By Professor Phoebe Phillips

Book Chapters

Pitiyarachchi O; Kokkinos J; Sharbeen G; Phillips PA; Gandy RC; Haghighi KS; Moses DA; Thompson SR; Borbasi JAL; Strutt R; Goldstein D, 2024, 'Management of Primary Pancreatic Cancer', in , Wiley, pp. 386 - 406, http://dx.doi.org/10.1002/9781119756422.ch20

McCarroll JA; Sharbeen G; Kavallaris M; Phillips PA, 2019, 'The use of star polymer nanoparticles for the delivery of siRNA to mouse orthotopic pancreatic tumor models', in RNA interference and cancer therapy : methods and protocols, pp. 329 - 353, http://dx.doi.org/10.1007/978-1-4939-9220-1_23

Sharbeen G; McAlpine SR; Phillips P, 2015, 'HSP47: The New Heat Shock Protein Therapeutic Target', in Topics in Medicinal Chemistry, Springer Berlin Heidelberg, http://dx.doi.org/10.1007/7355_2015_89

Erlich RB; Kavallaris M; McCarroll J; Phillips P, 2013, 'Nanotechnology, tumour biomarkers and RNA interference for personalized medicine applications', in Shiddiky MJA; Wee EJH; Rauf S; Trau M (ed.), Microfluidics, Nanotechnology and Disease Biomarkers for Personalized Medicine Applications, Nova Science Publishers, pp. 167 - 187, https://www.novapublishers.com/catalog/product_info.php?products_id=42427

Saluja AK; Singh VP; Phillips P, 2008, 'Physiology of Experimental Pancreatitis', in , Wiley, pp. 91 - 106, http://dx.doi.org/10.1002/9781444300123.ch8

Journal articles

Netto KG; Chiang S; Kokkinos J; Haghighi KS; Raina A; Pitiyarachchi O; Youkhana J; Truong Q; Wenholz D; Li X; Laczka O; Kumar N; Wilkinson J; Goldstein D; Sharbeen G; Phillips PA, 2024, 'Abstract B062: CRO67 has therapeutic potential against pancreatic tumor cells and cancer associated fibroblasts', Cancer Research, 84, pp. B062 - B062, http://dx.doi.org/10.1158/1538-7445.panca2023-b062

Chitty JL; Yam M; Perryman L; Parker AL; Skhinas JN; Setargew YFI; Mok ETY; Tran E; Grant RD; Latham SL; Pereira BA; Ritchie SC; Murphy KJ; Trpceski M; Findlay AD; Melenec P; Filipe EC; Nadalini A; Velayuthar S; Major G; Wyllie K; Papanicolaou M; Ratnaseelan S; Phillips PA; Sharbeen G; Youkhana J; Russo A; Blackwell A; Hastings JF; Lucas MC; Chambers CR; Reed DA; Stoehr J; Vennin C; Pidsley R; Zaratzian A; Da Silva AM; Tayao M; Charlton B; Herrmann D; Nobis M; Clark SJ; Biankin AV; Johns AL; Croucher DR; Nagrial A; Gill AJ; Grimmond SM; Chantrill LA; Chou A; Dwarte T; Metcalf XL; Jeong G; Kenyon L; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeo D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J, 2023, 'A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer', Nature Cancer, 4, pp. 1326 - 1344, http://dx.doi.org/10.1038/s43018-023-00614-y

Kokkinos J; Sharbeen G; Youkhana J; Boyer C; Goldstein D; Haghighi KS; McCarroll JA; Phillips PA, 2022, 'Abstract B076: βIII-Tubulin is a brake on extrinsic cell-death in pancreatic cancer', Cancer Research, 82, pp. B076 - B076, http://dx.doi.org/10.1158/1538-7445.panca22-b076

Kokkinos J; Sharbeen G; Haghighi KS; Youkhana J; Raina A; Pitiyarachchi O; Truong Q; Wenholz D; Laczka O; Kumar N; Goldstein D; Phillips PA, 2022, 'Abstract C073: CRO-67 is a novel therapeutic for pancreatic cancer: Implications for tumor and stromal reprogramming', Cancer Research, 82, pp. C073 - C073, http://dx.doi.org/10.1158/1538-7445.panca22-c073

