By Professor Stuart Graham Tangye

Journal articles

vijayan D; redzwan M; avery DT; wirasinha RC; brink R; walters G; adelstein S; kobayashi M; gray P; elliott M; king C; vinuesa C; ghilardi N; ma CS; Tangye SG; batten M, 2016, 'IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice', Journal of Immunology, 197, pp. 3008 - 3017, http://dx.doi.org/10.4049/jimmunol.1600652

Pelham SJ; Lenthall HC; Deenick EK; Tangye SG, 2016, 'Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome', Journal of Allergy and Clinical Immunology, 138, pp. 1210 - 1213.e5, http://dx.doi.org/10.1016/j.jaci.2016.04.020

Ma CS; Tangye SG, 2016, 'Cytotoxic T cells that escape exhaustion', NATURE, 537, pp. 312 - 314, http://dx.doi.org/10.1038/nature19428

Moens L; Kane A; Tangye SG, 2016, 'Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement', Immunology and Cell Biology, 94, pp. 774 - 786, http://dx.doi.org/10.1038/icb.2016.41

Woon HG; Braun A; Li J; Smith C; Edwards J; Sierro F; Feng CG; Khanna R; Elliot M; Bell A; Hislop AD; Tangye SG; Rickinson AB; Gebhardt T; Britton WJ; Palendira U, 2016, 'Compartmentalization of Total and Virus-Specific Tissue-Resident Memory CD8+ T Cells in Human Lymphoid Organs', PLoS Pathogens, 12, http://dx.doi.org/10.1371/journal.ppat.1005799

Ma CS; Wong N; Rao G; Nguyen A; Avery DT; Payne K; Torpy J; O'Young P; Deenick E; Bustamante J; Puel A; Okada S; Kobayashi M; Martinez-Barricarte R; Elliott M; Kilic SS; Baghdadi JE; Minegishi Y; Bousfiha A; Robertson N; Hambleton S; Arkwright PD; French M; Blincoe AK; Hsu P; Campbell DE; Stormon MO; Wong M; Adelstein S; Fulcher DA; Cook MC; Stepensky P; Boztug K; Beier R; Ikincioğullari A; Ziegler JB; Gray P; Picard C; Boisson-Dupuis S; Phan TG; Grimbacher B; Warnatz K; Holland SM; Uzel G; Casanova JL; Tangye SG, 2016, 'Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4⁺ T cells into distinct effector subsets', Journal of Experimental Medicine, 213, pp. 1589 - 1608, http://dx.doi.org/10.1084/jem.20151467

Ma CS, 2016, 'Human T Follicular Helper Cells in Primary Immunodeficiency: Quality Just as Important as Quantity', Journal of Clinical Immunology, 36, pp. 40 - 47, http://dx.doi.org/10.1007/s10875-016-0257-6

Gray PE; O’Brien TA; Wagle M; Tangye SG; Palendira U; Roscioli T; Choo S; Sutton R; Ziegler JB; Frith K, 2015, 'Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant', Journal of Clinical Immunology, 35, pp. 604 - 609, http://dx.doi.org/10.1007/s10875-015-0194-9

Ma CS; Wong N; Rao G; Avery DT; Torpy J; Hambridge T; Bustamante J; Okada S; Stoddard JL; Deenick EK; Pelham SJ; Payne K; Boisson-Dupuis S; Puel A; Kobayashi M; Arkwright PD; Kilic SS; El Baghdadi J; Nonoyama S; Minegishi Y; Mahdaviani SA; Mansouri D; Bousfiha A; Blincoe AK; French MA; Hsu P; Campbell DE; Stormon MO; Wong M; Adelstein S; Smart JM; Fulcher DA; Cook MC; Phan TG; Stepensky P; Boztug K; Kansu A; Ikincioʇullari A; Baumann U; Beier R; Roscioli T; Ziegler JB; Gray P; Picard C; Grimbacher B; Warnatz K; Holland SM; Casanova JL; Uzel G; Tangye SG, 2015, 'Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies', Journal of Allergy and Clinical Immunology, 136, pp. 993 - 1006.e1, http://dx.doi.org/10.1016/j.jaci.2015.05.036

