 'Pharmacology of modulators of alternative splicing', Pharmacological Reviews, vol. 69, pp. 63 - 79,

Batson J; Toop H; Daubney J; Liddell S; Stewart E; Bourne J; Blackley Z; Morris J; Bates DO, 2017, 'Optimisation of novel small molecule inhibitors of SRPK1-mediated VEGF-A splicing through modelling of permeability properties required for trans-scleral eye drop delivery', Acta Ophthalmologica, vol. 95,

Liddell S; Toop H; Stewart E; Daubney J; Bourne J; Batson J; Morris J; Bates D, 2017, 'Optimisation of potent topical SRPK1 inhibitors with improved retinal pharmacokinetics through ex vivo trans-scleral permeability modelling', Acta Ophthalmologica, vol. 95,

Rahman MM; Prünte L; Lebender LF; Patel BS; Gelissen I; Hansbro PM; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2016, 'The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells', Scientific Reports, vol. 6,

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence', Synlett, vol. 27, pp. 1237 - 1240,

Rahman MM; Rumzhum NN; Hansbro PM; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2016, 'Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells', Cellular Signalling, vol. 28, pp. 325 - 334,

Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 1480 - 1487,

Smith AM; Dun MD; Lee EM; Harrison C; Kahl R; Flanagan H; Panicker N; Mashkani B; Don AS; Morris J; Toop H; Lock RB; Powell JA; Thomas D; Guthridge MA; Moore A; Ashman LK; Skelding KA; Enjeti A; Verrills NM, 2016, 'Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors', Oncotarget, vol. 7, pp. 47465 - 47478,

Toop HD; Dun MD; Ross BK; Flanagan HM; Verrills NM; Morris JC, 2016, 'Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia', Organic and Biomolecular Chemistry, vol. 14, pp. 4605 - 4616,

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'ChemInform Abstract: Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence.', ChemInform, vol. 47,

Batson J; Toop HD; Allen C; Rowlinson J; Babaei-Jadidi R; Gibbons B; Zhang J; Wearmouth SF; Knapp S; Morris JC; Bates DO, 2016, 'Trans-scleral delivery of novel anti-angiogenic small molecule inhibitors of SRPK1', Acta Ophthalmologica, vol. 94,

Toop HD; Don AS; Morris JC, 2015, 'Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors', Organic and Biomolecular Chemistry, vol. 13, pp. 11593 - 11596,

Li JJ; Tay HL; Maltby S; Xiang Y; Eyers F; Hatchwell L; Zhou H; Toop HD; Morris JC; Nair P; Mattes J; Foster PS; Yang M, 2015, 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity', Journal of Allergy and Clinical Immunology, vol. 136, pp. 462 - 473,

Rahman MM; Rumzhum NN; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2015, 'Basal protein phosphatase 2A activity restrains cytokine expression: Role for MAPKs and tristetraprolin', Scientific Reports, vol. 5,

Rowlinson J; Batson J; Toop H; Allen C; Gibbons B; Babaei-Jadidi R; Zhang J; Wearmouth S; Knapp S; Morris J; Bates D, 2015, 'Novel SRPK1 inhibitors specifically target alternative splicing in human primary retinal epithelial cells', Acta Ophthalmologica, vol. 93, pp. n/a - n/a,

Batson J; Toop H; Rowlinson J; Allen C; Gibbons B; Zhang J; Wearmouth S; Knapp S; Morris J; Bates D, 2015, 'SRPK1 inhibitors as novel anti-angiogenic therapeutics for wet age-related macular degeneration (wAMD)', Acta Ophthalmologica, vol. 93, pp. n/a - n/a,

Bruce MI; Burgun A; Jevric M; Morris JC; Nicholson BK; Parker CR; Scoleri N; Skelton BW; Zaitseva NN, 2014, 'Some cyclic ligands obtained from reactions of polycyanocarbon-metal complexes Dedicated to our friend and colleague Claude Lapinte on his 65th birthday, in recognition of his extensive contributions to organo-iron chemistry.', Journal of Organometallic Chemistry, vol. 756, pp. 68 - 78,

Walker SR; Czyz ML; Morris JC, 2014, 'Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction', Organic Letters, vol. 16, pp. 708 - 711,

Hatchwell L; Girkin J; Dun MD; Morten M; Verrills N; Toop HD; Morris JC; Johnston SL; Foster PS; Collison A; Mattes J, 2014, 'Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A', Journal of Allergy and Clinical Immunology, vol. 133, pp. 1720 - 1727,

Antony S; Morris JC; Bell TDM; Brown T; Spiccia L; Harris HH, 2014, 'The H.G. Smith award article: Fluorescent analogues of NAMI-A: Synthesis, characterisation, fluorescent properties, and preliminary biological studies in human lung cancer cells', Australian Journal of Chemistry, vol. 67, pp. 1711 - 1717,

