By Associate Professor Luke Hesson

Book Chapters

Hesson LB; Sloane MA; Pritchard AL, 2019, 'The Clinical Utility of Epigenetics: A Case Study', in Clinical Epigenetics, pp. 247 - 265, http://dx.doi.org/10.1007/978-981-13-8958-0_11

Hesson LB; Pritchard AL, 2019, 'Genetics and Epigenetics: A Historical Overview', in Clinical Epigenetics, Springer Singapore, pp. 1 - 46, http://dx.doi.org/10.1007/978-981-13-8958-0_1

Kuroiwa-Trzmielina J; Hesson LB, 2016, 'Epigenetic Effects of Gut Microbiota on Obesity and Gastrointestinal Cancers', in Berger NA (ed.), EPIGENETICS, ENERGY BALANCE, AND CANCER, SPRINGER INTERNATIONAL PUBLISHING AG, pp. 167 - 189, http://dx.doi.org/10.1007/978-3-319-41610-6_7

Journal articles

Li Y; Cherepanoff S; Conway RM; Hesson LB; Long G; Garg N; Fung AT, 2024, 'Choroidal melanoma in a patient with multiple endocrine neoplasia type 1', Canadian Journal of Ophthalmology, http://dx.doi.org/10.1016/j.jcjo.2024.08.017

Lechpammer M; Todd A; Tang V; Morningstar T; Borowsky A; Shahlaie K; Kintner JA; McPherson JD; Bishop JW; Fereidouni F; Harmany ZT; Coley N; Zagzag D; Wong JWH; Tao J; Hesson LB; Burnett L; Levenson R, 2024, 'Neuropathological Applications of Microscopy with Ultraviolet Surface Excitation (MUSE): A Concordance Study of Human Primary and Metastatic Brain Tumors', Brain Sciences, 14, pp. 108, http://dx.doi.org/10.3390/brainsci14010108

Saya S; Chondros P; Abela A; Mihalopolous C; Chatterton ML; Gunn J; Chen TF; Polasek TM; Dettmann E; Brooks R; King M; Spencer L; Alphonse P; Milton S; Ramsay G; Siviour Z; Liew J; Ly P; Thoenig M; Seychell R; La Rocca F; Hesson LB; Mejias N; Sivertsen T; Galea MA; Bousman C; Emery J, 2023, 'The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care', Trials, 24, http://dx.doi.org/10.1186/s13063-023-07361-6

Lin V; Chung IY; Toumi E; McKay D; McKenzie J; McKelvie P; Zabih F; Hoffmeister A; Wright D; Ntzaferi A; Wu IJ; Hesson L; Fung A; Lim LA; Wong S; Field A; Earls P; Giblin M; Conway RM; Cherepanoff S, 2022, 'Biopsy for molecular risk stratification in uveal melanoma: Yields and molecular characteristics in 119 patients', Clinical and Experimental Ophthalmology, 50, pp. 50 - 61, http://dx.doi.org/10.1111/ceo.14022

Bournazos AM; Riley LG; Bommireddipalli S; Ades L; Akesson LS; Al-Shinnag M; Alexander SI; Archibald AD; Balasubramaniam S; Berman Y; Beshay V; Boggs K; Bojadzieva J; Brown NJ; Bryen SJ; Buckley MF; Chong B; Davis MR; Dawes R; Delatycki M; Donaldson L; Downie L; Edwards C; Edwards M; Engel A; Ewans LJ; Faiz F; Fennell A; Field M; Freckmann ML; Gallacher L; Gear R; Goel H; Goh S; Goodwin L; Hanna B; Harraway J; Higgins M; Ho G; Hopper BK; Horton AE; Hunter MF; Huq AJ; Josephi-Taylor S; Joshi H; Kirk E; Krzesinski E; Kumar KR; Lemckert F; Leventer RJ; Lindsey-Temple SE; Lunke S; Ma A; Macaskill S; Mallawaarachchi A; Marty M; Marum JE; McCarthy HJ; Menezes MP; McLean A; Milnes D; Mohammad S; Mowat D; Niaz A; Palmer EE; Patel C; Patel SG; Phelan D; Pinner JR; Rajagopalan S; Regan M; Rodgers J; Rodrigues M; Roxburgh RH; Sachdev R; Roscioli T; Samarasekera R; Sandaradura SA; Savva E; Schindler T; Shah M; Sinnerbrink IB; Smith JM; Smith RJ; Springer A; Stark Z; Strom SP; Sue CM; Tan K; Tan TY; Tantsis E; Tchan MC; Thompson BA; Trainer AH; van Spaendonck-Zwarts K; Walsh R; Warwick L; White S; White SM; Williams MG, 2022, 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, 24, pp. 130 - 145, http://dx.doi.org/10.1016/j.gim.2021.09.001

