By Associate Professor Luke Hesson

Journal articles

Metz AJ; Bourke MJ; Moss A; Dower A; Zarzour P; Hawkins NJ; Ward RL; Hesson L, 2013, 'A correlation of the endoscopic characteristics of colonic laterally spreading tumours (LSTs) with genetic alterations', European Journal of Gastroenterology and Hepatology, 25, pp. 319 - 326, http://dx.doi.org/10.1097/MEG.0b013e32835b57e7

Liu J; Hesson LB; Ward RL, 2013, 'Liquid chromatography tandem mass spectrometry for the measurement of global DNA methylation and hydroxymethylation', Journal of Proteomics & Bioinformatics, 01, http://dx.doi.org/10.4172/jpb.S2-005

Lau DT; Hesson LB; Norris MD; Marshall G; Haber M; Ashton LJ, 2012, 'Abstract 68: Beyond GWAS: The prognostic significance of promoter DNA methylation in patients with neuroblastoma.', Cancer Epidemiology, Biomarkers & Prevention, 21, pp. 68 - 68, http://dx.doi.org/10.1158/1055-9965.gwas-68

Hesson LB; Wong JWH; Sloane MA; Pimanda JE; Bourke MJ; Hawkins NJ; Ward RL, 2012, 'Nucleosome occupancy at unmethylated promoter CpG islands represents a novel mechanism of epigenetic gene silencing in cancer', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-990

Lau DT; Hesson LB; Norris MD; Haber M; Marshall GM; Ashton LJ, 2012, 'Prognostic significance of promoter DNA methylation in patients with neuroblastoma', CANCER RESEARCH, 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1425

Hesson L; Packham D; Pontzer E; Funchain P; Eng C; Ward RL, 2012, 'A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines', Biological Procedures Online, 14, pp. 1 - 8, http://dx.doi.org/10.1186/1480-9222-14-5

Lau DT; Hesson L; Norris MD; Marshall GM; Haber M; Ashton LJ, 2012, 'Prognostic Significance of Promoter DNA Methylation in Patients with Childhood Neuroblastoma', Clinical Cancer Research, 18, pp. 5690 - 5700, http://dx.doi.org/10.1158/1078-0432.CCR-12-0294

Liu J; Hesson L; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', CANCER PREVENTION RESEARCH, 5, pp. 921 - 929, http://dx.doi.org/10.1158/1940-6207.CAPR-11-0577

Liu JJ; Hesson LB; Rand KN; Molloy PL; Pimanda J; Ward RL, 2011, 'Analysis of global and repeat sequence DNA methylation in the blood and normal colonic mucosa of colorectal cancer patients, healthy individuals and patients with folate deficiency', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-91

Hesson LB; Patil V; Sloane M; Ward RL, 2011, 'Investigation of the molecular events associated with gene resilencing following withdrawal of epigenetic therapies', CANCER RESEARCH, 71, http://dx.doi.org/10.1158/1538-7445.AM2011-2000

Hesson LB; Latif F, 2011, 'RASSF2 (Ras association (RalGDS/AF-6) domain family member 2)', Atlas of Genetics and Cytogenetics in Oncology and Haematology, http://dx.doi.org/10.4267/2042/44798

Hesson LB; Latif F, 2011, 'RASSF6 (Ras association (RalGDS/AF-6) domain family member 6)', Atlas of Genetics and Cytogenetics in Oncology and Haematology, http://dx.doi.org/10.4267/2042/44939

Dunwell TL; Hesson L; Rauch TA; Wang L; Clark R; Dallol A; Gentle D; Catchpoole DR; Maher ER; Pfeifer G; Latif F, 2010, 'A Genome-wide screen identifies frequently methylated genes in haematological and epithelial cancers', Molecular Cancer, 9, pp. 44 - 44

Hesson L; Hitchins MP; Ward RL, 2010, 'Epimutations and cancer predisposition: importance and mechanisms', Current Opinion in Genetics and Development, 20, pp. 1 - 9

Hill VK; Hesson L; Dansranjavin T; Dallol A; Bieche I; Vacher S; Tommasi S; Dobbins TA; Gentle D; Euhus D; Dammann R; Ward RL; Minna JD; Maher ER; Pfeifer G; Latif F, 2010, 'Identification of 5 novel genes methylated in breast and other epithelial cancers', Molecular Cancer Research, 9, pp. 51 - 66, http://www.molecular-cancer.com/content/9/1/5110.1186/1476-4598-9-51

Hesson L; Donninger H; Latif F; Vos MD; Beebe K; Gordon L; Sidransky D; Liu JW; Schlegel T; Payne S; Hartmann A, 2010, 'The Ras effector RASSF2 controls the PAR-4 tumor suppressor.', Molecular and Cellular Biology, 30, pp. 2608 - 2620

