By Professor Jonathan Morris

Book Chapters

Morris JC; Phillips A; Wilde V, 2012, 'Marine Natural Product Synthesis', in Fattorusso E; Gerwick WH; Taglialatela-Scafati O (ed.), Handbook of Marine Natural Products, Springer reference, pp. 601 - 673, http://dx.doi.org/10.1007/978-90-481-3834-0_11

Journal articles

Wohlwend M; Laurila P-P; Goeminne LJE; Lima T; Daskalaki I; Li X; von Alvensleben G; Crisol B; Mangione R; Gallart-Ayala H; Burri O; Butler S; Morris J; Turner N; Ivanisevic J; Auwerx J, 2024, 'Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction', eLife, 12, http://dx.doi.org/10.7554/elife.90522.3

Wohlwend M; Laurila P-P; Goeminne LJE; Lima T; Daskalaki I; Li X; von Alvensleben G; Crisol B; Mangione R; Gallart-Ayala H; Burri O; Butler S; Morris J; Turner N; Ivanisevic J; Auwerx J, 2024, 'Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction.', Elife, 12, http://dx.doi.org/10.7554/eLife.90522

Diaz-Vegas A; Madsen S; Cooke KC; Carroll L; Khor JXY; Turner N; Lim XY; Astore MA; Morris JC; Don AS; Garfield A; Zarini S; Zemski Berry KA; Ryan AP; Bergman BC; Brozinick JT; James DE; Burchfield JG, 2023, 'Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle', eLife, 12, http://dx.doi.org/10.7554/elife.87340.3

Diaz-Vegas A; Madsen S; Cooke KC; Carroll L; Khor JXY; Turner N; Lim XY; Astore MA; Morris JC; Don AS; Garfield A; Zarini S; Berry KAZ; Ryan AP; Bergman BC; Brozinick JT; James DE; Burchfield JG, 2023, 'Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle', eLife, 12, http://dx.doi.org/10.7554/eLife.87340

Wahid M; Pratoomthai B; Egbuniwe IU; Evans HR; Babaei-Jadidi R; Amartey JO; Erdelyi V; Yacqub-Usman K; Jackson AM; Morris JC; Patel PM; Bates DO, 2023, 'Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion', Cancer Immunology, Immunotherapy, 72, pp. 4001 - 4014, http://dx.doi.org/10.1007/s00262-023-03534-z

Alalwany RH; Hawtrey T; Morgan K; Morris JC; Donaldson LF; Bates DO, 2023, 'Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease', Frontiers in Molecular Neuroscience, 16, http://dx.doi.org/10.3389/fnmol.2023.1181626

Malhi NK; Allen CL; Stewart E; Horton KL; Riu F; Batson J; Amoaku W; Morris JC; Arkill KP; Bates DO, 2022, 'Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy', American Journal of Physiology - Heart and Circulatory Physiology, 322, pp. H1014 - H1027, http://dx.doi.org/10.1152/AJPHEART.00001.2022

Maiocchi S; Ku J; Hawtrey T; De Silvestro I; Malle E; Rees M; Thomas SR; Morris JC, 2021, 'Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase', Chemical Research in Toxicology, 34, pp. 1681 - 1692, http://dx.doi.org/10.1021/acs.chemrestox.1c00094

Duchatel RJ; Mannan A; Woldu AS; Hawtrey T; Hindley PA; Douglas AM; Jackson ER; Findlay IJ; Germon ZP; Staudt D; Kearney PS; Smith ND; Hindley KE; Cain JE; André N; La Madrid AM; Nixon B; De Iuliis GN; Nazarian J; Irish K; Alvaro F; Eisenstat DD; Beck A; Vitanza NA; Mueller S; Morris JC; Dun MD, 2021, 'Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma', Neuro-Oncology Advances, 3, pp. vdab169 - vdab169, http://dx.doi.org/10.1093/noajnl/vdab169

Dun MD; Mannan A; Rigby CJ; Butler S; Toop HD; Beck D; Connerty P; Sillar J; Kahl RGS; Duchatel RJ; Germon Z; Faulkner S; Chi M; Skerrett-Byrne D; Murray HC; Flanagan H; Almazi JG; Hondermarck H; Nixon B; De Iuliis G; Chamberlain J; Alvaro F; de Bock CE; Morris JC; Enjeti AK; Verrills NM, 2020, 'Shwachman–Bodian–Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia', Leukemia, 34, http://dx.doi.org/10.1038/s41375-020-0814-0

