By Assistant Professor Paul Ekert

Journal articles

Ekert PG; Read SH; Silke J; Marsden VS; Kaufmann H; Hawkins CJ; Gerl R; Kumar S; Vaux DL, 2004, 'Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die', Journal of Cell Biology, 165, pp. 835 - 842, http://dx.doi.org/10.1083/jcb.200312031

Marsden VS; Ekert PG; Van Delft M; Vaux DL; Adams JM; Strasser A, 2004, 'Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9', Journal of Cell Biology, 165, pp. 775 - 780, http://dx.doi.org/10.1083/jcb.200312030

Knight MJ; Riffkin CD; Ekert PG; Ashley DM; Hawkins CJ, 2004, 'Caspase-8 Levels Affect Necessity for Mitochondrial Amplification in Death Ligand-Induced Glioma Cell Apoptosis', Molecular Carcinogenesis, 39, pp. 173 - 182, http://dx.doi.org/10.1002/mc.20011

Silke J; Kratina T; Ekert PG; Pakusch M; Vaux DL, 2004, 'Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis', Journal of Biological Chemistry, 279, pp. 4313 - 4321, http://dx.doi.org/10.1074/jbc.M305661200

Hennel SJ; Ekert PG; Volpe JJ; Inder TE, 2003, 'Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti', Pediatric Neurology, 29, pp. 148 - 150, http://dx.doi.org/10.1016/S0887-8994(03)00150-4

Read SH; Baliga BC; Ekert PG; Vaux DL; Kumar S, 2002, 'A novel Apaf-1-independent putative caspase-2 activation complex', Journal of Cell Biology, 159, pp. 739 - 745, http://dx.doi.org/10.1083/jcb.200209004

Jabbour AM; Ekert PG; Coulson EJ; Knight MJ; Ashley DM; Hawkins CJ, 2002, 'The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects againts apoptosis', Cell Death and Differentiation, 9, pp. 1311 - 1320, http://dx.doi.org/10.1038/sj.cdd.4401135

Marsden VS; O’Connor L; O’Reilly LA; Silke J; Metcalf D; Ekert PG; Huang DCS; Cecconi F; Kuida K; Tomaselli KJ; Roy S; Nicholson DW; Vaux DL; Bouillet P; Adams JM; Strasser A, 2002, 'Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome', Nature, 419, pp. 634 - 637, http://dx.doi.org/10.1038/nature01101

Silke J; Hawkins CJ; Ekert PG; Chew J; Day CL; Pakusch M; Verhagen AM; Vaux DL, 2002, 'The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites', Journal of Cell Biology, 157, pp. 115 - 124, http://dx.doi.org/10.1083/jcb.200108085

Verhagen AM; Silke J; Ekert PG; Pakusch M; Kaufmann H; Connolly LM; Day CL; Tikoo A; Burke R; Wrobel C; Moritz RL; Simpson RJ; Vaux DL, 2002, 'HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins', Journal of Biological Chemistry, 277, pp. 445 - 454, http://dx.doi.org/10.1074/jbc.M109891200

O’Reilly LA; Ekert P; Harvey N; Marsden V; Cullen L; Vaux DL; Hacker G; Magnusson C; Pakusch M; Cecconi F; Kuida K; Strasser A; Huang DCS; Kumar S, 2002, 'Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9', Cell Death and Differentiation, 9, pp. 832 - 841, http://dx.doi.org/10.1038/sj.cdd.4401033

Hawkins CJ; Silke J; Verhagen AM; Foster R; Ekert PG; Ashley DM, 2001, 'Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism', Apoptosis, 6, pp. 331 - 338, http://dx.doi.org/10.1023/A:1011329917895

Ekert PG; Silke J, 2001, 'Till death do us part', Cell Death and Differentiation, 8, pp. 662 - 664, http://dx.doi.org/10.1038/sj.cdd.4400895

Silke J; Ekert PG; Day CL; Hawkins CJ; Baca M; Chew J; Pakusch M; Verhagen AM; Vaux DL, 2001, 'Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP', EMBO Journal, 20, pp. 3114 - 3123, http://dx.doi.org/10.1093/emboj/20.12.3114

Ekert PG; Silke J; Hawkins CJ; Verhagen AM; Vaux DL, 2001, 'DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9', Journal of Cell Biology, 153, pp. 483 - 490, http://dx.doi.org/10.1083/jcb.152.3.483

Mills JF; Dargaville PA; Coleman LT; Rosenfeld JV; Ekert PG, 2001, 'Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging', Journal of Pediatrics, 138, pp. 105 - 108, http://dx.doi.org/10.1067/mpd.2001.109195

Silke J; Verhagen AM; Ekert PG; Vaux DL, 2000, 'Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid? [3]', Cell Death and Differentiation, 7, pp. 1275, http://dx.doi.org/10.1038/sj.cdd.4400790

Verhagen AM; Ekert PG; Pakusch M; Silke J; Connolly LM; Reid GE; Moritz RL; Simpson RJ; Vaux DL, 2000, 'Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins', Cell, 102, pp. 43 - 53, http://dx.doi.org/10.1016/S0092-8674(00)00009-X