Kreins AY; Ciancanelli MJ; Okada S; Kong XF; Ramírez-Alejo N; Kilic SS; El Baghdadi J; Nonoyama S; Mahdaviani SA; Ailal F; Bousfiha A; Mansouri D; Nievas E; Ma CS; Rao G; Bernasconi A; Kuehn HS; Niemela J; Stoddard J; Deveau P; Cobat A; Azbaoui SE; Sabri A; Lim CK; Sundin M; Avery DT; Halwani R; Grant AV; Boisson B; Bogunovic D; Itan Y; Moncada-Velez M; Martinez-Barricarte R; Migaud M; Deswarte C; Alsina L; Kotlarz D; Klein C; Muller-Fleckenstein I; Fleckenstein B; Cormier-Daire V; Rose-John S; Picard C; Hammarstrom L; Puel A; Al-Muhsen S; Abel L; Chaussabel D; Rosenzweig SD; Minegishi Y; Tangye SG; Bustamante J; Casanova JL; Boisson-Dupuis S, 2015, 'Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome', Journal of Experimental Medicine, 212, pp. 1641 - 1662, http://dx.doi.org/10.1084/jem.20140280

Tangye SG; Brink R; Goodnow CC; Phan TG, 2015, 'SnapShot: Interactions between B Cells and T Cells', Cell, 162, pp. 926 - 926.e1, http://dx.doi.org/10.1016/j.cell.2015.07.055

Okada S; Markle JG; Deenick EK; Mele F; Averbuch D; Lagos M; Alzahrani M; Al-Muhsen S; Halwani R; Ma CS; Wong N; Soudais C; Henderson LA; Marzouqa H; Shamma J; Gonzalez M; Martinez-Barricarte R; Okada C; Avery DT; Latorre D; Deswarte C; Jabot-Hanin F; Torrado E; Fountain J; Belkadi A; Itan Y; Boisson B; Migaud M; Lindestam Arlehamn CS; Sette A; Breton S; Cluskey J; Rossjohn J; De Villartay JP; Moshous D; Hambleton S; Latour S; Arkwright PD; Picard C; Lantz O; Engelhard D; Kobayashi M; Abel L; Cooper AM; Notarangelo LD; Boisson-Dupuis S; Puel A; Sallusto F; Bustamante J; Tangye SG; Casanova JL, 2015, 'Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations', Science, 349, pp. 606 - 613, http://dx.doi.org/10.1126/science.aaa4282

Tangye SG, 2015, 'Advances in IL-21 biology-enhancing our understanding of human disease', Current Opinion in Immunology, 34, pp. 107 - 115, http://dx.doi.org/10.1016/j.coi.2015.02.010

Wilson RP; Ives ML; Rao G; Lau A; Payne K; Kobayashi M; Arkwright PD; Peake J; Wong M; Adelstein S; Smart JM; French MA; Fulcher DA; Picard C; Bustamante J; Boisson-Dupuis S; Gray P; Stepensky P; Warnatz K; Freeman AF; Rossjohn J; McCluskey J; Holland SM; Casanova JL; Uzel G; Ma CS; Tangye SG; Deenick EK, 2015, 'STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function', Journal of Experimental Medicine, 212, pp. 855 - 864, http://dx.doi.org/10.1084/jem.20141992

Suan D; Nguyen A; Moran I; Bourne K; Hermes JR; Arshi M; Hampton HR; Tomura M; Miwa Y; Kelleher AD; Kaplan W; Deenick EK; Tangye SG; Brink R; Chtanova T; Phan TG, 2015, 'T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses', Immunity, 42, pp. 704 - 718, http://dx.doi.org/10.1016/j.immuni.2015.03.002

Tangye SG, 2015, 'Thucydides and longer-lived plasma cells', Blood, 125, pp. 1684 - 1685, http://dx.doi.org/10.1182/blood-2015-01-622514

Butt D; Chan TD; Bourne K; Hermes JR; Nguyen A; Statham A; O'Reilly LA; Strasser A; Price S; Schofield P; Christ D; Basten A; Ma CS; Tangye SG; Phan TG; Rao VK; Brink R, 2015, 'FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production', Immunity, 42, pp. 890 - 902, http://dx.doi.org/10.1016/j.immuni.2015.04.010

