Proteomics (the global analysis of proteins in biological systems) and its application to biomedical research, including the discovery of biomarkers in human disease.
In 1994, Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics (4,000+ copies sold). This, and a series of other seminal works, substantially contributed to the establishment of the proteome and of proteome research. Proteomics is the most widely adopted of the new -omics, is now included in biochemistry textbooks and the undergraduate...view more
In 1994, Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics (4,000+ copies sold). This, and a series of other seminal works, substantially contributed to the establishment of the proteome and of proteome research. Proteomics is the most widely adopted of the new -omics, is now included in biochemistry textbooks and the undergraduate curriculum.
Marc has published >130 peer-reviewed research papers, review papers and book chapters and has edited 2 books. Marc's research has tackled many of the key issues in proteomics. A particular strength has been the capacity to combine large-scale analytical techniques with complex bioinformatics to open new avenues for biological investigation. Current research interests are (i) the role of protein methylation in the proteome (ii) the dynamics of protein interaction networks and (iii) the analysis of next-generation sequencing data. You can find Marc's publications and citations here.
Marc directs two centres at UNSW: the NSW Systems Biology Initiative (http://www.systemsbiology.org.au/) and the Ramaciotti Centre for Gene Function Analysis (http://www.ramaciotti.unsw.edu.au/). These centres are funded by NCRIS, EIF Super Science, ARC LIEF and the NSW State Government Science Leveraging Fund.
Marc co-founded Proteome Systems Pty Ltd in 1999. Recently renamed to Tyrian Diagnostics, this proteomic diagnostics company is listed on the Australian Securities Exchange and has developed technology for rapid point-of-care diagnostic testing . Marc is also a co-founder and non-executive Director of Regeneus Pty Ltd, a privately held regenerative medicine company which uses autologous adult stem cells to treat a range of musculoskeletal disorders.
- 2011 - Director, Ramaciotti Centre for Gene Function Analysis
- 2008 - Director, NSW Systems Biology Initiative
- 2004 - Head of Proteomics, Proteome Systems Limited
- 1999 - Vice President Bioinformatics, Proteome Systems Limited
Honours & Awards
- ASBMB Beckman Coulter Discovery Science Award 2012 for distinguished contributions to the field of biochemistry and molecular biology.
- Elected as Council Member of the Human Proteome Organisation (HUPO) 2009-2011, 2011-2014.
- Senior Editor of Proteomics (2004-).
- Editorial board member of Bioinformatics and Biology Insights, Clincal Proteomics and systems biology journals including Bioinformatics and Biology Insights, Journal of Clinical Bioinformatic Science, Journal of Integrated Omics, Computer Science & Systems Biology Research. Previously served on the editorial board of Electrophoresis (1998-2000).
- Member of Advisory Boards of ARC Bioinformatics Centre of Excellence (2004-), NHMRC Australian Proteomics Computational Facility (2006-), Ramaciotti Centre for Gene Function Analysis (2007-), UNSW Analytical Centre (2007-), Macquarie University Centre of Research Expertise in Biomolecular Frontiers (2010-), Victorian Life Science Computational Initiative (2010-).
- Member of the Australian Government's Expert Task Force for Bioinformatics (2003-2005).
We have recently built the first protein 'methylation network' for any species. This project will study the dynamics of this network during the cell cycle and will identify protein complexes which have methylation-associated interactions. This will help us to understand the regulation, or 'control logic', of protein methylation. The study will be the most comprehensive analysis of protein methylation to date, and will shed new light on how and when this widespread modification exerts its effects.
The 'interactome', being the interactions of all proteins in the cell, has been intensively studied in yeast. However, we know very little about how the interactions of most proteins are regulated. In this study, we will test if protein methylation is a central means of regulating protein interactions. We will first screen the yeast proteome for protein methylation. We will use this information, and interactions from databases, to build the first methylation network for any cell. Finally, we will use two-hybrid analysis to test how methylation controls the interactions of proteins in this…