Ekert PA; Bucher DJ, 1999, 'Winter Use of Large-leafed Privet Ligustrum lucidum (Family: Oleaceae) by Birds in Suburban Lismore, New South Wales', Proceedings of the Linnean Society of New South Wales, 1999, pp. 29 - 38

Soilu-Hänninen M; Ekert P; Bucci T; Syroid D; Bartlett PF; Kilpatrick TJ, 1999, 'Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway', Journal of Neuroscience, 19, pp. 4828 - 4838, http://dx.doi.org/10.1523/jneurosci.19-12-04828.1999

Ekert PG; Silke J; Vaux DL, 1999, 'Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: Optimal caspase substrates are not necessarily optimal inhibitors', EMBO Journal, 18, pp. 330 - 338, http://dx.doi.org/10.1093/emboj/18.2.330

Ekert PG; Silke J; Vaux DL, 1999, 'Caspase inhibitors', Cell Death and Differentiation, 6, pp. 1081 - 1086, http://dx.doi.org/10.1038/sj.cdd.4400594

Hawkins CJ; Ekert PG; Uren AG; Holmgreen SP; Vaux DL, 1998, 'Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells', Cell Death and Differentiation, 5, pp. 569 - 576, http://dx.doi.org/10.1038/sj.cdd.4400389

Ekert P; Mougenot JF; De Lagausie P; Gerardin M; Le Bourgeois M; Munck A; Aigrain Y; Navarro J, 1998, 'Intussusception and appendiceal mucocele in a child with cystic fibrosis', Archives de Pediatrie, 5, pp. 400 - 403, http://dx.doi.org/10.1016/S0929-693X(98)80027-4

Raju NV; Ekert P; Kumar A; Perlman M, 1998, 'Base Deficit (BD) in Babies with Post-asphyxial Hypoxic Ischemic Encephalopathy (PA-HIE) and relationship to Outcome 1107', Pediatric Research, 43, pp. 190 - 190, http://dx.doi.org/10.1203/00006450-199804001-01128

Ekert PG; Huang D; Vaux DL, 1998, 'Cloning and testing new genes to block specific caspase family members.† 998', Pediatric Research, 43, pp. 172 - 172, http://dx.doi.org/10.1203/00006450-199804001-01019

Ekert P; Perlman M; Steinlin M; Hao Y, 1998, 'Predicting the Outcome of Postasphyxial Hypoxic-Ischemic Encephalopathy Within 4 Hours of Birth', Obstetrical & Gynecological Survey, 53, pp. 409 - 410, http://dx.doi.org/10.1097/00006254-199807000-00011

Barnett CP; Perlman M; Ekert PG, 1997, 'Clinicopathological correlations in postasphyxial organ damage: A donor organ perspective', Pediatrics, 99, pp. 797 - 799, http://dx.doi.org/10.1542/peds.99.6.797

Ekert P; MacLusky N; Luo XP; Lehotay DC; Smith B; Post M; Tanswell AK, 1997, 'Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism', Brain Research, 747, pp. 9 - 17, http://dx.doi.org/10.1016/S0006-8993(96)01201-2

Vaux DL; Hawkins CJ; Uren AG; Ekert PG, 1997, 'Motor neurone disease and the life of motor neurones', MEDICAL JOURNAL OF AUSTRALIA, 166, pp. 109 - 109, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WE11200025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Ekert PG; Vaux DL, 1997, 'Apoptosis and the immune system', British Medical Bulletin, 53, pp. 591 - 603, http://dx.doi.org/10.1093/oxfordjournals.bmb.a011632

Ekert PG; Vaux DL, 1997, 'Apoptosis, haemopoiesis and leukaemogenesis', Bailliere's Clinical Haematology, 10, pp. 561 - 576, http://dx.doi.org/10.1016/S0950-3536(97)80026-1

Ekert PG; Taylor MJ; Keenan NK; Boulton JE; Whyte HE, 1997, 'Early Somatosensory Evoked Potentials in Preterm Infants: Their Prognostic Utility', Neonatology, 71, pp. 83 - 91, http://dx.doi.org/10.1159/000244401

Ekert P; Perlman M; Steinlin M; Hao Y, 1997, 'Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth', Journal of Pediatrics, 131, pp. 613 - 617, http://dx.doi.org/10.1016/S0022-3476(97)70072-6

Ekert PG; Keenan NK; Whyte HE; Boulton J; Taylor MJ, 1997, 'Visual evoked potentials for prediction of neurodevelopmental outcome in preterm infants', Neonatology, 71, pp. 148 - 155, http://dx.doi.org/10.1159/000244410

Taylor MJ; Boor R; Ekert PG, 1996, 'Preterm maturation of the somatosensory evoked potential', Electroencephalography and Clinical Neurophysiology - Evoked Potentials, 100, pp. 448 - 452, http://dx.doi.org/10.1016/0168-5597(96)95218-1