Collison A; Li J; Pereira De Siqueira A; Zhang J; Toop HD; Morris JC; Foster PS; Mattes J, 2014, 'Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease', American Journal of Respiratory Cell and Molecular Biology, vol. 51, pp. 86 - 93,

Southam DC; Shand B; Buntine MA; Kable SH; Read JR; Morris JC, 2013, 'The timing of an experiment in the laboratory program is crucial for the student laboratory experience: Acylation of ferrocene as a case study', Chemistry Education Research and Practice, vol. 14, pp. 476 - 484,

Morris JC, 2013, 'Marine natural products: Synthetic aspects', Natural Product Reports, vol. 30, pp. 783 - 805,

Collison A; Hatchwell L; Verrils N; Wark PA; de Siqueira AP; Tooze M; Carpenter H; Don AS; Morris JC; Zimmermann N; Bartlett NW; Rothenberg NE; Johnston SL; Foster PS; Mattes J, 2013, 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, vol. 19, pp. 232 - 237,

Bloch WM; Derwent-Smith SM; Issa F; Morris JC; Rendina LM; Sumby CJ, 2012, 'ChemInform Abstract: Fused Pyrazino[2,3-b]indolizine and Indolizino[2,3-b]quinoxaline Derivatives: Synthesis, Structures, and Properties.', ChemInform, vol. 43, pp. no - no,

Kim HJ; Qiao Q; Toop HD; Morris JC; Don AS, 2012, 'A fluorescent assay for ceramide synthase activity', Journal of Lipid Research, vol. 53, pp. 1701 - 1707,

Bruce M; Morris JC; Skelton BW; White AH; Zaitseva NN, 2011, 'A percyanovinylidene-ruthenium complex, Ru{=C=C5(CN)3[=C(CN)2]2}(dppe)Cp*', Organometallics, vol. 30, pp. 653,

Armitt DJ; Bruce MI; Morris JC; Nicholson BK; Parker CR; Skelton BW; Zaitseva N, 2011, 'Bis(metallaethynyl) ketones: Synthesis and structure of {(Ph 3P)AuCC}2CO and attempted transmetalation: Formation and structure of [1,3-{Ru(dppe)Cp}2{ c -COC(OMe)CHCCH}] PF6', Organometallics, vol. 30, pp. 5452 - 5456,

Bloch WM; Derwent-smith SM; Issa F; Morris JC; Rendina LM; Sumby C, 2011, 'Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties', Tetrahedron, vol. 67, pp. 9368 - 9375,

Morris JC; Phillips A, 2011, 'Marine Natural Products: Synthetic Aspects', Natural Product Reports, vol. 28, pp. 269 - 289,

Bruce MI; Morris JC; Parker CR; Skelton BW, 2011, 'Nucleophilic properties of Ru(CCH)(dppe)Cp*esis and structure of Ru{c-CCArC(O)C(O)O}(dppe)Cp* [Ar = 2,4-(NO2)2C 6H3]', Journal of Organometallic Chemistry, vol. 696, pp. 3292 - 3295,

KING GR; MANDER LN; MONCK NJT; MORRIS JC; ZHANG H, 2010, 'ChemInform Abstract: A New and Efficient Strategy for the Total Synthesis of Polycyclic Diterpenoids: The Preparation of Gibberellins (.+-.)-GA103 and (.+-.)- GA73.', ChemInform, vol. 28, pp. no - no,

MANDER LN; MORRIS JC, 2010, 'ChemInform Abstract: Application of the Sharpless Asymmetric Dihydroxylation Methodology to the Enantioselective Preparation of 2,3-Dihydroxytetrahydro-2-naphthoic Esters.', ChemInform, vol. 29, pp. no - no,

MORRIS JC; MANDER LN; HOCKLESS DCR, 2010, 'ChemInform Abstract: Norcaradienes from the Intramolecular Cyclopropanation Reactions of Diazomethyl Ketones. Valuable Intermediates for the Synthesis of Polycyclic Diterpenes.', ChemInform, vol. 29, pp. no - no,

POUR M; KING GR; MONCK NJT; NATHANIEL JT; MORRIS JC; ZHANG H; MANDER LN, 2010, 'ChemInform Abstract: Synthetic and Structural Studies on Novel Gibberellins', ChemInform, vol. 29, pp. no - no,

Bungard CJ; Morris JC, 2010, 'ChemInform Abstract: An Efficient Preparation of 6-Alkoxy-Substituted Benzocyclobutenones', ChemInform, vol. 32, pp. no - no,

Anderson RJ; Morris JC, 2010, 'ChemInform Abstract: Total Synthesis of Variolin B.', ChemInform, vol. 33, pp. no - no,

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