Select Publications

Journal articles

Kendig MD; Hasebe K; Tajaddini A; Kaakoush NO; Westbrook RF; Morris MJ, 2022, 'The Benefits of Switching to a Healthy Diet on Metabolic, Cognitive and Gut Microbiome Parameters are Preserved in Adult Rat Offspring of Mothers Fed a High-Fat, High-Sugar Diet.', Mol Nutr Food Res, pp. e2200318, http://dx.doi.org/10.1002/mnfr.202200318

Podlesny D; Durdevic M; Paramsothy S; Kaakoush NO; Högenauer C; Gorkiewicz G; Walter J; Fricke WF, 2022, 'Identification of clinical and ecological determinants of strain engraftment after fecal microbiota transplantation using metagenomics', Cell Reports Medicine, vol. 3, http://dx.doi.org/10.1016/j.xcrm.2022.100711

Hasebe K; Kendig MD; Kaakoush NO; Tajaddini A; Westbrook RF; Morris MJ, 2022, 'The influence of maternal unhealthy diet on maturation of offspring gut microbiota in rat', Animal Microbiome, vol. 4, http://dx.doi.org/10.1186/s42523-022-00185-w

Jing W; Pilato JL; Kay C; Feng S; Tuipulotu DE; Mathur A; Shen C; Ngo C; Zhao A; Miosge LA; Ali SA; Gardiner EE; Awad MM; Lyras D; Robertson AAB; Kaakoush NO; Man SM, 2022, 'Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins', Science Immunology, vol. 7, pp. eabm1803, http://dx.doi.org/10.1126/sciimmunol.abm1803

Kaakoush NO; Olzomer EM; Kosasih M; Martin AR; Fargah F; Lambie N; Susic D; Hoehn KL; Farrell R; Byrne FL, 2022, 'Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice', Cancers, vol. 14, http://dx.doi.org/10.3390/cancers14092141

Haifer C; Paramsothy S; Kaakoush NO; Leong RW, 2022, 'Oral faecal microbiota transplantation in ulcerative colitis – Authors' reply', The Lancet Gastroenterology and Hepatology, vol. 7, pp. 286 - 287, http://dx.doi.org/10.1016/S2468-1253(22)00045-0

Haifer C; Paramsothy S; Kaakoush NO; Saikal A; Ghaly S; Yang T; Luu LDW; Borody TJ; Leong RW, 2022, 'Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial', The Lancet Gastroenterology and Hepatology, vol. 7, pp. 141 - 151, http://dx.doi.org/10.1016/S2468-1253(21)00400-3

Lu LDW; Singh H; Castaño-Rodríguez N; Leach ST; Riordan SM; Tedla N; Krishnan U; Kaakoush NO, 2022, 'Changes to the upper gastrointestinal microbiotas of children with reflux oesophagitis and oesophageal metaplasia', Microbial Genomics, vol. 8, http://dx.doi.org/10.1099/mgen.0.000870

Haifer C; Luu LDW; Paramsothy S; Borody TJ; Leong RW; Kaakoush NO, 2022, 'Microbial determinants of effective donors in faecal microbiota transplantation for UC', Gut, http://dx.doi.org/10.1136/gutjnl-2022-327742

Rodriguez Paris V; Wong XYD; Solon-Biet SM; Edwards MC; Aflatounian A; Gilchrist RB; Simpson SJ; Handelsman DJ; Kaakoush NO; Walters KA, 2022, 'The interplay between PCOS pathology and diet on gut microbiota in a mouse model', Gut Microbes, vol. 14, http://dx.doi.org/10.1080/19490976.2022.2085961

Parthasarathy R; Santiago F; McCluskey P; Kaakoush NO; Tedla N; Wakefield D, 2022, 'The microbiome in HLA-B27-associated disease: implications for acute anterior uveitis and recommendations for future studies', Trends in Microbiology, http://dx.doi.org/10.1016/j.tim.2022.08.008

Don Wai Luu L; Kaakoush NO; Castaño-Rodríguez N, 2022, 'The role of ATG16L2 in autophagy and disease', Autophagy, vol. 18, pp. 2537 - 2546, http://dx.doi.org/10.1080/15548627.2022.2042783

Deshpande NP; Riordan SM; Gorman CJ; Nielsen S; Russell TL; Correa-Ospina C; Fernando BSM; Waters SA; Castaño-Rodríguez N; Man SM; Tedla N; Wilkins MR; Kaakoush NO, 2021, 'Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus', Genome Medicine, vol. 13, pp. 133, http://dx.doi.org/10.1186/s13073-021-00951-6

