By Professor Nigel Turner

Journal articles

Liu M; Hancock SE; Sultani G; Wilkins BP; Ding E; Osborne B; Quek LE; Turner N, 2019, 'Snail-overexpression induces epithelialmesenchymal transition and metabolic reprogramming in human pancreatic ductal adenocarcinoma and non-tumorigenic ductal cells', Journal of Clinical Medicine, 8, http://dx.doi.org/10.3390/jcm8060822

Somers K; Wen VW; Middlemiss SMC; Osborne B; Forgham H; Jung MS; Karsa M; Clifton M; Bongers A; Gao J; Mayoh C; Raoufi-Rad N; Kusnadi EP; Hannan KM; Scott DA; Kwek A; Liu B; Flemming C; Chudakova DA; Pandher R; Failes TW; Lim J; Angeli A; Osterman AL; Imamura T; Kees UR; Supuran CT; Pearson RB; Hannan RD; Davis TP; McCarroll J; Kavallaris M; Turner N; Gudkov AV; Haber M; Norris MD; Henderson MJ, 2019, 'A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction', Oncogene, 38, pp. 3824 - 3842, http://dx.doi.org/10.1038/s41388-018-0666-5

Metcalfe LK; Smith GC; Turner N, 2019, 'Defining lipid mediators of insulin resistance: controversies and challenges', JOURNAL OF MOLECULAR ENDOCRINOLOGY, 62, pp. R65 - R82, http://dx.doi.org/10.1530/JME-18-0023

Metcalfe LK; Shepherd PR; Smith GC; Turner N, 2019, 'Metabolic characterisation of knock-in mice harbouring the ‘obesity variant’ of CREBRF', Obesity Research & Clinical Practice, 13, pp. 288 - 288, http://dx.doi.org/10.1016/j.orcp.2018.11.154

Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165, http://dx.doi.org/10.1038/s41467-018-05613-7

Bakshi I; Brown SHJ; Brandon AE; Suryana E; Mitchell TW; Turner N; Cooney GJ, 2018, 'Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-32354-w

Bentley NL; Fiveash CE; Osborne B; Quek LE; Ogura M; Inagaki N; Cooney GJ; Polly P; Montgomery MK; Turner N, 2018, 'Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice', Biochemical and Biophysical Research Communications, 503, pp. 1349 - 1355, http://dx.doi.org/10.1016/j.bbrc.2018.07.047

Du X; Turner N; Yang H, 2018, 'The role of oxysterol-binding protein and its related proteins in cancer', Seminars in Cell and Developmental Biology, 81, pp. 149 - 153, http://dx.doi.org/10.1016/j.semcdb.2017.07.017

Small L; Brandon AE; Quek LE; Krycer JR; James DE; Turner N; Cooney GJ, 2018, 'Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E258 - E266, http://dx.doi.org/10.1152/ajpendo.00386.2017

van Geldermalsen M; Quek LE; Turner N; Freidman N; Pang A; Guan YF; Krycer JR; Ryan R; Wang Q; Holst J, 2018, 'Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways', BMC Cancer, 18, pp. 689, http://dx.doi.org/10.1186/s12885-018-4599-8

Bakshi I; Suryana E; Small L; Quek LE; Brandon AE; Turner N; Cooney GJ, 2018, 'Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle', Journal of Endocrinology, 237, pp. 101 - 111, http://dx.doi.org/10.1530/JOE-17-0555

Shum AMY; Poljak A; Bentley NL; Turner N; Tan TC; Polly P, 2018, 'Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: Alterations in sarcomeric and mitochondrial protein expression', Oncotarget, 9, pp. 22001 - 22022, http://dx.doi.org/10.18632/oncotarget.25146

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20, http://dx.doi.org/10.1016/j.cell.2018.02.008

Holt LJ; Brandon AE; Small L; Suryana E; Preston E; Wilks D; Mokbel N; Coles CA; White JD; Turner N; Daly RJ; Cooney GJ, 2018, 'Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice', Endocrinology, 159, pp. 1339 - 1351, http://dx.doi.org/10.1210/en.2017-00851

