By Professor Susan Clark

Journal articles

Giles KA; Gould CM; Du Q; Skvortsova K; Song JZ; Maddugoda MP; Achinger-Kawecka J; Stirzaker C; Clark SJ; Taberlay PC, 2019, 'Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups', Epigenetics and Chromatin, 12, http://dx.doi.org/10.1186/s13072-019-0258-9

Skvortsova K; Masle-Farquhar E; Luu PL; Song JZ; Qu W; Zotenko E; Gould CM; Du Q; Peters TJ; Colino-Sanguino Y; Pidsley R; Nair SS; Khoury A; Smith GC; Miosge LA; Reed JH; Kench JG; Rubin MA; Horvath L; Bogdanovic O; Lim SM; Polo JM; Goodnow CC; Stirzaker C; Clark SJ, 2019, 'DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns', Cancer Cell, 35, pp. 297 - 314.e8, http://dx.doi.org/10.1016/j.ccell.2019.01.004

Salazar-Roa M; Trakala M; Álvarez-Fernández M; Valdés-Mora F; Zhong C; Muñoz J; Yu Y; Peters T; Graña O; Serrano R; Zapatero-Solana E; Abad M; Bueno MJ; de Cedrón MG; Fernández-Piqueras J; Serrano M; Blasco M; Wang D-Z; Clark S; Izpisua-Belmonte JC; Ortega S; Malumbres M, 2019, 'A novel microRNA-based strategy to expand the differentiation potency of stem cells', , http://dx.doi.org/10.1101/826446

Carpenter BL; Zhou W; Madaj Z; DeWitt AK; Ross JP; Grønbæk K; Liang G; Clark SJ; Molloy PL; Jones PA, 2018, 'Mother–child transmission of epigenetic information by tunable polymorphic imprinting', Proceedings of the National Academy of Sciences of the United States of America, 115, pp. E11970 - E11977, http://dx.doi.org/10.1073/pnas.1815005115

Holliday H; Baker LA; Junankar SR; Clark SJ; Swarbrick A, 2018, 'Epigenomics of mammary gland development', Breast Cancer Research, 20, http://dx.doi.org/10.1186/s13058-018-1031-x

O'Donoghue SI; Baldi BF; Clark SJ; Darling AE; Hogan JM; Kaur S; Maier-Hein L; McCarthy DJ; Moore WJ; Stenau E; Swedlow JR; Vuong J; Procter JB, 2018, 'Visualization of Biomedical Data', Annual Review of Biomedical Data Science, 1, pp. 1 - 30, http://dx.doi.org/10.1146/annurev-biodatasci-080917-013424

Nair SS; Luu PL; Qu W; Maddugoda M; Huschtscha L; Reddel R; Chenevix-Trench G; Toso M; Kench JG; Horvath LG; Hayes VM; Stricker PD; Hughes TP; White DL; Rasko JEJ; Wong JJL; Clark SJ, 2018, 'Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten', Epigenetics and Chromatin, 11, http://dx.doi.org/10.1186/s13072-018-0194-0

Pidsley R; Lawrence MG; Zotenko E; Niranjan B; Statham A; Song J; Chabanon RM; Qu W; Wang H; Richards M; Nair SS; Armstrong NJ; Nim HT; Papargiris M; Balanathan P; French H; Peters T; Norden S; Ryan A; Pedersen J; Kench J; Daly RJ; Horvath LG; Stricker P; Frydenberg M; Taylor RA; Stirzaker C; Risbridger GP; Clark SJ, 2018, 'Enduring epigenetic landmarks define the cancer microenvironment', Genome Research, 28, pp. 625 - 638, http://dx.doi.org/10.1101/gr.229070.117

Stirzaker C; Song JZ; Statham AL; Clark SJ, 2018, 'Bisulphite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq)', Methods in Molecular Biology, 1708, pp. 285 - 302, http://dx.doi.org/10.1007/978-1-4939-7481-8_15

Knaupp AS; Buckberry S; Pflueger J; Lim SM; Ford E; Larcombe MR; Rossello FJ; de Mendoza A; Alaei S; Firas J; Holmes ML; Nair SS; Clark SJ; Nefzger CM; Lister R; Polo JM, 2017, 'Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming', Cell Stem Cell, 21, pp. 834 - 845.e6, http://dx.doi.org/10.1016/j.stem.2017.11.007

Valdés-Mora F; Gould CM; Colino-Sanguino Y; Qu W; Song JZ; Taylor KM; Buske FA; Statham AL; Nair SS; Armstrong NJ; Kench JG; Lee KML; Horvath LG; Qiu M; Ilinykh A; Yeo-Teh NS; Gallego-Ortega D; Stirzaker C; Clark SJ; Valdes Mora F; Colino Sanguino Y; Sasidharan-Nair S, 2017, 'Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer', Nature Communications, 8, pp. 1346, http://dx.doi.org/10.1038/s41467-017-01393-8