Haifer C; Saikal A; Paramsothy R; Kaakoush NO; Leong RW; Borody TJ; Kamm MA; Paramsothy S, 2021, 'Response to faecal microbiota transplantation in ulcerative colitis is not sustained long term following induction therapy', Gut, vol. 70, pp. 2210 - 2211, http://dx.doi.org/10.1136/gutjnl-2020-323581

Haifer C; Saikal A; Paramsothy R; Kaakoush NO; Leong RW; Borody TJ; Kamm MA; Paramsothy S, 2021, 'Response to faecal microbiota transplantation in ulcerative colitis is not sustained long term following induction therapy', GUT, vol. 70, pp. 2210 - 2210, http://dx.doi.org/10.1136/gutjnl-2020-323581

Podlesny D; Durdevic M; Paramsothy S; Kaakoush NO; Högenauer C; Gorkiewicz G; Walter J; Fricke WF, 2021, 'Intraspecies strain exclusion, antibiotic pretreatment, and donor selection control microbiota engraftment after fecal transplantation', , http://dx.doi.org/10.1101/2021.08.18.21262200

An H; Richardson A; Rajasekariah P; Zhong L; Fernando BSM; Macmillan A; Klotzsch E; Bryant K; Kaakoush NO; Tedla N, 2021, 'Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers of Regulated Gene Expression and Translation', Journal of Proteome Research, vol. 20, pp. 3078 - 3089, http://dx.doi.org/10.1021/acs.jproteome.0c00946

Haifer C; Saikal A; Paramsothy S; Borody TJ; Ghaly S; Kaakoush NO; Leong R, 2021, 'Lyophilised orally administered faecal microbiota transplantation for Active Ulcerative Colitis (LOTUS study)', JOURNAL OF CROHNS & COLITIS, vol. 15, pp. S029 - S029, http://dx.doi.org/10.1093/ecco-jcc/jjab075.029

Haifer C; Paramsothy S; Borody TJ; Clancy A; Leong RW; Kaakoush NO, 2021, 'Long-term bacterial and fungal dynamics following oral lyophilized fecal microbiota transplantation in clostridioides difficile infection', mSystems, vol. 6, http://dx.doi.org/10.1128/MSYSTEMS.00905-20

Haifer C; Saikal A; Paramsothy S; Borody TJ; Ghaly DS; Kaakoush NO; Leong RW, 2021, '680 LYOPHILIZED ORALLY ADMINISTERED FECAL MICROBIOTA TRANSPLANTATION IN THE MANAGEMENT OF ULCERATIVE COLITIS (LOTUS STUDY) – RESULTS FROM THE INDUCTION PHASE OF A RANDOMIZED CONTROLLED TRIAL', Gastroenterology, vol. 160, pp. S - 135, http://dx.doi.org/10.1016/s0016-5085(21)01074-x

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', , http://dx.doi.org/10.1101/2021.04.05.437453

Fox D; Mathur A; Xue Y; Liu Y; Tan WH; Feng S; Pandey A; Ngo C; Hayward JA; Atmosukarto II; Price JD; Johnson MD; Jessberger N; Robertson AAB; Burgio G; Tscharke DC; Fox EM; Leyton DL; Kaakoush NO; Märtlbauer E; Leppla SH; Man SM, 2020, 'Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome', Nature Communications, vol. 11, http://dx.doi.org/10.1038/s41467-020-14534-3

Leigh SJ; Kaakoush NO; Bertoldo MJ; Westbrook RF; Morris MJ, 2020, 'Intermittent cafeteria diet identifies fecal microbiome changes as a predictor of spatial recognition memory impairment in female rats', Translational Psychiatry, vol. 10, pp. 36, http://dx.doi.org/10.1038/s41398-020-0734-9

Leigh SJ; Kaakoush NO; Westbrook RF; Morris MJ, 2020, 'Minocycline-induced microbiome alterations predict cafeteria diet-induced spatial recognition memory impairments in rats', Translational Psychiatry, vol. 10, pp. 92, http://dx.doi.org/10.1038/s41398-020-0774-1

Krishnan U; Singh H; Tedla N; Leach ST; Kaakoush NO, 2020, 'Presence of gastric pepsinogen in the trachea is associated with altered inflammation and microbial composition', Infection and Immunity, vol. 88, http://dx.doi.org/10.1128/IAI.00455-20

