By Professor Susan Clark

Journal articles

Melki JR; Vincent PC; Clark SJ, 1997, 'DNA methylation in leukemia', Experimental Hematology, 25, pp. 855

Warnecke PM; Stirzaker C; Melki JR; Millar DS; Paul CL; Clark SJ, 1997, 'Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA.', Nucleic Acids Res, 25, pp. 4422 - 4426, http://dx.doi.org/10.1093/nar/25.21.4422

Stirzaker C; Millar DS; Paul CL; Warnecke PM; Harrison J; Vincent PC; Frommer M; Clark SJ, 1997, 'Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors', Cancer Research, 57, pp. 2229 - 2237

Clark SJ; Harrison J; Molloy PL, 1997, 'Sp1 binding is inhibited by (m)Cp(m)CpG methylation', Gene, 195, pp. 67 - 71, http://www.ncbi.nlm.nih.gov/pubmed/9300822

Paul CL; Clark SJ, 1996, 'Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN analysis', Biotechniques, 21, pp. 126 - 133, http://www.ncbi.nlm.nih.gov/pubmed/8816247

Clark SJ; Harrison J; Frommer M, 1995, 'CpNpG methylation in mammalian cells', Nat Genet, 10, pp. 20 - 27, http://dx.doi.org/10.1038/ng0595-20

Harrison J; Molloy PL; Clark SJ, 1994, 'Direct cloning of polymerase chain reaction products in an XcmI T-vector', Anal Biochem, 216, pp. 235 - 236, http://www.ncbi.nlm.nih.gov/pubmed/8135360

Clark SJ; Harrison J; Paul CL; Frommer M, 1994, 'High sensitivity mapping of methylated cytosines', Nucleic Acids Res, 22, pp. 2990 - 2997, http://www.ncbi.nlm.nih.gov/pubmed/8065911

Grigg G; Clark S, 1994, 'Sequencing 5-methylcytosine residues in genomic DNA', Bioessays, 16, pp. 431 - 436, http://dx.doi.org/10.1002/bies.950160612

Greenwood PE; Clark SJ; Cahill AD; Trevallyn-Jones J; Tzipori S, 1988, 'Development and protective efficacy of a recombinant-DNA derived fimbrial vaccine against enterotoxic colibacillosis in neonatal piglets', Vaccine, 6, pp. 389 - 392, http://www.ncbi.nlm.nih.gov/pubmed/3057758

Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proceedings of the National Academy of Sciences of the United States of America, 79, pp. 749 - 753, http://dx.doi.org/10.1073/pnas.79.3.749

Rickles R; Marashi F; Sierra F; Clark S; Wells J; Stein J; Stein G, 1982, 'Analysis of histone gene expression during the cell cycle in HeLa cells by using cloned human histone genes', Proc Natl Acad Sci U S A, 79, pp. 749 - 753, http://www.ncbi.nlm.nih.gov/pubmed/6461006

Sierra F; Leza A; Marashi F; Plumb M; Rickles R; Van Dyke T; Clark S; Wells J; Stein GS; Stein JL, 1982, 'Human histone genes are interspersed with members of the Alu family and with other transcribed sequences', Biochem Biophys Res Commun, 104, pp. 785 - 792, http://www.ncbi.nlm.nih.gov/pubmed/6280702

Lichtler AC; Sierra F; Clark S; Wells JR; Stein JL; Stein GS, 1982, 'Multiple H4 histone mRNAs of HeLa cells are encoded in different genes', Nature, 298, pp. 195 - 198, http://www.ncbi.nlm.nih.gov/pubmed/6283378

Sierra F; Lichtler A; Marashi F; Rickles R; Van Dyke T; Clark S; Wells J; Stein G; Stein J, 1982, 'Organization of human histone genes', Proc Natl Acad Sci U S A, 79, pp. 1795 - 1799, http://www.ncbi.nlm.nih.gov/pubmed/6281786

Clark SJ; Krieg PA; Wells JR, 1981, 'Isolation of a clone containing human histone genes', Nucleic Acids Res, 9, pp. 1583 - 1590, http://www.ncbi.nlm.nih.gov/pubmed/6262733

Conference Papers

Conduit C; Mak B; Qu W; Yeung T; Bressel M; Cusick T; Dhillon HM; Lourenco RDA; Underhill C; Torres J; Crumbaker M; Honeyball F; Linton A; Sewak S; Chau NMH; Allen R; Davis ID; Clark SJ; Horvath L; Mahon KL, 2023, 'GUIDE: A randomized non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (ANZUP 1903).', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 02 June 2023 - 06 June 2023

