By Professor Till Boecking

Preprints

Hong J; Deshpande A; Thakare Y; Simonovsky L; Douglas AW; Mc Guinness C; Rotem-Dai N; Kortyna ML; Klarhof JO; Shi J; Boecking T; James LC; Francis AC; Rousso I; Aiken C, 2025, The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity., http://dx.doi.org/10.1101/2025.09.03.673798

Nilsson P; Robertson NO; Gustafsson N; Davies RB; Liew CW; Lyons A; Eichhorn R; Niman CS; Blab GA; Bromley EHC; Whitten AE; Duff AP; Unksov IN; Beech JP; Jönsson P; Böcking T; Höcker B; Woolfson DN; Forde NR; Linke H; Curmi PMG, 2025, An artificial motor protein that walks along a DNA track, http://dx.doi.org/10.1101/2025.03.07.641123

Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, Recognition of HIV-1 Capsid Licenses Innate Immune Response to Viral Infection, http://dx.doi.org/10.1101/2022.01.10.472699

Lau D; Walsh J; Peng W; Shah V; Turville S; Jacques D; Böcking T, 2019, Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes, http://dx.doi.org/10.1101/619841

Morling KL; Govasli ML; Graham B; Warne J; Harrison L; Thorne LG; Newton LS; Maw J; Touizer E; Sumner R; Oxenford S; Rowley J; Annett D; Jacques D; Böcking T; Pinotsis N; Selwood DL; Towers GJ, Allosteric capsid inhibitors and their escape mutants drive HIV-1 sensing, http://dx.doi.org/10.64898/2026.08.21.746246

Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, Dynamics of Tpm1.8 domains on actin filaments with single molecule resolution, http://dx.doi.org/10.1101/2020.06.15.152033

Badieyan S; Lichon D; Andreas MP; Gillies JP; Peng W; Shi J; DeSantis ME; Aiken CR; Böcking T; Giessen TW; Campbell EM; Cianfrocco MA, HIV-1 binds dynein directly to hijack microtubule transport machinery, http://dx.doi.org/10.1101/2023.08.29.555335

Dickson CF; Hertel S; Ruan J; Ariotti N; Tuckwell A; Li N; Al-Izzi SC; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores, http://dx.doi.org/10.1101/2023.03.23.534032

Alvarez LZ; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Faysal KMR; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV, http://dx.doi.org/10.1101/2022.01.21.477263

Gupta M; Waltmann C; Renner N; Wang Y; James LC; Jacques DA; Böcking T; Voth GA, Mechanistic Insights into Lenacapavir-Induced Off-Pathway HIV-1 Capsid Assembly, http://dx.doi.org/10.1101/2025.08.13.670175

Faysal KMR; Walsh J; Renner N; Márquez CL; Shah VB; Tuckwell AJ; Christie MP; Parker MW; Turville SG; Towers GJ; James L; Jacques DA; Böcking T, Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure, http://dx.doi.org/10.1101/2022.09.21.508807

Brown JWP; Alford RG; Walsh JC; Spinney RE; Xu SY; Hertel S; Berengut JF; Spenkelink LM; van Oijen AM; Böcking T; Morris RG; Lee LK, Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor, http://dx.doi.org/10.1101/2022.01.16.476526

Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y; Böcking T; Jacques DA, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy, http://dx.doi.org/10.1101/2020.11.13.382242

Mc Guinness C; Walsh JC; Bayly-Jones C; Dunstone MA; Christie MP; Morton CJ; Parker MW; Böcking T, Single-molecule analysis of the entire perfringolysin O pore formation pathway, http://dx.doi.org/10.1101/2021.10.19.464937

Marzano N; Johnston B; Paudel BP; Schmidberger J; Jergic S; Böcking T; Agostino M; Small I; van Oijen AM; Bond CS, Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein, http://dx.doi.org/10.1101/2024.04.22.590477

Yu R; Phalora P; Li N; Böcking T; Jacques DA, The Human T-cell Leukemia Virus capsid protein is a potential drug target, http://dx.doi.org/10.1101/2024.09.09.612167

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