By Professor Paul De Souza

Journal articles

Elias MG; Aputen AD; Fatima S; Mann TJ; Karan S; Mikhael M; de Souza P; Gordon CP; Scott KF; Aldrich-Wright JR, 2024, 'Chemotherapeutic Potential of Chlorambucil-Platinum(IV) Prodrugs against Cisplatin-Resistant Colorectal Cancer Cells', International Journal of Molecular Sciences, 25, http://dx.doi.org/10.3390/ijms25158252

Elias MG; Fatima S; Mann TJ; Karan S; Mikhael M; de Souza P; Gordon CP; Scott KF; Aldrich-Wright JR, 2024, 'Anticancer Effect of Pt^IIPHENSS, Pt^II5MESS, Pt^II56MESS and Their Platinum(IV)-Dihydroxy Derivatives against Triple-Negative Breast Cancer and Cisplatin-Resistant Colorectal Cancer', Cancers, 16, http://dx.doi.org/10.3390/cancers16142544

Redwood L; Saarinen K; Ivers R; Garne D; de Souza P; Bonney A; Rhee J; Mullan J; Thomas SJ, 2024, 'Alcohol consumption and health-related quality of life in regional, rural and metropolitan Australia: analysis of cross-sectional data from the Community Health and Rural/Regional Medicine (CHARM) study', Quality of Life Research, 33, pp. 349 - 360, http://dx.doi.org/10.1007/s11136-023-03522-x

Grebstad Tune B; Sareen H; Powter B; Kahana-Edwin S; Cooper A; Koh ES; Lee CS; Po JW; McCowage G; Dexter M; Cain L; O’Neill G; Prior V; Karpelowsky J; Tsoli M; Baumbusch LO; Ziegler D; Roberts TL; DeSouza P; Becker TM; Ma Y, 2023, 'From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients', Biomedicines, 11, http://dx.doi.org/10.3390/biomedicines11112907

Lim SH; Chua W; Ng W; Ip E; Marques TM; Tran NT; Gama-Carvalho M; Asghari R; Henderson C; Ma Y; de Souza P; Spring KJ, 2023, 'Circulating Tumour Cell Associated MicroRNA Profiles Change during Chemoradiation and Are Predictive of Response in Locally Advanced Rectal Cancer', Cancers, 15, http://dx.doi.org/10.3390/cancers15164184

Gao B; Voskoboynik M; Cooper A; Wilkinson K; Hoon S; Hsieh CY; Cai S; Tian YE; Bao J; Ma N; Wang C; Zhang M; Li B; Guo M; Zhou R; Wang X; Xu C; de Souza P, 2023, 'A phase 1 dose-escalation study of the poly(ADP-ribose) polymerase inhibitor senaparib in Australian patients with advanced solid tumors', Cancer, 129, pp. 1041 - 1050, http://dx.doi.org/10.1002/cncr.34662

Gano C; Fatima S; Failes T; Arndt G; Sajinovic M; Mahns D; Saedisomeolia A; Coorssen J; Bucci J; DeSouza P; Vafaee F; Scott K, 2023, 'Anti-cancer potential of synergistic phytochemical combinations is influenced by the genetic profiles of prostate cancer cell lines', Frontiers in Nutrition, http://dx.doi.org/10.3389/fnut.2023.1119274

Hnit SST; Yao M; Xie C; Bi L; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2022, 'Apigenin impedes cell cycle progression at G2 phase in prostate cancer cells', Discover Oncology, 13, pp. 44, http://dx.doi.org/10.1007/s12672-022-00505-1

Khan T; Lock JG; Ma Y; Harman DG; de Souza P; Chua W; Balakrishnar B; Scott KF; Becker TM, 2022, 'Choice of antibody is critical for specific and sensitive detection of androgen receptor splice variant-7 in circulating tumor cells', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-20079-w

de Souza PL; Aslan P; Clark W; Nour R; de Silva S, 2022, 'RESIRT: A Phase 1 Study of Selective Internal Radiation Therapy Using Yttrium-90 Resin Microspheres in Patients With Primary Renal Cell Carcinoma', Clinical Genitourinary Cancer, 20, pp. 442 - 451, http://dx.doi.org/10.1016/j.clgc.2022.05.006