Tangye SG, 2014, 'XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP', Journal of Clinical Immunology, 34, pp. 772 - 779, http://dx.doi.org/10.1007/s10875-014-0083-7

Kuehn HS; Ouyang W; Lo B; Deenick EK; Niemela JE; Avery DT; Schickel JN; Tran DQ; Stoddard J; Zhang Y; Frucht DM; Dumitriu B; Scheinberg P; Folio LR; Frein CA; Price S; Koh C; Heller T; Seroogy CM; Huttenlocher A; Rao VK; Su HC; Kleiner D; Notarangelo LD; Rampertaap Y; Olivier KN; McElwee J; Hughes J; Pittaluga S; Oliveira JB; Meffre E; Fleisher TA; Holland SM; Lenardo MJ; Tangye SG; Uzel G, 2014, 'Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4', Science, 345, pp. 1623 - 1627, http://dx.doi.org/10.1126/science.1255904

Hutchinson AT; Jones DR; McCauley Winter P; Tangye SG; Raison RL, 2014, 'Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts', Human Immunology, http://dx.doi.org/10.1016/j.humimm.2014.08.196

Tangye SG, 2014, 'XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP', Journal of Clinical Immunology, http://dx.doi.org/10.1007/s10875-014-0083-7

Reynaud CA; Tangye S, 2014, 'Editorial overview: Lymphocyte activation and effector functions', Current Opinion in Immunology, 28, pp. v - vii, http://dx.doi.org/10.1016/j.coi.2014.04.001

Kane A; Deenick EK; Ma CS; Cook MC; Uzel G; Tangye SG, 2014, 'STAT3 is a central regulator of lymphocyte differentiation and function', Current Opinion in Immunology, 28, pp. 49 - 57, http://dx.doi.org/10.1016/j.coi.2014.01.015

Tangye SG, 2014, 'The right ''Job'' for STAT3 mutant mice!', Blood, 123, pp. 2907 - 2909, http://dx.doi.org/10.1182/blood-2014-04-563726

Koganti S; Hui-Yuen J; McAllister S; Gardner B; Grasser F; Palendira U; Tangye SG; Freeman AF; Bhaduri-McIntosh S, 2014, 'STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation', Proceedings of the National Academy of Sciences of the United States of America, 111, pp. 4946 - 4951, http://dx.doi.org/10.1073/pnas.1400683111

Hutchinson AT; Jones DR; McCauley Winter P; Tangye SG; Raison RL, 2014, 'Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts', Human Immunology, 75, pp. 986 - 990, http://dx.doi.org/10.1016/j.humimm.2014.08.196

Moens L; Tangye SG, 2014, 'Cytokine-mediated regulation of plasma cell generation: IL-21 takes center stage', Frontiers in Immunology, 5, http://dx.doi.org/10.3389/fimmu.2014.00065

Lucas CL; Kuehn HS; Zhao F; Niemela JE; Deenick EK; Palendira U; Avery DT; Moens L; Cannons JL; Biancalana M; Stoddard J; Ouyang W; Frucht DM; Rao VK; Atkinson TP; Agharahimi A; Hussey AA; Folio LR; Olivier KN; Fleisher TA; Pittaluga S; Holland SM; Cohen JI; Oliveira JB; Tangye SG; Schwartzberg PL; Lenardo MJ; Uzel G, 2014, 'Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency', Nature Immunology, 15, pp. 88 - 97, http://dx.doi.org/10.1038/ni.2771

Reynaud CA; Tangye S, 2014, 'Editorial overview: Lymphocyte activation and effector functions.', Current opinion in immunology, 28

Ma CS; Uzel G; Tangye SG, 2014, 'Human T follicular helper cells in primary immunodeficiencies', Current Opinion in Pediatrics, 26, pp. 720 - 726, http://dx.doi.org/10.1097/MOP.0000000000000157

Menard L; Cantaert T; Chamberlain N; Tangye SG; Riminton S; Church JA; Klion A; Cunningham-Rundles C; Nichols KE; Meffre E, 2014, 'Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance', Journal of Allergy and Clinical Immunology, 133, pp. 1149 - 1161, http://dx.doi.org/10.1016/j.jaci.2013.10.051