Gifford G; Hesson L; Wong JWH; Carroll A; Gabrielli S; Bai LJ; Xia W; Stevenson W; Greenwood M, 2021, 'Poor mobilization of autologous CD34⁺ peripheral blood stem cells in haematology patients undergoing autologous stem cell transplantation is associated with the presence of variants in genes implicated in clonal haematopoiesis of indeterminant potential', British Journal of Haematology, 193, pp. 841 - 844, http://dx.doi.org/10.1111/bjh.17316

Palmer EE; Sachdev R; Macintosh R; Melo US; Mundlos S; Righetti S; Kandula T; Minoche AE; Puttick C; Gayevskiy V; Hesson L; Idrisoglu S; Shoubridge C; Thai MHN; Davis RL; Drew AP; Sampaio H; Andrews PI; Lawson J; Cardamone M; Mowat D; Colley A; Kummerfeld S; Dinger ME; Cowley MJ; Roscioli T; Bye A; Kirk E, 2021, 'Diagnostic Yield of Whole Genome Sequencing After Nondiagnostic Exome Sequencing or Gene Panel in Developmental and Epileptic Encephalopathies', Neurology, 96, pp. E1770 - E1782, http://dx.doi.org/10.1212/WNL.0000000000011655

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Subramanian S, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, 7, pp. eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929

Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Hung T; Power C; Hardy P; D D; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE; Chacon Fajardo D, 2021, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', Science Advances, pp. 2020.06.04.130872 - 2020.06.04.130872, http://dx.doi.org/10.1126/sciadv.abd1929

Van Ly D; Wang D; Conway RM; Giblin M; Liang S; Lukeis R; Lim LA; Hesson L; Cherepanoff S, 2020, 'Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase', Ocular Oncology and Pathology, 6, pp. 416 - 421, http://dx.doi.org/10.1159/000510393

Morris MJ; Hesson LB; Youngson NA, 2020, 'Non-CpG methylation biases bisulphite PCR towards low or unmethylated mitochondrial DNA: recommendations for the field', Environmental Epigenetics, 6, http://dx.doi.org/10.1093/eep/dvaa001

Poulos RC; Perera D; Packham D; Shah A; Janitz C; Pimanda JE; Hawkins N; Ward RL; Hesson LB; Wong JWH, 2019, 'Scarcity of Recurrent Regulatory Driver Mutations in Colorectal Cancer Revealed by Targeted Deep Sequencing', JNCI CANCER SPECTRUM, 3, http://dx.doi.org/10.1093/jncics/pkz012

Morris MJ; Hesson LB; Poulos RC; Ward RL; Wong JWH; Youngson NA, 2018, 'Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation', Biomarker Research, 6, http://dx.doi.org/10.1186/s40364-018-0151-x

Jacquelin S; Straube J; Cooper L; Vu T; Song A; Bywater M; Baxter E; Heidecker M; Wackrow B; Porter A; Ling V; Green J; Austin R; Kazakoff S; Waddell N; Hesson LB; Pimanda JE; Stegelmann F; Bullinger L; Döhner K; Rampal RK; Heckl D; Hill GR; Lane SW, 2018, 'Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation', Blood, 132, pp. 2707 - 2721, http://dx.doi.org/10.1182/blood-2018-04-846220

Liu Q; Thoms JAI; Nunez AC; Huang Y; Knezevic K; Packham D; Poulos RC; Williams R; Beck D; Hawkins NJ; Ward RL; Wong JWH; Hesson LB; Sloane MA; Pimanda JE, 2018, 'Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells', Clinical Cancer Research, 24, pp. 4602 - 4611, http://dx.doi.org/10.1158/1078-0432.CCR-17-3678

Unnikrishnan A; Vo ANQ; Pickford R; Raftery MJ; Nunez AC; Verma A; Hesson LB; Pimanda JE, 2018, 'AZA-MS: A novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo', Leukemia, 32, pp. 900 - 910, http://dx.doi.org/10.1038/leu.2017.340

Berbic M; Hesson L; Ho LL; Kyle P; Mina K, 2018, 'Case study – Reproductive risk of clinically relevant thalassaemia despite mild microcytosis and normal thalassaemia screen', Pathology, 50, pp. S63 - S63, http://dx.doi.org/10.1016/j.pathol.2017.12.148

