Select Publications
Conference Papers
, 2022, 'Establishment and application of patient-derived xenograft models for personalised medicine in paediatric cancer', Sydney, presented at Children’s Cancer Institute - Research Symposium 2022, Sydney, 06 December 2022
, 2022, 'MULTI-PLATFORM TYROSINE KINASE PROFILING REVEALS NOVEL ACTIONABLE FGFR ABERRATIONS ACROSS PEDIATRIC AND ADOLESCENT AND YOUNG ADULT SARCOMAS', Vancouver, Canada, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting 2022, Vancouver, Canada, 17 November 2022
, 2021, 'Supporting clinical decision-making for PI3K/AKT/mTOR inhibitors for high-risk paediatric and adolescent and young adult (AYA) sarcoma', Virtual, presented at The Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Annual Scientific Meeting, Virtual, 24 June 2021
, 2021, 'Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR', in Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR, American Association for Cancer Research (AACR), PA, Philadelphia, pp. 639 - 639, presented at AACR 2021, PA, Philadelphia, 10 April 2021 - 21 May 2021, http://dx.doi.org/10.1158/1538-7445.AM2021-639
, 2020, 'POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 289 - 290, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100066&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2020, 'TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, pp. 292 - 292, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100077&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2020, 'Supporting clinical decision-making for PI3K/AKT/MTOR inhibitors for high-risk paediatric and AYA sarcoma', Virtual, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting 2020, Virtual, 18 November 2020
, 2020, 'Supporting clinical decision-making for PI3K/AKT/MTOR inhibitors for high-risk paediatric sarcoma patients', Virtual, presented at KCA Symposium 2020, Virtual, 17 September 2020
, 2020, 'Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in Cancer Research, American Association for Cancer Research (AACR), pp. ia13 - ia13, http://dx.doi.org/10.1158/1538-7445.pedca19-ia13
, 2020, 'Precision medicine for high-risk paediatric and AYA sarcomas', Lorne, presented at Lorne Cancer 2020, Lorne, 13 February 2020
, 2019, 'Personalised medicine for high-risk paediatric and AYA sarcoma patients', Tokyo, Japan, presented at Connective Tissue Oncology Society (CTOS) Annual Meeting, Tokyo, Japan, 13 November 2019, https://www.ctos.org/Portals/0/PDF/2019%20CTOS%20Final%20Program.pdf
, 2019, 'Precision medicine for high-risk paediatric and AYA sarcomas', Sydney, presented at Kids Cancer Alliance - Annual Meeting, Sydney, 31 October 2019, https://kca.org.au/wp-content/uploads/2019/11/2019-ECR-and-Student-Event-Program.pdf
, 2019, 'Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation', in Cancer Research, American Association for Cancer Research (AACR), pp. 2616 - 2616, http://dx.doi.org/10.1158/1538-7445.am2019-2616
, 2019, 'Abstract 2616: A novel iron-chelating agent reduces MYC transcription via E2F gene family regulation', American Association for Cancer Research (AACR), pp. 2616 - 2616, presented at Molecular and Cellular Biology / Genetics, http://dx.doi.org/10.1158/1538-7445.sabcs18-2616
, 2019, 'Abstract 3659: Alyref is a novel binding partner and co-factor for MYCN-driven oncogenesis in neuroblastoma', American Association for Cancer Research (AACR), pp. 3659 - 3659, presented at Tumor Biology, http://dx.doi.org/10.1158/1538-7445.sabcs18-3659
, 2019, 'Abstract 3809: Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells', in Cancer Research, American Association for Cancer Research (AACR), pp. 3809 - 3809, http://dx.doi.org/10.1158/1538-7445.am2019-3809
, 2019, 'Abstract 3809: Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells', American Association for Cancer Research (AACR), pp. 3809 - 3809, presented at Experimental and Molecular Therapeutics, http://dx.doi.org/10.1158/1538-7445.sabcs18-3809
, 2018, 'Chromatin destabilization by CBL0137 and panobinostat leads to complete tumour regression of childhood neuroblastoma in immunocompetent transgenic mice', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, IRELAND, Dublin, pp. E25 - E25, presented at 30th EORTC-NCI-AACR Symposium, IRELAND, Dublin, 13 November 2018 - 16 November 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000461258600045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2018, 'Abstract 2453: Eradication of neuroblastoma by suppressing the expression of a single noncoding RNA', in Cancer Research, American Association for Cancer Research (AACR), pp. 2453 - 2453, http://dx.doi.org/10.1158/1538-7445.am2018-2453