Clark SJ; Molloy PL, 2017, 'Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation', Cancer Cell, 32, pp. 278 - 280, http://dx.doi.org/10.1016/j.ccell.2017.08.016

Mahon KL; Qu W; Lin H-M; Spielman C; Cain D; Jacobs C; Chi KN; De Bono JS; Higano CS; Clark SJ; Horvath L, 2017, 'Post hoc analysis of a phase III study to test the association between circulating methylated glutathione s transferase (mGSTP1) DNA levels and response to docetaxel (DTX) in metastatic castration resistant prostate cancer (mCRPC).', Journal of Clinical Oncology, 35, pp. 5014 - 5014, http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5014

Skvortsova K; Zotenko E; Luu PL; Gould CM; Nair SS; Clark SJ; Stirzaker C; Sasidharan-Nair S, 2017, 'Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA', Epigenetics and Chromatin, 10, pp. 16, http://dx.doi.org/10.1186/s13072-017-0123-7

Stirzaker C; Song JZ; Ng W; Du Q; Armstrong NJ; Locke WJ; Statham AL; French H; Pidsley R; Valdes-Mora F; Zotenko E; Clark SJ, 2017, 'Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer', Oncogene, 36, pp. 1328 - 1338, http://dx.doi.org/10.1038/onc.2016.297

Achinger-Kawecka J; Clark SJ, 2017, 'Disruption of the 3D cancer genome blueprint', Epigenomics, 9, pp. 47 - 55, http://dx.doi.org/10.2217/epi-2016-0111

Lawrence M; Pidlsey R; Zotenko E; Niranjan B; Nair S; French H; Statham A; Song J; Chabanon R; Papargiris M; Ellem S; Frydenberg M; Pedersen J; Stirzaker C; Taylor R; Clark S; Risbridger G, 2017, 'Hypomethylation of estrogen receptor alpha: a landmark in the epigenome landscape of prostate cancer stroma', CLINICAL ENDOCRINOLOGY, 86, pp. 23 - 23, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000393453600061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Pidsley R; Zotenko E; Peters TJ; Lawrence MG; Risbridger GP; Molloy P; Van Djik S; Muhlhausler B; Stirzaker C; Clark SJ, 2016, 'Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling', Genome Biology, 17, pp. 208, http://dx.doi.org/10.1186/s13059-016-1066-1

Pidsley R; Zotenko E; Peters TJ; Lawrence MG; Risbridger GP; Molloy P; Van Djik S; Muhlhausler B; Stirzaker C; Clark SJ, 2016, 'Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling', GENOME BIOLOGY, 17, http://dx.doi.org/10.1186/s13059-016-1066-1

Mathe A; Wong-Brown M; Locke WJ; Stirzaker C; Braye SG; Forbes JF; Clark SJ; Avery-Kiejda KA; Scott RJ, 2016, 'DNA methylation profile of triple negative breast cancer-specific genes comparing lymph node positive patients to lymph node negative patients', Scientific Reports, 6, pp. 33435, http://dx.doi.org/10.1038/srep33435

Milevskiy MJG; Al-Ejeh F; Saunus JM; Northwood KS; Bailey PJ; Betts JA; Reed AEMC; Nephew KP; Stone A; Gee JMW; Dowhan DH; Dray E; Shewan AM; French JD; Edwards SL; Clark SJ; Lakhani SR; Brown MA, 2016, 'Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer', Human Molecular Genetics, 25, pp. 3269 - 3283, http://dx.doi.org/10.1093/hmg/ddw177

Lim AM; Wong NC; Pidsley R; Zotenko E; Corry J; Dobrovic A; Clark SJ; Rischin D; Solomon B, 2016, 'Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas', Clinical Epigenetics, 8, http://dx.doi.org/10.1186/s13148-016-0235-0

Bock C; Halbritter F; Carmona FJ; Tierling S; Datlinger P; Assenov Y; Berdasco M; Bergmann AK; Booher K; Busato F; Campan M; Dahl C; Dahmcke CM; Diep D; Fernández AF; Gerhauser C; Haake A; Heilmann K; Holcomb T; Hussmann D; Ito M; Kläver R; Kreutz M; Kulis M; Lopez V; Nair SS; Paul DS; Plongthongkum N; Qu W; Queirós AC; Reinicke F; Sauter G; Schlomm T; Statham A; Stirzaker C; Strogantsev R; Urdinguio RG; Walter K; Weichenhan D; Weisenberger DJ; Beck S; Clark SJ; Esteller M; Ferguson-Smith AC; Fraga MF; Guldberg P; Hansen LL; Laird PW; Martín-Subero JI; Nygren AOH; Peist R; Plass C; Shames DS; Siebert R; Sun X; Tost J; Walter J; Zhang K, 2016, 'Quantitative comparison of DNA methylation assays for biomarker development and clinical applications', Nature Biotechnology, 34, pp. 726 - 737, http://dx.doi.org/10.1038/nbt.3605

