By Professor Laurent Billot

Preprints

He Z; Yu F; Cro S; Billot L, 2026, Rapid evaluation and calibration of Bayesian group sequential designs via conjugate-mixture semi-simulation, http://dx.doi.org/10.48550/arxiv.2607.22900

Orué A; Dinart D; Billot L; Bellera C; Rondeau V, 2026, Empirical comparison of win ratio and joint frailty models for recurrent event endpoints with applications in oncology and cardiology, http://dx.doi.org/10.48550/arxiv.2512.13629

He Z; Yu F; Cro S; Billot L, 2026, From aggressive to conservative early stopping in Bayesian group sequential designs, http://dx.doi.org/10.48550/arxiv.2601.10590

Billot L; Coggan S; Fan L; Perkovic V; Yu XQ; Badve SV; Jardine M; Ning T; Chen W; Monaghan H; Chen M; He Z; Ma G; Kotwal S; Wong MG, 2026, Statistical Analysis Plan for the Aspiring to Reduce Events in Dialysis Trial (ASPIRED), http://dx.doi.org/10.64898/2026.01.12.26343774

He Z; Cro S; Billot L, 2025, Optimal scheduling of interim analyses in group sequential trials, http://dx.doi.org/10.48550/arxiv.2509.05537

Ghosh A; Rastogi A; Billot L; Thout SR; Hirst J; Praveen D; Votruba N; Majumdar S, 2025, A cluster randomised trial of a complex intervention to reduce anaemia and cardiometabolic risk during pregnancy and in the first year following birth in women living in rural India, http://dx.doi.org/10.1101/2025.06.30.25330566

Devaux A; Li Q; Billot L; Venkatesh B; Ramanan M, 2025, Balanced Electrolyte solution versus Saline Trial for Diabetic KetoAcidosis-Statistical Analysis Plan, http://dx.doi.org/10.1101/2025.10.26.25337451

Billot L; Shan S; Rodgers A; Anderson C; Bliss R, 2025, Statistical analysis plan for the TRIDENT trial, http://dx.doi.org/10.1101/2025.08.24.25334319

Shan S; Billot L; Ferreira M, 2025, Text Message intervention to improve function in people with low back pain (TEXT4myBACK): Statistical Analysis Plan, http://dx.doi.org/10.1101/2025.06.03.25328920

Ghosh A; Billot L; Yatirajula SK; Thornicroft G; Maulik P, 2024, Statistical Analysis Plan for Adolescents’ Resilience and Treatment Needs for Mental health in Indian Slums (ARTEMIS) study: a cluster randomized trial, http://dx.doi.org/10.31219/osf.io/fr2sv

Chen C; Ouyang M; Ong S; Zhang L; Zhang G; Delcourt C; Mair G; Liu L; Billot L; Li Q; Chen X; Parsons M; Broderick J; Demchuk A; Bath P; Donnan G; Levi C; Chalmers J; Lindley R; Martins S; Pontes-Neto O; Venturelli PM; Olavarría V; Lavados P; Robinson T; Wardlaw J; Li G; Wang X; Song L; Anderson C; Investigators ENCHANTED, 2023, Effects of Intensive Blood Pressure Lowering on Cerebral Ischaemia in Thrombolysed Patients: Insights from the Enchanted Trial, http://dx.doi.org/10.2139/ssrn.4314023

Ghosh A; Billot L; Daniel M; Maulik P; Peiris D, 2022, Statistical Analysis Plan for the SMART Mental Health study, http://dx.doi.org/10.31219/osf.io/96w5c

Yatirajula SK; Kallakuri S; Paslawar S; Mukherjee A; Bhattacharya A; Chatterjee S; Sagar R; Kumar A; Lempp H; Raman U; Singh R; Essue B; Billot L; Peiris D; Norton R; Thornicroft G; Maulik P, 2022, An intervention to reduce stigma and improve management of depression, risk of suicide/self-harm and other significant emotional or medically unexplained complaints among adolescents living in urban slums: protocol for the ARTEMIS project, http://dx.doi.org/10.21203/rs.3.rs-1550030/v1

Billot L; Cuthbertson B; Finfer S; Goodman F; Gordon A; Myburgh J; Seppelt I, 2021, SuDDICU Protocol, http://dx.doi.org/10.31219/osf.io/324me