Small L; Brandon AE; Turner N; Cooney GJ, 2018, 'Modeling insulin resistance in rodents by alterations in diet: What have high-fat and high-calorie diets revealed?', American Journal of Physiology - Endocrinology and Metabolism, 314, pp. E251 - E265, http://dx.doi.org/10.1152/ajpendo.00337.2017

Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism', Cell Reports, 21, pp. 3536 - 3547, http://dx.doi.org/10.1016/j.celrep.2017.11.085

Montgomery MK; Brown SHJ; Mitchell TW; Coster ACF; Cooney GJ; Turner N, 2017, 'Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains', Scientific Reports, 7, pp. 13914, http://dx.doi.org/10.1038/s41598-017-14214-1

Sultani G; Samsudeen AF; Osborne B; Turner N, 2017, 'NAD⁺: A key metabolic regulator with great therapeutic potential', Journal of Neuroendocrinology, 29, http://dx.doi.org/10.1111/jne.12508

Wang D; Opperhuizen AL; Reznick J; Turner N; Su Y; Cooney GJ; Kalsbeek A, 2017, 'Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus', Brain Research, 1671, pp. 93 - 101, http://dx.doi.org/10.1016/j.brainres.2017.07.006

Smith GC, 2017, 'FOX01 Is the Headline Akt Regulating Hepatic Glucose Metabolism', Endocrinology

Houweling PJ; Berman YD; Turner N; Quinlan KGR; Seto JT; Yang N; Lek M; MacArthur DG; Cooney G; North KN, 2017, 'Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans', International Journal of Obesity, 41, pp. 1154 - 1157, http://dx.doi.org/10.1038/ijo.2017.72

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689, http://dx.doi.org/10.1038/ncomms14689

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, 7, pp. 40159, http://dx.doi.org/10.1038/srep40159

Hardie R-A; van Dam E; Cowley M; Han T-L; Balaban S; Pajic M; Pinese M; Iconomou M; Shearer RF; McKenna J; Miller D; Waddell N; Pearson JV; Grimmond SM; Australian Pancreatic Cancer Genome Initiative ; Sazanov L; Biankin AV; Villas-Boas S; Hoy AJ; Turner N; Saunders DN; Hardie R, 2017, 'Mitochondrial mutations and metabolic adaptation in pancreatic cancer', Cancer & Metabolism, 5, pp. 2, http://dx.doi.org/10.1186/s40170-017-0164-1

Montgomery MK; Brown SHJ; Lim XY; Fiveash CE; Osborne B; Bentley NL; Braude JP; Mitchell TW; Coster ACF; Don AS; Cooney GJ; Schmitz-Peiffer C; Turner N, 2016, 'Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 1828 - 1839, http://dx.doi.org/10.1016/j.bbalip.2016.08.016

Osborne B; Bentley NL; Montgomery MK; Turner N, 2016, 'The role of mitochondrial sirtuins in health and disease', Free Radical Biology and Medicine, 100, pp. 164 - 174, http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.197

Parker AL; Turner N; McCarroll JA; Kavallaris M, 2016, 'βIII-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells', Carcinogenesis, 37, pp. 787 - 798, http://dx.doi.org/10.1093/carcin/bgw058

Couttas TA; Kain N; Suchowerska AK; Quek LE; Turner N; Fath T; Garner B; Don AS, 2016, 'Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease', Neurobiology of Aging, 43, pp. 89 - 100, http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.027

Turner N; Zeng XY; Osborne B; Rogers S; Ye JM, 2016, 'Repurposing Drugs to Target the Diabetes Epidemic', Trends in Pharmacological Sciences, 37, pp. 379 - 389, http://dx.doi.org/10.1016/j.tips.2016.01.007

Quek LE; Liu M; Joshi S; Turner N, 2016, 'Fast exchange fluxes around the pyruvate node: A leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment', Cancer and Metabolism, 4, http://dx.doi.org/10.1186/s40170-016-0153-9

Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2^-/- mice', Journal of Endocrinology, 228, pp. 127 - 134, http://dx.doi.org/10.1530/JOE-15-0444

Liu M; Quek L-E; Sultani G; Turner N, 2016, 'Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma', Cancer & Metabolism, 4, pp. 19, http://dx.doi.org/10.1186/s40170-016-0160-x

