Select Publications
Book Chapters
2016, 'TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Compendium of Inflammatory Diseases, Springer Basel, pp. 1236 - 1245, http://dx.doi.org/10.1007/978-3-7643-8550-7_54
,2016, 'TGF beta Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-0348-0620-6_54-2
,2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2816 - 2821, http://dx.doi.org/10.1007/978-3-662-46875-3_3704
,2014, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1 - 6, http://dx.doi.org/10.1007/978-3-642-27841-9_3704-2
,2014, 'TGF-b Superfamily Cytokine MIC-1/GDF15 in Health and Inflammatory Diseases', in Encyclopedia of Inflammatory Diseases, Springer Basel, pp. 1 - 13, http://dx.doi.org/10.1007/978-3-0348-0620-6_54-1
,2011, 'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 2285 - 2289, http://dx.doi.org/10.1007/978-3-642-16483-5_3704
,2001, 'MIC-1 and other TGF-β superfamily members in inflammation', in TGF-β and Related Cytokines in Inflammation, Birkhäuser Basel, pp. 1 - 9, http://dx.doi.org/10.1007/978-3-0348-8354-2_1
,1997, 'Scleroderma: Clinical features and pathogenesis', in Clinical Immunology, Academic Press Inc Elsevier Science, San Diego, Ca, USA, pp. 346 - 356
,1996, 'The pathogenesis of pulmonary manifestations of connective tissue diseases', in Lung Immunopathology, Butterworth Heinemann Press, Boston, USA, pp. 147 - 164
,'MIC-1', in Encyclopedia of Cancer, Springer Berlin Heidelberg, pp. 1870 - 1873, http://dx.doi.org/10.1007/978-3-540-47648-1_3704
,Journal articles
2024, 'GDF15 research from bench to bedside', Cancer Cell, 42, pp. 1823 - 1824, http://dx.doi.org/10.1016/j.ccell.2024.10.002
,2024, 'Humans without GDF15 reassure drug developers', Nature Metabolism, 6, pp. 1850 - 1851, http://dx.doi.org/10.1038/s42255-024-01136-2
,2024, 'Clinical validation of circulating GDF15/MIC-1 as a marker of response to docetaxel and survival in men with metastatic castration-resistant prostate cancer', Prostate, 84, pp. 747 - 755, http://dx.doi.org/10.1002/pros.24691
,2024, 'Mucosal-associated invariant T (MAIT) cells exhibit restricted T cell receptor β constant region usage, obfuscating assessment of T cell clonality', Pathology, 56, pp. S114 - S114, http://dx.doi.org/10.1016/j.pathol.2023.12.376
,2024, 'Novel clinical applications of functional assays to measure antigen-specific cellular immunity', Pathology, 56, pp. S27 - S27, http://dx.doi.org/10.1016/j.pathol.2023.12.101
,2023, 'GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway', Cell Metabolism, 35, pp. 1341 - 1355.e3, http://dx.doi.org/10.1016/j.cmet.2023.06.009
,2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477
,2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002
,2021, 'Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-84881-8
,2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449
,2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', PLoS ONE, 15, http://dx.doi.org/10.1371/journal.pone.0233846
,2020, 'Professor Ronald Penny IN MEMORIAM', AIDS, 34, pp. 959 - 960, http://dx.doi.org/10.1097/QAD.0000000000002520
,2020, 'Vale Ron Penny AO (1936-2019): pioneer of clinical immunology OBITUARY', CLINICAL & TRANSLATIONAL IMMUNOLOGY, 9, http://dx.doi.org/10.1002/cti2.1119
,2019, 'MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury', Journal of Neurotrauma, 36, pp. 3410 - 3421, http://dx.doi.org/10.1089/neu.2019.6421
,2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5
,2019, 'Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration resistant prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p032
,2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384
,2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018
,2018, 'A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood', Frontiers in Genetics, 9, pp. 97, http://dx.doi.org/10.3389/fgene.2018.00097
,2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258
,2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005
,2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156
,2017, 'The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome', Journal of Biological Chemistry, 292, pp. 12077 - 12087, http://dx.doi.org/10.1074/jbc.M117.797126
,2017, 'Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, 8, pp. 417 - 427, http://dx.doi.org/10.1002/jcsm.12169
,2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, 12, pp. e0168416, http://dx.doi.org/10.1371/journal.pone.0168416
,2017, 'Macrophage Inhibitory Cytokine 1 (MIC1/GDF15) as a Novel Serum Biomarker of Colonic Neoplasia', Gastroenterology, 152, pp. S1030 - S1030, http://dx.doi.org/10.1016/s0016-5085(17)33483-2
,2016, 'Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study', Biochemistry, 55, pp. 3825 - 3833, http://dx.doi.org/10.1021/acs.biochem.6b00080
,2016, 'Phase II trial of circulating cytokines as markers of docetaxel (DTX) resistance in metastatic castrate-resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, 34, pp. 5039 - 5039, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.5039
,2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119
,2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242
,2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316
,2015, 'An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity incommunity-dwelling older individuals', Psychoneuroendocrinology, 62, pp. 80 - 88, http://dx.doi.org/10.1016/j.psyneuen.2015.07.610
,2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, 10, pp. e0133362, http://dx.doi.org/10.1371/journal.pone.0133362
,2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74
,2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100
,2015, 'The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals', PLoS ONE, 10, pp. e0123399, http://dx.doi.org/10.1371/journal.pone.0123399
,2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, 10, pp. e0115189, http://dx.doi.org/10.1371/journal.pone.0115189
,, 2015, 'Abstracts of the 2(nd) Cancer Cachexia Conference, Montreal, Canada, 26-28 September 2014.', J Cachexia Sarcopenia Muscle, 6, pp. 2 - 31, http://dx.doi.org/10.1002/jcsm.12004
2015, 'Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assay', Pathology, 47, pp. S94 - S94, http://dx.doi.org/10.1097/01.pat.0000461601.28805.d5
,2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, 9, pp. e100370, http://dx.doi.org/10.1371/journal.pone.0100370
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