Lock FE; Underhill-Day N; Dunwell TL; Matallanas D; Cooper W; Hesson L; Recino A; Ward A; Pavlova TV; Zabarovsky ER; Grant M; Maher ER; Chalmers AD; Kolch W; Latif F, 2010, 'The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kB signaling pathways', Oncogene, 29, pp. 4307 - 4316

Dunwell TL; Hesson L; Pavlova TV; Zabarovska V; Kashuba V; Catchpoole DR; Chiaramonte R; Brini AT; Griffiths M; Maher ER; Zabarovsky ER; Latif F, 2009, 'Epigenetic analysis of childhood acute lymphoblastic leukemia', , 4, pp. 185 - 193

Dallol A; Hesson L; Matallanas D; Cooper WN; O''neill E; Maher ER; Kolch W; Latif F, 2009, 'Ran GTPase is a RASSF1A effector involved in controlling microtubule organisation', , 19, pp. 1227 - 1232

Cooper W; Hesson L; Matallanas D; Dallol A; Von Kriegsheim A; Ward RL; Kolch W; Latif F, 2009, 'RASSF2 associates with and stabilizes the proapoptotic kinase MST2', Oncogene, 28, pp. 2988 - 2998

Hesson L; Dunwell TL; Cooper WN; Catchpoole DR; Brini AT; Chiaramonte R; Chalmers AD; Griffiths M; Maher ER; Latif F, 2009, 'The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias', Molecular Cancer, 8, pp. 42 - 42

Morton S; Hesson L; Peggie M; Cohen P, 2008, 'Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.', FEBS Letters, 582, pp. 997 - 1002

Hesson L; Krex D; Latif F, 2008, 'Epigenetic markers of human gliomas – prospects for therapeutic intervention', Expert Review of Neurotherapeutics, 8, pp. 1475 - 1496

Cooper WN; Dickinson RE; Dallol A; Hesson LB; Bieche I; Clark GJ; Maher ER; Zabarovsky ER; Latif F, 2008, 'RASSF2 can suppress the growth of breast cancer cell lines and is epigenetically inactivated in breast tumours', Breast Cancer Research, 10, http://dx.doi.org/10.1186/bcr1893

Cooper WN; Dickinson RE; Dallol A; Grigorieva EV; Pavlova TV; Hesson L; Bieche I; Broggini M; Maher ER; Zabarovsky ER; Clark GJ; Latif F, 2007, 'Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer', Oncogene, 27, pp. 1805 - 1811

Hesson L; Cooper WN; Latif F, 2007, 'Evaluation of the 3p21.3 Tumour-suppressor Gene Cluster', Oncogene, 26, pp. 7283 - 7301

Allen NPC; Donninger H; Vos MD; Eckfeld K; Hesson L; Gordon L; Birrer MJ; Latif F; Clark GJ, 2007, 'RASSF6 is a novel member of the RASSF family of tumor suppressors.', Oncogene, 26, pp. 6203 - 6211

Hesson L; Cooper WN; Latif F, 2007, 'The role of RASSF1A methylation in cancer', Disease Markers, 23, pp. 73 - 87

Vos MD; Dallol A; Eckfeld K; Allen NPC; Donninger H; Hesson L; Calvisi D; Latif F; Clark GJ, 2006, 'The RASSF1A tumor suppressor activates Bax via MOAP-1', The Journal of Biological Chemistry, 281, pp. 4557 - 4563

Caren H; Ejeskar K; Fransson S; Hesson L; Latif F; Sjoberg RM; Krona C; Martinsson T, 2005, 'A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation', Molecular Cancer, 4, pp. 10

Hesson L; Wilson R; Morton D; Walker M; Maher ER; Latif F, 2005, 'CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations', Oncogene, 24, pp. 3987 - 3994

Elam C; Hesson L; Vos MD; Eckfeld K; Ellis CA; Bell A; Krex D; Birrer MJ; Latif F; Clark GJ, 2005, 'RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential', Cancer research, 65, pp. 3117 - 3125

Hesson L; Bieche I; Krex D; Criniere E; Hoang-xuan K; Maher ER; Latif F, 2004, 'Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas', Oncogene, 23, pp. 2408 - 2419

Fenton SL; Dallol A; Agathanggelou A; Hesson L; Ahmed-choudhury J; Baksh S; Sardet C; Dammann R; Minna JD; Downward J; Maher ER; Latif F, 2004, 'Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene', Cancer research, 64, pp. 102 - 107

Dallol A; Agathanggelou A; Fenton SL; Hesson L; Ahmed-choudhury J; Vos MD; Clark GJ; Downward J; Maher ER; Latif F, 2004, 'RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics', Cancer research, 64, pp. 4112 - 4116

Eckfeld K; Hesson L; Vos MD; Bieche I; Latif F; Clark GJ, 2004, 'RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family', Cancer research, 64, pp. 8688 - 8693

