By Associate Professor John Walter Frew

Journal articles

Zouboulis CC; Benhadou F; Byrd AS; Chandran NS; Giamarellos-Bourboulis EJ; Fabbrocini G; Frew JW; Fujita H; González-López MA; Guillem P; Gulliver WPF; Hamzavi I; Hayran Y; Hórvath B; Hüe S; Hunger RE; Ingram JR; Jemec GBE; Ju Q; Kimball AB; Kirby JS; Konstantinou MP; Lowes MA; MacLeod AS; Martorell A; Marzano AV; Matusiak Ł; Nassif A; Nikiphorou E; Nikolakis G; Nogueira da Costa A; Okun MM; Orenstein LAV; Pascual JC; Paus R; Perin B; Prens EP; Röhn TA; Szegedi A; Szepietowski JC; Tzellos T; Wang B; van der Zee HH, 2020, 'What causes hidradenitis suppurativa ?—15 years after', Experimental Dermatology, 29, pp. 1154 - 1170, http://dx.doi.org/10.1111/exd.14214

Tee MW; Avarbock AB; Ungar J; Frew JW, 2020, 'Rapid resolution of pyoderma gangrenosum with brodalumab therapy', JAAD Case Reports, 6, pp. 1167 - 1169, http://dx.doi.org/10.1016/j.jdcr.2020.08.033

Frew JW; Navrazhina K; Grand D; Sullivan-Whalen M; Gilleaudeau P; Garcet S; Ungar J; Krueger JG, 2020, 'The effect of subcutaneous brodalumab on clinical disease activity in hidradenitis suppurativa: An open-label cohort study', Journal of the American Academy of Dermatology, 83, pp. 1341 - 1348, http://dx.doi.org/10.1016/j.jaad.2020.05.007

Garcia-Doval I; Segovia E; Hunter H; Frew J; Naldi L, 2020, 'The value of case reports in pharmacovigilance', British Journal of Dermatology, 183, pp. 795 - 796, http://dx.doi.org/10.1111/bjd.19504

Naik HB; Alhusayen R; Frew J; Guilbault S; Ingram JR; Lowes MA; Marzano AV; Paul M; Villumsen B; Yannuzzi CA, 2020, 'Global Hidradenitis Suppurativa COVID-19 Registry: a registry to inform data-driven management practices', British Journal of Dermatology, 183, pp. 780 - 781, http://dx.doi.org/10.1111/bjd.19345

Frew JW; Jiang CS; Singh N; Grand D; Navrazhina K; Vaughan R; Krueger JG, 2020, 'Malignancy and infection risk during adalimumab therapy in hidradenitis suppurativa', Clinical and Experimental Dermatology, 45, pp. 859 - 865, http://dx.doi.org/10.1111/ced.14264

Frew JW, 2020, 'Anti–Saccharomyces cervisiae antibodies in hidradenitis suppurativa: More than a gut feeling', Journal of Allergy and Clinical Immunology, 146, pp. 458, http://dx.doi.org/10.1016/j.jaci.2020.03.022

Frew JW, 2020, 'Primary imputation methods impact efficacy results in hidradenitis suppurativa clinical trials', Journal of the American Academy of Dermatology, 83, pp. 663 - 665, http://dx.doi.org/10.1016/j.jaad.2020.03.078

Kamil MAA; Chandran NS; Sulistyaningrum SK; Rajagopalan M; Tahiliani S; Hsiao J; Naik H; Shi V; Frew JW, 2020, 'The Asia Pacific Hidradenitis Suppurativa (APHiS) foundation: promoting hidradenitis suppurativa research in the Asia Pacific', International Journal of Dermatology, 59, pp. e289 - e290, http://dx.doi.org/10.1111/ijd.14960

Frew JW; Piguet V, 2020, 'Ex Vivo Models and Interpretation of Mechanistic Studies in Hidradenitis Suppurativa', Journal of Investigative Dermatology, 140, pp. 1323 - 1326, http://dx.doi.org/10.1016/j.jid.2020.02.014

Frew JW, 2020, 'Hidradenitis suppurativa is an autoinflammatory keratinization disease: A review of the clinical, histologic, and molecular evidence', JAAD International, 1, pp. 62 - 72, http://dx.doi.org/10.1016/j.jdin.2020.05.005

Frew JW, 2020, 'The contradictory inefficacy of methotrexate in hidradenitis suppurativa: a need to revise pathogenesis or acknowledge disease heterogeneity?', Journal of Dermatological Treatment, 31, pp. 422 - 423, http://dx.doi.org/10.1080/09546634.2019.1601668