Collison AM; Li J; De Siqueira AP; Lv X; Toop HD; Morris JC; Starkey MR; Hansbro PM; Zhang J; Mattes J, 2019, 'TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis', BMC Pulmonary Medicine, 19, pp. 31, http://dx.doi.org/10.1186/s12890-019-0786-x

Nair PM; Starkey MR; Haw TJ; Liu G; Collison AM; Mattes J; Wark PA; Morris JC; Verrills NM; Clark AR; Ammit AJ; Hansbro PM, 2019, 'Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease', Clinical and Translational Immunology, 8, pp. e01084, http://dx.doi.org/10.1002/cti2.1084

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Tzelepis K; De Braekeleer E; Aspris D; Barbieri I; Vijayabaskar MS; Liu WH; Gozdecka M; Metzakopian E; Toop HD; Dudek M; Robson SC; Hermida-Prado F; Yang YH; Babaei-Jadidi R; Garyfallos DA; Ponstingl H; Dias JML; Gallipoli P; Seiler M; Buonamici S; Vick B; Bannister AJ; Rad R; Prinjha RK; Marioni JC; Huntly B; Batson J; Morris JC; Pina C; Bradley A; Jeremias I; Bates DO; Yusa K; Kouzarides T; Vassiliou GS, 2018, 'SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4', Nature Communications, 9, pp. 5378, http://dx.doi.org/10.1038/s41467-018-07620-0

Nair PM; Starkey MR; Haw TJ; Liu G; Horvat JC; Morris JC; Verrills NM; Clark AR; Ammit AJ; Hansbro PM, 2017, 'Targeting PP2A and proteasome activity ameliorates features of allergic airway disease in mice', Allergy: European Journal of Allergy and Clinical Immunology, 72, pp. 1891 - 1903, http://dx.doi.org/10.1111/all.13212

Batson J; Toop H; Daubney J; Liddell S; Stewart E; Bourne J; Blackley Z; Morris J; Bates DO, 2017, 'Optimisation of novel small molecule inhibitors of SRPK1-mediated VEGF-A splicing through modelling of permeability properties required for trans-scleral eye drop delivery', ACTA OPHTHALMOLOGICA, 95, http://dx.doi.org/10.1111/j.1755-3768.2017.02612

Liddell S; Toop H; Stewart E; Daubney J; Bourne J; Batson J; Morris J; Bates D, 2017, 'Optimisation of potent topical SRPK1 inhibitors with improved retinal pharmacokinetics through ex vivo trans-scleral permeability modelling', ACTA OPHTHALMOLOGICA, 95, http://dx.doi.org/10.1111/j.1755-3768.2017.0F081

Toop HD; Brusnahan JS; Morris JC, 2017, 'Concise Total Synthesis of Dioncophylline E through an ortho-Arylation Strategy', Angewandte Chemie - International Edition, 56, pp. 8536 - 8538, http://dx.doi.org/10.1002/anie.201701136

Maiocchi SL; Morris JC; Rees MD; Thomas SR, 2017, 'Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents', Biochemical Pharmacology, 135, pp. 90 - 115, http://dx.doi.org/10.1016/j.bcp.2017.03.016

Li Y; Zhou T; Wang Y; Ning C; Lv Z; Han G; Morris JC; Taylor EN; Wang R; Xiao H; Hou C; Ma Y; Shen B; Feng J; Guo R; Li Y; Chen G, 2017, 'The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation', Oncogene, 36, pp. 3760 - 3771, http://dx.doi.org/10.1038/onc.2017.2

Batson J; Toop HD; Redondo C; Babaei-Jadidi R; Chaikuad A; Wearmouth SF; Gibbons B; Allen C; Tallant C; Zhang J; Du C; Hancox JC; Hawtrey T; Da Rocha J; Griffith R; Knapp S; Bates DO; Morris JC, 2017, 'Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease', ACS Chemical Biology, 12, pp. 825 - 832, http://dx.doi.org/10.1021/acschembio.6b01048

Bates DO; Morris JC; Oltean S; Donaldson LF, 2017, 'Pharmacology of modulators of alternative splicing', Pharmacological Reviews, 69, pp. 63 - 79, http://dx.doi.org/10.1124/pr.115.011239

