By Professor Samuel Norbert Breit

Journal articles

Breit SN; Brown DA; Tsai VWW, 2024, 'GDF15 research from bench to bedside', Cancer Cell, 42, pp. 1823 - 1824, http://dx.doi.org/10.1016/j.ccell.2024.10.002

Breit SN; O’Rahilly S, 2024, 'Humans without GDF15 reassure drug developers', Nature Metabolism, 6, pp. 1850 - 1851, http://dx.doi.org/10.1038/s42255-024-01136-2

Mahon KL; Sutherland SIM; Lin HM; Stockler MR; Gurney H; Mallesara G; Briscoe K; Marx G; Higano CS; de Bono JS; Chi KN; Clark G; Breit SN; Brown DA; Horvath LG, 2024, 'Clinical validation of circulating GDF15/MIC-1 as a marker of response to docetaxel and survival in men with metastatic castration-resistant prostate cancer', Prostate, 84, pp. 747 - 755, http://dx.doi.org/10.1002/pros.24691

Pathmanandavel K; Jackson K; Le S; Alves M; Foley E; Tangye S; Ma C; Deenick E; Tong W; Carr A; Breit S; Sewell W; Kane A, 2024, 'Mucosal-associated invariant T (MAIT) cells exhibit restricted T cell receptor β constant region usage, obfuscating assessment of T cell clonality', Pathology, 56, pp. S114 - S114, http://dx.doi.org/10.1016/j.pathol.2023.12.376

Pathmanandavel K; Le S; Xie S; Alves M; Foley E; Kelleher A; Zaunders J; Carr A; Tong W; Breit S; Sewell W; Kane A, 2024, 'Novel clinical applications of functional assays to measure antigen-specific cellular immunity', Pathology, 56, pp. S27 - S27, http://dx.doi.org/10.1016/j.pathol.2023.12.101

Breit SN; Manandhar R; Zhang HP; Lee-Ng M; Brown DA; Tsai VWW, 2023, 'GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway', Cell Metabolism, 35, pp. 1341 - 1355.e3, http://dx.doi.org/10.1016/j.cmet.2023.06.009

Thai LM; O'Reilly L; Reibe-Pal S; Sue N; Holliday H; Small L; Schmitz-Peiffer C; Dhenni R; Wang-Wei Tsai V; Norris N; Yau B; Zhang X; Lee K; Yan C; Shi YC; Kebede MA; Brink R; Cooney GJ; Irvine KM; Breit SN; Phan TG; Swarbrick A; Biden TJ, 2023, 'β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling', iScience, 26, http://dx.doi.org/10.1016/j.isci.2023.106477

Breit SN; Brown DA; Tsai VWW, 2023, 'GDF15 analogs as obesity therapeutics', Cell Metabolism, 35, pp. 227 - 228, http://dx.doi.org/10.1016/j.cmet.2023.01.002

Trend S; Leffler J; Jones AP; Cha L; Gorman S; Brown DA; Breit SN; Kermode AG; French MA; Ward NC; Hart PH, 2021, 'Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis', Scientific Reports, 11, http://dx.doi.org/10.1038/s41598-021-84881-8

Breit SN; Brown DA; Tsai VWW, 2021, 'The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?', Annual Review of Physiology, 83, pp. 127 - 151, http://dx.doi.org/10.1146/annurev-physiol-022020-045449

Husaini Y; Tsai VWW; Manandhar R; Zhang HP; Lee-Ng KKM; Lebhar H; Marquis CP; Brown DA; Breit SN, 2020, 'Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity', PLoS ONE, 15, http://dx.doi.org/10.1371/journal.pone.0233846

Kelleher A; Breit S; Levy JA, 2020, 'Professor Ronald Penny IN MEMORIAM', AIDS, 34, pp. 959 - 960, http://dx.doi.org/10.1097/QAD.0000000000002520

Breit S; Ziegler J; Kelleher AD, 2020, 'Vale Ron Penny AO (1936-2019): pioneer of clinical immunology OBITUARY', CLINICAL & TRANSLATIONAL IMMUNOLOGY, 9, http://dx.doi.org/10.1002/cti2.1119

Hassanpour Golakani M; Mohammad MG; Li H; Gamble J; Breit SN; Ruitenberg MJ; Brown DA, 2019, 'MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury', Journal of Neurotrauma, 36, pp. 3410 - 3421, http://dx.doi.org/10.1089/neu.2019.6421