Billot L; Myburgh J; Goodman F; Finfer S; Seppelt I; Gordon A; Cuthbertson B, 2020, Statistical Analysis Plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit (SuDDICU) study, http://dx.doi.org/10.31219/osf.io/bd7t4

Billot L; Finfer S; Micallef S, 2020, Statistical Analysis Plan for the Plasma-Lyte 148® versUs Saline Study (PLUS) trial, http://dx.doi.org/10.31219/osf.io/8gk3n

Li X; Duolikun N; Cheng F; Billot L; Jia W; Zhang P, 2020, Road to Hierarchical Diabetes Management at Primary Care (ROADMAP) Study in China: Protocol for the Statistical Analysis of a Cluster Randomized Controlled Trial (Preprint), http://dx.doi.org/10.2196/preprints.18333

Billot L; Serhal S; Armour C, 2020, Pharmacy Trial Program – Asthma and Rhinitis Control (PTP-ARC) trial: Statistical Analysis Plan, http://dx.doi.org/10.31219/osf.io/mjzrn

Hankey G; Hackett ML; Almeida OP; Flicker L; Mead GE; Dennis MS; Etherton-Beer C; Ford AH; Billot L; Jan S; Lundström E; Anderson CS; Thang-Nguyen H; Gommans J; Yi Q, 2020, Effects of Fluoxetine on Functional Recovery after Acute Stroke (AFFINITY): A Randomised, Double-Blind, Placebo-Controlled Trial, http://dx.doi.org/10.2139/ssrn.3559565

Billot L; Coombs D; Machado GC; Maher C, 2019, Sydney Health Partners Emergency Department (SHaPED) trial - Statistical Analysis Plan, http://dx.doi.org/10.31219/osf.io/9g6cx

Hirst JE; Votruba N; Billot L; Arora V; Thout SR; Peiris D; Patel A; Norton R; Mullins E; Sharma A; Kennedy S; Jha V; Praveen D, A community-based intervention to improve screening, referral, and follow-up of non-communicable diseases and anaemia amongst pregnant and postpartum women in rural India: study protocol for a cluster randomised trial, http://dx.doi.org/10.21203/rs.3.rs-2938523/v1

Shan S; Billot L; Du X; Dong J; Anderson C, A hospital-based cluster-randomized controlled trial of free influenza vaccination before hospital discharge compared to routine care in patients with heart failure (PANDA II): Statistical Analysis Plan, http://dx.doi.org/10.1101/2024.12.20.24319430

Nagraj S; Kennedy S; Jha V; Norton R; Hinton L; Billot L; Rajan E; Mohammed Abdul A; Phalswal A; Arora V; Praveen D; Hirst J, A Mobile Clinical Decision Support System for High-Risk Pregnant Women in Rural India (SMARThealth Pregnancy): Pilot Cluster Randomized Controlled Trial (Preprint), http://dx.doi.org/10.2196/preprints.44362

Melman A; Teng MJ; Coombs DM; Li Q; Billot L; Lung T; Rogan E; Marabani M; Hutchings O; Maher CG; Machado GC, A Virtual Hospital Model of Care for Low Back Pain, Back@Home: Protocol for a Hybrid Effectiveness-Implementation Type-I Study (Preprint), http://dx.doi.org/10.2196/preprints.50146

Kumar A; Venkatesh B; Finfer S; Delaney A; Thompson K; Middleton PM; Aneman A; Shetty K; Bhonagiri D; Saxena M; Haren FMPV; Bradford C; Reece G; Rodda S; Mackellar C; Bass F; Tsang L; Li S; Kwok R; Buckley A; Zou A; Sridha S; Hu D; Iskandar M; Frost S; Headington T; Connor G; Klironomos A; Shan S; Li Y; Anderson B; Sidoli R; Inskip D; Lam M; Fuller G; Yu C; Sigurdson B; McNulty R; Sadeghpour M; Billot L; Hammond N, Accuracy of the modified Global Burden of Disease International Classification of Diseases coding methods for identifying sepsis: A prospective multicentre cohort study, http://dx.doi.org/10.21203/rs.3.rs-6198956/v1

Yang Z; Jones C; Billot L; Shan S; Devaux A; Day R; Hamilton M; Koes B; Latimer J; Maher C; McLachlan A; McLachlan H; Webb M; Lin C, Complier average causal effect (CACE) of oxycodone/naloxone for acute spinal pain: a reanalysis the OPAL trial data ------A Protocol, http://dx.doi.org/10.31219/osf.io/pb647