Sareen H; Ma Y; Becker TM; Roberts TL; de Souza P; Powter B, 2022, 'Molecular Biomarkers in Glioblastoma: A Systematic Review and Meta-Analysis', International journal of molecular sciences, 23, http://dx.doi.org/10.3390/ijms23168835

Jeffreys SA; Becker TM; Khan S; Soon P; Neubauer H; de Souza P; Powter B, 2022, 'Prognostic and Predictive Value of CCND1/Cyclin D1 Amplification in Breast Cancer With a Focus on Postmenopausal Patients: A Systematic Review and Meta-Analysis', Frontiers in Endocrinology, 13, http://dx.doi.org/10.3389/fendo.2022.895729

Fatima S; Ma Y; Safrachi A; Haider S; Spring KJ; Vafaee F; Scott KF; Roberts TL; Becker TM; de Souza P, 2022, 'Harnessing Liquid Biopsies to Guide Immune Checkpoint Inhibitor Therapy', Cancers, 14, http://dx.doi.org/10.3390/cancers14071669

Khan T; Becker TM; Scott KF; Descallar J; de Souza P; Chua W; Ma Y, 2022, 'Prognostic and Predictive Value of Liquid Biopsy-Derived Androgen Receptor Variant 7 (AR-V7) in Prostate Cancer: A Systematic Review and Meta-Analysis', Frontiers in Oncology, 12, http://dx.doi.org/10.3389/fonc.2022.868031

Young FP; Becker TM; Nimir M; Opperman T; Chua W; Balakrishnar B; de Souza P; Ma Y, 2022, 'Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR', Journal of Clinical Medicine, 11, http://dx.doi.org/10.3390/jcm11010257

Rottey S; Clarke J; Aung K; Machiels JP; Markman B; Heinhuis KM; Millward M; Lolkema M; Patel SP; De Souza P; Duca M; Curigliano G; Santoro A; Koyama T; Brown M; Vezina H; He C; Siu-Chung Chu Q, 2022, 'Phase I/IIa Trial of BMS-986148, an Anti-mesothelin Antibody-drug Conjugate, Alone or in Combination with Nivolumab in Patients with Advanced Solid Tumors', Clinical Cancer Research, 28, pp. 95 - 105, http://dx.doi.org/10.1158/1078-0432.CCR-21-1181

Lai HC; Ho UY; James A; De Souza P; Roberts TL, 2022, 'RNA metabolism and links to inflammatory regulation and disease', Cellular and Molecular Life Sciences, 79, http://dx.doi.org/10.1007/s00018-021-04073-5

Scott KF; Mann TJ; Fatima S; Sajinovic M; Razdan A; Kim RR; Cooper A; Roohullah A; Bryant KJ; Gamage KK; Harman DG; Vafaee F; Graham GG; Church WB; Russell PJ; Dong Q; de Souza P, 2021, 'Human group iia phospholipase A2 —three decades on from its discovery', Molecules, 26, http://dx.doi.org/10.3390/molecules26237267

Lee DH; Roohullah A; Cho BC; Lemech C; de Souza P; Millward M; Choi J; Park KE; Lee M; Kim Y; Park S; Lee J; Kim J; Shin YK; Han J-Y, 2021, 'Phase I dose-escalation study to evaluate safety and clinical activity of c-MET inhibitor ABN401 in patients with advanced solid tumor', ANNALS OF ONCOLOGY, 32, pp. S1029 - S1030, http://dx.doi.org/10.1016/j.annonc.2021.08.1958

Hnit SST; Ding R; Bi L; Xie C; Yao M; De Souza P; Xu L; Li Z; Dong Q, 2021, 'Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest', Biomedicine and Pharmacotherapy, 141, http://dx.doi.org/10.1016/j.biopha.2021.111795