Frew JW; Grand D; Navrazhina K; Krueger JG, 2020, 'Beyond antibodies: B cells in Hidradenitis Suppurativa: Bystanders, contributors or therapeutic targets?', Experimental Dermatology, 29, pp. 509 - 515, http://dx.doi.org/10.1111/exd.14092

Frew JW; Jiang CS; Singh N; Grand D; Navrazhina K; Vaughan R; Krueger JG, 2020, 'Clinical response rates, placebo response rates, and significantly associated covariates are dependent on choice of outcome measure in hidradenitis suppurativa: A post hoc analysis of PIONEER 1 and 2 individual patient data', Journal of the American Academy of Dermatology, 82, pp. 1150 - 1157, http://dx.doi.org/10.1016/j.jaad.2019.12.044

Price KN; Frew JW; Hsiao JL; Shi VY, 2020, 'COVID-19 and immunomodulator/immunosuppressant use in dermatology', Journal of the American Academy of Dermatology, 82, pp. e173 - e175, http://dx.doi.org/10.1016/j.jaad.2020.03.046

Navrazhina K; Frew JW; Krueger JG, 2020, 'Interleukin 17C is elevated in lesional tissue of hidradenitis suppurativa', British Journal of Dermatology, 182, pp. 1045 - 1047, http://dx.doi.org/10.1111/bjd.18556

Frew JW; Navrazhina K, 2020, 'No evidence that impaired Notch signalling differentiates hidradenitis suppurativa from other inflammatory skin diseases', British Journal of Dermatology, 182, pp. 1042 - 1043, http://dx.doi.org/10.1111/bjd.18593

Frew JW, 2020, 'Putting nodule counts behind us: hidradenitis suppurativa outcome measures independent of descriptive semantics', British Journal of Dermatology, 182, pp. 829 - 830, http://dx.doi.org/10.1111/bjd.18436

Phan K; Tatian A; Woods J; Cains G; Frew JW, 2020, 'Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta-analysis', International Journal of Dermatology, 59, pp. 221 - 228, http://dx.doi.org/10.1111/ijd.14697

Navrazhina K; Frew JW, 2020, 'Consensus definitions of disease activity in hidradenitis suppurativa: crossing the semantic gap', British Journal of Dermatology, 182, pp. 7, http://dx.doi.org/10.1111/bjd.18468

Grand D; Navrazhina K; Frew JW, 2020, 'Integrating complement into the molecular pathogenesis of Hidradenitis Suppurativa', Experimental Dermatology, 29, pp. 86 - 92, http://dx.doi.org/10.1111/exd.14056

Garcet S; Frew JW; Navrazhina K; Krueger J, 2020, '062 Hidradenitis suppurativa RNA-seq skin transcriptome overlaps with psoriasis vulgaris and reveals a marked upregulation of multiple targetable cytokines', Journal of Investigative Dermatology, 140, pp. S7 - S7, http://dx.doi.org/10.1016/j.jid.2020.03.064

Navrazhina K; Frew JW; Grand D; Sullivan-Whalen MM; Gilleaudeau P; Krueger JG, 2020, '14928 Epithelialized tracts are active mediators of inflammation in hidradenitis suppurativa', Journal of the American Academy of Dermatology, 83, pp. AB24 - AB24, http://dx.doi.org/10.1016/j.jaad.2020.06.184

Grand D; Frew JW; Navrazhina K; Krueger J, 2020, '520 Establishing the analytical and clinical validity of sonographic biomarkers in hidradenitis suppurativa', Journal of Investigative Dermatology, 140, pp. S71 - S71, http://dx.doi.org/10.1016/j.jid.2020.03.529

Navrazhina K; Frew JW; Gulati N; Grand D; Garcet S; Mitsui H; Krueger JG, 2020, '703 Laser Capture Microdissection and genetic analysis identify dysplastic nevi as a subgroup of common nevi rather than a progressive state towards melanoma', Journal of Investigative Dermatology, 140, pp. S94 - S94, http://dx.doi.org/10.1016/j.jid.2020.03.715

Frew JW; Navrazhina K; Garcet S; Krueger J, 2020, '880 Targeted IL-17RA antagonism ameliorates histological and transcriptomic features of hidradenitis suppurativa: A proof of concept study', Journal of Investigative Dermatology, 140, pp. S115 - S115, http://dx.doi.org/10.1016/j.jid.2020.03.896