Melman A; Teng MJ; Coombs DM; Li Q; Billot L; Lung T; Rogan E; Marabani M; Hutchings O; Maher CG; Machado GC, Correction: A Virtual Hospital Model of Care for Low Back Pain, Back@Home: Protocol for a Hybrid Effectiveness-Implementation Type-I Study (Preprint), http://dx.doi.org/10.2196/preprints.60298

Chen C; Ouyang M; Delcourt C; Song L; Billot L; Anderson CS, Effect of blood pressure control on cerebral infarction in the Enhanced Control of Hypertension and Thrombolysis Stroke (ENCHANTED) study: statistical analysis plan, http://dx.doi.org/10.31219/osf.io/8v3b9

Redfern J; Hafiz N; Tu Q; Knight A; Hespe C; Chow CK; Briffa T; Gallagher R; Reid CM; Hare D; Manandi D; Zwar N; Woodward M; Jan S; Atkins ER; Laba T-L; Halcomb E; Billot L; Usherwood T; Hyun K, Effectiveness of data-driven quality improvement on hospitalizations and health outcomes for people with coronary heart disease in primary care (QUEL): a cluster randomised controlled trial with 24-month follow-up, http://dx.doi.org/10.1101/2025.06.12.25329537

Shan S; Billot L; Machado G; Maher C, Effectiveness of primary-contact physiotherapy in managing musculoskeletal conditions in emergency departments: Statistical analysis plan for the RESHAP-ED randomised controlled trial, http://dx.doi.org/10.1101/2025.11.06.25339640

Gamble AR; Ferreira GE; Maher CG; Anderson DB; Hutton JM; de Campos TF; MacPherson S; Han CS; Sawan M; Harris I; Adie S; Hassett L; Legg C; Van Gelder J; Halliday M; Boogs M; Charteris R; Williams C; Billot L; Fullwood D; Riley-Gibson E; Molineux E; Tambree K; Tchan M; Sharma S; Zadro JR, Experience-Based Co-Design of the Virtual Physiotherapist-led Evaluation of Referrals for spine surgery (VIPER) model of care: study protocol, http://dx.doi.org/10.1101/2025.10.15.25338120

Shanthakumar M; Billot L; Ferreira M, HEalth literacy in Low back Pain – the HELP! media intervention study: A stepped wedge cluster randomised trial, http://dx.doi.org/10.64898/2025.12.11.25342096

Wang X; Ren X; Li Q; Ouyang M; Chen C; Delcourt C; Chen X; Wang J; Robinson T; Arima H; Ma L; Hu X; You C; Li G; Yang J; Lin Y; Billot L; Muñoz-Venturelli P; Martins S; Pontes-Neto OM; Liu L; Chalmers J; Song L; Anderson CS; Investigators TI, Optimizing blood pressure in acute intracerebral hemorrhage: protocol for a prospective individual participant data meta-analysis of the four INTERACT trials, http://dx.doi.org/10.1101/2025.03.03.25323285

Young P; Devaux A; Li Q; Billot L; Davis J; Delaney A; Finfer S; Hammond N; Micallef S; Seppelt I; Venkatesh B; Myburgh JA, Selective digestive tract decontamination in critically ill adults with acute brain injuries: a Post-Hoc analysis of a Randomized Clinical Trial., http://dx.doi.org/10.21203/rs.3.rs-3412001/v1

de Campos TF; Gamble AR; Ferreira GE; Maher CG; Anderson DB; Hutton JM; MacPherson S; Han CS; Sawan M; Harris I; Adie S; Hassett L; Legg C; Van Gelder J; Halliday M; Boogs M; Charteris R; Williams C; Billot L; Fullwood D; Riley-Gibson E; Molineux E; Tambree K; Tchan M; Sharma S; Haynes A; Moujalli J; Wong E; Zadro JR, Stakeholder perceptions of the VIrtual Physiotherapist-led Evaluation of low back pain Referrals to spine surgeons (VIPER) model of care: a qualitative study, http://dx.doi.org/10.1101/2025.10.29.25338508

Liu X; Billot L; Devaux A; Maher C; Lin C; Day RO; Ivers R; Underwood M; McLachlan AJ; Richards B; Finnerup NB; Taing C; Tong K; Jamshidi M; Hassan M; Hamilton M; Atkins E; Ferreira G, Statistical Analysis Plan (SAP) – DREAM: an adaptive, randomised, placebo-controlled trial of duloxetine for reducing leg pain in people with chronic sciatica, http://dx.doi.org/10.64898/2026.07.12.26357883

