By Professor Till Boecking

Book Chapters

Böcking T; Upadhyayula S; Rapoport I; Capraro BR; Kirchhausen T, 2018, 'Reconstitution of clathrin coat disassembly for fluorescence microscopy and single-molecule analysis', in Clathrin-Mediated Endocytosis. Methods in Molecular Biology, Humana Press, New York, NY, pp. 121 - 146, http://dx.doi.org/10.1007/978-1-4939-8719-1_10

Boecking T; Gooding JJ, 2007, 'Biomimetic Membranes for Biosensor Applications', in Martin DK (ed.), Nanobiotechnology for Biomimetic Membranes, Springer Publishing Company, USA, pp. 127 - 166

Journal articles

Nilsson P; Robertson NO; Gustafsson N; Davies RB; Liew CW; Lyons A; Eichhorn R; Niman CS; Blab GA; Bromley EHC; Whitten AE; Duff AP; Unksov IN; Beech JP; Jönsson P; Böcking T; Höcker B; Woolfson DN; Forde NR; Linke H; Curmi PMG, 2026, 'Clocked stepping of an artificial protein walker along a DNA track', Nature Nanotechnology, 21, pp. 987 - 995, http://dx.doi.org/10.1038/s41565-026-02211-3

Gupta M; Waltmann C; Renner N; Wang Y; James LC; Jacques DA; Böcking T; Voth GA, 2026, 'Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly', Proceedings of the National Academy of Sciences of the United States of America, 123, http://dx.doi.org/10.1073/pnas.2524995123

Hong J; Deshpande A; Thakare Y; Simonovsky L; Douglas ADW; Guinness CM; Rotem-Dai N; Kortyna ML; Ole Klarhof J; Shi J; James LC; Boecking T; Francis AC; Rousso I; Aiken C, 2026, 'The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid', Plos Pathogens, 22, http://dx.doi.org/10.1371/journal.ppat.1013910

Yu R; Phalora P; Li N; Böcking T; Jacques DA, 2025, 'The Human T-cell Leukemia Virus capsid protein is a potential drug target', Nature Communications, 16, http://dx.doi.org/10.1038/s41467-025-65899-2

Renner N; Kleinpeter A; Mallery DL; Albecka A; Rifat Faysal KM; Böcking T; Saiardi A; Freed EO; James LC, 2025, 'Author Correction: HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly (Nature Structural & Molecular Biology, (2023), 30, 3, (370-382), 10.1038/s41594-022-00887-4)', Nature Structural and Molecular Biology, 32, pp. 1839, http://dx.doi.org/10.1038/s41594-025-01667-6

Badieyan S; Lichon D; Keceli SK; Andreas MP; Gillies JP; Peng W; Shi J; DeSantis ME; Aiken CR; Böcking T; Giessen TW; Campbell EM; Cianfrocco MA, 2025, 'HIV-1 binds dynein directly to hijack microtubule transport machinery', Science Advances, 11, http://dx.doi.org/10.1126/sciadv.adn6796

Lou J; Pandžić E; Böcking T; Deng Q; Rossy J; Gaus K, 2025, 'Step-Wise Assembly of LAT Signaling Clusters Immediately After T Cell Receptor Triggering Contributes to Signal Propagation', International Journal of Molecular Sciences, 26, http://dx.doi.org/10.3390/ijms26094076

Marzano N; Johnston B; Paudel BP; Schmidberger J; Jergic S; Böcking T; Agostino M; Small I; Van Oijen AM; Bond CS, 2024, 'Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein', Nucleic Acids Research, 52, pp. 14154 - 14170, http://dx.doi.org/10.1093/nar/gkae984

Dickson CF; Hertel S; Tuckwell AJ; Li N; Ruan J; Al-Izzi SC; Ariotti N; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2024, 'The HIV capsid mimics karyopherin engagement of FG-nucleoporins', Nature, 626, pp. 836 - 842, http://dx.doi.org/10.1038/s41586-023-06969-7

Faysal KMR; Walsh JC; Renner N; Márquez CL; Shah VB; Tuckwell AJ; Christie MP; Parker MW; Turville SG; Towers GJ; James LC; Jacques DA; Böcking T, 2024, 'Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure', eLife, 13, http://dx.doi.org/10.7554/eLife.83605

Renner N; Kleinpeter A; Mallery DL; Albecka A; Rifat Faysal KM; Böcking T; Saiardi A; Freed EO; James LC, 2023, 'HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly', Nature Structural and Molecular Biology, 30, pp. 370 - 382, http://dx.doi.org/10.1038/s41594-022-00887-4

Johnstone BA; Joseph R; Christie MP; Morton CJ; McGuiness C; Walsh JC; Böcking T; Tweten RK; Parker MW, 2022, 'Cholesterol-dependent cytolysins: The outstanding questions', IUBMB Life, 74, pp. 1169 - 1179, http://dx.doi.org/10.1002/iub.2661