Ma Z; Wong SW; Forgham H; Esser L; Lai M; Leiske MN; Kempe K; Sharbeen G; Youkhana J; Mansfeld F; Quinn JF; Phillips PA; Davis TP; Kavallaris M; McCarroll JA, 2022, 'Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth', Biomaterials, 285, http://dx.doi.org/10.1016/j.biomaterials.2022.121539

Farr KP; Moses D; Haghighi KS; Phillips PA; Hillenbrand CM; Chua BH, 2022, 'Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities', Cancers, 14, http://dx.doi.org/10.3390/cancers14102539

Cong VT; Tilley RD; Sharbeen G; Phillips PA; Gaus K; Gooding JJ, 2021, 'How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells', Chemical Science, 12, pp. 15407 - 15417, http://dx.doi.org/10.1039/d1sc04656j

Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, 11, pp. 1944, http://dx.doi.org/10.1038/s41598-021-81299-0

Liu D; Sharbeen G; Phillips P; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Scarpa A; Lawlor RT; Corbo V; Bassi C; Biankin AV; Jamieson NB; Chang DK; Dreyer SB; Ford CE, 2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21, http://dx.doi.org/10.1186/s12885-021-08952-9

Phillips PA, 2021, 'Abstract IA-008: The KPC model has helped advance pancreatic cancer therapy: Disagree', Cancer Research, 81, http://dx.doi.org/10.1158/1538-7445.panca21-ia-008

Cong VT; Wang W; Tilley RD; Sharbeen G; Phillips PA; Gaus K; Gooding JJ, 2021, 'Can the Shape of Nanoparticles Enable the Targeting to Cancer Cells over Healthy Cells?', Advanced Functional Materials, 31, http://dx.doi.org/10.1002/adfm.202007880

Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479, http://dx.doi.org/10.1158/0008-5472.CAN-20-2496

Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells', Advanced Biology, 5, pp. e2000525, http://dx.doi.org/10.1002/adbi.202000525

Kokkinos J; Jensen A; Sharbeen G; McCarroll JA; Goldstein D; Haghighi KS; Phillips PA, 2021, 'Does the microenvironment hold the hidden key for functional precision medicine in pancreatic cancer?', Cancers, 13, http://dx.doi.org/10.3390/cancers13102427

Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Cancer‐Associated Fibroblasts: Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells (Adv. Biology 6/2021)', Advanced Biology, 5, http://dx.doi.org/10.1002/adbi.202170064

Kokkinos J; Ignacio RM; Haghighi K; Kopecky C; Sharbeen G; Gonzales-Aloy E; Youkhana J; Butler L; Goldstein D; McCarroll J; Phillips P, 2021, 'Patient-derived pancreatic tumours in a dish: implications for real-time precision medicine', HPB, 23, pp. S235 - S235, http://dx.doi.org/10.1016/j.hpb.2020.11.590

Barrera LN; Evans A; Lane B; Brumskill S; Oldfield FE; Campbell F; Andrews T; Lu Z; Perez-Mancera PA; Liloglou T; Ashworth M; Jalali M; Dawson R; Nunes Q; Phillips PA; Timms JF; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2020, 'Fibroblasts from distinct pancreatic pathologies exhibit disease-specific properties', Cancer Research, 80, pp. 2861 - 2873, http://dx.doi.org/10.1158/0008-5472.CAN-19-3534

Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, 240, http://dx.doi.org/10.1016/j.biomaterials.2019.119742

Tjandra KC; McCarthy N; Yang L; Laos AJ; Sharbeen G; Phillips PA; Forgham H; Sagnella SM; Whan RM; Kavallaris M; Thordarson P; McCarroll JA, 2020, 'Identification of Novel Medulloblastoma Cell-Targeting Peptides for Use in Selective Chemotherapy Drug Delivery', Journal of Medicinal Chemistry, 63, pp. 2181 - 2193, http://dx.doi.org/10.1021/acs.jmedchem.9b00851