Wasinger VC; Lu K; Yau YY; Nash J; Lee J; Chang J; Paramsothy S; Kaakoush NO; Mitchell HM; Leong RWL, 2020, 'Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for ‘leaky-gut’ in inflammatory bowel disease', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-69746-w

Britton GJ; Contijoch EJ; Spindler MP; Aggarwala V; Dogan B; Bongers G; Mateo LS; Baltus A; Das A; Gevers D; Borody TJ; Kaakoush NO; Kamm MA; Mitchell H; Paramsothy S; Clemente JC; Colombel JF; Simpson KW; Dubinsky MC; Grinspan A; Faith JJ, 2020, 'Defined microbiota transplant restores Th17/RORγt+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, pp. 21536 - 21545, http://dx.doi.org/10.1073/pnas.1922189117

Leigh SJ; Kaakoush NO; Escorihuela RM; Westbrook RF; Morris MJ, 2020, 'Treadmill exercise has minimal impact on obesogenic diet-related gut microbiome changes but alters adipose and hypothalamic gene expression in rats', Nutrition and Metabolism, vol. 17, pp. 71, http://dx.doi.org/10.1186/s12986-020-00492-6

Kaakoush NO, 2020, 'Fecal transplants as a microbiome-based therapeutic', Current Opinion in Microbiology, vol. 56, pp. 16 - 23, http://dx.doi.org/10.1016/j.mib.2020.05.008

Kaakoush NO, 2020, 'Sutterella Species, IgA-degrading Bacteria in Ulcerative Colitis', Trends in Microbiology, vol. 28, pp. 519 - 522, http://dx.doi.org/10.1016/j.tim.2020.02.018

Leonardi I; Paramsothy S; Doron I; Semon A; Kaakoush NO; Clemente JC; Faith JJ; Borody TJ; Mitchell HM; Colombel JF; Kamm MA; Iliev ID, 2020, 'Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis', Cell Host and Microbe, vol. 27, pp. 823 - 829.e3, http://dx.doi.org/10.1016/j.chom.2020.03.006

Paris VR; Kaakoush NO; Solon-Biet SM; Edwards MC; Ledger WL; Gilchrist RB; Simpson SJ; Handelsman DJ; Walters KA, 2020, 'MON-022 Dissecting the Interplay Between Diet and PCOS Pathology on Gut Microbiota in a PCOS Mouse Model', Journal of the Endocrine Society, vol. 4, http://dx.doi.org/10.1210/jendso/bvaa046.568

Castaño-Rodríguez N; Paramsothy S; Kaakoush NO, 2020, 'Promise of Fecal Microbiota Transplantation Therapy in Pouchitis', Digestive Diseases and Sciences, vol. 65, pp. 1107 - 1110, http://dx.doi.org/10.1007/s10620-019-05831-z

Ghaly S; Kaakoush NO; Hart PH, 2020, 'Effects of UVR exposure on the gut microbiota of mice and humans', Photochemical and Photobiological Sciences, vol. 19, pp. 20 - 28, http://dx.doi.org/10.1039/c9pp00443b

Haifer C; Paramsothy S; Borody TJ; Clancy A; Kingston-Smith H; Leong RW; Kaakoush NO, 2020, 'Mo1929 ORALLY ADMINISTERED LYOPHILIZED FECAL MICROBIOTA TRANSPLANTATION IN CLOSTRIDIOIDES DIFFICILE INFECTION - LONG TERM CLINICAL AND MICROBIOLOGICAL OUTCOMES', Gastroenterology, vol. 158, pp. S - 981, http://dx.doi.org/10.1016/s0016-5085(20)33126-7

Coffey MJ; Nielsen S; Wemheuer B; Kaakoush NO; Garg M; Needham B; Pickford R; Jaffe A; Thomas T; Ooi CY, 2019, 'Gut Microbiota in Children With Cystic Fibrosis: A Taxonomic and Functional Dysbiosis', Scientific Reports, vol. 9, pp. 18593, http://dx.doi.org/10.1038/s41598-019-55028-7

Vinasco K; Mitchell HM; Kaakoush NO; Castaño-Rodríguez N, 2019, 'Microbial carcinogenesis: Lactic acid bacteria in gastric cancer', Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1872, pp. 188309, http://dx.doi.org/10.1016/j.bbcan.2019.07.004

Paramsothy S; Kaakoush NO, 2019, 'Reply', Gastroenterology, vol. 157, pp. 1165 - 1166, http://dx.doi.org/10.1053/j.gastro.2019.08.005