Tsai VWW; Zhang HP; Manandhar R; Schofield P; Christ D; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Brown DA; Breit SN, 2019, 'GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS', International Journal of Obesity, 43, pp. 2370 - 2380, http://dx.doi.org/10.1038/s41366-019-0365-5

Mahon KL; Lin HM; Lee-Ng M; Cain D; Jacobs C; Stockler MR; Gurney H; Mallesara G; Briscoe K; Marx G; Higano C; de BJS; Chi KN; Breit SN; Brown DA; Horvath LG, 2019, 'Clinical validation of circulating cytokines as markers of prognosis and response to docetaxel in men with metastatic castration resistant prostate cancer', Oncology Abstracts, http://dx.doi.org/10.1530/oncolabs.1.p032

Tsai VWW; Brown DA; Breit SN, 2018, 'Targeting the divergent TGFb superfamily cytokine MIC-1/GDF15 for therapy of anorexia/ cachexia syndromes', Current Opinion in Supportive and Palliative Care, 12, pp. 404 - 409, http://dx.doi.org/10.1097/SPC.0000000000000384

Tsai VWW; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases', Cell Metabolism, 28, pp. 353 - 368, http://dx.doi.org/10.1016/j.cmet.2018.07.018

Jiang J; Thalamuthu A; Ho JE; Mahajan A; Ek WE; Brown DA; Breit SN; Wang TJ; Gyllensten U; Chen MH; Enroth S; Januzzi JL; Lind L; Armstrong NJ; Kwok JB; Schofield PR; Wen W; Trollor JN; Johansson Å; Morris AP; Vasan RS; Sachdev PS; Mather KA; Schofield P, 2018, 'A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood', Frontiers in Genetics, 9, pp. 97, http://dx.doi.org/10.3389/fgene.2018.00097

Tsai VW; Zhang HP; Manandhar R; Lee-Ng KKM; Lebhar H; Marquis CP; Husaini Y; Sainsbury A; Brown DA; Breit SN, 2018, 'Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity', International Journal of Obesity, 42, pp. 561 - 571, http://dx.doi.org/10.1038/ijo.2017.258

Breit SN; Tsai VWW; Brown DA, 2017, 'Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway', Trends in Molecular Medicine, 23, pp. 1065 - 1067, http://dx.doi.org/10.1016/j.molmed.2017.10.005

Danta M; Barber DA; Zhang HP; Lee-Ng M; Baumgart SWL; Tsai VWW; Husaini Y; Saxena M; Marquis CP; Errington W; Kerr S; Breit SN; Brown DA, 2017, 'Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia', Alimentary Pharmacology and Therapeutics, 46, pp. 347 - 354, http://dx.doi.org/10.1111/apt.14156

Domingo-Fernández R; Coll RC; Kearney J; Breit S; O’Neill LAJ, 2017, 'The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome', Journal of Biological Chemistry, 292, pp. 12077 - 12087, http://dx.doi.org/10.1074/jbc.M117.797126

Borner T; Arnold M; Ruud J; Breit SN; Langhans W; Lutz TA; Blomqvist A; Riediger T, 2017, 'Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15', Journal of Cachexia, Sarcopenia and Muscle, 8, pp. 417 - 427, http://dx.doi.org/10.1002/jcsm.12169

Low JK; Ambikairajah A; Shang K; Brown DA; Tsai VWW; Breit SN; Karl T, 2017, 'First behavioural characterisation of a knockout mouse model for the transforming growth factor (TGF)-β superfamily cytokine, MIC-1/GDF15', PLoS ONE, 12, pp. e0168416, http://dx.doi.org/10.1371/journal.pone.0168416

Baumgart S; Barber DA; Zhang HP; Lee-Ng M; Breit S; Brown D; Danta M, 2017, 'Macrophage Inhibitory Cytokine 1 (MIC1/GDF15) as a Novel Serum Biomarker of Colonic Neoplasia', Gastroenterology, 152, pp. S1030 - S1030, http://dx.doi.org/10.1016/s0016-5085(17)33483-2

Hare JE; Goodchild SC; Breit SN; Curmi PMG; Brown LJ, 2016, 'Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study', Biochemistry, 55, pp. 3825 - 3833, http://dx.doi.org/10.1021/acs.biochem.6b00080