Lin X; Jiang C; Wang Z; Arima H; Wang X; Billot L; Neal B; Rodgers A; Hillis GS; Patel A; Biostat QLM; Dong J; Du X; Ma C; Anderson CS, Statistical Analysis Plan (SAP): A randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: the CRAFT trial, http://dx.doi.org/10.1101/2025.06.19.25329849

Liu X; Teng MJ; Billot L; Maher C; Zadro J; Traeger A, Statistical Analysis Plan for RECITAL: a non-inferiority randomised control trial evaluating a virtual fracture clinic compared with in-person care for people with simple fractures, http://dx.doi.org/10.1101/2025.08.07.25333243

Billot L; Gore J; Atherton J; Berry C; Brachmann J; Ganesan A; Hillis G; Jung W; Prasad S; Selvanayagam J, Statistical Analysis Plan for the Cardiac Magnetic Resonance GUIDEd Management of Mild-moderate Left Ventricular Systolic Dysfunction (CMR GUIDE) trial, http://dx.doi.org/10.64898/2026.01.13.26344019

Herbert R; Billot L; Harvey L, Statistical Analysis Plan for the Early & Intensive SCI-MT Trial, http://dx.doi.org/10.31219/osf.io/ms4ef

Billot L; Venkatesh B; Finfer S; Cohen J; Rajbhandari D; Myburgh J; Walsham J, Statistical Analysis Plan for the Fludrocortisone Dose Response Relationship in Septic Shock (FluDReSS) trial, http://dx.doi.org/10.31219/osf.io/hb6f5

Ghosh A; Bhattacharya A; Jha V; Vijayaraghavan BKT; Bassi A; Rajbhandari D; Donaldson L; Billot L; Kunigari M; Hammond N; John O; Joshi R; Myatra SN; Arfin S; Venkatesh B, Statistical Analysis Plan for the HydrOxychloroquine Prophylaxis Evaluation (HOPE) trial, http://dx.doi.org/10.31219/osf.io/uw3ed

Billot L; Chen C; Song L; Lin Y; Liu F; Chen X; Arima H; Bath PM; Ford GA; Robinson T; Sandset EC; Saver JL; Sprigg N; van der Worp B; Yang J; Li G; Anderson CS, Statistical Analysis Plan for the INTEnsive ambulance-delivered blood pressure Reduction in hyper-Acute stroke Trial (INTERACT4), http://dx.doi.org/10.31219/osf.io/qj6u8

Billot L; Song L; Hu X; Ma L; Ouyang M; Chen X; You C; Anderson CS, Statistical Analysis Plan for the INTEnsive care bundle with blood pressure Reduction in Acute Cerebral haemorrhage Trial (INTERACT3), http://dx.doi.org/10.31219/osf.io/m54jc

Billot L; O'Connor D; Maguire B; Schram D; Ma R; Buchbinder R; Maher C; McCaffery K; Traeger A; Albarqouni L; Gorelik A, Statistical Analysis Plan for the MSK DI AF trial, http://dx.doi.org/10.31219/osf.io/prnd2

Billot L; Bompoint S; Ouyang M; Xu L; Wang X; Malavera A; Johnson B; Summers D; Khatri P; Muñoz-Venturelli P; Day D; Sui Y; Song L; Zaidi WAW; Thang NH; Delcourt C; Robinson T; Jan S; Lindley RI; Urrutia VC; Anderson CS, Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST), http://dx.doi.org/10.1101/2024.12.17.24319094

Billot L; Song L; Yang P; Liu J; Anderson CS, Statistical Analysis Plan for the second ENhanced Control of Hypertension And Thrombectomy strokE stuDy (ENCHANTED2), http://dx.doi.org/10.31219/osf.io/qkwn9

Billot L; Monaghan H; Wong MG; Perkovic V, Statistical Analysis Plan for the Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING), http://dx.doi.org/10.31219/osf.io/d7qrw

Billot L; Wong MG; De Vriese A; Collister D; Flahault A; Mushahar L; Ramachandran R; Skhiri H; Shaman A; Menne J; Gallagher M, Statistical Analysis Plan for the Treatment of Cardiovascular disease with low dose Rivaroxaban in Advanced CKD (TRACK) trial, http://dx.doi.org/10.1101/2025.11.25.25340065

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