Tangye SG, 2014, 'T cells require DOCK8 for flexibility and function', Journal of Experimental Medicine, 211, pp. 2482 - 2483, http://dx.doi.org/10.1084/jem.21113insight2

Berglund LJ; Avery DT; Ma CS; Moens L; Deenick EK; Bustamante J; Boisson-Dupuis S; Wong M; Adelstein S; Arkwright PD; Bacchetta R; Bezrodnik L; Dadi H; Roifman CM; Fulcher DA; Ziegler JB; Smart JM; Kobayashi M; Picard C; Durandy A; Cook MC; Casanova JL; Uzel G; Tangye SG, 2013, 'IL-21 signalling via STAT3 primes human näive B cells to respond to IL-2 to enhance their differentiation into plasmablasts', Blood, 122, pp. 3940 - 3950, http://dx.doi.org/10.1182/blood-2013-06-506865

Boisson B; Wang YD; Bosompem A; Ma CS; Lim A; Kochetkov T; Tangye SG; Casanova JL; Conley ME, 2013, 'A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR^- B cells', Journal of Clinical Investigation, 123, pp. 4781 - 4785, http://dx.doi.org/10.1172/JCI71927

Deenick EK; Avery DT; Chan A; Berglund LJ; Ives ML; Moens L; Stoddard JL; Bustamante J; Boisson-Dupuis S; Tsumura M; Kobayashi M; Arkwright PD; Averbuch D; Engelhard D; Roesler J; Peake J; Wong M; Adelstein S; Choo S; Smart JM; French MA; Fulcher DA; Cook MC; Picard C; Durandy A; Klein C; Holland SM; Uzel G; Casanova JL; Ma CS; Tangye SG, 2013, 'Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells', Journal of Experimental Medicine, 210, pp. 2739 - 2753, http://dx.doi.org/10.1084/jem.20130323

Hill ER; Kogantil S; Zhi J; Megyola C; Freeman AF; Palendira U; Tangye SG; Farrell PJ; Bhaduri-McIntosh S, 2013, 'Signal transducer and activator of transcription 3 limits epstein-barr virus lytic activation in B lymphocytes', Journal of Virology, 87, pp. 11438 - 11446, http://dx.doi.org/10.1128/JVI.01762-13

He J; Tsai LM; Leong YA; Hu X; Ma CS; Chevalier N; Sun X; Vandenberg K; Rockman S; Ding Y; Zhu L; Wei W; Wang C; Karnowski A; Belz GT; Ghali JR; Cook MC; Riminton DS; Veillette A; Schwartzberg PL; Mackay F; Brink R; Tangye SG; Vinuesa CG; Mackay CR; Li Z; Yu D, 2013, 'Circulating precursor CCR7^loPD-1^hi CXCR5⁺ CD4⁺ T cells indicate tfh cell activity and promote antibody responses upon antigen reexposure', Immunity, 39, pp. 770 - 781, http://dx.doi.org/10.1016/j.immuni.2013.09.007

Agrawal S; Smith SABC; Tangye SG; Sewell WA, 2013, 'Transitional B cell subsets in human bone marrow', Clinical and Experimental Immunology, 174, pp. 53 - 59, http://dx.doi.org/10.1111/cei.12149

Byun M; Ma Cindy S. CS; Akçay A; Pedergnana V; Palendira U; Myoung J; Avery DT; Liu Y; Abhyankar A; Lorenzo L; Schmidt M; Lim HK; Cassar O; Migaud M; Rozenberg F; Canpolat N; Aydogan G; Fleckenstein B; Bustamante J; Picard C; Gessain A; Jouanguy E; Cesarman E; Olivier M; Gros P; Abel L; Croft M; Tangye SG; Casanova JL, 2013, 'Inherited human OX40 deficiency underlying classic kaposi sarcoma of childhood', Journal of Experimental Medicine, 210, pp. 1743 - 1759, http://dx.doi.org/10.1084/jem.20130592

Tangye SG, 2013, 'To B1 or not to B1: that really is still the question!', Blood, 121, pp. 5109 - 5110, http://dx.doi.org/10.1182/blood-2013-05-500074

