The role and regulation of protein methylation: a study using the recently developed methylation network of yeast

We have recently built the first protein 'methylation network' for any species. This project will study the dynamics of this network during the cell cycle and will identify protein complexes which have methylation-associated interactions. This will help us to understand the regulation, or 'control logic', of protein methylation. The study will be the most comprehensive analysis of protein methylation to date, and will shed new light on how and when this widespread modification exerts its effects.