Rahman MM; Prünte L; Lebender LF; Patel BS; Gelissen I; Hansbro PM; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2016, 'The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells', Scientific Reports, 6, pp. 37297, http://dx.doi.org/10.1038/srep37297

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'Concise Synthesis of Dictyoquinazol A via a Dimerisation-Cyclocondensation Sequence', Synlett, 27, pp. 1237 - 1240, http://dx.doi.org/10.1055/s-0035-1561569

Rahman MM; Rumzhum NN; Hansbro PM; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2016, 'Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells', Cellular Signalling, 28, pp. 325 - 334, http://dx.doi.org/10.1016/j.cellsig.2016.01.009

Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, 24, pp. 1480 - 1487, http://dx.doi.org/10.1016/j.bmc.2016.02.016

Smith AM; Dun MD; Lee EM; Harrison C; Kahl R; Flanagan H; Panicker N; Mashkani B; Don AS; Morris J; Toop H; Lock RB; Powell JA; Thomas D; Guthridge MA; Moore A; Ashman LK; Skelding KA; Enjeti A; Verrills NM, 2016, 'Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors', Oncotarget, 7, pp. 47465 - 47478, http://dx.doi.org/10.18632/oncotarget.10167

Toop HD; Dun MD; Ross BK; Flanagan HM; Verrills NM; Morris JC, 2016, 'Development of novel PP2A activators for use in the treatment of acute myeloid leukaemia', Organic and Biomolecular Chemistry, 14, pp. 4605 - 4616, http://dx.doi.org/10.1039/c6ob00556j

Wangsahardja J; Marcolin GM; Lizarme Y; Morris JC; Hunter L, 2016, 'ChemInform Abstract: Concise Synthesis of Dictyoquinazol A via a Dimerisation—Cyclocondensation Sequence.', ChemInform, 47, http://dx.doi.org/10.1002/chin.201640213

Batson J; Toop HD; Allen C; Rowlinson J; Babaei‐Jadidi R; Gibbons B; Zhang J; Wearmouth SF; Knapp S; Morris JC; Bates DO, 2016, 'Trans‐scleral delivery of novel anti‐angiogenic small molecule inhibitors of SRPK1', Acta Ophthalmologica, 94, http://dx.doi.org/10.1111/j.1755-3768.2016.0702

Toop HD; Don AS; Morris JC, 2015, 'Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors', Organic and Biomolecular Chemistry, 13, pp. 11593 - 11596, http://dx.doi.org/10.1039/c5ob01931a

Li JJ; Tay HL; Maltby S; Xiang Y; Eyers F; Hatchwell L; Zhou H; Toop HD; Morris JC; Nair P; Mattes J; Foster PS; Yang M, 2015, 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity', Journal of Allergy and Clinical Immunology, 136, pp. 462 - 473, http://dx.doi.org/10.1016/j.jaci.2014.11.044

Rahman MM; Rumzhum NN; Morris JC; Clark AR; Verrills NM; Ammit AJ, 2015, 'Basal protein phosphatase 2A activity restrains cytokine expression: Role for MAPKs and tristetraprolin', Scientific Reports, 5, http://dx.doi.org/10.1038/srep10063

Batson J; Toop H; Rowlinson J; Allen C; Gibbons B; Zhang J; Wearmouth S; Knapp S; Morris J; Bates D, 2015, 'SRPK1 inhibitors as novel anti‐angiogenic therapeutics for wet age‐related macular degeneration (wAMD)', Acta Ophthalmologica, 93, http://dx.doi.org/10.1111/j.1755-3768.2015.0435

Rowlinson J; Batson J; Toop H; Allen C; Gibbons B; Babaei‐Jadidi R; Zhang J; Wearmouth S; Knapp S; Morris J; Bates D, 2015, 'Novel SRPK1 inhibitors specifically target alternative splicing in human primary retinal epithelial cells', Acta Ophthalmologica, 93, http://dx.doi.org/10.1111/j.1755-3768.2015.0625

Bruce MI; Burgun A; Jevric M; Morris JC; Nicholson BK; Parker CR; Scoleri N; Skelton BW; Zaitseva NN, 2014, 'Some cyclic ligands obtained from reactions of polycyanocarbon-metal complexes Dedicated to our friend and colleague Claude Lapinte on his 65th birthday, in recognition of his extensive contributions to organo-iron chemistry.', Journal of Organometallic Chemistry, 756, pp. 68 - 78, http://dx.doi.org/10.1016/j.jorganchem.2013.12.038

