Select Publications

Journal articles

Tsai VW W; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KK M; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, http://dx.doi.org/10.1038/s41366-019-0365-5

Tsai VW W; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes', Current opinion in supportive and palliative care, vol. 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384

Tsai VW W; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, vol. 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018

Jiang J; Thalamuthu A; Ho JE; Mahajan A; Ek WE; Brown DA; Breit SN; Wang TJ; Gyllensten U; Chen MH; Enroth S; Januzzi JL; Lind L; Armstrong NJ; Kwok JB; Schofield PR; Wen W; Trollor JN; Johansson Å; Morris AP; Vasan RS; Sachdev PS; Mather KA, 2018, 'A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood', Frontiers in Genetics, vol. 9, http://dx.doi.org/10.3389/fgene.2018.00097

Tsai VW; Zhang HP; Manandhar R; Lee-Ng KK M; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, vol. 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258

Breit SN; Tsai VW W; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, vol. 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005

Domingo-Fernández R; Coll RC; Kearney J; Breit S; O’Neill LA J, 2017, 'The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome', Journal of Biological Chemistry, vol. 292, pp. 12077 - 12087, http://dx.doi.org/10.1074/jbc.M117.797126

Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SW L; Tsai VW W; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, vol. 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156

Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VW W; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0168416

Borner T; Arnold M; Ruud J; Breit SN; Langhans W; Lutz TA; Blomqvist A; Riediger T, 2017, 'Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, vol. 8, pp. 417 - 427, http://dx.doi.org/10.1002/jcsm.12169

Salao K; Jiang L; Li H; Tsai VW W; Husaini Y; Curmi PM G; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, vol. 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119

Hare JE; Goodchild SC; Breit SN; Curmi PM G; Brown LJ, 2016, 'Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study', Biochemistry, vol. 55, pp. 3825 - 3833, http://dx.doi.org/10.1021/acs.biochem.6b00080

Tsai VW W; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, vol. 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242

Sasson SC; McGill K; Wienholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, vol. 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316

Jiang J; Trollor JN; Brown DA; Crawford JD; Thalamuthu A; Smith E; Breit SN; Liu T; Brodaty H; Baune BT; Sachdev PS; Wen W, 2015, 'An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals', Psychoneuroendocrinology, vol. 62, pp. 80 - 88, http://dx.doi.org/10.1016/j.psyneuen.2015.07.610

Tsai VW W; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PM G; Angstmann CN; Lee-Ng KK M; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0133362

Jiang J; Wen W; Brown DA; Crawford J; Thalamuthu A; Smith E; Breit SN; Liu T; Zhu W; Brodaty H; Baune BT; Trollor JN; Sachdev PS, 2015, 'The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0123399

Fisher OM; Levert-Mignon AJ; Lord SJ; Lee-Ng KK M; Botelho NK; Falkenback D; Thomas ML; Bobryshev YV; Whiteman DC; Brown DA; Breit SN; Lord RV, 2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, vol. 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100

Mahon KL; Lin HM; Castillo L; Lee BY; Lee-Ng M; Chatfield MD; Chiam K; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Daly RJ; Henshall SM; Horvath LG, 2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, vol. 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74

Husaini Y; Lockwood GP; Nguyen TV; Tsai VW W; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0115189

Tsai VW W; Manandhar R; Jrøgensen SB; Lee-Ng KK M; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0100370

Mohammad MG; Tsai VW W; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, vol. 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Jiang L; Phang JM; Yu J; Harrop SJ; Sokolova AV; Duff AP; Wilk KE; Alkhamici H; Breit SN; Valenzuela SM; Brown LJ; Curmi PM G, 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, vol. 1838, pp. 643 - 657, http://dx.doi.org/10.1016/j.bbamem.2013.05.025

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E, 2013, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study', Aging Cell, vol. 12, pp. 882 - 889, http://dx.doi.org/10.1111/acel.12116

Jiang L; Salao K; Li H; Rybicka JM; Yates RM; Luo XW; Shi XX; Kuffner T; Tsai VW-W; Husaini Y; Wu L; Brown DA; Grewal T; Brown LJ; Curmi PM G; Breit SN, 2012, 'Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification', Journal of Cell Science, vol. 125, pp. 5479 - 5488, http://dx.doi.org/10.1242/jcs.110072

Johnen H; Kuffner T; Brown DA; Wu BJ; Stocker R; Breit SN, 2012, 'Increased expression of the TGF-b superfamily cytokine MIC-1/GDF15 protects ApoE−/− mice from the development of atherosclerosis', Cardiovascular Pathology, vol. 21, pp. 499 - 505, http://dx.doi.org/10.1016/j.carpath.2012.02.003

