By Assistant Professor Paul Ekert

Journal articles

Sandow JJ; Jabbour AM; Condina MR; Daunt CP; Stomski FC; Green BD; Riffkin CD; Hoffmann P; Guthridge MA; Silke J; Lopez AF; Ekert PG, 2012, 'Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death', Cell Death and Differentiation, 19, pp. 633 - 641, http://dx.doi.org/10.1038/cdd.2011.131

Hercus TR; Broughton SE; Ekert PG; Ramshaw HS; Perugini M; Grimbaldeston M; Woodcock JM; Thomas D; Pitson S; Hughes T; D'Andrea RJ; Parker MW; Lopez AF, 2012, 'The GM-CSF receptor family: Mechanism of activation and implications for disease', Growth Factors, 30, pp. 63 - 75, http://dx.doi.org/10.3109/08977194.2011.649919

Jabbour AM; Gordon L; Daunt CP; Green BD; Kok CH; D'Andrea R; Ekert PG, 2012, 'p53-dependent transcriptional responses to interleukin-3 signaling', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0031428

Hahn CN; Chong CE; Carmichael CL; Wilkins EJ; Brautigan PJ; Li XC; Babic M; Lin M; Carmagnac A; Lee YK; Kok CH; Gagliardi L; Friend KL; Ekert PG; Butcher CM; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS; Scott HS, 2011, 'Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia', Nature Genetics, 43, pp. 1012 - 1019, http://dx.doi.org/10.1038/ng.913

Ekert PG; Jabbour AM, 2011, 'Critical Evaluation of Antiepileptic Drugs in Epileptic Pregnant Women - Hungarian Experiences', The Open Cell Signaling Journal, 3, pp. 20 - 26, http://dx.doi.org/10.2174/1876390101103010020

Scott HS; Hahn CN; Carmichael CL; Wilkins EJ; Chong C-E; Brautigan PJ; Li X-C; Stankovic M; Lin M; Carmagnac A; Butcher CM; Friend KL; Ekert PG; Kok CH; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS, 2010, 'GATA2 is a New Predisposition Gene for Familial Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)', Blood, 116, http://dx.doi.org/10.1182/blood.v116.21.lba-3.lba-3

Geest CR; Wensveen FM; Libregts SFWM; de Bruin AM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2010, 'Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis', Blood, 116, pp. 4235 - 4235, http://dx.doi.org/10.1182/blood.v116.21.4235.4235

Oberle C; Huai J; Reinheckel T; Tacke M; Rassner M; Ekert PG; Buellesbach J; Borner C, 2010, 'Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes', Cell Death and Differentiation, 17, pp. 1167 - 1178, http://dx.doi.org/10.1038/cdd.2009.214

Brumatti G; Salmanidis M; Ekert PG, 2010, 'Crossing paths: Interactions between the cell death machinery and growth factor survival signals', Cellular and Molecular Life Sciences, 67, pp. 1619 - 1630, http://dx.doi.org/10.1007/s00018-010-0288-8

Jabbour AM; Daunt CP; Green BD; Vogel S; Gordon L; Lee RS; Silke N; Pearson RB; Vandenberg CJ; Kelly PN; Nutt SL; Strasser A; Borner C; Ekert PG, 2010, 'Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation', Blood, 115, pp. 344 - 352, http://dx.doi.org/10.1182/blood-2009-07-230730

Kok CH; Brown AL; Ekert PG; D'Andrea RJ, 2010, 'Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML', Leukemia, 24, pp. 1239 - 1243, http://dx.doi.org/10.1038/leu.2010.85

Lopez AF; Hercus TR; Ekert P; Littler DR; Guthridge M; Thomas D; Ramshaw HS; Stomski F; Perugini M; D'Andrea R; Grimbaldeston M; Parker MW, 2010, 'Molecular basis of cytokine receptor activation', IUBMB Life, 62, pp. 509 - 518, http://dx.doi.org/10.1002/iub.350

Algar EM; Muscat A; Dagar V; Rickert C; Chow CW; Biegel JA; Ekert PG; Saffery R; Craig J; Johnstone RW; Ashley DM, 2009, 'Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors', PLoS ONE, 4, http://dx.doi.org/10.1371/journal.pone.0004482

Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG, 2009, 'Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim', Cell Death and Differentiation, 16, pp. 555 - 563, http://dx.doi.org/10.1038/cdd.2008.179

Hercus TR; Thomas D; Guthridge MA; Ekert PG; King-Scott J; Parker MW; Lopez AF, 2009, 'The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease', Blood, 114, pp. 1289 - 1298, http://dx.doi.org/10.1182/blood-2008-12-164004

Callus BA; Moujallad DM; Silke J; Gerl R; Jabbour AM; Ekert PG; Vaux DL, 2008, 'Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins', JOURNAL OF MOLECULAR BIOLOGY, 384, pp. 313 - 323, http://dx.doi.org/10.1016/j.jmb.2008.09.041