Ekert PG; MacLusky N; Becker L; Post M; Tanswell AK, 1996, 'DEXAMETHASONE NEUROPROTECTION IS ASSOCIATED WITH PRESERVED EXPRESSION OF BCL-2 AND SUPPRESSION OF GLIAL FIBRILLARY ACID PROTEIN (GFAP). ▴ 1226', Pediatric Research, 39, pp. 207 - 207, http://dx.doi.org/10.1203/00006450-199604001-01248

Ekert PG; MacLusky N; Ping X; Lahotay D; Post M; Tanswell AK, 1996, 'DEXAMETHASONE PREVENTS APOPTOSIS IN A RAT MODEL OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE) BY A FREE RADICAL INDEPENDENT MECHANISM. ▴ 1227', Pediatric Research, 39, pp. 207 - 207, http://dx.doi.org/10.1203/00006450-199604001-01249

Barnett CP; Ekert PG; Perlman M, 1996, 'SERUM TRANSAMINASE MEASUREMENTS IN POST-ASPHYXIAL (PA) HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE). 1743', Pediatric Research, 39, pp. 293 - 293, http://dx.doi.org/10.1203/00006450-199604001-01767

Kalidasan V; Ekert P; Beasley SW, 1994, 'Associations of urachal abnormalities: Does patency of the urachus occur because of distal urinary tract obstruction?', Pediatric Surgery International, 9, pp. 381 - 382, http://dx.doi.org/10.1007/BF01686007

Steinlin M; Ekert PG; Blaser S; Otsubo H; Taylor MJ; Whyte HE; Perlman M, 1994, 'Prediction of severe adverse outcome after moderate or severe birth asphyxia', Pediatric Neurology, 11, pp. 81 - 81, http://dx.doi.org/10.1016/0887-8994(94)90146-5

Ekert P; Metreau JM; Zafrani ES; Fabre M; Buffet C; Etienne JP; Dhumeaux D, 1991, 'Hepatic cholesterol ester storage disease: Two new cases diagnosed in adults', Gastroenterologie Clinique et Biologique, 15, pp. 441 - 444

GARGOT D; CADRANEL JF; EKERT P; NOVELLO P; ZYLBERBERG H; BENHAMOU Y, 1990, 'CHRONIC-PANCREATITIS', GAZETTE MEDICALE, 97, pp. 41 - 44, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1990EA70500008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Dewan PA; Ekert P; Keogh EJ; Solomon JR, 1989, 'Epithelial bridging on burn patients following primary excision and grafting', Burns, 15, pp. 129 - 131, http://dx.doi.org/10.1016/0305-4179(89)90145-9

EKERT P; TIBBALLS J; GORMAN D, 1988, 'Three patients with carbon monoxide poisoning treated with hyperbaric oxygen therapy', Journal of Paediatrics and Child Health, 24, pp. 194 - 196, http://dx.doi.org/10.1111/j.1440-1754.1988.tb00324.x

Conference Papers

Perkins C; Barger Z; Fordham A; Salib A; Lim Kam Sian T; Daly R; Ekert P; Fleuren E, 2024, 'Phosphoproteomic profiling for novel target identification in childhood sarcomas: Paving the road towards improved outcomes for relapsed and metastatic osteosarcoma', Sydney, Australia, presented at ZERO Childhood Cancer National Symposium “Precision in Action: Collaboration Driving Cancer Breakthroughs”, Sydney, Australia, 08 May 2024

Perkins C; Barger Z; Fordham A; Salib A; Lim Kam Sian T; Daly R; Ekert P; Fleuren E, 2023, 'Phosphoproteomic profiling for novel target identification in childhood sarcomas: Paving the road towards improved outcomes for relapsed and metastatic osteosarcoma', Melbourne (Cape Schanck), presented at Cell Signalling and its Therapeutic Implications (CSTI 2023), Melbourne (Cape Schanck), 15 May 2023, https://drive.google.com/file/d/1G0HeWsknc2z2W3Tq0rTQkECg4SLzgTsO/view

Vijayasubhash V; Cowley M; Haber M; Sutton R; Trahair T; Norris M; Marshall G; Kamili A; Atkinson C; Ekert P; Huang L; Venn N; Fletcher J; Henderson M, 2021, 'Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR', in Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR, American Association for Cancer Research (AACR), pp. 639 - 639, presented at AACR 2021, http://dx.doi.org/10.1158/1538-7445.AM2021-639

Salmon JM; Pomilio G; Moujalled DM; Macraild S; Teh CE; Riajl S; Ivey A; Teh T-C; Ekert PG; Kraus-Berthier L; Kloos I; Schoumacher M; Gray D; Wei AH, 2018, 'Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117403

Brown LM; Huckstep H; Sandow J; Bartolo RC; Davidson N; Schmidt B; Bjelosevic S; Johnstone RW; Oshlack A; Davis M; Ekert PG, 2018, 'Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes', in BLOOD, AMER SOC HEMATOLOGY, CA, San Diego, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), CA, San Diego, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117844

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