Rare earth metallic oxide nanoparticles made from cerium oxide, called nanoceria, are of interest due to their ability to react catalytically with oxygen free radicals providing anti-oxidant properties. Excessive production of oxygen free radicals underpins inflammatory diseases such as rheumatoid arthritis and atherosclerosis as well as other pathologies including cancer and diabetes. Hence anti-oxidant therapies are of clinical interest. We are currently investigating the mechanisms of interactions of these nanoparticles with the dynamic cell environment to understand the clinical applications of these particles in the areas of cancer, cardiovascular disease and arthritis. We functionalise these nanoceria with various biological molecules to create cell-selective particles with tailored biological responses.
Australian Research Council Discovery Project