Researcher

Professor Marc Wilkins

My Expertise

Proteomics (the global analysis of proteins in biological systems) and its application in biomedical research with particular interests in protein methylation and protein-protein interaction networks. 

Genomics, including emerging technology, and use in biomedical research. 

Molecular systems biology using the bioinformatics of proteomics, transcriptomics and networks. 

 

Biography

Research Contribution

In 1994, Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics (4,000+ copies sold). This, and a series of other seminal works, substantially contributed to the establishment of the proteome and of proteome research. Proteomics is now widely adopted, is included in biochemistry textbooks and is part of the undergraduate curriculum.

Marc has...view more

Research Contribution

In 1994, Marc Wilkins developed the concept of the proteome and coined the term. In 1997 he co-wrote and co-edited the first book on proteomics (4,000+ copies sold). This, and a series of other seminal works, substantially contributed to the establishment of the proteome and of proteome research. Proteomics is now widely adopted, is included in biochemistry textbooks and is part of the undergraduate curriculum.

Marc has published >200 peer-reviewed research papers, review papers and book chapters and has edited 2 books.  Marc's research has tackled many of the key issues in proteomics. A particular strength has been the capacity to combine large-scale analytical techniques with complex bioinformatics to open new avenues for biological investigation. Current research interests are (i) the role of protein methylation in the proteome (ii) the dynamics of protein interaction networks, studied with crosslinking mass spectrometry. Marc is also an active researcher in genomics and transcriptomics, where his extended team has technical expertise in next-generation sequencing and the bioinformatic analysis of resulting data. Recent highlights include the koala genome project. You can find all Marc's publications and citations here.

Marc directs two centres at UNSW: the NSW Systems Biology Initiative and the Ramaciotti Centre for Genomics. These centres are or have been funded by NCRIS, EIF Super Science, ARC LIEF and the NSW State Government SLF and RAAP schemes. 

Marc co-founded Proteome Systems Pty Ltd in 1999. Recently renamed to Tyrian Diagnostics, this proteomic diagnostics company was listed on the Australian Securities Exchange (ASX) and has developed technology for rapid point-of-care diagnostic testing . Marc is also a co-founder of Regeneus Pty Ltd, a regenerative medicine company which uses autologous adult stem cells to treat a range of musculoskeletal disorders. This company was listed on the ASX in 2013. 

Professional Experience

  • 2016 - Executive Management, Genomics, Bioplatforms Australia 
  • 2011 - Director, Ramaciotti Centre for Genomics
  • 2008 - Director, NSW Systems Biology Initiative
  • 2005 - Professor of Systems Biology, UNSW
  • 1999 - 2005 Vice President Bioinformatics then Head of Proteomics, Proteome Systems Limited

Honours & Awards

  • Awarded a Doctor of Science (D. Sc.) in October 2017 for outstanding contributions to research in proteomics, post-translational modifications and protein interaction networks.
  • ASBMB Beckman Coulter Discovery Science Award 2012 for distinguished contributions to the field of biochemistry and molecular biology.
  • Elected as Council Member of the Human Proteome Organisation (HUPO) 2009-2011, 2011-2014, 2015-2018, 2019-2021.
  • Senior Editor of Proteomics (2004-2013).
  • Member of the Scientific Advisory Boards of the Integrated Materials Design Centre (IMDC, 2015-2017), EMBL Australia Bioinformatics Advisory Committee (2011-2015), Victorian Life Science Computational Initiative (VLSCI) (2009-2015), the Macquarie University Biomolecular Frontiers Centre of Research
    Excellence (2009-), the NHMRC Australian Proteomics Computational Facility (APCF) (2007-2011) and the ARC Centre of Excellence in Bioinformatics (2006-2011). 
  • Contributions to policy in NSW State Government on the NSW Health Genomics Strategy (2018, 2019), the Australian National Genomics Policy framework (2017), New Zealand Government genomics research strategy (2017) and member of the Australian Government's Expert Task Force for Bioinformatics (2003-2005).

My Research Supervision


Areas of supervision

Wet lab - proteomics of protein methylation, regulation of histone and non-histone protein methyltransferases, proteome-scale crosslinking mass spectrometry for network generation, large-scale monitoring of changes in protein-protein interactions via crosslinking mass spectrometry

Dry lab - bioinformatics tool development for proteomics, bioinformatics of next-generation sequencing (genome assembly, transcriptomics)


Currently supervising

Always interested to have enthusiastic students join the lab!

Previous lab members include 25 honours students (including 5 who won the UNSW University Medal), 12 PhD students and 5 Masters by Research students 


My Teaching

Coordinator of BIOC3111. Teaching into 7 other undergraduate courses. 

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Location

Room 2112, Building E26
Biological Sciences South


Map reference (Google map)

Contact

(+61 2) 9385 3633
(+61 2) 9385 1483