Longatte G; Lisi F; Chen X; Walsh J; Wang W; Ariotti N; Boecking T; Gaus K; Gooding JJ, 2022, 'Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers', Physical Chemistry Chemical Physics, 24, pp. 28029 - 28039, http://dx.doi.org/10.1039/d2cp03627d

Zuliani-Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Rifat Faysal KM; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, 'Evasion of cGAS and TRIM5 defines pandemic HIV', Nature Microbiology, 7, pp. 1762 - 1776, http://dx.doi.org/10.1038/s41564-022-01247-0

Lau D; Márquez CL; Parker MW; Böcking T, 2022, 'Negative Staining Transmission Electron Microscopy of HIV Viral Particles Permeabilized with PFO and Capsid Stabilized with IP6', Bio Protocol, 12, http://dx.doi.org/10.21769/BioProtoc.4536

Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, 'Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA', Molecular Cell, 82, pp. 2871 - 2884.e6, http://dx.doi.org/10.1016/j.molcel.2022.06.010

Brown JWP; Alford RG; Walsh JC; Spinney RE; Xu SY; Hertel S; Berengut JF; Spenkelink LM; Van Oijen AM; Böcking T; Morris RG; Lee LK, 2022, 'Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor', ACS Nano, 16, pp. 6455 - 6467, http://dx.doi.org/10.1021/acsnano.2c00699

Longatte G; Lisi F; Bakthavathsalam P; Böcking T; Gaus K; Tilley RD; Gooding JJ, 2022, 'Biomolecular Binding under Confinement: Statistical Predictions of Steric Influence in Absence of Long-Distance Interactions', Chemphyschem, 23, pp. e202100765, http://dx.doi.org/10.1002/cphc.202100765

Zhang MJ; Stear JH; Jacques DA; Böcking T, 2022, 'Insights into HIV uncoating from single-particle imaging techniques', Biophysical Reviews, 14, pp. 23 - 32, http://dx.doi.org/10.1007/s12551-021-00922-6

Guinness CM; Walsh JC; Bayly-Jones C; Dunstone MA; Christie MP; Morton CJ; Parker MW; Bocking T, 2022, 'Single-molecule analysis of the entire perfringolysin O pore formation pathway', Elife, 11, http://dx.doi.org/10.7554/eLife.74901

Ni T; Zhu Y; Yang Z; Xu C; Chaban Y; Nesterova T; Ning J; Böcking T; Parker MW; Monnie C; Ahn J; Perilla JR; Zhang P, 2021, 'Structure of native HIV-1 cores and their interactions with IP6 and CypA', Science Advances, 7, http://dx.doi.org/10.1126/sciadv.abj5715

Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, 93, pp. 3786 - 3793, http://dx.doi.org/10.1021/acs.analchem.0c04250

Mallery DL; Kleinpeter AB; Renner N; Rifat Faysal KM; Novikova M; Kiss L; Wilson MSC; Ahsan B; Ke Z; Briggs JAG; Saiardi A; Böcking T; Freed EO; James LC, 2021, 'A stable immature lattice packages IP6 for HIV capsid maturation', Science Advances, 7, pp. 1 - 18, http://dx.doi.org/10.1126/sciadv.abe4716

Renner N; Mallery DL; Faysal KMR; Peng W; Jacques DA; Böcking T; James LC, 2021, 'A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly', PLoS Pathogens, 17, pp. 1 - 22, http://dx.doi.org/10.1371/JOURNAL.PPAT.1009164

Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, 2020, 'Dynamics of Tpm1.8 domains on actin filaments with single-molecule resolution', Molecular Biology of the Cell, 31, pp. 2452 - 2462, http://dx.doi.org/10.1091/MBC.E19-10-0586

Helbig KJ; Bull RA; Ambrose R; Beard MR; Blanchard H; Böcking T; Chua B; Colmant AMG; Crosse KM; Purcell DFJ; Fraser J; Hayward JA; Hamilton ST; Husain M; MacDiarmid R; MacKenzie JM; Moseley GW; Nguyen THO; Quiñones-Mateu ME; Robinson K; Rodrigo C; Rodriguez-Andres J; Rudd PA; Werno A; White P; Young P; Speck P; Hibma M; Drummer HE; Tachedjian G, 2020, 'Tenth scientific biennial meeting of the australasian virology society - AVS10 2019', Viruses, 12, pp. 621, http://dx.doi.org/10.3390/v12060621

Lau D; Walsh JC; Mousapasandi A; Ariotti N; Shah VB; Turville S; Jacques DA; Böcking T, 2020, 'Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders', Langmuir, 36, pp. 3624 - 3632, http://dx.doi.org/10.1021/acs.langmuir.0c00103

Mallery DL; Faysal KMR; Kleinpeter A; Wilson MSC; Vaysburd M; Fletcher AJ; Novikova M; Böcking T; Freed EO; Saiardi A; James LC, 2019, 'Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication', Cell Reports, 29, pp. 3983 - 3996.e4, http://dx.doi.org/10.1016/j.celrep.2019.11.050