Da silva NF; Gentle D; Hesson L; Morton D; Latif F; Maher ER, 2003, 'Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer', Journal of Medical Genetics, 40, pp. 820 - 824

Agathanggelou A; Dallol A; Zochbauer-muller S; Morrissey C; Honorio S; Hesson L; Martinsson T; Fong KM; Kuo MJ; Yuen PW; Maher ER; Minna JD; Latif F, 2003, 'Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers', Oncogene, 22, pp. 1580 - 1588

Dallol A; Krex D; Hesson L; Eng C; Maher ER; Latif F, 2003, 'Frequent epigenetic inactivation of the SLIT2 gene in gliomas', Oncogene, 22, pp. 4611 - 4616

Morris MR; Hesson L; Wagner KJ; Morgan NV; Astuti D; Lees RD; Cooper WN; Lee J; Gentle D; Macdonald F; Kishida T; Grundy R; Yao M; Latif F; Maher ER, 2003, 'Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma', Oncogene, 22, pp. 6794 - 6801

Hesson L; Dallol A; Minna JD; Maher ER; Latif F, 2003, 'NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancers', Oncogene, 22, pp. 947 - 954

Conference Papers

Patil V; Sloane MA; Wong JW; Liu J; Ward RL; Hesson LB, 2013, 'Abstract 2983: Gene resilencing following decitabine therapy is initiated by nucleosome reoccupancy and is related to CpG island shore methylation.', in Cancer Research, American Association for Cancer Research (AACR), pp. 2983 - 2983, http://dx.doi.org/10.1158/1538-7445.am2013-2983

Sloane M; Hesson L; Wong J; Pimanda J; Bourke M; Hawkins N; Ward R, 2012, 'Inactivation of the deubiquitinase USP44 is an early event in the formation of colorectal cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM2012-LB-375

Metz AJ; Bourke MJ; Moss A; Hesson L; Ward R, 2011, 'A Correlation of the Endoscopic Characteristics of Colonic Laterally Spreading Tumours (LSTS) With Genetic Mutations', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, IL, Chicago, pp. S191 - S191, presented at Conference on Digestive Disease Week 2011, IL, Chicago, 07 May 2011 - 10 May 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290167300770&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Hill V; Hesson L; Dansranjavin T; Dallol A; Bieche I; Tommasi S; Dobbins T; Gentle D; Euhus D; Dammann R; Ward RL; Minna J; Maher ER; Pfeifer G; Latif F, 2010, 'MIRA (methylated CpG island recovery assay) assay identifies frequently methylated genes in breast cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.AM10-165

Conference Posters

Metz AJ; Bourke MJ; Moss A; Hesson L; Ward R, 2010, 'A correlation of the endoscopic characteristics of colonic laterally spreading tumours (LSTs) with genetic mutations', Vol. 25, pp. A78 - A78, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000283321200212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts

Unnikrishnan A; Quynh AVN; Pickford R; Nunez A; Hesson L; Pimanda J, 2017, 'A NOVEL MASS SPECTROMETRY METHOD REVEALS THE INTRACELLULAR PHARMACOKINETICS OF AZACYTIDINE THERAPY IN VIVO', in HAEMATOLOGICA, FERRATA STORTI FOUNDATION, SPAIN, Madrid, Vol. 102, pp. 258 - 259, presented at 22nd Congress of the European-Hematology-Association, SPAIN, Madrid, 22 June 2017 - 25 June 2017

Chandrakanthan V; Yeola A; Kwan JC; Oliver RA; Qiao Q; Kang YC; Zarzour P; Beck D; Boelen L; Unnikrishnan A; Villanueva JE; Nunez AC; Knezevic K; Palu C; Nasrallah R; Carnell M; Macmillan A; Whan R; Yu Y; Hardy P; Grey ST; Gladbach A; Delerue F; Ittner L; Mobbs R; Walkley CR; Purton LE; Ward RL; Wong JWH; Hesson LB; Walsh W; Pimanda JE, 2016, 'PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells', in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, Vol. 113, pp. E2306 - E2315, http://dx.doi.org/10.1073/pnas.1518244113

Sloane M; Liu Q; Nunez A; Packham D; Kwok C-T; Suthers G; Du Sart D; Williams R; Hesson L; Ward R, 2015, 'TRANSLATING BASIC RESEARCH INTO THE CLINICAL MANAGEMENT OF FAMILIES WITH LYNCH SYNDROME', in Asia-Pacific Journal of Clinical Oncology, WILEY-BLACKWELL, Vol. 11, pp. 102 - 102, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364320800126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Liu J; Hesson LB; Meagher AP; Bourke MJ; Hawkins NJ; Rand KN; Molloy PL; Pimanda JE; Ward RL, 2012, 'Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-3125

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