Lawrence MG; Pidsley R; Zotenko E; Niranjan B; Statham A; Song J; Armstrong N; Pedersen J; Frydenberg M; Taylor R; Stirzaker C; Risbridger G; Clark S, 2017, 'Abstract 1997: Charting the DNA methylation landscape of prostate cancer associated fibroblasts', in Cancer Research, American Association for Cancer Research (AACR), pp. 1997 - 1997, http://dx.doi.org/10.1158/1538-7445.am2017-1997

Milevskiy MJ; Al-Ejeh F; Saunus JM; Northwood KS; McCart-Reed AE; Dray E; Nephew K; Bailey PJ; Betts JA; Stone A; Gee JMW; Shewan AM; French JD; Edwards SL; Clark SJ; Lakhani SR; Brown MA, 2016, 'Abstract 1980: Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability', in Cancer Research, American Association for Cancer Research (AACR), pp. 1980 - 1980, http://dx.doi.org/10.1158/1538-7445.am2016-1980

Clark S, 2014, 'WHOLE GENOME METHYLATION SEQUENCING IDENTIFIES POTENTIAL EPIGENETIC-BASED CANCER BIOMARKERS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 18 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344745100037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler M; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark S; Swarbrick A; Daly R; Horvath L, 2014, 'CIRCULATING MICRORNAS ASSOCIATED WITH DOCETAXEL-RESISTANT CASTRATION-RESISTANT PROSTATE CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 26 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Clark SJ, 2014, 'EPIGENETIC REMODELING AND REPLICATION TIMING IN CANCER', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 28 - 28, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mahon K; Qu W; Devaney J; Paul C; Castillo L; Chatfield M; Boyer M; Stockler M; Marx G; Gurney H; Mallesara G; Molloy P; Horvath L; Clark S, 2014, 'METHYLATED GLUTATHIONE S-TRANSFERASE 1 (MGSTP1) ASA POTENTIAL PLASMA EPIGENETIC MARKER OF PROGNOSIS AND RESPONSE TO CHEMOTHERAPY IN CASTRATE-RESISTANT PROSTATE CANCER (CRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 27 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339716200013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Stirzaker C; Song JZ; Statham AL; Robinson M; Lacaze P; Coolen M; Moreno CS; Warren K; Clark SJ, 2009, 'CONSOLIDATION OF THE CANCER EPIGENOME TO REGIONS OF UNIFORM CHROMATIN', in CELLULAR ONCOLOGY, IOS PRESS, SCOTLAND, Edinburgh, pp. 136 - 136, presented at 3rd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SCOTLAND, Edinburgh, 01 April 2009 - 05 April 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265635300098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Stirzaker C; Song JZ; Statham AL; Robinson M; Lacaze P; Coolen M; Moreno CS; Warren K; Clark SJ, 2009, 'CONSOLIDATION OF THE CANCER EPIGENOME TO REGIONS OF UNIFORM CHROMATIN', in CELLULAR ONCOLOGY, SPRINGER, SCOTLAND, Edinburgh, pp. 101 - 101, presented at 3rd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SCOTLAND, Edinburgh, 01 April 2009 - 05 April 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265635300028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Coolen M; Song J; Statham AL; Lacaze P; Moreno CS; Kaplan W; Stirzaker C; Clark SJ, 2008, 'Long range epigenetic silencing (LRES): A common phenomenon in prostate cancer', in CELLULAR ONCOLOGY, IOS PRESS, SPAIN, Madrid, pp. 225 - 225, presented at 2nd Marie Curie-Genome Architecture in Relation to Disease Meeting (MC-GARD), SPAIN, Madrid, 04 May 2008 - 07 May 2008, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000255341800005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Frigola J; Song JZ; Stirzaker C; Peinado MA; Clark SJ, 2006, 'Epigenetic Silent Neighborhoods in Cancer Cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454606204232&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Melki JR; Vincent PC; Clark SJ, 1997, 'DNA methylation in leukemia.', in EXPERIMENTAL HEMATOLOGY, CARDEN JENNINGS PUBL CO LTD, pp. 444 - 444, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997XR33000430&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Tian L; Jiao X; Wang C; Ertel A; Soccio R; Chen ER; Győrffy B; Sante GD; Zhong Z; Addya S; McCue PA; Kossenkov AV; Achinger-Kawecka J; Clark S; Pestell RG, 2024, 'Abstract 3582: PPAR gamma acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding', in Cancer Research, American Association for Cancer Research (AACR), Vol. 84, pp. 3582 - 3582, http://dx.doi.org/10.1158/1538-7445.am2024-3582

Meyer B; Stirzaker C; Ramkomuth S; Harvey K; Swarbrick A; Clark SJ; O'Toole S; Pidsley R, 2024, 'Detailed DNA methylation characterisation of phyllodes tumours identifies a signature of malignancy and distinguishes phyllodes from metaplastic breast carcinoma', in Pathology, Elsevier, Vol. 56, pp. s70 - s71, http://dx.doi.org/10.1016/j.pathol.2023.12.241