Walton SJ; Lewis A; Jeffery R; Thompson H; Feakins R; Giannoulatou E; Yau C; Lindsay JO; Clark SK; Silver A, 2016, 'Familial adenomatous patients with desmoid tumours show increased expression of miR-34a in serum and high levels in tumours', Oncoscience, 3, pp. 173 - 185, http://dx.doi.org/10.18632/oncoscience.312

Colino-Sanguino Y; Clark SJ; Valdes-Mora F, 2016, 'H2A.Z acetylation and transcription: Ready, steady, go!', Epigenomics, 8, pp. 583 - 586, http://dx.doi.org/10.2217/epi-2016-0016

Hou L; Heilbronner U; Degenhardt F; Adli M; Akiyama K; Akula N; Ardau R; Arias B; Backlund L; Banzato CEM; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Birner A; Brichant-Petitjean C; Bui ET; Cervantes P; Chen GB; Chen HC; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Étain B; Falkai P; Forstner AJ; Frisén L; Fullerton JM; Gard S; Garnham JS; Goes FS; Grof P; Gruber O; Hashimoto R; Hauser J; Herms S; Hoffmann P; Hofmann A; Jamain S; Jiménez E; Kahn JP; Kassem L; Kittel-Schneider S; Kliwicki S; König B; Kusumi I; Lackner N; Laje G; Landén M; Lavebratt C; Leboyer M; Leckband SG; Jaramillo CAL; Macqueen G; Manchia M; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nöthen MM; Ösby U; Ozaki N; Perlis RH; Pfennig A; Reich-Erkelenz D; Rouleau GA; Schofield PR; Schubert KO; Schweizer BW; Seemüller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Smoller JW; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Volkert J; Witt S; Wright A; Young LT; Zandi PP; Potash JB; Depaulo JR; Mitchell P; Baune B; Schofield P, 2016, 'Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study', The Lancet, 387, pp. 1085 - 1093, http://dx.doi.org/10.1016/S0140-6736(16)00143-4

Stirzaker C; Zotenko E; Clark SJ, 2016, 'Genome-wide DNA methylation profiling in triple-negative breast cancer reveals epigenetic signatures with important clinical value', Molecular and Cellular Oncology, 3, http://dx.doi.org/10.1080/23723556.2015.1038424

Achinger-Kawecka J; Taberlay PC; Clark SJ, 2016, 'Alterations in three-dimensional organization of the cancer genome and epigenome', Cold Spring Harbor Symposia on Quantitative Biology, 81, pp. 41 - 51, http://dx.doi.org/10.1101/sqb.2016.81.031013

Taberlay PC; Achinger-Kawecka J; Lun ATL; Buske FA; Sabir KS; Gould CM; Zotenko E; Bert SA; Giles KA; Bauer D; Smyth GK; Stirzaker C; O Donoghue SI; Clark SJ, 2016, 'Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations', Genome Research, 26, pp. 719 - 731

Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13, http://dx.doi.org/10.1371/journal.pbio.1002330

Varinli H; Statham AL; Clark SJ; Molloy PL; Ross JP, 2015, 'COBRA-seq: Sensitive and quantitative methylome profiling', Genes, 6, pp. 1140 - 1163, http://dx.doi.org/10.3390/genes6041140

Du Q; Luu PL; Stirzaker C; Clark SJ, 2015, 'Methyl-CpG-binding domain proteins: Readers of the epigenome', Epigenomics, 7, pp. 1051 - 1073, http://dx.doi.org/10.2217/epi.15.39

Stone A; Zotenko E; Locke WJ; Korbie D; Millar EKA; Pidsley R; Stirzaker C; Graham P; Trau M; Musgrove EA; Nicholson RI; Gee JMW; Clark SJ, 2015, 'DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms8758

Phua YW; Nguyen A; Roden DL; Elsworth B; Deng N; Nikolic I; Yang J; Mcfarland A; Russell R; Kaplan W; Cowley MJ; Nair R; Zotenko E; O'Toole S; Tan SX; James DE; Clark SJ; Kouros-Mehr H; Swarbrick A, 2015, 'MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene', Breast Cancer Research, http://dx.doi.org/10.1186/s13058-015-0593-0

Lawrence M; Pidsley R; Ellem S; Furic L; Nair S; French H; Stratham A; Larsson O; Frydenberg M; Pedersen J; Buchanan G; Taylor R; Clark S; Risbridger G, 2015, 'Oestrogen receptor α promotes prostate cancer progression through dual actions in both epithelia and stroma', Endocrine Abstracts, http://dx.doi.org/10.1530/endoabs.37.oc8.5