Frew JW; Navrazhina K; Byrd AS; Garg A; Ingram JR; Kirby JS; Lowes MA; Naik H; Piguet V; Prens EP, 2019, 'Defining lesional, perilesional and unaffected skin in hidradenitis suppurativa: proposed recommendations for clinical trials and translational research studies', British Journal of Dermatology, 181, pp. 1339 - 1341, http://dx.doi.org/10.1111/bjd.18309

Frew J; Wu X; Hsiung GY; Feldman HH; Mackenzie IR; Nygaard HB, 2019, 'Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation', STEM CELL RESEARCH, 41, http://dx.doi.org/10.1016/j.scr.2019.101582

Frew JW; Navrazhina K, 2019, 'Into the (gluteal) fold: pilonidal disease and hidradenitis suppurativa – association or continuum?', British Journal of Dermatology, 181, pp. 1121, http://dx.doi.org/10.1111/bjd.18300

Byrd AS; Dina Y; Okoh UJ; Quartey QQ; Carmona-Rivera C; Williams DW; Kerns ML; Miller RJ; Petukhova L; Naik HB; Barnes LA; Shipman WD; Caffrey JA; Sacks JM; Milner SM; Aliu O; Broderick KP; Kim D; Liu H; Dillen CA; Ahn R; Frew JW; Kaplan MJ; Kang S; Garza LA; Miller LS; Alavi A; Lowes MA; Okoye GA, 2019, 'Specimen Collection for Translational Studies in Hidradenitis Suppurativa', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-48226-w

Grand D; Navrazhina K; Frew JW, 2019, 'A Scoping Review of Non-invasive Imaging Modalities in Dermatological Disease: Potential Novel Biomarkers in Hidradenitis Suppurativa', Frontiers in Medicine, 6, pp. 253, http://dx.doi.org/10.3389/fmed.2019.00253

FREW J; MURRELL DF, 2019, 'Epidermolizis bülloza yaşam kalitesi puanlarının klinik uygulamalarının geliştirilmesi: QOLEB anketinde klinik olarak anlamlı sonuçların tanımlanması', Mucosa, 2, pp. 68 - 75, http://dx.doi.org/10.33204/mucosa.598339

Frew JW; Navrazhina K, 2019, 'In silico Analysis of Gamma-Secretase-Complex Mutations in Hidradenitis Suppurativa Demonstrates Disease-Specific Substrate Recognition and Cleavage Alterations', Frontiers in Medicine, 6, http://dx.doi.org/10.3389/fmed.2019.00206

Frew JW; Hawkes JE; Sullivan-Whalen M; Gilleaudeau P; Krueger JG, 2019, 'Inter-rater reliability of phenotypes and exploratory genotype–phenotype analysis in inherited hidradenitis suppurativa', British Journal of Dermatology, 181, pp. 566 - 571, http://dx.doi.org/10.1111/bjd.17695

Tatiane A; Slape D; Lawless R; Frew JW, 2019, 'A systematic review of reported cases of pachyonychia congenita tarda', Clinical and Experimental Dermatology, 44, pp. 606 - 612, http://dx.doi.org/10.1111/ced.13980

Frew JW, 2019, 'Assessing the efficacy of new biologic therapies in hidradenitis suppurativa: consistency vs. bias in outcome measures in moderate and severe disease', Journal of the European Academy of Dermatology and Venereology, 33, pp. e298 - e300, http://dx.doi.org/10.1111/jdv.15572

Frew JW; Navrazhina K; Marohn M; Lu PJC; Krueger JG, 2019, 'Contribution of fibroblasts to tunnel formation and inflammation in hidradenitis suppurativa/ acne inversa', Experimental Dermatology, 28, pp. 886 - 891, http://dx.doi.org/10.1111/exd.13978