Crawford G; Enders A; Gileadi U; Stankovic S; Zhang Q; Lambe T; Crockford TL; Lockstone HE; Freeman A; Arkwright PD; Smart JM; Ma CS; Tangye SG; Goodnow CC; Cerundolo V; Godfrey DI; Su HC; Randall KL; Cornall RJ, 2013, 'DOCK8 is critical for the survival and function of NKT cells', Blood, 122, pp. 2052 - 2061, http://dx.doi.org/10.1182/blood-2013-02-482331

Ives ML; Ma CS; Palendira U; Chan A; Bustamante J; Boisson-Dupuis S; Arkwright PD; Engelhard D; Averbuch D; Magdorf K; Roesler J; Peake J; Wong M; Adelstein S; Choo S; Smart JM; French MA; Fulcher DA; Cook MC; Picard C; Durandy A; Tsumura M; Kobayashi M; Uzel G; Casanova JL; Tangye SG; Deenick EK, 2013, 'Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8⁺ T-cell memory formation and function', Journal of Allergy and Clinical Immunology, 132, pp. 400 - 411.e9, http://dx.doi.org/10.1016/j.jaci.2013.05.029

Tangye SG; Ma CS; Brink R; Deenick EK, 2013, 'The good, the bad and the ugly-T FH cells in human health and disease', Nature Reviews Immunology, 13, pp. 412 - 426, http://dx.doi.org/10.1038/nri3447

Belz G; Tangye SG; Liston A, 2012, 'A new ICB sister journal focuses on clinical and translational immunology', Clinical and Translational Immunology, 1, http://dx.doi.org/10.1038/cti.2012.3

Tangye SG; Brink R, 2012, 'A helping hand from neutrophils in T cell-independent antibody responses?', Nature Immunology, 13, pp. 111 - 113, http://dx.doi.org/10.1038/ni.2214

Cliffe S; Bloch D; Suryani S; Kamsteeg E; Avery D; Palendira U; Church J; Wainstein B; Trizzino A; Lefranc G; Akatcherian C; Megarbane A; Gilissen C; Moshous D; Reichenbach J; Misbah S; Salzer U; Abinun M; Ong P; Stepensky P; Ruga E; Ziegler JB; Wong M; Tangye SG; Lindeman R; Buckley M; Roscioli T, 2012, 'Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome', Journal of Allergy and Clinical Immunology, 130, pp. 735 - 742, http://dx.doi.org/10.1016/j.jaci.2012.02.054

Tangye SG, 2012, 'Defects in lymphocyte function and interactions in primary immunodeficiencies: insights into disease pathogenesis', Pathology, 44, pp. S39 - S39, http://dx.doi.org/10.1016/s0031-3025(16)32689-7

Palendira U; Bell A; Ma CS; Abbott RJM; Phan TG; Riminton DS; Choo S; Smart J; Lougaris V; Giliani S; Buckley RH; Grimbacher B; Alvaro F; Klion AD; Nichols K; Adelstein S; Rickinson A; Tangye SG, 2012, 'Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus', Journal of Experimental Medicine, 209, pp. 913 - 924, http://dx.doi.org/10.1084/jem.20112391

Ma C; Avery D; Chan A; Batten ML; Bustamante J; Boisson-Dupuis S; Arkwright PD; Kreins AY; Averbuch D; Engelhard D; Magdorf K; Kilic S; Minegishi Y; Gray PE, 2012, 'Functional STAT3 deficiency compromises the generation of human T follicular helper cells', Blood, 119, pp. 3997 - 4008, http://dx.doi.org/10.1182/blood-2011-11-392985

Crequer A; Troeger A; Patino E; Ma CS; Picard C; Pedergnana V; Fieschi C; Lim A; Abhyankar A; Gineau L; Mueller-Fleckenstein I; Schmidt M; Taieb A; Kreuger J; Abela L; Tangye SG; Orth G; Williams DA; Casanova J-L; Jouanguy E, 2012, 'Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections', Journal of Clinical Investigation, 122, pp. 3239 - 3247, http://dx.doi.org/10.1172/JCI62949

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