Breit SN; Carrero JJ; Tsai VW-W; Yagoutifam N; Luo W; Kuffner T; Bauskin AR; Wu L; Jiang L; Barany P; Heimburger O; Murikami M-A; Apple FS; Marquis CP; Macia L; Lin S; Sainsbury A; Herzog H; Law M; Stenvinkel P; Brown DA, 2012, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease', Nephrology Dialysis Transplantation, vol. 27, pp. 70 - 75, http://dx.doi.org/10.1093/ndt/gfr575

Brown DA; Hance KW; Rogers CJ; Sansbury LB; Albert PS; Murphy G; Laiyemo AO; Wang Z; Cross AJ; Schatzkin A; Danta M; Srasuebkul P; Amin J; Law M; Breit SN; Lanza E, 2012, 'Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?', Cancer Epidemiology Biomarkers & Prevention, vol. 21, pp. 337 - 346, http://dx.doi.org/10.1158/1055-9965.epi-11-0786

Tsai VW W; Husaini Y; Manandhar R; Lee-Ng KK M; Zhang HP; Harriott K; Jiang L; Lin S; Sainsbury A; Brown DA; Breit SN, 2012, 'Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, vol. 3, pp. 239 - 243, http://dx.doi.org/10.1007/s13539-012-0082-6

Mahon KL; Chatfield MD; Lee-Ng M; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Sutherland RL; Horvath L, 2011, 'Cytokines' profiles to predict chemotherapy outcome in castration-resistant prostate cancer (CRPC).', J Clin Oncol, vol. 29, pp. 4598, http://www.ncbi.nlm.nih.gov/pubmed/28023791

Brown DA; Tsai VW W; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE, 2011, 'CCAAT/enhancer binding protein-delta (C/EBPdelta) regulates Th17/Treg balance via an antigen presenting cell - interleukin-10 dependent mechanism in neuroinflammation', MULTIPLE SCLEROSIS JOURNAL, vol. 17, pp. S344 - S344, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209137301142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Tsai VW W; Mohammad MG; Tolhurst O; Breit SN; Sawchenko PE; Brown DA, 2011, 'CCAAT/Enhancer Binding Protein-  Expression by Dendritic Cells Regulates CNS Autoimmune Inflammatory Disease', Journal of Neuroscience, vol. 31, pp. 17612 - 17621, http://dx.doi.org/10.1523/jneurosci.3449-11.2011

Goodchild SC; Angstmann CN; Breit SN; Curmi PM G; Brown LJ, 2011, 'Transmembrane Extension and Oligomerization of the CLIC1 Chloride Intracellular Channel Protein upon Membrane Interaction', Biochemistry, vol. 50, pp. 10887 - 10897, http://dx.doi.org/10.1021/bi2012564

Mynott AV; Harrop SJ; Brown LJ; Breit SN; Kobe B; Curmi PM G, 2011, 'Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4', FEBS Journal, vol. 278, pp. 1662 - 1675, http://dx.doi.org/10.1111/j.1742-4658.2011.08086.x

Breit SN; Johnen H; Cook AD; Tsai VW W; Mohammad MG; Kuffner T; Zhang HP; Marquis CP; Jiang L; Lockwood G; Lee-Ng M; Husaini Y; Wu L; Hamilton JA; Brown DA, 2011, 'The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism', Growth Factors, vol. 29, pp. 187 - 195, http://dx.doi.org/10.3109/08977194.2011.607137

Qiu MR; Jiang L; Matthaei KI; Schoenwaelder SM; Kuffner T; Mangin P; Joseph JE; Low J; Connor D; Valenzuela SM; Curmi PM G; Brown LJ; Mahaut-Smith M; Jackson SP; Breit SN, 2010, 'Erratum: Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene', Genesis, vol. 48, pp. 351 - 351, http://dx.doi.org/10.1002/dvg.20616

Skipworth RJ E; Deans DA C; Tan BH L; Sangster K; Paterson-Brown S; Brown DA; Hunter M; Breit SN; Ross JA; Fearon KC H, 2010, 'Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer.', Br J Cancer, vol. 102, pp. 665 - 672, http://dx.doi.org/10.1038/sj.bjc.6605532

Qiu MR; Jiang L; Matthaei KI; Schoenwaelder SM; Kuffner T; Mangin P; Joseph JE; Low J; Connor D; Valenzuela SM; Curmi PM G; Brown LJ; Mahaut-Smith M; Jackson SP; Breit SN, 2010, 'Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.', Genesis, vol. 48, pp. 127 - 136, http://dx.doi.org/10.1002/dvg.20590