Scarisbrick JJ; Quaglino P; Prince HM; Papadavid E; Hodak E; Bagot M; Servitje O; Berti E; Ortiz-Romero P; Stadler R; Patsatsi A; Knobler R; Guenova E; Child F; Whittaker S; Nikolaou V; Tomasini C; Amitay I; Naveh HP; Ram-Wolff C; Battistella M; Alberti-Violetti S; Stranzenbach R; Gargallo V; Muniesa C; Koletsa T; Jonak C; Porkert S; Mitteldorf C; Estrach T; Combalia A; Marschalko M; Csomor J; Szepesi A; Cozzio A; Dummer R; Pimpinelli N; Grandi V; Beylot-Barry M; Pham-Ledard A; Wobser M; Geissinger E; Wehkamp U; Weichenthal M; Cowan R; Parry E; Harris J; Wachsmuth R; Turner D; Bates A; Healy E; Trautinger F; Latzka J; Yoo J; Vydianath B; Amel-Kashipaz R; Marinos L; Oikonomidi A; Stratigos A; Vignon-Pennamen M-D; Climent F; Gonzalez-Barca E; Georgiou E; Senetta R; Zinzani P; Vakeva L; Ranki A; Busschots A-M; Hauben E; Bervoets A; Woei-A-Jin FJSH; Matin R; Collins G; Weatherhead S; Frew J; Bayne M; Dunnill G; McKay P; Arumainathan A; Azurdia R; Benstead K; Twigger R; Rieger K; Brown R; Sanchez JA; Miyashiro D; Akilov O; McCann S; Sahi H; Damasco M; Querfeld C; Folkes A; Bur C; Klemke C-D; Enz P; Pujol R; Quint K; Geskin L; Hong E; Evison F; Vermeer M; Cerroni L; Kempf W; Kim Y; Willemze R, 2019, 'The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients', BRITISH JOURNAL OF DERMATOLOGY, 181, pp. 350 - 357, http://dx.doi.org/10.1111/bjd.17258

Frew JW, 2019, 'Lack of photographic documentation undermines assessment of hidradenitis suppurativa phenotypes: reply from the author', British Journal of Dermatology, 181, pp. 225, http://dx.doi.org/10.1111/bjd.17934

Frew JW, 2019, 'Hidradenitis suppurativa and diabetes: big data bias masks a true association', Clinical and Experimental Dermatology, 44, pp. e151 - e152, http://dx.doi.org/10.1111/ced.13954

Slape D; Tang J; Lawless R; McCrossin I; Frew JW, 2019, 'A retrospective cohort study of melanoma prevalence stratified by body site in a Regional Australian Population 1994-2017: Site-specific protective mechanisms', Photodermatology Photoimmunology and Photomedicine, 35, pp. 135 - 140, http://dx.doi.org/10.1111/phpp.12436

Frew JW, 2019, 'Complement, hidradenitis suppurativa and pathogen-driven positive selection', British Journal of Dermatology, 180, pp. 685 - 686, http://dx.doi.org/10.1111/bjd.17426

Frew JW, 2019, 'Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory Pathways Into a Cohesive Pathogenic Model', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00302

Frew JW, 2019, 'We need to talk about Notch: Notch dysregulation as an epiphenomenon in inflammatory skin disease', British Journal of Dermatology, 180, pp. 431 - 432, http://dx.doi.org/10.1111/bjd.17414

Frew JW; Hawkes JE; Krueger JG, 2019, 'A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa [version 2; peer review: 2 approved]', F1000Research, 7, http://dx.doi.org/10.12688/f1000research.17268.2

Frew JW, 2019, 'Commentary: Hidradenitis Commentary: Hidradenitis Suppurativa: A Systematic Review Integrating Inflammatory pathways into a cohensive pathogenic model', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2018.02965

Venning V; Yhao E; Huynh E; Frew JW, 2019, 'Cutaneous neonatal Langerhans cell histiocytosis: A systematic review of case reports [version 1; peer review: 1 approved with reservations, 1 not approved]', F1000Research, 8, http://dx.doi.org/10.12688/F1000RESEARCH.17664.1

Shavit E; Alavi A; Bechara FG; Bennett RG; Bourcier M; Cibotti R; Daveluy S; Frew JW; Garg A; Hamzavi I; Hoffman LK; Hsaio J; Kirby JS; Lev-Tov H; Martinez E; Micheletti R; Naik HB; Nassif A; Nicholson C; Parks-Miller A; Patel Z; Piguet V; Ramesh M; Resnik B; Sayed C; Schultz G; Siddiqui A; Tan J; Wortsman X; Lowes MA, 2019, 'Proceeding report of the Second Symposium on Hidradenitis Suppurativa Advances (SHSA) 2017', Experimental Dermatology, 28, pp. 94 - 103, http://dx.doi.org/10.1111/exd.13849

Frew JW, 2019, 'The hygiene hypothesis, old friends, and new genes', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00388

Frew JW; Hawkes JE; Krueger JG, 2019, 'Topical, systemic and biologic therapies in hidradenitis suppurativa: pathogenic insights by examining therapeutic mechanisms', Therapeutic Advances in Chronic Disease, 10, http://dx.doi.org/10.1177/2040622319830646

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