Piha-Paul SA; Thein KZ; De Souza P; Kefford R; Gangadhar T; Smith C; Schuster S; Zamboni WC; Dees CE; Markman B, 2021, 'First‐in‐human, phase I/IIa study of CRLX301, a nanoparticle drug conjugate containing docetaxel, in patients with advanced or metastatic solid malignancies', Investigational New Drugs, 39, pp. 1047 - 1056, http://dx.doi.org/10.1007/s10637-021-01081-x

Garrett C; Becker TM; Lynch D; Po J; Xuan W; Scott KF; De Souza P, 2021, 'Comparison of neutrophil to lymphocyte ratio and prognostic nutritional index with other clinical and molecular biomarkers for prediction of glioblastoma multiforme outcome', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0252614

Roohullah A; Ganju V; Zhang F; Zhang L; Yu T; Wilkinson K; Cooper A; de Souza P, 2021, 'First-in-human phase 1 dose escalation study of HX009, a novel recombinant humanized anti-PD-1 and CD47 bispecific antibody, in patients with advanced malignancies.', JOURNAL OF CLINICAL ONCOLOGY, 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.2517

Lee DH; Roohullah A; Cho BC; Lemech CR; de Souza PL; Millward M; Choi JY; Park KE; Lee M; Kim Y; Shin Y; Han J-Y, 2021, 'Trial in progress: A phase 1-2 multicenter, open-label, dose-escalation and dose-expansion study to evaluate the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of ABN401 in patients with advanced solid tumors.', JOURNAL OF CLINICAL ONCOLOGY, 39, http://dx.doi.org/10.1200/JCO.2021.39.15_suppl.TPS3157

Ardern-Holmes S; White C; Bahure S; So S; McCowage G; Hovey E; Troon S; De Souza P; Simes J; Slancar M; Dexter M; Wong M, 2021, 'The Effect of Bevacizumab on Vestibular Schwannoma Related to Neurofibromatosis Type 2', Australasian Journal of Neuroscience, 31, pp. 5 - 14, http://dx.doi.org/10.21307/ajon-2021-002

Powter B; Jeffreys SA; Sareen H; Cooper A; Brungs D; Po J; Roberts T; Koh ES; Scott KF; Sajinovic M; Vessey JY; de Souza P; Becker TM, 2021, 'Human TERT promoter mutations as a prognostic biomarker in glioma', Journal of Cancer Research and Clinical Oncology, 147, pp. 1007 - 1017, http://dx.doi.org/10.1007/s00432-021-03536-3

Ding PN; Roberts TL; Chua W; Becker TM; Caixeiro N; de Souza P; Gao B; Lee CK; Itchins M; Westman H; Clarke S; Blinman P; Kao S; John T; Leal JL; Bray VJ, 2021, 'Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib', Translational Lung Cancer Research, 10, pp. 1623 - 1634, http://dx.doi.org/10.21037/tlcr-20-1125

Lai HC; James A; Luff J; De Souza P; Quek H; Ho U; Lavin MF; Roberts TL, 2021, 'Regulation of RNA degradation pathways during the lipopolysaccharide response in Macrophages', Journal of Leukocyte Biology, 109, pp. 593 - 603, http://dx.doi.org/10.1002/JLB.2AB0420-151RR

Nabil WNN; Xi Z; Song Z; Jin L; Zhang XD; Zhou H; De Souza P; Dong Q; Xu H, 2021, 'Towards a framework for better understanding of quiescent cancer cells', Cells, 10, pp. 1 - 19, http://dx.doi.org/10.3390/cells10030562

Cameron B; Webber K; Li H; Bennett BK; Boyle F; de Souza P; Wilcken N; Lynch J; Friedlander M; Goldstein D; Lloyd AR, 2021, 'Genetic associations of fatigue and other symptoms following breast cancer treatment: A prospective study', Brain, Behavior, and Immunity - Health, 10, pp. 100189, http://dx.doi.org/10.1016/j.bbih.2020.100189

