Researcher

Professor Samuel Norbert Breit

My Expertise

Immunology; rheumatology; connective tissue diseases such as rheumatoid arthritis, Sjogren's syndrome,SLE scleroderma & interstitial lung diseases - cytokines & biological response modifiers; gene cloning; genetic engineering; biopharmaceuticals.

Field of Research (FoR)

Biography

Prof Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital Sydney. As a Professor of Medicine at UNSW, he heads the Inflammation and Cytokine Biology Research Program at St Vincent’s Centre of Applied Medical Research. He has a career long interest in biomedical research,  has a long track record of project grant support and has published over 160 papers in peer-reviewed journals. Prof Breit’s group has...view more

Prof Breit is a Clinical Immunologist and Immunopathologist at St Vincent’s Hospital Sydney. As a Professor of Medicine at UNSW, he heads the Inflammation and Cytokine Biology Research Program at St Vincent’s Centre of Applied Medical Research. He has a career long interest in biomedical research,  has a long track record of project grant support and has published over 160 papers in peer-reviewed journals. Prof Breit’s group has spearheaded the investigation of 2 important molecules his research group first discovered and characterised over a decade ago: the intracellular chloride ion channel protein CLIC1 and the divergent TGF-b superfamily cytokine MIC-1/GDF15. With the latter molecule, through an evolving understanding of its biology and potential clinical application, Prof Breit has then been able to take his basic discoveries, from the bench to the bedside. These discoveries have been licensed to several major international companies where they will be applied to patient diagnosis and therapy: MIC-1/GDF15 diagnostic technology can be used in the diagnosis and management of cancer and cardiovascular disease, whilst therapeutic applications include the treatment of inflammatory diseases, obesity and cancer associated syndromes. Prof Breit’s seminal studies on the role and pathogenesis of MIC-1/GDF15 in cancer anorexia/cachexia and appetite regulation have been recently recognised by the NHMRC, by inclusion in the NHMRC Publication “Ten best projects 2011”.

Prof Breit collaborates widely and maintains an active research program, involving post-doctoral scientist and PhD students, directed to understanding the biology, mode of action, disease association and therapeutic application of the 2 molecules identified above: MIC-1/GDF15 and CLIC1. A summary of the research activities of Prof Breit's research group and their selected publications can be found on:

www.amr.org.au/our-programs/37-inflammation/57-samuel-breit-research-group


My Qualifications

MBBS, MD, FRACP, FRCPA


My Research Supervision


Areas of supervision

Project: The role of the TGFb superfamily cytokine MIC-1/GDF15 in the regulation of inflammatory responses
Discipline: Immunology, metabolism, inflammation
Project level: PhD
Supervisor: Team led by Prof Samuel Breit
Project commencement: immediately, contingent on PhD scholarship funding
Contact: Prof Samuel Breit at s.breit@amr.org.au
 

 
Project: The role of the TGFb superfamily cytokine MIC-1/GDF15 in regulation of tumor immunity
Discipline: Immunology, metabolism, inflammation, cancer biology
Project level: PhD
Supervisor: Team led by Prof Samuel Breit
Project commencement: immediately, contingent on PhD scholarship funding
Contact: Prof Samuel Breit at s.breit@amr.org.au

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Location

St Vincent's Hospital, Sydney campus:
L8, Lowy Packer Building, 405 Liverpool St., Darlinghurst. 2010.

Contact

+61 (0)2 8382 4952
+61 (0)2 8382 4965