Valdés-Mora F; Clark SJ, 2015, 'Prostate cancer epigenetic biomarkers: next-generation technologies', Oncogene, 34, pp. 1609 - 1618, http://dx.doi.org/10.1038/onc.2014.111

Statham AL; Taberlay PC; Kelly TK; Jones PA; Clark SJ, 2015, 'Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines', Genomics Data, 3, pp. 94 - 96, http://dx.doi.org/10.1016/j.gdata.2014.11.012

Clark S; Sarlin P; Sharma A; Sisson SA, 2015, 'Increasing dependence on foreign water resources? An assessment of trends in global virtual water flows using a self-organizing time map', Ecological Informatics, 26, pp. 192 - 202, http://dx.doi.org/10.1016/j.ecoinf.2014.05.012

Stirzaker C; Zotenko E; Song JZ; Qu W; Nair SS; Locke WJ; Stone A; Armstong NJ; Robinson MD; Dobrovic A; Avery-Kiejda KA; Peters KM; French JD; Stein S; Korbie DJ; Trau M; Forbes JF; Scott RJ; Brown MA; Francis GD; Clark SJ, 2015, 'Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value', Nature Communications, 6, pp. 5899 - 5899, http://dx.doi.org/10.1038/ncomms6899

Peters TJ; Buckley MJ; Statham AL; Pidsley R; Samaras K; V Lord R; Clark SJ; Molloy PL, 2015, 'De novo identification of differentially methylated regions in the human genome', Epigenetics and Chromatin, 8, http://dx.doi.org/10.1186/1756-8935-8-6

Van Dijk SJ; Molloy PL; Varinli H; Morrison JL; Muhlhausler BS; Buckley M; Clark SJ; McMillen IC; Noakes M; Samaras K; Tellam RL, 2015, 'Epigenetics and human obesity', International Journal of Obesity, 39, pp. 85 - 97, http://dx.doi.org/10.1038/ijo.2014.34

Locke WJ; Zotenko E; Stirzaker C; Robinson MD; Hinshelwood RA; Stone A; Reddel RR; Huschtscha LI; Clark SJ, 2015, 'Coordinated epigenetic remodelling of transcriptional networks occurs during early breast carcinogenesis', Clinical Epigenetics, 7, http://dx.doi.org/10.1186/s13148-015-0086-0

Korbie D; Lin E; Wall D; Nair SS; Stirzaker C; Clark SJ; Trau M, 2015, 'Multiplex bisulfite PCR resequencing of clinical FFPE DNA', Clinical Epigenetics, 7, pp. 28, http://dx.doi.org/10.1186/s13148-015-0067-3

Mahon KL; Qu W; Devaney J; Paul C; Castillo L; Wykes RJ; Chatfield MD; Boyer MJ; Stockler MR; Marx G; Gurney H; Mallesara G; Molloy PL; Horvath LG; Clark SJ, 2014, 'Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer', British Journal of Cancer, 111, pp. 1802 - 1809, http://dx.doi.org/10.1038/bjc.2014.463

Ali NA; Wu J; Hochgräfe F; Chan H; Nair R; Ye S; Zhang L; Lyons RJ; Pinese M; Lee HC; Armstrong N; Ormandy CJ; Clark SJ; Swarbrick A; Daly RJ, 2014, 'Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways', Breast Cancer Research, 16, http://dx.doi.org/10.1186/s13058-014-0437-3

Taberlay PC; Statham AL; Kelly TK; Clark SJ; Jones PA, 2014, 'Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer', Genome Research, 24, pp. 1421 - 1432, http://dx.doi.org/10.1101/gr.163485.113

Clark S; Sisson SA; Sharma A, 2014, 'A dimension range representation (DRR) measure for self-organizing maps', Pattern Recognition, http://dx.doi.org/10.1016/j.patcog.2015.11.002

Skulte KA; Phan L; Clark SJ; Taberlay PC, 2014, 'Chromatin remodeler mutations in human cancers: Epigenetic implications', Epigenomics, 6, pp. 397 - 414, http://dx.doi.org/10.2217/epi.14.37

Warton K; Lin V; Navin T; Armstrong NJ; Kaplan W; Ying K; Gloss B; Mangs H; Nair SS; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2014, 'Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma', BMC Genomics, 15, http://dx.doi.org/10.1186/1471-2164-15-476

Lin HM; Castillo L; Mahon KL; Chiam K; Lee BY; Nguyen Q; Boyer MJ; Stockler MR; Pavlakis N; Marx G; Mallesara G; Gurney H; Clark SJ; Swarbrick A; Daly RJ; Horvath LG, 2014, 'Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer', British Journal of Cancer, 110, pp. 2462 - 2471, http://dx.doi.org/10.1038/bjc.2014.181

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