Razdan A; Main NM; Chiu V; Shackel NA; de Souza P; Bryant K; Scott KF, 2021, 'Targeting the eicosanoid pathway in hepatocellular carcinoma', AMERICAN JOURNAL OF CANCER RESEARCH, 11, pp. 2456 - 2476, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000667209700006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Jeffreys SA; Powter B; Balakrishnar B; Mok K; Soon P; Franken A; Neubauer H; Souza PD; Becker TM, 2020, 'Endocrine resistance in breast cancer: The role of estrogen receptor stability', Cells, 9, pp. 1 - 23, http://dx.doi.org/10.3390/cells9092077

Broom A; Parker R; Raymond S; Kirby E; Lewis S; Kokanović R; Adams J; de Souza P; Woodland L; Wyld D; Lwin Z; Koh ES, 2020, 'The (Co)Production of Difference in the Care of Patients With Cancer From Migrant Backgrounds', Qualitative Health Research, 30, pp. 1619 - 1631, http://dx.doi.org/10.1177/1049732320930699

Ackland SP; Michael M; de Souza P; Martin JH; Clarke SJ; Francis K; Karapetis CS; Gurney H, 2020, 'Science and art of anticancer drug dosing: nine steps to personalised therapy', Internal Medicine Journal, 50, pp. 992 - 996, http://dx.doi.org/10.1111/imj.14948

Reardon DA; Brandes AA; Omuro A; Mulholland P; Lim M; Wick A; Baehring J; Ahluwalia MS; Roth P; Bähr O; Phuphanich S; Sepulveda JM; De Souza P; Sahebjam S; Carleton M; Tatsuoka K; Taitt C; Zwirtes R; Sampson J; Weller M, 2020, 'Effect of Nivolumab vs Bevacizumab in Patients with Recurrent Glioblastoma: The CheckMate 143 Phase 3 Randomized Clinical Trial', JAMA Oncology, 6, pp. 1003 - 1010, http://dx.doi.org/10.1001/jamaoncol.2020.1024

Sareen H; Garrett C; Lynch D; Powter B; Brungs D; Cooper A; Po J; Koh ES; Vessey JY; McKechnie S; Bazina R; Sheridan M; van Gelder J; Darwish B; Jaeger M; Roberts TL; De Souza P; Becker TM, 2020, 'The role of liquid biopsies in detecting molecular tumor biomarkers in brain cancer patients', Cancers, 12, pp. 1 - 16, http://dx.doi.org/10.3390/cancers12071831

de Souza PL; Capp AL; Chikhladze N; Mezvrishvili Z; Messina M; Mautner G, 2020, 'Phase I study of a novel S1P inhibitor, NOX66, in combination with radiotherapy in patients with metastatic castration-resistant prostate cancer.', Journal of Clinical Oncology, 38, pp. 5533 - 5533, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.5533

Lynch D; Powter B; Po JW; Cooper A; Garrett C; Koh ES; Sheridan M; van Gelder J; Darwish B; Mckechnie S; Bazina R; Jaeger M; Roberts TL; de Souza P; Becker TM, 2020, 'Isolation of circulating tumor cells from glioblastoma patients by direct immunomagnetic targeting', Applied Sciences (Switzerland), 10, http://dx.doi.org/10.3390/app10093338

Wimmer M; Zauner R; Ablinger M; Pinõ´ n-Hofbauer J; Guttmann-Gruber C; Reisenberger M; Lettner T; Niklas N; Proell J; Sajinovic M; De Souza P; Hainzl S; Kocher T; Murauer EM; Bauer JW; Strunk D; Reichelt J; Mellick AS; Wally V, 2020, 'A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas', Cell Communication and Signaling, 18, http://dx.doi.org/10.1186/s12964-020-00550-9

Hnit SST; Yao M; Xie C; Ge G; Bi L; Jin S; Jiao L; Xu L; Long L; Nie H; Jin Y; Rogers L; Suchowerska N; Wong M; Liu T; De Souza P; Li Z; Dong Q, 2020, 'Transcriptional regulation of G2/M regulatory proteins and perturbation of G2/M Cell cycle transition by a traditional Chinese medicine recipe', Journal of Ethnopharmacology, 251, pp. 112526, http://dx.doi.org/10.1016/j.jep.2019.112526