Salmanidis M; Brumatti G; Jabbour AM; Green BD; Silke J; Bouillet P; Ekert PG, 2008, 'Regulated Hox Gene Expression Reveals a Novel Role for Hox Genes in Myeloid Cell Proliferation and Survival', Blood, 112, pp. 5323 - 5323, http://dx.doi.org/10.1182/blood.v112.11.5323.5323

Callus BA; Ekert PG; Heraud JE; Jabbour AM; Kotevski A; Vince JE; Silke J; Vaux DL, 2008, 'Cytoplasmic p53 is not required for PUMA-induced apoptosis [1]', Cell Death and Differentiation, 15, pp. 213 - 215, http://dx.doi.org/10.1038/sj.cdd.4402245

Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Arnoult D; Strasser A, 2007, 'Response: Does Bid Play a Role in the DNA Damage Response?', Cell, 130, pp. 10 - 11, http://dx.doi.org/10.1016/j.cell.2007.06.037

Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Strasser A, 2007, 'The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest', Cell, 129, pp. 423 - 433, http://dx.doi.org/10.1016/j.cell.2007.03.017

Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DCS; Kile BT, 2007, 'Programmed Anuclear Cell Death Delimits Platelet Life Span', Cell, 128, pp. 1173 - 1186, http://dx.doi.org/10.1016/j.cell.2007.01.037

Verhagen AM; Kratina TK; Hawkins CJ; Silke J; Ekert PG; Vaux DL, 2007, 'Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs', Cell Death and Differentiation, 14, pp. 348 - 357, http://dx.doi.org/10.1038/sj.cdd.4402001

Ekert PG; Jabbour AM; Manoharan A; Heraud JE; Yu J; Pakusch M; Michalak EM; Kelly PN; Callus B; Kiefer T; Verhagen A; Silke J; Strasser A; Borner C; Vaux DL, 2006, 'Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma', Blood, 108, pp. 1461 - 1468, http://dx.doi.org/10.1182/blood-2006-03-014209

Tan TY; Jameson JL; Campbell PE; Ekert PG; Zacharin M; Savarirayan R, 2006, 'Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review', American Journal of Medical Genetics, Part A, 140, pp. 1778 - 1784, http://dx.doi.org/10.1002/ajmg.a.31365

Pardo J; Urban C; Galvez EM; Ekert PG; Müller U; Kwon-Chung J; Lobigs M; Müllbacher A; Wallich R; Borner C; Simon MM, 2006, 'The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice', Journal of Cell Biology, 174, pp. 509 - 519, http://dx.doi.org/10.1083/jcb.200604044

Jabbour AM; Puryer MA; Yu JY; Lithgow T; Riffkin CD; Ashley DM; Vaux DL; Ekert PG; Hawkins CJ, 2006, 'Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1', Journal of Cell Science, 119, pp. 2572 - 2582, http://dx.doi.org/10.1242/jcs.02985

Filan PM; Mills JF; Clarnette TD; Ekert H; Ekert P, 2005, 'Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: A potential role for recombinant factor VIIa', Journal of Pediatrics, 147, pp. 857 - 859, http://dx.doi.org/10.1016/j.jpeds.2005.07.034

Ekert PG; Vaux DL, 2005, 'The mitochondrial death squad: Hardened killers or innocent bystanders?', Current Opinion in Cell Biology, 17, pp. 626 - 630, http://dx.doi.org/10.1016/j.ceb.2005.09.001

Silke J; Kratina T; Chu D; Ekert PG; Day CL; Pakusch M; Huang DCS; Vaux DL, 2005, 'Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance', Proceedings of the National Academy of Sciences of the United States of America, 102, pp. 16182 - 16187, http://dx.doi.org/10.1073/pnas.0502828102

Ho PK; Jabbour AM; Ekert PG; Hawkins CJ, 2005, 'Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7', FEBS Journal, 272, pp. 1401 - 1414, http://dx.doi.org/10.1111/j.1742-4658.2005.04573.x

Filan PM; Woodward M; Ekert PG, 2005, 'Images in paediatrics: Stuck long line syndrome', Archives of Disease in Childhood, 90, pp. 558, http://dx.doi.org/10.1136/adc.2004.069559

Valianpour F; Mitsakos V; Schlemmer D; Towbin JA; Taylor JM; Ekert PG; Thorburn DR; Munnich A; Wanders RJA; Barth PG; Vaz FM, 2005, 'Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis', Journal of Lipid Research, 46, pp. 1182 - 1195, http://dx.doi.org/10.1194/jlr.M500056-JLR200

Jabbour AM; Ho PK; Puryer MA; Ashley DM; Ekert PG; Hawkins CJ, 2004, 'The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast', Cell Death and Differentiation, 11, pp. 1309 - 1316, http://dx.doi.org/10.1038/sj.cdd.4401501