Mahon KL; Lin H-M; Spielman C; Lee-Ng M; Gurney H; Mallesara G; Stockler MR; Briscoe KP; Marx GM; Breit SN; Brown DA; Horvath L, 2016, 'Phase II trial of circulating cytokines as markers of docetaxel (DTX) resistance in metastatic castrate-resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, 34, pp. 5039 - 5039, http://dx.doi.org/10.1200/jco.2016.34.15_suppl.5039

Salao K; Jiang L; Li H; Tsai VWW; Husaini Y; Curmi PMG; Brown LJ; Brown DA; Breit SN, 2016, 'CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis', Biology Open, 5, pp. 620 - 630, http://dx.doi.org/10.1242/bio.018119

Tsai VWW; Lin S; Brown DA; Salis A; Breit SN, 2016, 'Anorexia-cachexia and obesity treatment may be two sides of the same coin: Role of the TGF-b superfamily cytokine MIC-1/GDF15', International Journal of Obesity, 40, pp. 193 - 197, http://dx.doi.org/10.1038/ijo.2015.242

Sasson SC; McGill K; Wienholt L; Carr A; Brown DA; Kelleher AD; Breit SN; Sewell WA, 2015, 'Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay', Pathology, 47, pp. 564 - 569, http://dx.doi.org/10.1097/PAT.0000000000000316

Jiang J; Trollor JN; Brown DA; Crawford JD; Thalamuthu A; Smith E; Breit SN; Liu T; Brodaty H; Baune BT; Sachdev PS; Wen W, 2015, 'An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity incommunity-dwelling older individuals', Psychoneuroendocrinology, 62, pp. 80 - 88, http://dx.doi.org/10.1016/j.psyneuen.2015.07.610

Tsai VWW; Macia L; Feinle-Bisset C; Manandhar R; Astrup A; Raben A; Lorenzen JK; Schmidt PT; Wiklund F; Pedersen NL; Campbell L; Kriketos A; Xu A; Pengcheng Z; Jia W; Curmi PMG; Angstmann CN; Lee-Ng KKM; Zhang HP; Marquis CP; Husaini Y; Beglinger C; Lin S; Herzog H; Brown DA; Sainsbury A; Breit SN; Lee-Ng M, 2015, 'Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI', PLoS ONE, 10, pp. e0133362, http://dx.doi.org/10.1371/journal.pone.0133362

Mahon KL; Lin HM; Castillo L; Lee BY; Lee-Ng M; Chatfield MD; Chiam K; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Daly RJ; Henshall SM; Horvath LG, 2015, 'Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer', British Journal of Cancer, 112, pp. 1340 - 1348, http://dx.doi.org/10.1038/bjc.2015.74

Fisher OM; Levert-Mignon AJ; Lord SJ; Lee-Ng KKM; Botelho NK; Falkenback D; Thomas ML; Bobryshev YV; Whiteman DC; Brown DA; Breit SN; Lord RV, 2015, 'MIC-1/GDF15 in Barrett's oesophagus and oesophageal adenocarcinoma', British Journal of Cancer, 112, pp. 1384 - 1391, http://dx.doi.org/10.1038/bjc.2015.100

Jiang J; Wen W; Brown DA; Crawford J; Thalamuthu A; Smith E; Breit SN; Liu T; Zhu W; Brodaty H; Baune BT; Trollor JN; Sachdev PS, 2015, 'The relationship of serum macrophage inhibitory cytokine - 1 levels with gray matter volumes in community-dwelling older individuals', PLoS ONE, 10, pp. e0123399, http://dx.doi.org/10.1371/journal.pone.0123399

Husaini Y; Lockwood GP; Nguyen TV; Tsai VWW; Mohammad MG; Russell PJ; Brown DA; Breit SN, 2015, 'Macrophage inhibitory cytokine-1 (MIC-1/GDF15) gene deletion promotes cancer growth in TRAMP prostate cancer prone mice', PLoS ONE, 10, pp. e0115189, http://dx.doi.org/10.1371/journal.pone.0115189

, 2015, 'Abstracts of the 2(nd) Cancer Cachexia Conference, Montreal, Canada, 26-28 September 2014.', J Cachexia Sarcopenia Muscle, 6, pp. 2 - 31, http://dx.doi.org/10.1002/jcsm.12004