Tiedemann RL; Du Q; Dickson BM; Kong X; Chomiak AA; Zhou W; Johnson BK; Baylin SB; Jones PA; Clark SJ; Rothbart SB, 2020, 'High‐resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation', in The FASEB Journal, Wiley, Vol. 34, pp. 1 - 1, http://dx.doi.org/10.1096/fasebj.2020.34.s1.05966

Stirzaker C; Chia KM; Portman N; Milioli HH; Clifton S; Achinger-Kawecka J; Nair S; Lim E; Clark S, 2019, 'DNA demethylation agents as a therapeutic approach in endocrine-resistant breast cancer', in Oncolabs, presented at 7th PacRim Breast & Prostate Cancer Meeting, http://dx.doi.org/10.1530/oncolabs.1.P049

Mathe A; Wong-Brown M; Morten BC; Braye SG; Locke WJ; Stirzaker C; Clark SJ; Scott R; Avery-Kiejda KA, 2018, 'Defining the Key Mediators of Breast Cancer Progression and Treatment Resistance in the triple Negative Subtype', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 14, pp. 9 - 9, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446654600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Horvath LG; Mahon KL; Qu W; Lin HM; Spielman C; Cain D; Jacobs C; Stockler MR; de Bono JS; Higano CS; Chi KN; Clark SJ, 2018, 'Post Hoc Analysis of a Phase III Study to Test the Association Between Circulating Methylated Glutathione S Transferase (mGSTP1) DNA Levels and Response to Docetaxel (DTX) in Metastatic Castration-Resistant Prostate Cancer (mCRPC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 14, pp. 51 - 52, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000439493100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Mathe A; Wong-Brown M; Locke W; Stirzaker C; Braye S; Forbes J; Clark S; Avery-Kiejda K; Scott R, 2016, 'DNA METHYLATION PROFILE OF TRIPLE NEGATIVE BREAST CANCER-SPECIFIC GENES COMPARING LYMPH NODE POSITIVE PATIENTS TO LYMPH NODE NEGATIVE PATIENTS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 27 - 27, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387772400056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Vuocolo T; Statham A; Bauer DC; McWilliam S; Nair SS; Morrison JL; Zhang S; Buckley M; McMillen IC; Clark SJ; Tellam RL, 2016, 'A hierarchy of epigenetic changes in the developmental transition from brown to white perirenal adipose tissue.', in JOURNAL OF ANIMAL SCIENCE, OXFORD UNIV PRESS INC, Vol. 94, pp. 9 - 10, http://dx.doi.org/10.2527/jas2016.94supplement49a

Lawrence M; Pidsley R; Ellem S; Furic L; Nair S; French H; Statham A; Larsson O; Frydenberg M; Pedersen J; Buchanan G; Taylor R; Clark S; Risbridger G, 2015, 'Surveying the epigenome landscape of the prostate cancer microenvironment: identification of estrogen receptor alpha as a key differentially methylated gene', in CLINICAL ENDOCRINOLOGY, WILEY, AUSTRALIA, Adelaide, Vol. 84, pp. 20 - 20, presented at Annual Scientific Meeting of the Endocrine-Society-of-Australia, AUSTRALIA, Adelaide, 23 August 2015 - 26 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000372310400056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Gallego-Ortega D; Ledger A; Roden D; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Lee B; Kaplan W; Salomon R; Piggin C; Rabinovich B; Millar E; Chtanova T; Swarbrick A; Clark S; Ormandy C, 2015, 'The ETS transcription factor ELF5 drives metastasis via angiogenesis and recruitment of Gr-1+ CD11b+ myeloid derived suppressor cells in luminal breast cancer', in Clinical and Experimental Metastasis, Springer Verlag (Germany), Vol. 32, pp. 203 - 203, presented at MRS 15th International biennial congress of the metastasis research society

Working Papers

Du Q; Smith GC; Luu PL; Ferguson JM; Armstrong NJ; Caldon CE; Campbell E; Nair SS; Zotenko E; Gould CM; Buckley M; Kaczorowski D; Barton K; Deveson IW; Smith MA; Powell JE; Skvortsova K; Stirzaker C; Achinger-Kawecka J; Clark SJ, DNA methylation is required to maintain DNA replication timing precision and 3D genome integrity, Cold Spring Harbor Laboratory, http://dx.doi.org10.1101/2020.10.15.338855

Preprints

Du Q; Bert S; Armstrong N; Caldon E; Song J; Nair S; Gould C; Luu PL; Khoury A; Qu W; Zotenko E; Stirzaker C; Clark S, 2018, Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements, http://dx.doi.org/10.1101/251280