Kokkinos J; Sharbeen G; Haghighi K; Ignacio RM; Kopecky C; Gonzales-Aloy E; Youkhana J; Pandzic E; Boyer C; Davis T; Butler L; Goldstein D; McCarroll J; Phillips P, 2020, 'Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue', , http://dx.doi.org/10.1101/2020.07.30.223925

Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637, http://dx.doi.org/10.1038/s41467-019-10968-6

Barrera LN; Evans A; Lane B; Brumskill S; Oldfield F; Campbell F; Andrews T; Lu Z; Perez-Mancera PA; Liloglou T; Jalali M; Dawson R; Nunes Q; Phillips P; Timms JF; Menon U; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2019, 'PDAC-associated fibroblasts are less responsive to an anti-fibrotic stimulus and more responsive to a positive regulator of fibroblast activation than normal activated fibroblasts', Pancreatology, 19, pp. S158 - S158, http://dx.doi.org/10.1016/j.pan.2019.05.423

Pinho AV; Van Bulck M; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Leuckx G; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, 9, http://dx.doi.org/10.1038/s41467-018-07497-z

Barrera L; Evans A; Lane B; Brumskill S; Oldfield F; Campbell F; Andrews T; Perez-Mancera P; Liloglou T; Phillips P; Halloran C; Greenhalf W; Neoptolemos JP; Costello E, 2018, 'Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile', Pancreatology, 18, pp. S94 - S94, http://dx.doi.org/10.1016/j.pan.2018.05.254

Akerman A; Sharbeen G; Holst J; Youkhana J; McCarroll J; Goldstein D; Erkan M; Phillips P, 2018, 'Targeting a solute carrier to metabolically reprogram tumour-promoting stromal cells in pancreatic cancer', Pancreatology, 18, pp. S156 - S156, http://dx.doi.org/10.1016/j.pan.2018.05.419

Yeo D; Phillips P; Baldwin GS; He H; Nikfarjam M, 2017, 'Inhibition of group 1 p21-activated kinases suppresses pancreatic stellate cell activation and increases survival of mice with pancreatic cancer', International Journal of Cancer, 140, pp. 2101 - 2111, http://dx.doi.org/10.1002/ijc.30615

Sharbeen G; Youkhana J; Mawson A; McCarroll J; Nunez A; Biankin A; Johns A; Goldstein D; Phillips P, 2017, 'MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity', Oncotarget, 8, pp. 9216 - 9229, http://dx.doi.org/10.18632/oncotarget.13985

Rooman I; Pinho A; Phillips P; Biankin A; Wu J, 2017, 'Altered Slit-Robo signalling activates TGF-beta signalling and stroma remodelling in the pancreas.', Pancreatology, 17, pp. S6 - S7, http://dx.doi.org/10.1016/j.pan.2017.05.020

Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22

Sharbeen G; McCarroll J; Liu J; Youkhana J; Limbri LF; Biankin AV; Johns A; Kavallaris M; Goldstein D; Phillips PA, 2016, 'Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids', Neoplasia (United States), 18, pp. 753 - 764, http://dx.doi.org/10.1016/j.neo.2016.10.011

McCarroll JA; Teo J; Boyer C; Youkhana J; Sagnella S; Duong H; Sharbeen G; Goldstein D; Davis T; Kavallaris M; Phillips P; Liu J, 2016, 'A rationally optimized nanoparticle system for the delivery of RNA interference therapeutics into pancreatic tumors in vivo.', Biomacromolecules, 17, pp. 2337 - 2351, http://dx.doi.org/10.1021/acs.biomac.6b00185

Barrera L; Lane B; Brumskill S; Oldfield F; Lamond R; Wilkinson L; Bermejo-Rodriguez C; Aughton K; Sanna R; Nunes Q; Perez-Mancera P; Campbell F; Andrews T; Phillips P; Halloran C; Sutton R; Greenhalf W; Neoptolemos J; Costello E, 2016, 'Identification of novel signalling pathways dysregulated in pancreatic cancer-associated fibroblasts', Pancreatology, 16, pp. S31 - S31, http://dx.doi.org/10.1016/j.pan.2016.05.106