, 2017, 'Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia', in Cancer Research, American Association for Cancer Research (AACR), pp. 1175 - 1175, http://dx.doi.org/10.1158/1538-7445.am2017-1175
, 2017, 'Abstract 1956: ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression', in Cancer Research, American Association for Cancer Research (AACR), pp. 1956 - 1956, http://dx.doi.org/10.1158/1538-7445.am2017-1956
, 2017, 'Abstract 2006: AMX-513 polyamine depletion therapy inhibits tumor growth and reverses immunosuppression in cancers including MYC-driven neuroblastoma and pancreatic cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 2006 - 2006, http://dx.doi.org/10.1158/1538-7445.am2017-2006
, 2017, 'Abstract 4883: Targeting tumor-amplified ODC1 with difluoromethylornithine (DFMO) inhibits global protein translation and has antitumor activity in neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 4883 - 4883, http://dx.doi.org/10.1158/1538-7445.am2017-4883
, 2017, 'Abstract 4056: A modulator of multidrug resistance protein 1 selectively depletes glutathione and synergizes with L-buthionine sulfoximine to sensitize MRP1-expressing cancer cells to chemotherapy', in Cancer Research, American Association for Cancer Research (AACR), DC, Washington, pp. 4056 - 4056, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), DC, Washington, 01 April 2017 - 05 April 2017, http://dx.doi.org/10.1158/1538-7445.am2017-4056
, 2016, 'Abstract 1340: Dextran-Catechin conjugate: An anticancer nano-modified natural compound targeting copper metabolism in neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 1340 - 1340, http://dx.doi.org/10.1158/1538-7445.am2016-1340
, 2016, 'Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis', in Cancer Research, American Association for Cancer Research (AACR), pp. 2450 - 2450, http://dx.doi.org/10.1158/1538-7445.am2016-2450
, 2016, 'Targeting PA2G4, a novel MYCN co-factor, for the treatment of neuroblastoma', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, pp. S7 - S7, http://dx.doi.org/10.1016/S0959-8049(16)61016-X
, 2016, 'COMBINATION OF EPIGENETIC MODIFIERS CBL0137 AND PANOBINOSTAT IS HIGHLY POTENT IN VITRO AND IN VIVO FOR DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, ENGLAND, Liverpool, pp. 51 - 51, presented at 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), ENGLAND, Liverpool, 12 June 2016 - 15 June 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379749000196&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2016, 'Abstract 51: Molecular profiling of relapsed childhood cancer', in Clinical Cancer Research, American Association for Cancer Research (AACR), pp. 51 - 51, http://dx.doi.org/10.1158/1557-3265.pmsclingen15-51
, 2015, 'Abstract 313: Examining the role of ABCA1 cholesterol transporter in ovarian cancer spheroids', in Cancer Research, American Association for Cancer Research (AACR), pp. 313 - 313, http://dx.doi.org/10.1158/1538-7445.am2015-313
, 2015, 'Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes', in Cancer Research, American Association for Cancer Research (AACR), pp. 488 - 488, http://dx.doi.org/10.1158/1538-7445.am2015-488
, 2015, 'Abstract 962: PA2G4 predicts poor prognosis in neuroblastoma patients and promotes neuroblastoma progression by enhancing MYCN protein stability', in Cancer Research, American Association for Cancer Research (AACR), pp. 962 - 962, http://dx.doi.org/10.1158/1538-7445.am2015-962
, 2015, 'MYCN and is a therapeutic target in neuroblastoma', in MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, CA, La Jolla, presented at AACR Special Conference on Myc - From Biology to Therapy, CA, La Jolla, 07 January 2015 - 10 January 2015, http://dx.doi.org/10.1158/1557-3125,MYC15-PRO9
, 2015, 'ASSOCIATION OF ABCA1 CHOLESTEROL TRANSPORTER WITH POOR OUTCOME AND AGGRESSIVE PHENOTYPE IN SEROUS OVARIAN CANCER', in Asia-Pacific Journal of Clinical Oncology, WILEY-BLACKWELL, pp. 114 - 114