Ekert PG; Read SH; Silke J; Marsden VS; Kaufmann H; Hawkins CJ; Gerl R; Kumar S; Vaux DL, 2004, 'Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die', Journal of Cell Biology, 165, pp. 835 - 842, http://dx.doi.org/10.1083/jcb.200312031

Marsden VS; Ekert PG; Van Delft M; Vaux DL; Adams JM; Strasser A, 2004, 'Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9', Journal of Cell Biology, 165, pp. 775 - 780, http://dx.doi.org/10.1083/jcb.200312030

Knight MJ; Riffkin CD; Ekert PG; Ashley DM; Hawkins CJ, 2004, 'Caspase-8 Levels Affect Necessity for Mitochondrial Amplification in Death Ligand-Induced Glioma Cell Apoptosis', Molecular Carcinogenesis, 39, pp. 173 - 182, http://dx.doi.org/10.1002/mc.20011

Silke J; Kratina T; Ekert PG; Pakusch M; Vaux DL, 2004, 'Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis', Journal of Biological Chemistry, 279, pp. 4313 - 4321, http://dx.doi.org/10.1074/jbc.M305661200

Hennel SJ; Ekert PG; Volpe JJ; Inder TE, 2003, 'Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti', Pediatric Neurology, 29, pp. 148 - 150, http://dx.doi.org/10.1016/S0887-8994(03)00150-4

Read SH; Baliga BC; Ekert PG; Vaux DL; Kumar S, 2002, 'A novel Apaf-1-independent putative caspase-2 activation complex', Journal of Cell Biology, 159, pp. 739 - 745, http://dx.doi.org/10.1083/jcb.200209004

Jabbour AM; Ekert PG; Coulson EJ; Knight MJ; Ashley DM; Hawkins CJ, 2002, 'The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects againts apoptosis', Cell Death and Differentiation, 9, pp. 1311 - 1320, http://dx.doi.org/10.1038/sj.cdd.4401135

Marsden VS; O’Connor L; O’Reilly LA; Silke J; Metcalf D; Ekert PG; Huang DCS; Cecconi F; Kuida K; Tomaselli KJ; Roy S; Nicholson DW; Vaux DL; Bouillet P; Adams JM; Strasser A, 2002, 'Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome', Nature, 419, pp. 634 - 637, http://dx.doi.org/10.1038/nature01101

Silke J; Hawkins CJ; Ekert PG; Chew J; Day CL; Pakusch M; Verhagen AM; Vaux DL, 2002, 'The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites', Journal of Cell Biology, 157, pp. 115 - 124, http://dx.doi.org/10.1083/jcb.200108085

Verhagen AM; Silke J; Ekert PG; Pakusch M; Kaufmann H; Connolly LM; Day CL; Tikoo A; Burke R; Wrobel C; Moritz RL; Simpson RJ; Vaux DL, 2002, 'HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins', Journal of Biological Chemistry, 277, pp. 445 - 454, http://dx.doi.org/10.1074/jbc.M109891200

O’Reilly LA; Ekert P; Harvey N; Marsden V; Cullen L; Vaux DL; Hacker G; Magnusson C; Pakusch M; Cecconi F; Kuida K; Strasser A; Huang DCS; Kumar S, 2002, 'Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9', Cell Death and Differentiation, 9, pp. 832 - 841, http://dx.doi.org/10.1038/sj.cdd.4401033

Hawkins CJ; Silke J; Verhagen AM; Foster R; Ekert PG; Ashley DM, 2001, 'Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism', Apoptosis, 6, pp. 331 - 338, http://dx.doi.org/10.1023/A:1011329917895

Ekert PG; Silke J, 2001, 'Till death do us part', Cell Death and Differentiation, 8, pp. 662 - 664, http://dx.doi.org/10.1038/sj.cdd.4400895

Silke J; Ekert PG; Day CL; Hawkins CJ; Baca M; Chew J; Pakusch M; Verhagen AM; Vaux DL, 2001, 'Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP', EMBO Journal, 20, pp. 3114 - 3123, http://dx.doi.org/10.1093/emboj/20.12.3114

Ekert PG; Silke J; Hawkins CJ; Verhagen AM; Vaux DL, 2001, 'DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9', Journal of Cell Biology, 153, pp. 483 - 490, http://dx.doi.org/10.1083/jcb.152.3.483

Mills JF; Dargaville PA; Coleman LT; Rosenfeld JV; Ekert PG, 2001, 'Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging', Journal of Pediatrics, 138, pp. 105 - 108, http://dx.doi.org/10.1067/mpd.2001.109195

Silke J; Verhagen AM; Ekert PG; Vaux DL, 2000, 'Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid? [3]', Cell Death and Differentiation, 7, pp. 1275, http://dx.doi.org/10.1038/sj.cdd.4400790

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