Jacquelin S; Straube J; Song A; Cooper L; Vu T; Heidecker M; Pimanda J; Hesson L; Hill G; Cloonan N; Heckl D; Lane S, 2017, 'IN VIVO CRISPR EDITING OF DNMT3A IN JAK2V617F HEMATOPOIETIC STEM CELLS INDUCES MYELOFIBROSIS', EXPERIMENTAL HEMATOLOGY, 53, pp. S95 - S95, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000972742900206&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Luo A; Leach ST; Barres R; Hesson LB; Grimm MC; Simar D, 2017, 'The microbiota and epigenetic regulation of t helper 17/regulatory T cells: In search of a balanced immune system', Frontiers in Immunology, 8, pp. 417, http://dx.doi.org/10.3389/fimmu.2017.00417

Ma SSQ; Henry CE; Llamosas E; Higgins R; Daniels B; Hesson LB; Hawkins NJ; Ward RL; Ford CE, 2017, 'Validation of specificity of antibodies for immunohistochemistry: the case of ROR2', Virchows Archiv : an international journal of pathology, 470, pp. 99 - 108, http://dx.doi.org/10.1007/s00428-016-2019-5

Ma SSQ; Henry CE; Llamosas E; Higgins R; Daniels B; Hesson LB; Hawkins NJ; Ward RL; Ford CE, 2016, 'Erratum to: Validation of specificity of antibodies for immunohistochemistry: the case of ROR2 (Virchows Archiv, (2016), 10.1007/s00428-016-2019-5)', Virchows Archiv, 469, pp. 717, http://dx.doi.org/10.1007/s00428-016-2036-4

Hesson LB; Ng B; Zarzour P; Srivastava S; Kwok CT; Packham D; Nunez AC; Beck D; Ryan R; Dower A; Ford CE; Pimanda JE; Sloane MA; Hawkins NJ; Bourke MJ; Wong JWH; Ward RL, 2016, 'Integrated genetic, epigenetic, and transcriptional profiling identifies molecular pathways in the development of laterally spreading tumors', Molecular Cancer Research, 14, pp. 1217 - 1228, http://dx.doi.org/10.1158/1541-7786.MCR-16-0175

Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M; Liu JJ, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936, http://dx.doi.org/10.4103/1008-682X.163190

Liu Q; Hesson LB; Nunez AC; Packham D; Hawkins NJ; Ward RL; Sloane MA, 2016, 'Pathogenic germline MCM9 variants are rare in Australian Lynch-like syndrome patients', Cancer Genetics, 209, pp. 497 - 500, http://dx.doi.org/10.1016/j.cancergen.2016.10.001

Ma S; srivastava S; llamosas E; hawkins N; hesson L; ward R; Ford C, 2016, 'ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration.', BMC Cancer, 16, pp. 508, http://dx.doi.org/10.1186/s12885-016-2576-7

Srivastava S; Ludwig AK; Wong JWH; Hesson LB, 2016, 'An investigation of the potential for epigenetic inactivation by transcription read-through in a sporadic colorectal cancer', Gene, 585, pp. 154 - 158, http://dx.doi.org/10.1016/j.gene.2016.03.031

Liu Q; Thompson BA; Ward RL; Hesson LB; Sloane MA, 2016, 'Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome', Human Mutation, 37, pp. 417 - 426, http://dx.doi.org/10.1002/humu.22971

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'Pdgf-ab and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', Proceedings of the National Academy of Sciences of the United States of America, 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Liu Q; Hesson LB; Nunez AC; Packham D; Williams R; Ward RL; Sloane MA, 2016, 'A cryptic paracentric inversion of MSH2 exons 2-6 causes Lynch syndrome', Carcinogenesis, 37, pp. 10 - 17, http://dx.doi.org/10.1093/carcin/bgv154

Thoms JAI; Knezevic K; Liu JJ; Glaros EN; Thai T; Qiao Q; Campbell H; Packham D; Huang Y; Papathanasiou P; Tunningley R; Whittle B; Yeung AWS; Chandrakanthan V; Hesson L; Chen V; Wong JWH; Purton LE; Ward RL; Thomas SR; Pimanda JE, 2016, 'Arrested hematopoiesis and vascular relaxation defects in mice with a mutation in Dhfr', Molecular and Cellular Biology, 36, pp. 1222 - 1236, http://dx.doi.org/10.1128/MCB.01035-15

Sloane MA; Ward RL; Hesson LB, 2016, 'Defining the criteria for identifying constitutional epimutations', Clinical Epigenetics, 8, http://dx.doi.org/10.1186/s13148-016-0207-4