Walker SR; Czyz ML; Morris JC, 2014, 'Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction', Organic Letters, 16, pp. 708 - 711, http://dx.doi.org/10.1021/ol403390m

Hatchwell L; Girkin J; Dun MD; Morten M; Verrills N; Toop HD; Morris JC; Johnston SL; Foster PS; Collison A; Mattes J, 2014, 'Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A', Journal of Allergy and Clinical Immunology, 133, pp. 1720 - 1727, http://dx.doi.org/10.1016/j.jaci.2013.11.014

Antony S; Morris JC; Bell TDM; Brown T; Spiccia L; Harris HH, 2014, 'The H.G. Smith award article: Fluorescent analogues of NAMI-A: Synthesis, characterisation, fluorescent properties, and preliminary biological studies in human lung cancer cells', Australian Journal of Chemistry, 67, pp. 1711 - 1717, http://dx.doi.org/10.1071/CH14205

Collison A; Li J; Pereira De Siqueira A; Zhang J; Toop HD; Morris JC; Foster PS; Mattes J, 2014, 'Tumor necrosis factor-related apoptosis-inducing ligand regulates hallmark features of airways remodeling in allergic airways disease', American Journal of Respiratory Cell and Molecular Biology, 51, pp. 86 - 93, http://dx.doi.org/10.1165/rcmb.2013-0490OC

Southam DC; Shand B; Buntine MA; Kable SH; Read JR; Morris JC, 2013, 'The timing of an experiment in the laboratory program is crucial for the student laboratory experience: Acylation of ferrocene as a case study', Chemistry Education Research and Practice, 14, pp. 476 - 484, http://dx.doi.org/10.1039/c3rp00011g

Morris JC, 2013, 'Marine natural products: Synthetic aspects', Natural Product Reports, 30, pp. 783 - 805, http://dx.doi.org/10.1039/c3np20116c

Collison A; Hatchwell L; Verrils N; Wark PA; de Siqueira AP; Tooze M; Carpenter H; Don AS; Morris JC; Zimmermann N; Bartlett NW; Rothenberg NE; Johnston SL; Foster PS; Mattes J, 2013, 'The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity', Nature Medicine, 19, pp. 232 - 237, http://dx.doi.org/10.1038/nm.3049

Bloch WM; Derwent‐Smith SM; Issa F; Morris JC; Rendina LM; Sumby CJ, 2012, 'ChemInform Abstract: Fused Pyrazino[2,3‐b]indolizine and Indolizino[2,3‐b]quinoxaline Derivatives: Synthesis, Structures, and Properties.', ChemInform, 43, http://dx.doi.org/10.1002/chin.201231183

Kim HJ; Qiao Q; Toop HD; Morris JC; Don AS, 2012, 'A fluorescent assay for ceramide synthase activity', Journal of Lipid Research, 53, pp. 1701 - 1707

Bruce M; Morris JC; Skelton BW; White AH; Zaitseva NN, 2011, 'A percyanovinylidene-ruthenium complex, Ru{=C=C5(CN)3[=C(CN)2]2}(dppe)Cp*', Organometallics, 30, pp. 653

Armitt DJ; Bruce MI; Morris JC; Nicholson BK; Parker CR; Skelton BW; Zaitseva N, 2011, 'Bis(metallaethynyl) ketones: Synthesis and structure of {(Ph 3P)AuCC}2CO and attempted transmetalation: Formation and structure of [1,3-{Ru(dppe)Cp}2{ c -COC(OMe)CHCCH}] PF6', Organometallics, 30, pp. 5452 - 5456, http://dx.doi.org/10.1021/om200659t

Bloch WM; Derwent-smith SM; Issa F; Morris JC; Rendina LM; Sumby C, 2011, 'Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties', Tetrahedron, 67, pp. 9368 - 9375, http://dx.doi.org/10.1016/j.tet.2011.09.133

Morris JC; Phillips A, 2011, 'Marine Natural Products: Synthetic Aspects', Natural Product Reports, 28, pp. 269 - 289, http://dx.doi.org/10.1039/C0NP00066C

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