Ho V; Chung L; Singh A; Lea V; Abubakar A; Lim SH; Chua W; Ng W; Lee M; Roberts TL; de Souza P; Lee CS, 2020, 'Aberrant expression of RAD52, its prognostic impact in rectal cancer and association with poor survival of patients', International Journal of Molecular Sciences, 21, http://dx.doi.org/10.3390/ijms21051768

Toh JWT; Lim SH; Mackenzie S; de Souza P; Bokey L; Chapuis P; Spring KJ, 2020, 'Association between microsatellite instability status and peri-operative release of circulating tumour cells in colorectal cancer', Cells, 9, http://dx.doi.org/10.3390/cells9020425

Bi L; Xie C; Jiao L; Jin S; Hnit SST; Mu Y; Wang Y; Wang Q; Ge G; Wang Y; Zhao X; Shi X; Kang Y; De Souza P; Liu T; Zhou J; Xu L; Dong Q, 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, 24, pp. 2229 - 2239, http://dx.doi.org/10.1111/jcmm.14897

Kato H; de Souza P; Kim SW; Lickliter JD; Naito Y; Park K; Kumar S; Mugundu GM; Bang YJ, 2020, 'Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study', Targeted Oncology, 15, pp. 75 - 84, http://dx.doi.org/10.1007/s11523-020-00701-5

Tjokrowidjaja A; Goldstein D; Hudson HM; Lord SJ; Gebski V; Clarke S; de Souza P; Motzer RJ; Lee CK, 2020, 'The impact of neutrophil-lymphocyte ratio on risk reclassification of patients with advanced renal cell cancer to guide risk-directed therapy', Acta Oncologica, 59, pp. 20 - 27, http://dx.doi.org/10.1080/0284186X.2019.1656342

Aghajani MJ; Yang T; Schmitz U; James A; McCafferty CE; de Souza P; Niles N; Roberts TL, 2020, 'Epithelial-to-mesenchymal transition and its association with PD-L1 and CD8 in thyroid cancer', Endocrine Connections, 9, pp. 1028 - 1041, http://dx.doi.org/10.1530/EC-20-0268

Khan T; Scott KF; Becker TM; Lock J; Nimir M; Ma Y; De Souza P, 2020, 'The Prospect of Identifying Resistance Mechanisms for Castrate-Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial-to-Mesenchymal Transition a Key Player?', Prostate Cancer, 2020, http://dx.doi.org/10.1155/2020/7938280

de Souza P; Gao B; Voskoboynik M; Wilkinson K; Cooper A; Hoon S-N; Palmieri D; Cai S; Tian YE; Hsieh C-Y; Ma N; Xu C; Chen Y; Yang S; Zhang S, 2020, '574P Updated results of phase I study of senaparib (IMP4297) in Australian patients with advanced solid tumours', Annals of Oncology, 31, pp. S490 - S490, http://dx.doi.org/10.1016/j.annonc.2020.08.688

Clarke J; Chu S-C; Siu LL; Machiels J-P; Markman B; Heinhuis K; Millward M; Lolkema M; Patel SP; Souza PD; Curigliano G; Santoro A; Brown M; Fleming R; Vezina H; He C; Rottey S, 2019, 'Abstract B057: BMS-986148, an anti-mesothelin antibody-drug conjugate (ADC), alone or in combination with nivolumab demonstrates clinical activity in patients with select advanced solid tumors', Molecular Cancer Therapeutics, 18, pp. B057 - B057, http://dx.doi.org/10.1158/1535-7163.targ-19-b057

Aghajani MJ; Cooper A; McGuire H; Jeffries T; Saab J; Ismail K; de Souza P; Bray V; Fazekas de St Groth B; Niles N; Roberts TL, 2019, 'Pembrolizumab for anaplastic thyroid cancer: a case study', Cancer Immunology, Immunotherapy, 68, pp. 1921 - 1934, http://dx.doi.org/10.1007/s00262-019-02416-7

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