Montgomery MK; Fiveash CE; Braude JP; Osborne B; Brown SHJ; Mitchell TW; Turner N, 2015, 'Disparate metabolic response to fructose feeding between different mouse strains', Scientific Reports, 5, http://dx.doi.org/10.1038/srep18474

Le Couteur DG; Tay SS; Solon-Biet S; Bertolino P; McMahon AC; Cogger VC; Colakoglu F; Warren A; Holmes AJ; Pichaud N; Horan M; Correa C; Melvin RG; Turner N; O. Ballard JW; Ruohonen K; Raubenheimer D; Simpson SJ, 2015, 'The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 70, pp. 1499 - 1507, http://dx.doi.org/10.1093/gerona/glu196

Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253, http://dx.doi.org/10.1042/BJ20150602

Turner N; Robker RL, 2015, 'Developmental programming of obesity and insulin resistance: Does mitochondrial dysfunction in oocytes play a role?', Molecular Human Reproduction, 21, pp. 23 - 30, http://dx.doi.org/10.1093/molehr/gau042

Brandon AE; Tid-Ang J; Wright LE; Stuart E; Suryana E; Bentley N; Turner N; Cooney GJ; Ruderman NB; Kraegen EW, 2015, 'Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance', PLoS ONE, 10, http://dx.doi.org/10.1371/journal.pone.0121959

Turner N; Robker RL, 2015, 'Developmental programming of obesity and insulin resistance: does mitochondrial dysfunction in oocytes play a role?', Molecular Human Reproduction, 21, pp. 23 - 30

Joshi S; Liu M; Turner N, 2015, 'Diabetes and its link with cancer: Providing the fuel and spark to launch an aggressive growth regime', BioMed Research International, 2015, http://dx.doi.org/10.1155/2015/390863

Montgomery MK; Turner N, 2015, 'Mitochondrial dysfunction and insulin resistance: An update', Endocrine Connections, 4, pp. r1 - r15, http://dx.doi.org/10.1530/EC-14-0092

Liu M; Montgomery MK; Fiveash CE; Osborne B; Cooney GJ; Bell-Anderson K; Turner N, 2014, 'PPARα -independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis', Scientific Reports, 4, http://dx.doi.org/10.1038/srep05538

Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, 3, pp. 465 - 473, http://dx.doi.org/10.1016/j.molmet.2014.02.005

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, 19, pp. 418 - 430, http://dx.doi.org/10.1016/j.cmet.2014.02.009

Sullivan K; El-hoss J; Quinlan KGR; Deo N; Garton F; Seto JTC; Gdalevitch M; Turner N; Cooney GJ; Kolanczyk M; North KN; Little DG; Schindeler A, 2014, 'NF1 is a critical regulator of muscle development and metabolism', Human Molecular Genetics, 23, pp. 1250 - 1259, http://dx.doi.org/10.1093/hmg/ddt515

Barbour JA; Turner N, 2014, 'Mitochondrial stress signaling promotes cellular adaptations', International Journal of Cell Biology, http://dx.doi.org/10.1155/2014/156020

Girgis CM; Clifton-Bligh RJ; Turner N; Lau SL; Gunton JE, 2014, 'Effects of vitamin D in skeletal muscle: Falls, strength, athletic performance and insulin sensitivity', Clinical Endocrinology, 80, pp. 169 - 181, http://dx.doi.org/10.1111/cen.12368

Turner N; Cooney GJ; Kraegen EW; Bruce CR, 2014, 'Fatty acid metabolism, energy expenditure and insulin resistance in muscle', Journal of Endocrinology, 220, http://dx.doi.org/10.1530/JOE-13-0397

Osborne B; Cooney GJ; Turner N, 2014, 'Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?', Biochimica et Biophysica Acta - General Subjects, 1840, pp. 1295 - 1302, http://dx.doi.org/10.1016/j.bbagen.2013.08.016

Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, 3, pp. 419 - 431, http://dx.doi.org/10.1016/j.molmet.2014.02.004

Mokbel N; Hoffman NJ; Girgis CM; Small L; Turner N; Daly RJ; Cooney GJ; Holt LJ, 2014, 'Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation', Journal of Cellular Physiology, 229, pp. 1753 - 1764, http://dx.doi.org/10.1002/jcp.24628

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