Sharbeen G; Youkhana J; McCarroll J; Akerman A; Goldstein D; Phillips P, 2016, 'MutY-Homolog modulates pancreatic cancer cell survival and chemoresistance', Pancreatology, 16, pp. S5 - S5, http://dx.doi.org/10.1016/j.pan.2016.05.024

Yeo D; He H; Phillips P; Baldwin G; Nikfarjam M, 2016, 'Targeting PAK1 in pancreatic stellate cells increases pancreatic cancer survival', Pancreatology, 16, pp. S26 - S27, http://dx.doi.org/10.1016/j.pan.2016.05.092

Glass JJ; Phillips PA; Gunning PW; Stehn JR, 2015, 'Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells', BMC Cancer, 15, http://dx.doi.org/10.1186/s12885-015-1741-8

Sharbeen G; McCarroll J; Goldstein D; Phillips PA, 2015, 'Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer', Frontiers in Nutrition, 2, pp. 10, http://dx.doi.org/10.3389/fnut.2015.00010

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Murchie S; Bowyer MC; Phillips PA; Scarlett CJ, 2015, 'Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts', International Journal of Food Science and Technology, 50, pp. 169 - 177, http://dx.doi.org/10.1111/ijfs.12618

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Munro B; Bowyer MC; Chalmers AC; Sakoff JA; Phillips PA; Scarlett CJ, 2015, 'Physicochemical, antioxidant and anti-cancer activity of a Eucalyptus robusta (Sm.) leaf aqueous extract', Industrial Crops and Products, 64, pp. 167 - 174, http://dx.doi.org/10.1016/j.indcrop.2014.10.061

McCarroll JA; Dwarte T; Baigude H; Dang J; Yang L; Erlich RB; Kimpton K; Teo J; Sagnella SM; Akerfeldt MC; Liu J; Phillips PA; Rana TM; Kavallaris M, 2015, 'Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer', Oncotarget, 6, pp. 12020 - 12034, http://dx.doi.org/10.18632/oncotarget.2664

McCarroll JA; Sharbeen G; Liu J; Youkhana J; Goldstein D; McCarthy N; Limbri LF; Dischl D; Ceyhan GO; Erkan M; Johns AL; Biankin AV; Kavallaris M; Phillips PA; Johns A, 2015, 'βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer', Oncotarget, 6, pp. 2235 - 2249, http://dx.doi.org/10.18632/oncotarget.2946

Barrera L; Lane B; Brumskill S; Oldfield F; Nunes Q; Campbell F; Andrews T; Phillips P; Halloran C; Greenhalf W; Neoptolemos J; Costello E, 2015, 'Simultaneous integration of microRNA and mRNA expression in the analysis of quiescent and activated human fibroblasts in the diseased pancreas', Pancreatology, 15, pp. S19 - S20, http://dx.doi.org/10.1016/j.pan.2015.05.103

Luo AS; Lim A; Jung HJ; Phillips PA; Grimm MC, 2014, 'Retinoic acid is required for the generation of protective appendiceal regulatory T cells', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, pp. 20 - 20, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000343863000041&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vuong QV; Hirun S; Phillips PA; Chuen TLK; Bowyer MC; Goldsmith CD; Scarlett CJ, 2014, 'Fruit-derived phenolic compounds and pancreatic cancer: Perspectives from Australian native fruits', Journal of Ethnopharmacology, 152, pp. 227 - 242, http://dx.doi.org/10.1016/j.jep.2013.12.023

Vuong QV; Hirun S; Chuen TLK; Goldsmith CD; Bowyer MC; Chalmers AC; Phillips PA; Scarlett CJ, 2014, 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, 4, pp. 134 - 140, http://dx.doi.org/10.1016/j.hermed.2014.04.003

McCarroll JA; Naim S; Sharbeen G; Russia N; Lee J; Kavallaris M; Goldstein D; Phillips PA, 2014, 'Role of pancreatic stellate cells in chemoresistance in pancreatic cancer', Frontiers in Physiology, 5 APR, pp. 141, http://dx.doi.org/10.3389/fphys.2014.00141

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