Lau D; Walsh JC; Peng W; Shah VB; Turville S; Jacques DA; Böcking T, 2019, 'Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes', ACS Applied Materials and Interfaces, 11, pp. 34586 - 34594, http://dx.doi.org/10.1021/acsami.9b08521

James LC; Böcking T, 2019, 'Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid', Cell Host and Microbe, 26, pp. 151 - 153, http://dx.doi.org/10.1016/j.chom.2019.07.011

Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific Reports, 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9

Márquez CL; Lau D; Walsh J; Faysal KMR; Parker MW; Turville SG; Böcking T, 2019, 'Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro', Bio Protocol, 9, http://dx.doi.org/10.21769/BioProtoc.3297

Battle AR; Norton RS; Böcking T; Noji H; Kim KK; Nagayama K, 2019, 'Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2–6, 2018', Biophysical Reviews, 11, pp. 245 - 247, http://dx.doi.org/10.1007/s12551-019-00553-y

Peng W; Shi J; Márquez CL; Lau D; Walsh J; Faysal KMR; Byeon CH; Byeon IJL; Aiken C; Böcking T, 2019, 'Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A', Retrovirology, 16, pp. 10, http://dx.doi.org/10.1186/s12977-019-0471-4

Janco M; Böcking T; He S; Coster ACF, 2018, 'Interactions of tropomyosin Tpm1.1 on a single actin filament: A method for extraction and processing of high resolution TIRF microscopy data', Plos One, 13, pp. e0208586, http://dx.doi.org/10.1371/journal.pone.0208586

Zhao M; Nicovich PR; Janco M; Deng Q; Yang Z; Ma Y; Böcking T; Gaus K; Gooding JJ, 2018, 'Ultralow- and Low-Background Surfaces for Single-Molecule Localization Microscopy of Multistep Biointerfaces for Single-Molecule Sensing', Langmuir, 34, pp. 10012 - 10018, http://dx.doi.org/10.1021/acs.langmuir.8b01487

Márquez CL; Lau D; Walsh J; Shah V; McGuinness C; Wong A; Aggarwal A; Parker MW; Jacques DA; Turville S; Böcking T, 2018, 'Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis', Elife, 7, http://dx.doi.org/10.7554/eLife.34772

Mallery DL; Márquez CL; McEwan WA; Dickson CF; Jacques DA; Anandapadamanaban M; Bichel K; Towers GJ; Saiardi A; Böcking T; James LC, 2018, 'IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis', Elife, 7, http://dx.doi.org/10.7554/eLife.35335

Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC; Lastra Cagigas M, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, 131, pp. jcs212654, http://dx.doi.org/10.1242/jcs.212654

Ramdzan YM; Trubetskov MM; Ormsby AR; Newcombe EA; Sui X; Tobin MJ; Bongiovanni MN; Gras SL; Dewson G; Miller JML; Finkbeiner S; Moily NS; Niclis J; Parish CL; Purcell AW; Baker MJ; Wilce JA; Waris S; Stojanovski D; Böcking T; Ang CS; Ascher DB; Reid GE; Hatters DM, 2017, 'Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis', Cell Reports, 19, pp. 919 - 927, http://dx.doi.org/10.1016/j.celrep.2017.04.029

Nicovich PR; Walsh J; Böcking T; Gaus K, 2017, 'NicoLase - An open-source diode laser combiner, fiber launch, and sequencing controller for fluorescence microscopy', Plos One, 12, pp. e0173879, http://dx.doi.org/10.1371/journal.pone.0173879

Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, 73, pp. 729 - 738, http://dx.doi.org/10.1002/cm.21342

Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I; Parton RG; Böcking T; Gambin Y; Ariotti N, 2016, 'Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence', Scientific Reports, 6, pp. 37630, http://dx.doi.org/10.1038/srep37630

Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', Bioarchitecture, 6, pp. 61 - 75, http://dx.doi.org/10.1080/19490992.2016.1201619

Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, 44, pp. 1411 - 1420, http://dx.doi.org/10.1093/nar/gkv1466

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, pp. 19816, http://dx.doi.org/10.1038/srep19816

Pham S; Tabarin T; Garvey M; Pade C; Rossy J; Monaghan P; Hyatt A; Böcking T; Leis A; Gaus K; Mak J, 2015, 'Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry', Virology, 486, pp. 121 - 133, http://dx.doi.org/10.1016/j.virol.2015.09.006

Polling S; Ormsby AR; Wood RJ; Lee K; Shoubridge C; Hughes JN; Thomas PQ; Griffin MDW; Hill AF; Bowden Q; Böcking T; Hatters DM, 2015, 'Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation', Nature Structural and Molecular Biology, 22, pp. 1008 - 1015, http://dx.doi.org/10.1038/nsmb.3127

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