Riebler A; Menigatti M; Song JZ; Statham AL; Stirzaker C; Mahmud N; Mein CA; Clark SJ; Robinson MD, 2013, BayMeth: Improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach, http://dx.doi.org/10.48550/arxiv.1312.3115

Salazar-Roa M; Trakala M; Álvarez-Fernández M; Valdés-Mora F; Zhong C; Muñoz J; Yu Y; Peters TJ; Graña O; Serrano R; Zapatero-Solana E; Abad M; Bueno MJ; de Cedrón MG; Fernández-Piqueras J; Serrano M; Blasco MA; Wang D-Z; Clark SJ; Izpisua-Belmonte JC; Ortega S; Malumbres M, A novel microRNA-based strategy to expand the differentiation potency of stem cells, http://dx.doi.org/10.1101/826446

Lam D; Clark S; Stirzaker C; Pidsley R, Advances in Prognostic Methylation Biomarkers for Prostate Cancer, http://dx.doi.org/10.20944/preprints202010.0154.v1

Campbell EM; Laven-Law G; Jones A; Challis D; Peters TJ; Smith G; Colino-Sanguino Y; Moulder D; Du Q; Giles KA; Thomson DW; Stirzaker C; Hickey TA; Mora FV; Khoury A; Clark SJ; Achinger-Kawecka J, Androgen stimulation rapidly reorganizes temporal 3D genome and epigenome states to trigger AR-mediated transcription in prostate cancer, http://dx.doi.org/10.1101/2024.12.17.628805

Giles KA; Gould CM; Achinger-Kawecka J; Page SG; Kafer G; Luu P-L; Cesare AJ; Clark SJ; Taberlay PC, BRG1 promotes transcriptional patterns that are permissive to proliferation in cancer cells, http://dx.doi.org/10.1101/2020.07.03.187385

Angeloni A; Hammond JM; Peters TJ; Reis ALM; Kemp L; Amos T; Gamaarachchi H; Humphries S; Wilmott LA; Pal S; Masamsetti VP; Weatherstone M; Ip KCK; Pazaky K; Steel A; Lyons R; Walters ED; Liu N; Tam P; Polo JM; Waters P; Clark SJ; Richards LJ; Smith AD; Lee H; Deveson IW; Griffith OW; Skvortsova K, DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage, http://dx.doi.org/10.1101/2025.11.09.686659

Skvortsova K; Angeloni A; Hammond J; Peters T; Reis ALM; Kemp L; Amos T; Gamaarachchi H; Humphries S; Wilmott L; Pal S; Masamsetti VP; Weatherstone M; Ip KCK; Pazaky K; Steel A; Lyons R; Walters E; Liu N; Tam P; Polo J; Waters P; Clark S; Richards L; Smith A; Lee H; Deveson I; Griffith O, DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage, http://dx.doi.org/10.21203/rs.3.rs-8110586/v1

Achinger-Kawecka J; Stirzaker C; Portman N; Campbell E; Chia K-M; Du Q; Laven-Law G; Nair SS; Yong A; Wilkinson A; Clifton S; Milioli HH; Alexandrou S; Caldon CE; Song J; Khoury A; Meyer B; Gee JMW; Schmitt A; Wong ES; Hickey TE; Lim E; Clark SJ, Epigenetic therapy targets the 3D epigenome in endocrine-resistant breast cancer, http://dx.doi.org/10.1101/2021.06.21.449340

González-Rajal Á; D’Araujo TY; Ovchinnikov V; Alcalá JLG-J; Wang T; Lausen B; Brethouwer T; Angeloni A; Ross SE; Burgos-Ruiz AM; Álvarez-Presas M; Mota-Gómez I; Acemel RD; Harris RJ; Loi-Luu P; Jimenez GE; Daners A; Ferguson JM; Hammond JM; Gamaarachchi H; Degnan BM; Degnan SM; Mackay JP; Undheim EAB; Ruiz-Trillo I; Clark SJ; Tena JJ; Lupiáñez DG; Church SH; Dunn CW; Marletaz F; Deveson IW; Cummins SF; Neely GG; de Mendoza A; Bogdanovic O, Integrative genomics of the siphonophore Physalia utriculus reveals the regulatory logic of colonial division of labour and the molecular basis of venom activity, http://dx.doi.org/10.64898/2026.08.01.742136

King HE; O’Connell S; Kavanagh D; Mason S; McCool C; Fernandez-Chamorro J; Chaffer C; Clark SJ; Vieira HGS; Sterne-Weiler T; Weatheritt RJ, Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response, http://dx.doi.org/10.1101/2025.07.14.664827

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