Sasson SC; McGill K; Wienholt L; Carr A; Brown D; Kelleher AD; Breit SN; Sewell WA, 2015, 'Retrospective audit of the freeliteTM serum free light chain (SFLC) assay: testing patterns, concordance with serum and urine electrophoresis/immunofixation and correlation with the N latex FLC assay', Pathology, 47, pp. S94 - S94, http://dx.doi.org/10.1097/01.pat.0000461601.28805.d5

Tsai VWW; Manandhar R; Jrøgensen SB; Lee-Ng KKM; Zhang HP; Marquis CP; Jiang L; Husaini Y; Lin S; Sainsbury A; Sawchenko PE; Brown DA; Breit SN; Lee-Ng M, 2014, 'The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract', PLoS ONE, 9, pp. e100370, http://dx.doi.org/10.1371/journal.pone.0100370

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA; Hassanpour Golakani M, 2014, 'Immune cell trafficking from the brain maintains CNS immune tolerance', Journal of Clinical Investigation, 124, pp. 1228 - 1241, http://dx.doi.org/10.1172/JCI71544

Mohammad MG; Tsai VWW; Ruitenberg MJ; Hassanpour M; Li H; Hart PH; Breit SN; Sawchenko PE; Brown DA, 2014, 'A forebrain-immune cell pathway for the maintenance of CNS immune tolerance', Neurology, Psychiatry and Brain Research, 20, pp. 8 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.144

Jiang L; Phang JM; Yu J; Harrop SJ; Sokolova AV; Duff AP; Wilk KE; Alkhamici H; Breit SN; Valenzuela SM; Brown LJ; Curmi PMG, 2014, 'CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: A smoking gun?', Biochimica et Biophysica Acta - Biomembranes, 1838, pp. 643 - 657, http://dx.doi.org/10.1016/j.bbamem.2013.05.025

Tsai VW-W; Macia L; Manandhar R; Wiklund F; Grönberg H; Pedersen N; Lee-Ng M; Zhang HP; Brown D; Herzog H; Sainsbury A; Breit SN, 2014, 'Macrophage inhibitory cytokine 1 (MIC-1/GDF15), a novel regulator of body weight and appetite and a potential therapeutic for obesity', Obesity Research & Clinical Practice, 8, pp. 105 - 105, http://dx.doi.org/10.1016/j.orcp.2014.10.191

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown DA, 2014, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – The Sydney Memory and Aging Study', Neurology, Psychiatry and Brain Research, 20, pp. 9 - 9, http://dx.doi.org/10.1016/j.npbr.2014.01.145

Averaimo S; Abeti R; Savalli N; Brown LJ; Curmi PMG; Breit SN; Mazzanti M, 2013, 'Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties', PLoS ONE, 8, pp. e74523, http://dx.doi.org/10.1371/journal.pone.0074523

Fuchs T; Trollor JN; Crawford J; Baune BT; Samaras K; Campbell L; Breit SN; Brodaty H; Sachdev P; Smith E; Brown D, 2013, 'Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline – the Sydney Memory and Ageing Study', Aging Cell, 12, pp. 882 - 889, http://dx.doi.org/10.1111/acel.12116

Horvath L; Chatfield MD; Lee-Ng M; Lin H-M; Castillo L; Breit SN; Brown DA; Molloy MP; Marx GM; Pavlakis N; Boyer MJ; Stockler MR; Wykes R; Henshall SM; Mahon KL, 2013, 'The role of macrophages in docetaxel (DTX) resistance in castrate-resistant prostate cancer (CRPC).', Journal of Clinical Oncology, 31, pp. e22175 - e22175, http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22175

Mohammad MG; Hassanpour M; Tsai VW-W; Li H; Ruitenberg MJ; Booth D; Serrats J; Hart PH; Symonds GP; Sawchenko P; Breit SN; Brown DA; Hassanpour Golakani M, 2013, 'Dendritic cells and multiple sclerosis: Disease, tolerance and therapy', International Journal of Molecular Sciences, 14, pp. 547 - 562, http://dx.doi.org/10.3390/ijms14010547

Tsai VW-W; Macia L; Johnen H; Kuffner T; Manadhar R; Jorgensen ; Lee-Ng KKM; Hong PZ; Wu L; Marquis C; Jiang L; Husaini Y; Lin S; Herzog H; Brown DA; Sainsbury-Salis A; Breit SN; Zhang H, 2013, 'TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator', PLoS ONE, 8, pp. e55174, http://dx.doi.org/10.1371/journal.pone.0055174

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