, 2014, 'NOVEL STRATEGIES TO TARGET THE C5 SUBCLASS OF HIGH-GRADE SEROUS OVARIAN CANCER (HGSC) USING PATIENT-DERIVED XENOGRAFTS.', in INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, LIPPINCOTT WILLIAMS & WILKINS, pp. 1018 - 1019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344966501301&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2014, 'TARGETING MITOCHONDRIA AND CELL METABOLISM AS A NOVEL THERAPEUTIC APPROACH IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, SINGAPORE, Singapore, pp. 47 - 47, presented at 16th International Symposium on Pediatric Neuro-Oncology (ISPNO), SINGAPORE, Singapore, 28 June 2014 - 02 July 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337924200179&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2014, '422 CBL0137, a novel NFkB suppressor and p53 activator, is highly effective in pre-clinical models of neuroblastoma', in European Journal of Cancer, Elsevier, pp. 135, http://dx.doi.org/10.1016/s0959-8049(14)70548-9
, 2013, 'TARGETING MITOCHONDRIA AND METABOLISM AS A NOVEL THERAPEUTIC APPROACH IN THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, FL, Fort Lauderdale, pp. 21 - 21, presented at 2nd Annual Pediatric Neuro-Oncology Basic and Translational Research Conference, FL, Fort Lauderdale, 16 May 2013 - 17 May 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318570500078&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
, 2013, 'Abstract 2759: Anticancer compound curaxin CBL0137, that simultaneously suppresses NF-κB and activates p53, is highly effective in two independent mouse models of neuroblastoma.', in Cancer Research, American Association for Cancer Research (AACR), pp. 2759 - 2759, http://dx.doi.org/10.1158/1538-7445.am2013-2759
, 2013, 'Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.', in Cancer Research, American Association for Cancer Research (AACR), pp. 3808 - 3808, http://dx.doi.org/10.1158/1538-7445.am2013-3808
, 2013, 'Abstract 5043: The facilitates chromatin transcription (FACT) protein complex promotes neuroblastoma tumor initiation.', in Cancer Research, American Association for Cancer Research (AACR), pp. 5043 - 5043, http://dx.doi.org/10.1158/1538-7445.am2013-5043
, 2012, 'Abstract 1834: Targeting ABC transporters in cancer through small molecule inhibitors', in Cancer Research, American Association for Cancer Research (AACR), pp. 1834 - 1834, http://dx.doi.org/10.1158/1538-7445.am2012-1834
, 2012, 'Abstract 789: GSTP1 expression is regulated by MycN and is a marker of poor outcome in childhood neuroblastoma', in Cancer Research, American Association for Cancer Research (AACR), pp. 789 - 789, http://dx.doi.org/10.1158/1538-7445.am2012-789
, 2011, 'A multi-stage genome-wide association study on response to chemotherapy in ovarian cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2011-4679
, 2011, 'Abstract 1660: Cholesterol efflux transporter gene expression predicts clinical outcome in serous ovarian cancer', in Cancer Research, American Association for Cancer Research (AACR), pp. 1660 - 1660, http://dx.doi.org/10.1158/1538-7445.am2011-1660
, 2011, 'Abstract 617: Small molecule that simultaneously inhibits Myc oncoprotein and activates HIF1A', in Cancer Research, American Association for Cancer Research (AACR), pp. 617 - 617, http://dx.doi.org/10.1158/1538-7445.am2011-617
, 2011, 'Abstract 954: ABCC/MRP multidrug transporters contribute to neuroblastoma biology, pathogenesis and clinical outcome, independently of any role in cytotoxic drug efflux', in Cancer Research, American Association for Cancer Research (AACR), pp. 954 - 954, http://dx.doi.org/10.1158/1538-7445.am2011-954
, 2011, 'Abstract LB-367: New evidence supports the potential use of methotrexate in children with MYCN -amplified neuroblastoma.', in Cancer Research, American Association for Cancer Research (AACR), pp. lb-367-lb-367, http://dx.doi.org/10.1158/1538-7445.am2011-lb-367
, 2010, 'Abstract 4869: Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', in Cancer Research, American Association for Cancer Research (AACR), pp. 4869 - 4869, http://dx.doi.org/10.1158/1538-7445.am10-4869
, 2010, 'Abstract 888: Reduced folate carrier gene polymorphism (RFC 80G>A): Associations with clinical outcome in NMYC amplified neuroblastoma patients', in Cancer Research, American Association for Cancer Research (AACR), pp. 888 - 888, http://dx.doi.org/10.1158/1538-7445.am10-888