Sloane MA; Nunez AC; Packham D; Kwok CT; Suthers G; Hesson LB; Ward RL, 2015, 'Mosaic epigenetic inheritance as a cause of early-onset colorectal cancer', JAMA Oncology, 1, pp. 953 - 957, http://dx.doi.org/10.1001/jamaoncol.2015.1484

Zarzour P; Boelen L; Luciani F; Beck D; Sakthianandeswaren A; Mouradov D; Sieber OM; Hawkins NJ; Hesson LB; Ward RL; Wong JWH, 2015, 'Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas', Genes Chromosomes and Cancer, 54, pp. 303 - 314, http://dx.doi.org/10.1002/gcc.22243

Hesson LB; Packham D; Kwok CT; Nunez AC; Ng B; Schmidt C; Fields M; Wong JW; Sloane MA; Ward RL, 2015, 'Lynch Syndrome associated with two MLH1 promoter variants and allelic imbalance of MLH1 expression.', Human Mutation, 36, pp. 622 - 630, http://dx.doi.org/10.1002/humu.22785

Poulos RC; Sloane MA; Hesson LB; Wong JWH, 2015, 'The search for cis-regulatory driver mutations in cancer genomes', Oncotarget, 6, pp. 32509 - 32525, http://dx.doi.org/10.18632/oncotarget.5085

Hesson LB; Sloane MA; Wong JWH; Nunez AC; Srivastava S; Ng B; Hawkins NJ; Bourke MJ; Ward RL, 2014, 'Altered promoter nucleosome positioning is an early event in gene silencing', Epigenetics, 9, pp. 1422 - 1430, http://dx.doi.org/10.4161/15592294.2014.970077

Hesson LB; Ward RL, 2014, 'Discrimination of pseudogene and parental gene dna methylation using allelic bisulfite sequencing', Methods in Molecular Biology, 1167, pp. 265 - 274, http://dx.doi.org/10.1007/978-1-4939-0835-6_18

Simar D; Versteyhe S; Donkin I; Liu J; Hesson L; Nylander V; Fossum A; Barres R, 2014, 'DNA Methylation Is Altered In B And NK Lymphocytes In Obese And Type 2 Diabetic Human', Metabolism: clinical and experimental, 63, pp. 1188 - 1197, http://dx.doi.org/10.1016/j.metabol.2014.05.014

Sloane MA; Wong JWH; Perera D; Nunez AC; Pimanda JE; Hawkins NJ; Sieber OM; Bourke MJ; Hesson LB; Ward RL, 2014, 'Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia', Epigenetics, 9, pp. 1092 - 1100, http://dx.doi.org/10.4161/epi.29222

Patil V; Ward RL; Hesson LB, 2014, 'The evidence for functional non-CpG methylation in mammalian cells', Epigenetics, 9, pp. 823 - 828, http://dx.doi.org/10.4161/epi.28741

Sloane MA; Hesson LB; Ward RL, 2014, 'Epimutations and cancer susceptibility', , http://dx.doi.org/10.1002/9780470015902.a0024615

Sloane MA; Hesson LB; Nunez AC; Thompson BA; Ward RL, 2014, 'Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients', Clinical Epigenetics, 6, pp. 32, http://dx.doi.org/10.1186/s13148-014-0032-6

Hesson LB; Ward RL, 2014, 'The importance of distinguishing pseudogenes from parental genes', Clinical Epigenetics, 6, pp. 33, http://dx.doi.org/10.1186/s13148-014-0033-5

Sloane MA; Hesson LB; Nunez AC; Thompson BA; Ward RL, 2014, 'Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients', Clinical Epigenetics, 6, pp. 32 - 32, http://dx.doi.org/10.1186/preaccept-1571082317134727

Zarzour P; Hesson LB; Ward RL, 2013, 'Establishing the clinical utility of epigenetic markers in cancer: Many challenges ahead', Epigenomics, 5, pp. 513 - 523, http://dx.doi.org/10.2217/epi.13.53

Hesson L, 2013, 'Gut microbiota and obesity-related gastrointestinal cancer: a focus on epigenetics', Translational Gastrointestinal Cancer, 2, pp. 204 - 210

Hesson LB; Patil V; Sloane MA; Nunez AC; Liu J; Pimanda JE; Ward RL, 2013, 'Reassembly of Nucleosomes at the MLH1 Promoter Initiates Resilencing Following Decitabine Exposure', PLoS Genetics, 9, http://dx.doi.org/10.1371/journal.pgen.1003636

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