Littler DR; Brown LJ; Breit SN; Perrakis A; Curmi PM G, 2010, 'Structure of human CLIC3 at 2 A resolution.', Proteins, vol. 78, pp. 1594 - 1600, http://dx.doi.org/10.1002/prot.22675

Roth P; Junker M; Tritschler I; Mittelbronn M; Dombrowski Y; Breit SN; Tabatabai G; Wick W; Weller M; Wischhusen J, 2010, 'GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas', Clinical Cancer Research, vol. 16, pp. 3851 - 3859, http://dx.doi.org/10.1158/1078-0432.ccr-10-0705

Bauskin AR; Jiang L; Luo XW; Wu L; Brown DA; Breit SN, 2010, 'The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores', Journal of Interferon & Cytokine Research, vol. 30, pp. 389 - 397, http://dx.doi.org/10.1089/jir.2009.0052

Wiklund FE; Bennet AM; Magnusson PK E; Eriksson UK; Lindmark F; Wu L; Yaghoutyfam N; Marquis CP; Stattin P; Pedersen NL; Adami H-O; Grönberg H; Breit SN; Brown DA, 2010, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15): a new marker of all-cause mortality', Aging Cell, vol. 9, pp. 1057 - 1064, http://dx.doi.org/10.1111/j.1474-9726.2010.00629.x

Goodchild SC; Howell MW; Littler DR; Mandyam RA; Sale KL; Mazzanti M; Breit SN; Curmi PM G; Brown LJ, 2010, 'Metamorphic Response of the CLIC1 Chloride Intracellular Ion Channel Protein upon Membrane Interaction', Biochemistry, vol. 49, pp. 5278 - 5289, http://dx.doi.org/10.1021/bi100111c

Littler DR; Harrop SJ; Goodchild SC; Phang JM; Mynott AV; Jiang L; Valenzuela SM; Mazzanti M; Brown LJ; Breit SN; Curmi PM G, 2010, 'The enigma of the CLIC proteins: Ion channels, redox proteins, enzymes, scaffolding proteins?', FEBS Letters, vol. 584, pp. 2093 - 2101, http://dx.doi.org/10.1016/j.febslet.2010.01.027

Horvath L; Zhao L; Lee B; Brown D; Molloy M; Marx G; Boyer M; Breit S; Sutherland R; Henshall S, 2009, 'Identification of candidate biomarkers of therapeutic response to docetaxel in hormone-refractory prostate cancer by proteomic profiling.', J Clin Oncol, vol. 27, pp. 11010, http://www.ncbi.nlm.nih.gov/pubmed/27963974

Brown DA; Lindmark F; Stattin P; Bälter K; Adami H-O; Zheng SL; Xu J; Isaacs WB; Grönberg H; Breit SN; Wiklund FE, 2009, 'Macrophage inhibitory cytokine 1: a new prognostic marker in prostate cancer.', Clin Cancer Res, vol. 15, pp. 6658 - 6664, http://dx.doi.org/10.1158/1078-0432.CCR-08-3126

Shnaper S; Desbaillets I; Brown DA; Murat A; Migliavacca E; Schluep M; Ostermann S; Hamou M-F; Stupp R; Breit SN; de Tribolet N; Hegi ME, 2009, 'Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome', International Journal of Cancer, vol. 125, pp. 2624 - 2630, http://dx.doi.org/10.1002/ijc.24639

Goodchild SC; Howell MW; Cordina NM; Littler DR; Breit SN; Curmi PM G; Brown LJ, 2009, 'Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane', European Biophysics Journal, vol. 39, pp. 129 - 138, http://dx.doi.org/10.1007/s00249-009-0450-0

Zhao L; Lee BY; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Kaplan W; Breit SN; Sutherland RL; Henshall SM; Horvath LG, 2009, 'Identification of Candidate Biomarkers of Therapeutic Response to Docetaxel by Proteomic Profiling', Cancer Research, vol. 69, pp. 7696 - 7703, http://dx.doi.org/10.1158/0008-5472.can-08-4901

Wakchoure S; Swain TM; Hentunen TA; Bauskin AR; Brown DA; Breit SN; Vuopala KS; Harris KW; Selander KS, 2009, 'Expression of macrophage inhibitory cytokine-1 in prostate cancer bone metastases induces osteoclast activation and weight loss', The Prostate, vol. 69, pp. 652 - 661, http://dx.doi.org/10.1002/pros.20913


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