Simovic I; Castaño-Rodríguez N; Kaakoush NO, 2019, 'OPCML: A Promising Biomarker and Therapeutic Avenue', Trends in Cancer, vol. 5, pp. 463 - 466, http://dx.doi.org/10.1016/j.trecan.2019.06.002

Pinget G; Tan J; Janac B; Kaakoush NO; Angelatos AS; O’sullivan J; Koay YC; Sierro F; Davis J; Divakarla SK; Khanal D; Moore RJ; Stanley D; Chrzanowski W; Macia L, 2019, 'Corrigendum: Impact of the food additive titanium dioxide (e171) on gut microbiota-host interaction (Front. Nutr., (2019), 6, 10.3389/fnut.2019.00057)', Frontiers in Nutrition, vol. 6, http://dx.doi.org/10.3389/fnut.2019.00100

Krishnan U; Singh H; Kaakoush N, 2019, 'DOZ047.04: Upper gastrointestinal microbiome in esophageal atresia', Diseases of the Esophagus, vol. 32, http://dx.doi.org/10.1093/dote/doz047.04

Krishnan U; Singh H; Kaakoush N; Leach S, 2019, 'DOZ047.18: Diagnosing reflux aspiration in esophageal atresia: role of microbiome and pepsin', Diseases of the Esophagus, vol. 32, http://dx.doi.org/10.1093/dote/doz047.18

Pinget G; Tan J; Janac B; Kaakoush NO; Angelatos AS; O'Sullivan J; Koay YC; Sierro F; Davis J; Divakarla SK; Khanal D; Moore RJ; Stanley D; Chrzanowski W; Macia L, 2019, 'Impact of the food additive titanium dioxide (e171) on gut microbiota-host interaction', Frontiers in Nutrition, vol. 6, http://dx.doi.org/10.3389/fnut.2019.00057

Ong KL; Hui N; Januszewski AS; Kaakoush NO; Xu A; Fayyad R; DeMicco DA; Jenkins AJ; Keech AC; Waters DD; Barter PJ; Rye KA, 2019, 'High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study)', Metabolism: Clinical and Experimental, vol. 93, pp. 93 - 99, http://dx.doi.org/10.1016/j.metabol.2018.11.006

Paramsothy S; Nielsen S; Kamm MA; Deshpande NP; Faith JJ; Clemente JC; Paramsothy R; Walsh AJ; van den Bogaerde J; Samuel D; Leong RWL; Connor S; Ng W; Lin E; Borody TJ; Wilkins MR; Colombel JF; Mitchell HM; Kaakoush NO, 2019, 'Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis', Gastroenterology, vol. 156, pp. 1440 - 1454.e2, http://dx.doi.org/10.1053/j.gastro.2018.12.001

Mathur A; Feng S; Hayward JA; Ngo C; Fox D; Atmosukarto II; Price JD; Schauer K; Märtlbauer E; Robertson AAB; Burgio G; Fox EM; Leppla SH; Kaakoush NO; Man SM, 2019, 'A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome', Nature Microbiology, vol. 4, pp. 362 - 374, http://dx.doi.org/10.1038/s41564-018-0318-0

Leong RWL; Kaakoush NO; Yau YY; Wasinger VC, 2019, 'Editorial: metabolomic biomarkers for colorectal adenocarcinoma and in the differentiation between irritable bowel syndrome and ulcerative colitis in clinical remission— confounded by the gut microbiome?', Alimentary Pharmacology and Therapeutics, vol. 49, pp. 1086 - 1087, http://dx.doi.org/10.1111/apt.15171

Deshpande NP; Riordan SM; Castaño-Rodríguez N; Wilkins MR; Kaakoush NO, 2018, 'Signatures within the esophageal microbiome are associated with host genetics, age, and disease', Microbiome, vol. 6, pp. 227, http://dx.doi.org/10.1186/s40168-018-0611-4

Castaño-Rodríguez N; Popple GL; Porras-Hurtado GL; Cardona-Deazza JL; Montoya-Martinez JJ; Cadavid-Velez AJ; Toro-Hidalgo HW; Cobo-Alvarado AR; Del Socorro Hincapié-Rincón O; Riordan SM; Kaakoush NO, 2018, 'OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus', Biomarker Research, vol. 6, pp. 35, http://dx.doi.org/10.1186/s40364-018-0150-y

Ghaly S; Kaakoush NO; Lloyd F; McGonigle T; Mok D; Baird A; Klopcic B; Gordon L; Gorman S; Forest C; Bouillon R; Lawrance IC; Hart PH, 2018, 'High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-29759-y


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